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Keywords: podocyte
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Clin Sci (Lond) (2019) 133 (1): 9–21.
Published: 03 January 2019
... is likely due to NMD, resulting in podocalyxin deficiency. Functional consequences caused by the PODXL nonsense mutations were inferred by siRNA knockdown in cultured podocytes and podocalyxin down-regulation by siRNA resulted in decreased RhoA and ezrin activities, cell migration and stress fiber formation...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
Clin Sci (Lond) (2014) 126 (5): 315–328.
Published: 25 October 2013
...Mervi Ristola; Sanna Lehtonen Nephrin and Neph-family proteins [Neph1–3 (nephrin-like 1–3)] belong to the immunoglobulin superfamily of cell-adhesion receptors and are expressed in the glomerular podocytes. Both nephrin and Neph-family members function in cell adhesion and signalling, and thus...
Clin Sci (Lond) (2007) 112 (6): 325–335.
Published: 12 February 2007
...Jean-Louis R. Michaud; Chris R. J. Kennedy The glomerular filtration barrier consists of the fenestrated endothelium, the glomerular basement membrane and the terminally differentiated visceral epithelial cells known as podocytes. It is now widely accepted that damage to, or originating within...
Clin Sci (Lond) (2004) 107 (6): 533–538.
Published: 24 November 2004
... and to suggest a possible explanation for the link between albuminuria and insulin resistance. Correspondence: Professor Peter Mathieson (email p.mathieson@bris.ac.uk ). The Biochemical Society 2004 albuminuria basement membrane endothelial cell glomerular filtration nephrotic syndrome podocyte...
Clin Sci (Lond) (2004) 107 (2): 125–136.
Published: 27 July 2004
... José G. van den Berg (email j.g.vandenberg@amc.uva.nl ). 26 3 2004 11 5 2004 25 5 2004 25 5 2004 The Biochemical Society 2004 allergy atopy focal and segmental glomerulosclerosis (FSGS) minimal change nephrotic syndrome (MCNS) nephrotic syndrome podocyte...
Clin Sci (Lond) (2001) 101 (4): 439–446.
Published: 20 September 2001
... of mRNAs for neuropilin-1, neuropilin-2 and soluble neuropilin was studied in whole kidney, sieved glomeruli and cultured podocytes by reverse transcription-PCR, and neuropilin-1 mRNA expression in isolated single glomeruli was analysed by nested reverse transcription-PCR. The expression of neuropilin-1...