... is likely due to NMD, resulting in podocalyxin deficiency. Functional consequences caused by the PODXL nonsense mutations were inferred by siRNA knockdown in cultured podocytes and podocalyxin down-regulation by siRNA resulted in decreased RhoA and ezrin activities, cell migration and stress fiber formation...

...Lulu Jiang; Ishita Dasgupta; Jenny A. Hurcombe; Heather F. Colyer; Peter W. Mathieson; Gavin I. Welsh Our clinical and laboratory data suggest that levamisole should be added to the list of immunotherapeutic agents that have direct actions on podocytes and point to the usefulness of levamisole...

... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...

...)-immunopositive podocyte numbers were found to be lower in the untreated glomeruli of mice with diabetes. The expression of podocin and nephrin were continually decreased in mice with diabetes between 18 and 22 weeks of age. These changes are indicative of podocyte injury and the administration of valsartan...

...Mervi Ristola; Sanna Lehtonen Nephrin and Neph-family proteins [Neph1–3 (nephrin-like 1–3)] belong to the immunoglobulin superfamily of cell-adhesion receptors and are expressed in the glomerular podocytes. Both nephrin and Neph-family members function in cell adhesion and signalling, and thus...

...Jean-Louis R. Michaud; Chris R. J. Kennedy The glomerular filtration barrier consists of the fenestrated endothelium, the glomerular basement membrane and the terminally differentiated visceral epithelial cells known as podocytes. It is now widely accepted that damage to, or originating within...

... and to suggest a possible explanation for the link between albuminuria and insulin resistance. Table 1 Podocyte genes, effects of mutations and putative functions Human diseases are autosomal recessive unless stated. NS, nephrotic syndrome; FSGS, focal segmental glomerulosclerosis. Effect...

... José G. van den Berg (email [email protected] ). 26 3 2004 11 5 2004 25 5 2004 25 5 2004 The Biochemical Society 2004 allergy atopy focal and segmental glomerulosclerosis (FSGS) minimal change nephrotic syndrome (MCNS) nephrotic syndrome podocyte...

... of mRNAs for neuropilin-1, neuropilin-2 and soluble neuropilin was studied in whole kidney, sieved glomeruli and cultured podocytes by reverse transcription-PCR, and neuropilin-1 mRNA expression in isolated single glomeruli was analysed by nested reverse transcription-PCR. The expression of neuropilin-1...