... ethics committee, and all patients (and their parents if under 17 years old) gave their informed and written consent to the study. Key words: congenital heart diswe, cyanosis, hypoxia. nuclear magnetic resonance spectroscopy, polycythaemia, skeletal muscle. Abbreviations: PCr, phosphocreatine; pHi...

... is associated with increased serum erythropoietin levels both by day and by night. © 1993 The Biochemical Society and the Medical Research Society 1993 circadian rhythm chronic bronchitis emphysema erythropoietin hypoxaemia polycythaemia Clinical Science (1993) 84, 319-324 (Printed in Great...

...A. R. Douglas; J. C. Moore-Gillon; J. W. S. Sheldon; I. R. Cameron 1. Polycythaemia occurs in man secondary to chronic hypoxaemia, and may lead to morbidity from hyperviscosity of the blood. Hypoxaemic rats develop similar changes. We have investigated the effect of the calcium antagonist verapamil...

...P. J. W. Wallis; J. D. Skehan; A. C. Newland; J. A. Wedzicha; P. G. Mills; D. W. Empey 1. Reducing packed cell volume has been advocated as a therapeutic procedure in patients with polycythaemia secondary to hypoxic cor pulmonale. The aim of this investigation was to evaluate the effects...

... role of intermittent hypoxia in producing polycythaemia and pulmonary hypertension has been the subject of much speculation. Our results show that intermittent hypoxia is a potent stimulus to erythropoiesis and to pulmonary hypertension, reflected in RV hypertrophy. They support the view...

...J. A. Wedzicha; P. Mary Cotes; D. W. Empey; A. C. Newland; J. P. Royston; R. C. Tam 1. We studied 20 patients with chronic airflow obstruction, 10 patients without polycythaemia and 10 patients with compensatory polycythaemia having respectively mean red cell mass 24.7 (sd 4.2) and 47.8 ( sd 7.5...

...J. A. Wedzicha; F. E. Cotter; P. J. W. Wallis; A. C. Newland; D. W. Empey 1. The transfer factor for carbon monoxide and its subdivisions, the membrane diffusing capacity ( D m ) and the pulmonary capillary blood volume ( V c ), were measured in 16 patients with polycythaemia secondary to chronic...