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Keywords: platelet-derived growth factor receptor (PDGFR)
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Articles

Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

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Rikard G. Fred, Santosh Kumar Boddeti, Marcus Lundberg, Nils Welsh
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (1): 17–28.
https://doi.org/10.1042/CS20130560
Published: 27 August 2014
...Rikard G. Fred; Santosh Kumar Boddeti; Marcus Lundberg; Nils Welsh Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic and multi-functional type I cell surface membrane protein, which is known to be phosphorylated by the activated platelet-derived growth factor receptor (PDGFR...
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Articles

Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

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Dariush Mokhtari, Nils Welsh
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (4): 241–247.
https://doi.org/10.1042/CS20090348
Published: 09 November 2009
... Journal compilation © 2010 Biochemical Society 2010 β-cell diabetes imatinib c-Abl platelet-derived growth factor receptor (PDGFR) tyrosine kinase inhibitor Patients diagnosed with T1D (Type 1 diabetes) have usually lost a substantial proportion of their β-cells and therefore...
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