...-aminolaevulinate synthase and accumulation of porphyrins with uroporphyrin and heptacarboxylic porphyrin predominating. 2. Diltiazem, another calcium channel blocking drug, did not affect uroporphyrinogen decarboxylase activity and had a slight effect only on the accumulation of porphyrins. 3. Experiments...

... excretions of porphyrins plus their precursors were also determined. 2. In liver homogenates from subjects of each group, addition of an exogenous system for generation of succinyl-coenzyme A (CoA), including succinic thiokinase, resulted in appreciable enhancement of activity beyond that obtained without...

...T. K. With 1. A simple chromatographic method for the study of porphyrins in erythrocytes and blood plasma, requiring little technician time, is described. The findings in adults and neonates are presented as well as those from severely ill patients. 2. The regular occurrence of uro-, copro...

...M. J. Brodie; D. J. M. Graham; G. G. Thompson; M. R. Moore; A. Goldberg 1. Kryptopyrrole (2,4-dimethyl-3-ethyl pyrrole) was shown to elevate the urinary porphyrin excretion and the hepatic content of porphyrins in the rat. The simultaneous administration of δ-aminolaevulinic acid increased...

... porphyrins studied as a function of time. In one of these patients the study was repeated after partial depletion of stored liver porphyrins by low-dose chloroquine therapy. 2. Maximal radioactive incorporation into the urinary porphyrins was generally inversely related to the degree of carboxylation. In all...