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Keywords: podocytes
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Clin Sci (Lond) (2022) 136 (20): 1467–1470.
Published: 26 October 2022
...Sanket Patel; Kalyani Kulkarni; Tahir Hussain Podocyte injury due to either drug, toxin, infection, or metabolic abnormality is a great concern as it increases the risk of developing focal segmental glomerulosclerosis (FSGS) and proteinuric kidney diseases. The direct podocyte injury due...
Articles
Clin Sci (Lond) (2022) 136 (10): 715–731.
Published: 20 May 2022
...Min-Chun Liao; Kana N. Miyata; Shiao-Ying Chang; Xin-Ping Zhao; Chao-Sheng Lo; Mohamad-Ali El-Mortada; Junzheng Peng; Isabelle Chenier; Michifumi Yamashita; Julie R. Ingelfinger; John S.D. Chan; Shao-Ling Zhang Podocyte damage and loss are the early event in the development of focal segmental...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
... of all chronic kidney diseases (CKDs). Podocytes play a key role in maintaining the permselectivity of the glomerular filtration barrier (GFB) and injury of the podocyte, leading to foot process (FP) effacement and podocyte loss, the unifying underlying mechanism of proteinuric glomerulopathies...
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Articles
Clin Sci (Lond) (2020) 134 (11): 1245–1253.
Published: 05 June 2020
...Paul A. Reynolds Chronic kidney disease (CKD) substantially reduces quality of life and leads to premature death for thousands of people each year. Dialysis and kidney organ transplants remain prevalent therapeutic avenues but carry significant medical, economic and social burden. Podocytes...
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Articles
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
... 05 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarkers diabetes diabetic kidney disease glomerulus GSK-3β inflammation lncRNA mesangial cells pathogenesis podocytes renal tubular cells therapies Diabetic...
Articles
Clin Sci (Lond) (2019) 133 (3): 443–447.
Published: 08 February 2019
... identified a common theme: familial podocytopathies are frequently caused by genes selectively expressed in podocytes. Podocalyxin is a podocyte-specific surface sialomucin that has long been known to play important roles in podocyte morphogenesis and function. Few studies, however, have shown a conclusive...
Articles
Clin Sci (Lond) (2016) 130 (24): 2317–2327.
Published: 15 November 2016
... pathways in T-helper 2 (Th2) cytokine associated minimal change nephrotic syndrome (MCNS). We hypothesized that IL-13 may act directly on podocytes, causing podocyte foot process effacement and hence proteinuria in our rat model of minimal change-like nephropathy. The present study aimed firstly...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1225–1236.
Published: 11 November 2015
...-A is constitutively expressed in podocytes [ 11 – 13 ] whereas its receptors VEGFR-1 and VEGFR-2 are predominately localized on the glomerular endothelial cells [ 11 , 14 ]. It is proposed that podocyte VEGF-A binds to its receptors on the endothelium of the capillary lumen by diffusive flux, an event that occurs...