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Keywords: portal hypertension
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Clin Sci (Lond) (2022) 136 (20): 1449–1466.
Published: 26 October 2022
...Hui-Chun Huang; Ching-Chih Chang; Chon Kit Pun; Ming-Hung Tsai; Chiao-Lin Chuang; Shao-Jung Hsu; Yi-Hsiang Huang; Ming-Chih Hou; Fa-Yauh Lee Exposure to low temperatures has been associated with increased gastroesophageal variceal bleeding in patients with cirrhosis and portal hypertension; however...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (6): 425–429.
Published: 25 March 2022
...Emilie K. Mitten; György Baffy In this commentary, we discuss new findings indicating that microbiota transplantation has favorable impact on portal hypertension (PH) in the experimental model of cirrhosis induced by bile duct ligation (BDL) (Huang et al.; Clin Sci (Lond) (2021) 135(24): 2709–2728...
Clin Sci (Lond) (2021) 135 (24): 2709–2728.
Published: 15 December 2021
...Hui-Chun Huang; Ming-Hung Tsai; Ching-Chih Chang; Chon Kit Pun; Yi-Hsiang Huang; Ming-Chih Hou; Fa-Yauh Lee; Shao-Jung Hsu Liver cirrhosis and portal hypertension is the end of chronic liver injury with hepatic, splanchnic and portosystemic collateral systems dysregulation. Liver injury...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (12): 1341–1343.
Published: 28 June 2018
...Audrey Payancé; Pierre-Emmanuel Rautou Data on the consequences of cirrhosis regression on portal hypertension and on splanchnic and systemic hemodynamic are scarce. Previous studies have reported a decrease in hepatic venous pressure gradient following antiviral treatment in patients...
Clin Sci (Lond) (2018) 132 (6): 669–683.
Published: 26 March 2018
...Shao-Jung Hsu; Ming-Hung Tsai; Ching-Chih Chang; Yu-Hsin Hsieh; Hui-Chun Huang; Fa-Yauh Lee; Chiao-Ling Chuang; Ming-Chih Hou; Shou-Dong Lee Liver cirrhosis is characterized by portal hypertension. However, the alteration of portal hypertension-related derangements during cirrhosis resolution...
Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
... intrahepatic resistance, increased portal-systemic collaterals and abnormal intra- and extra-hepatic vascular responsiveness. These derangements aggravate portal hypertension-related complications such as gastro-oesophageal variceal bleeding. Homocysteine, a substance implicated in cardiovascular diseases, has...
Clin Sci (Lond) (2015) 129 (10): 875–883.
Published: 01 September 2015
... Roberto Lambertucci; Anna Mae Diehl Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. We evaluated the hypothesis that schistosome...
Includes: Supplementary data
Clin Sci (Lond) (2013) 125 (2): 67–75.
Published: 26 March 2013
... flow portal hypertension • The death rate from portal hypertensive bleeding in cirrhotic patients is still high. The role of calcium in portal hemodynamics is poorly documented, despite the beneficial role of this electrolyte in achieving a diuresis in patients and experimental models...
Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
... to the pathophysiology of portal hypertension in cirrhosis. Although the intrahepatic circulation in cirrhosis is hypercontractile in response to AngII, resulting in increased hepatic resistance, the splanchnic vasculature is hyporesponsive, promoting the development of the hyperdynamic circulation that characterizes...
Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... methyl ester) and the CGRP (calcitonin gene-related peptide) receptor antagonist CGRP-(8–37) in mesenteric segments from ST (short-term; 1 month) and LT (long-term; 21 months) SO (sham-operated) and pre-hepatic PH (portal hypertensive) rats. The vasomotor responses to NA (noradrenaline), the NO donor DEA...
Clin Sci (Lond) (2011) 121 (12): 545–554.
Published: 22 August 2011
...Jing-Yi Lee; Teh-Ia Huo; Hui-Chun Huang; Fa-Yauh Lee; Han-Chieh Lin; Chiao-Lin Chuang; Ching-Chih Chang; Sun-Sang Wang; Shou-Dong Lee Gastro-oesophageal variceal haemorrhage is one of the most dreadful complications of portal hypertension and can be controlled with vasoconstrictors. Nevertheless...
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
...Javier Blanco-Rivero; Ma Angeles Aller; Jaime Arias; Mercedes Ferrer; Gloria Balfagón In the present study, we have analysed both the effect of long-term portal hypertension on the vasomotor response to acetylcholine in rat aorta and the mechanism involved in this response. For this purpose, sham...
Clin Sci (Lond) (2009) 116 (12): 851–859.
Published: 14 May 2009
... was steeper in subjects with alcoholic aetiology as compared with viral aetiology ( P =0.02), suggesting that these patients have a further QTc prolongation when heart rate decreases. The plasma calcium concentration was inversely correlated with QTc ( P <0.001). The presence of severe portal hypertension...
Clin Sci (Lond) (2002) 103 (1): 43–51.
Published: 07 June 2002
... response of resistance microvessels, despite adequate baroreceptor function. carotid baroreceptors portal hypertension spectral analysis systemic haemodynamics transcranial Doppler. Correspondence: Dr Giorgio La Villa (e-mail g.lavilla@dmi.unifi.it ). 20 10 2001 8 2 2002 25...
Clin Sci (Lond) (2000) 99 (6): 475–482.
Published: 07 November 2000
...Chi-Jen CHU; Shwu-Ling WU; Fa-Yauh LEE; Sun-Sang WANG; Full-Young CHANG; Han-Chieh LIN; Che-Chang CHAN; Shou-Dong LEE Hyposensitivity to vasopressin is a well documented phenomenon in animals with portal hypertension and patients with cirrhosis subject to haemorrhage. Haemorrhage is associated...
Clin Sci (Lond) (2000) 99 (5): 455–460.
Published: 27 October 2000
... channels. Correspondence : Dr Noemí M. Atucha (e-mail ntma@fcu.um.es ). 10 3 2000 27 6 2000 26 7 2000 The Biochemical Society and the Medical Research Society © 2000 2000 isolated and perfused mesentery liver cirrhosis methoxamine nitric oxide portal hypertension...
Clin Sci (Lond) (1999) 96 (5): 475–481.
Published: 14 April 1999
...Panagiotis VLAVIANOS; Padraik MAC MATHUNA; Roger WILLIAMS; David WESTABY We investigated the haemodynamic response to volume depletion and subsequent repletion in patients with cirrhosis and portal hypertension. Twelve patients with compensated cirrhosis and portal hypertension were included...
Clin Sci (Lond) (1998) 96 (1): 41–47.
Published: 01 January 1999
...Claire CONNOLLY; Teresa CAWLEY; P. Aiden MCCORMICK; James R. DOCHERTY We have examined the effects of pre-hepatic portal hypertension on the responsiveness of aorta from Wistar and Sprague–Dawley rats. Rats were made portal hypertensive by creating a calibrated portal vein stenosis, or sham...
Clin Sci (Lond) (1998) 95 (5): 629–636.
Published: 01 November 1998
...Chi-Jen CHU; Fa-Yauh LEE; Sun-Sang WANG; Full-Young CHANG; Han-Chieh LIN; Ming-Chih HOU; Shwu-Ling WU; Chung-Ching TAI; Che-Chang CHAN; Shou-Dong LEE 1. Hyposensitivity to vasopressin is a well-documented phenomenon in animals with portal hypertension and patients with cirrhosis subjected...
Clin Sci (Lond) (1998) 94 (6): 645–650.
Published: 01 June 1998
...Han-Chieh Lin; Yi-Tsau Huang; Yuh-Ren Cheng; Ming-Chih Hou; Fa-Yauh Lee; Full-Young Chang; Yang-Te Tsai; Shou-Dong Lee 1. Both octreotide and isosorbide dinitrate have been shown to have portal hypotensive effects in animals with portal hypertension. Moreover, in both animals and humans with portal...
Clin Sci (Lond) (1998) 94 (4): 367–371.
Published: 01 April 1998
...Che-Chang Chan; Fa-Yauh Lee; Sun-Sang Wang; Full-Young Chang; Han-Chieh Lin; Hwai-Jeng Lin; Chi-Jen Chu; Shwu-Ling Wu; Chun-Ching Tai; Shou-Dong Lee 1. Portal hypertension and hyperdynamic circulation have been postulated to play a role in the pathogenesis of portal hypertensive gastropathy...
Clin Sci (Lond) (1997) 93 (3): 219–225.
Published: 01 September 1997
...Chi-Jen Chu; Fa-Yauh Lee; Sun-Sang Wang; LU Rei-Hwa; Yang-Te Tsai; Han-Chieh Lin; Ming-Chih Hou; Che-Chang Chan; Shou-Dong Lee 1. Hyperdynamic circulation observed in portal hypertensive states is characterized by generalized vasodilatation, increased cardiac index and increased systemic...
Clin Sci (Lond) (1997) 92 (5): 433–443.
Published: 01 May 1997
... cirrhosis hepatorenal syndrome portal hypertension renal blood flow Clinical Science (1997) 92,433-443 (Printed in Great Britain) 433 Editorial Review The hepatorenal syndrome Kevin MOORE Department of Medicine, Royal Free Hospital School of Medicine, London, U. K. 1. The hepatorenal syndrome...
Clin Sci (Lond) (1996) 91 (5): 601–606.
Published: 01 November 1996
...Yi-Tsau Huang; Ju-Fen Tsai; Tsun-Bin Liu; Chuang-Ye Hong; May C.-M. Yang; Han-Chieh Lin 1. It has been reported that octreotide partially corrects the hyperdynamic state in patients and animals with portal hypertension. The aim of the present study was to investigate whether chronic administration...
Clin Sci (Lond) (1996) 91 (1): 29–33.
Published: 01 July 1996
...Thierry Soupison; Song Yang; Catherine Bernard; Richard Moreau; Philippe Kirstetter; Mark D'Almeida; Stéphane Cailmail; Alain Tedgui; Didier Lebrec 1. Although pentoxifylline has been shown to reduce portal hypertension, the mechanism for this is unclear. Since pentoxifylline decreases tumour...
Clin Sci (Lond) (1993) 84 (2): 185–192.
Published: 01 February 1993
... and the Medical Research Society 1993 cirrhosis isolated perfused rat liver portal hypertension portal pressure Clinical Science (1993) 84, 185492 (Printed in Great Britain) I85 Augmented portal flow in the isolated perfused cirrhotic rat liver: a haemodynamic and morphological study Jorge E. CARDOSO...
Clin Sci (Lond) (1992) 83 (1): 41–45.
Published: 01 July 1992
...M. Dagenais; G. Pomier-Layrargues; B. Rocheleau; L. Giroux; P.-M. Huet 1. The systemic and splanchnic haemodynamic effects of pentifylline (40 mg/kg body weight intravenously) were assessed in rats with portal hypertension associated either with CCl 4 -induced cirrhosis ( n = 13) or portal vein...
Clin Sci (Lond) (1990) 78 (2): 193–197.
Published: 01 February 1990
... from 13.9 ± 0.7 to 16.5 ± 0.8 mmHg and portal tributary blood flow from 16.4 ± 1.3 to 28.2 ± 3.2 ml/min. Consequently, collateral vascular resistance significantly decreased from 7.0 ± 0. 5 × 10 3 to 4.9 ± 0.4 × 10 3 kPa l −1 s. 4. This study shows that in rats with portal hypertension, portal-systemic...
Clin Sci (Lond) (1989) 77 (1): 7–9.
Published: 01 July 1989
..., the beneficial effect of somatostatin analogue for the treatment of gastrointestinal bleeding due to portal hypertension. They suggest that administration of this substance should be started as soon as possible after the beginning of haemorrhage and continued after the cessation of bleeding. 13 2 1989...
Clin Sci (Lond) (1988) 74 (4): 433–436.
Published: 01 April 1988
... decreases in peripheral haemodynamics. 21 9 1987 9 10 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 forearm blood flow portal hypertension systemic circulation Clinical Science (1988) 74,433-436 433 Effects of nitroglycerin on forearm haemodynamics...
Clin Sci (Lond) (1986) 71 (6): 743–747.
Published: 01 December 1986
... of this study was to investigate clinical conditions in which increased Droduction of prostacyclin has been reported* 6-ox0- Key words: atheroma, portal hypertension, prosta- prostaglandin F,, (6-oxo-PGF1,) is the stable hydro- lysis product of PGI, and was measured in plasma cyclin, surgery. Abbreviations: GC...
Clin Sci (Lond) (1985) 68 (1): 23–28.
Published: 01 January 1985
...D. Lebrec; L. Blanchet 1. Splanchnic organ blood flow and cardiac output were measured by the microsphere method in fasted rats with prehepatic portal hypertension due to portal vein stenosis, in rats with intrahepatic portal hypertension due to bile duct ligation, and in unoperated normal rats. 2...
Clin Sci (Lond) (1982) 63 (1): 29–32.
Published: 01 July 1982
... in portal blood flow which is related, in part, to a reduction in cardiac output; (c) propranolol does not alter hepatic blood flow in normal rats or in rats with portal hypertension. 21 9 1981 26 1 1982 11 12 1981 © 1982 The Biochemical Society and the Medical Research Society 1982...