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Keywords: platelets
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Articles
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
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Clin Sci (Lond) (2020) 134 (21): 2807–2822.
Published: 03 November 2020
...Sarah M. Hicks; Christine S.M. Lee; Sidra A. Ali; Philip Y. Choi; Elizabeth E. Gardiner Platelets have a predominant role in haemostasis, the maintenance of blood volume and emerging roles as innate immune cells, in wound healing and in inflammatory responses. Platelets express receptors...
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Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
...Erik Westein; Thomas Hoefer; Anna C. Calkin Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond...
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Clin Sci (Lond) (2016) 130 (24): 2295–2303.
Published: 10 November 2016
...Joan Raouf; Fariborz Mobarrez; Karin Larsson; Per-Johan Jakobsson; Marina Korotkova Microsomal prostaglandin E 2 synthase-1 (mPGES-1) constitutes an essential player in inflammation and is involved in the pathogenesis of rheumatoid arthritis. Platelets participate in the regulation of inflammatory...
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Clin Sci (Lond) (2016) 130 (6): 441–442.
Published: 04 February 2016
...David W. Essex; A. Koneti Rao Platelets play a major role in the complex interactions involved in blood coagulation via multiple mechanisms. As reported in this issue, Schoergenhofer et al. tested the hypothesis that platelet inhibition by prasugrel, a potent platelet P2Y 12 ADP receptor antagonist...
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Clin Sci (Lond) (2005) 109 (3): 267–276.
Published: 24 August 2005
... in the ischaemic region. In conclusion, IP abolished angioplasty-induced myeloperoxidase release by preventing activated platelet-induced P-selectin release via a K ATP -channel-initiated pathway. Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory...
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Clin Sci (Lond) (1999) 96 (4): 431–436.
Published: 01 April 1999
... released from platelets. We herein summarize recent observations that collectively support the hypothesis that LPA may play a key role in the pathogenesis of initiation and progression of proliferative glomerulonephritis. LPA synergistically stimulates mesangial cell proliferation in combination...
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Clin Sci (Lond) (1998) 94 (1): 79–85.
Published: 01 January 1998
... fluorescent probes exploring either the outer membrane leaflet [trimethylamino-diphenylhexatriene (TMA-DPH)] or the lipid membrane core [diphenylhexatriene (DPH)], in platelets and erythrocytes of genetically hypertensive rats of the Prague hereditary hypertriglyceridaemic (HTG) strain. The relationships...
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Clin Sci (Lond) (1997) 93 (3): 249–255.
Published: 01 September 1997
...H. A. de Silva; J. G. Carver; J. K. Aronson 1. Previous electrophysiological studies have suggested the presence of K Ca and K v channels in human platelets. However, the pharmacology of these channels has not been defined. 2. We have studied potassium channels in human platelets by measuring...
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Clin Sci (Lond) (1996) 90 (5): 363–368.
Published: 01 May 1996
...Philip R. Belcher; Angela J. Drake-Holland; John W. Hynd; Mark I. M. Noble 1. Recurrent occlusion after thrombolysis may be caused by thrombin receptor-mediated platelet thrombosis occurring in a residual stenosis. To test the relative importance of the platelet thrombin receptor under conditions...
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Clin Sci (Lond) (1996) 90 (1): 13–19.
Published: 01 January 1996
... with urinary albumin excretion rates. 2. We have estimated platelet sodium-activated proton efflux (Na + /H + exchange rate), based on a fluorimetric method, in 43 type 2 diabetic patients, of whom 29 were normoalbuminuric and 14 microalbuminuric, and in 10 non-diabetic control subjects. The factors measured...
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Clin Sci (Lond) (1994) 86 (3): 263–268.
Published: 01 March 1994
... on platelet membrane microviscosity in hypertension-prone and -resistant Sabra rats. 2. Sixteen hypertension-prone and 14 hypertension-resistant Sabra rats were submitted to either a low-salt (0.25% NaCl) or a high-salt (4% NaCl) diet for 3–4 weeks. Platelet membrane anisotropy was determined, in the presence...
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Clin Sci (Lond) (1992) 83 (3): 313–318.
Published: 01 September 1992
...M. P. Gordge; G. H. Neild 1. Platelets from patients on haemodialysis showed a loss of sensitivity to nitric oxide, reflected by a reduction in the ability of nitric oxide both to inhibit thrombin-induced aggregation and to increase intraplatelet cyclic GMP levels. Responses of platelets from...
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Clin Sci (Lond) (1992) 82 (4): 353–355.
Published: 01 April 1992
...S. D. Kristensen; J. F. Martin © 1992 The Biochemical Society and the Medical Research Society 1992 atherosclerosis megakaryocytes platelet volume platelet-derived growth factor platelets Clinical Science (1992) 82, 353-355 (Printed in Great Britain) Editorial Review 353...
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Clin Sci (Lond) (1992) 82 (1): 113–116.
Published: 01 January 1992
...C. C. T. Smith; B. N. C. Prichard; D. J. Betteridge 1. Plasma and platelet free catecholamine concentrations were measured in 22 normal subjects and in 10 treated and 11 untreated patients with heterozygous familial hypercholesterolaemia. 2. Plasma noradrenaline concentrations were significantly...
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Clin Sci (Lond) (1991) 81 (1): 11–15.
Published: 01 July 1991
...C. Rångemark; Å. Wennmalm 1. Cigarette smoking is known to increase the risk of cardiovascular disease in both men and women. Experimental and epidemiological studies have demonstrated that cigarette smoking is associated with several indices of increased platelet activation and platelet/vessel...
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Clin Sci (Lond) (1991) 80 (3): 205–211.
Published: 01 March 1991
...Kim-Hanh Le Quan Sang; Thérèse Montenay-Garestier; Marie-Aude Devynck 1. The metabolism of blood platelets, taken as an accessible model of excitable cells, has been reported to be altered in hypertension. Most of the identified alterations concern the functions of various plasma membrane...
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Clin Sci (Lond) (1991) 80 (2): 101–105.
Published: 01 February 1991
...Pietro Amedeo Modesti; Rosanna Abbate; Gian Franco Gensini; Andrea Colella; Gian Gastone Neri Serneri 1. Human platelet thromboxane A 2 receptor expression on the membrane surface is possibly dynamically regulated by changes either in the ligand concentration or in membrane fluidity. An increased...
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Clin Sci (Lond) (1989) 77 (2): 183–188.
Published: 01 August 1989
...A. F. Dominiczak; J. J. Morton; G. Murray; P. F. Semple 1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium...
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Clin Sci (Lond) (1989) 76 (1): 67–71.
Published: 01 January 1989
...S. M. Barr; K. R. Lees; L. Butters; A. O'Donnell; P. C. Rubin 1. Basal and stimulated platelet intracellular free calcium concentrations were measured in non-pregnant women and in third trimester patients who were either normotensive or who had pregnancy-induced hypertension or pre-eclampsia...
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Clin Sci (Lond) (1987) 73 (5): 525–529.
Published: 01 November 1987
...A. M. Van Rij; C. Wade; I. Kirk; C. Thomson; M. F. Robinson 1. Arachidonic acid metabolism through the lipoxygenase pathway in platelets was investigated in 11 patients with low selenium (Se) nutritional status and compared with 14 patients with a normal Se status. 2. Plasma and whole blood Se...
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Clin Sci (Lond) (1986) 70 (5): 495–500.
Published: 01 May 1986
...C. C. T. Smith; A. P. Wilson; B. N. C. Prichard; D. J. Betteridge 1. Using high-performance liquid chromatography with electrochemical detection, we have studied the release of endogenous catecholamines from washed platelets induced to aggregate by ADP and thrombin. 2. Washed platelets exhibit...
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Clin Sci (Lond) (1985) 69 (2): 235–238.
Published: 01 August 1985
...N. Mishra; C. A. Hamilton; C. R. Jones; C. Leslie; J. L. Reid 1. α 2 -Adrenoceptors on blood platelets have been widely used as a model for α-adrenoceptors in less accessible tissues. 2. The effect of oestrogen (200 μg/day intramuscularly) on α 2 -adrenoceptor number and function was studied...
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Clin Sci (Lond) (1985) 69 (1): 1–6.
Published: 01 July 1985
...C. C. T. Smith; L. D. Curtis; A. P. Delamothe; B. N. C. Prichard; D. J. Betteridge 1. We have used high-performance liquid chromatography with electrochemical detection to measure content of adrenaline and noradrenaline in platelets in 13 normal subjects at rest. 2. Subjects were exercised to raise...
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Clin Sci (Lond) (1985) 68 (6): 701–707.
Published: 01 June 1985
...R. D. Hughes; D. A. Lane; H. Ireland; P. G. Langley; A. E. S. Gimson; Roger Williams 1. The concentration in plasma of fibrinogen derivatives fibrinopeptide A (FPA) and Bβ1-42 and the platelet release products β-thromboglobulin (βTG) and platelet factor 4 (PF4) have been determined in patients...
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Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
.... 2. α 2 -Adrenoceptor stimulation in platelets showed an increased sensitivity to adrenaline, as determined by sensitivity in counteracting the inhibitor effect of PGI 2 on intracellular free calcium concentration in untreated patients with essential hypertension, when compared with treated patients...
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Clin Sci (Lond) (1985) 68 (s10): 21s–24s.
Published: 01 January 1985
... antagonists in blocking the B-HT 933-induced contractile responses of the dog saphenous vein and preventing adrenaline-induced aggregation of human platelets. 5. Together with previously published data derived from tritium overflow studies on rabbit pulmonary arteries and displacement of [ 3 H]-rauwolscine...
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Clin Sci (Lond) (1984) 67 (5): 551–555.
Published: 01 November 1984
...C. A. Jackson; M. Greaves; A. J. M. Boulton; J. D. Ward; F. E. Preston 1. The effect of improved glycaemic control, effected by 16 weeks continuous subcutaneous insulin infusion (CSII), on platelet aggregation and platelet prostaglandin biosynthesis has been assessed in a group of 11 diabetic...
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Clin Sci (Lond) (1984) 66 (6): 717–723.
Published: 01 June 1984
...I. Aracon-Birlouez; T. Montenay-Carestier; M. A. Devynck 1. Fluorescence Dolarization of dbhenvlhexa-triene embedded in membranes was used as an index of ‘microviscosity’ in platelets and ervthro—cyte ghosts of spontaneously hypertensive rats of the Okamoto-Aoki strain (SHR), Wistar-Kyoto strain...
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Clin Sci (Lond) (1984) 66 (6): 725–731.
Published: 01 June 1984
...Yuan Ding; Christopher J. Kenyon; Peter F. Semple 1. Platelets were prepared from peripheral venous blood on iso-osmotic density gradients of Percoll, resulting in a good recovery of cells (50–80%) which were relatively free of contaminating blood cells (erythrocyte <0.1%, leucocyte <0.1%). 2...
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Clin Sci (Lond) (1984) 66 (5): 605–612.
Published: 01 May 1984
...L. Neyses; R. Locher; M. Wehling; H. Pech; W. Tenschert; W. Vetter 1. It has recently been claimed that there are angiotensin II (ANG II) receptors on human mononuclear cells and on platelets and this has been used for investigating the regulation of the renin-angiotensin system in hypertension. We...
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Clin Sci (Lond) (1984) 66 (4): 443–451.
Published: 01 April 1984
...R. F. W. Moulds; V. Iwanov; R. L. Medcalf 1. The contractile responses of spiral strips of human digital arteries to samples of a suspension of human platelets aggregated by thrombin have been studied at different time intervals after aggregation. 2. Platelets added to the arterial strips 1 min...
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Clin Sci (Lond) (1984) 66 (1): 55–62.
Published: 01 January 1984
... clearance that was closer than the reciprocal of the t 1/2 of HD-RBC clearance ( r = 0.89, P < 0.001 at high coating; r = 0.76, P < 0.05 at low coating) but significantly closer only at high coating. 4. Splenic blood flow, measured using indium labelled platelets in ten subjects, correlated closely...
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Clin Sci (Lond) (1983) 64 (6): 637–642.
Published: 01 June 1983
... lipoprotein-cholesterol levels decreased markedly, but pre-exchange levels were not achieved within 2 weeks. High density lipoprotein-cholesterol and apolipoprotein A-I levels also fell but returned to the original concentration after only 5 days. 2. Platelet aggregation and [ 14 C]serotonin release were...
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Clin Sci (Lond) (1983) 64 (1): 63–68.
Published: 01 January 1983
...F. J. Lofts; P. K. Moore 1. Human platelet-rich plasma incubated at 37°C generates an antiaggregatory prostaglandin which is spasmogenic on gastrointestinal smooth muscle. 2. Platelet-rich plasma from female donors generated more biological activity and was more sensitive to the anti-aggregatory...