... Address: Department of Materia Medica, Uni- versity of Glasgow, Stobhill General Hospital, Glasgow, Scotland, U.K. Correspondence: Dr J . C. McGrath, Institute of Physiology, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Key words: a-adrenoceptor subtypes, blood pressure, noradrenaline, prazosin...

...Henry L. Elliott; David J. Sumner; Kathleen McLean; Peter C. Rubin; John L. Reid 1. The responsiveness of α-receptors was compared in six young and six healthy elderly subjects by evaluating the haemodynamic effects of the a, antagonist prazosin and the pressor responses to the a, agonist...

...M. Andréjak; P. Fievet; R. Makdassi; E. Comoy; J. F. De Fremont; B. Coevoet; A. Fournier 1. In four patients, whose hypertension was not controlled (supine blood pressure > 150–90 mmHg) by addition of 5 mg/day of prazosin to previous treatment (diuretics and β-blockers), clonidine (150–450 μg...

...A. Morganti; Carla Sala; Anna Palermo; Lucia Turolo; A. Zanchetti 1. The possibility that the juxtaglomerular α 1 -adrenoceptors mediate an inhibitory action on renin release in man was examined in seven patients with essential hypertension, by measuring (i) the acute effects of prazosin (0.25 mg...

...D. McAreavey; A. M. M. Cumming; V. P. Sood; B. J. Leckie; J. J. Morton; G. D. Murray; J. I. S. Robertson 1. We studied the effect of oral prazosin on blood pressure, plasma active renin and angiotensin II in 16 recumbent hypertensive patients between 09.00 and 12.00 hours. 2. In untreated patients...

...S. N. Hunyor; G. I. Nelson; G. L. Donnelly 1. Twelve hypertensive patients with cardiomegaly were treated with equivalent antihypertensive doses of prazosin (11 weeks) and β-adrenoceptor-blocking drug (9 weeks) in random crossover fashion. 2. At the end of each treatment period haemodynamic...

...S. Z. Langer; R. Massingham; N. B. Shepperson 1. In the autoperfused hind limb of the dog prazosin (10μg/kg intravenously) markedly antagonized responses to lumbar sympathetic stimulation, whereas responses to injected nor-adrenaline were largely unaffected. 2. In β-adrenoreceptor- and ganglion...

...G. S. Stokes; J. C. Monaghan; G. W. Frost; E. P. MacCarthy 1. The fall in blood pressure produced by a test dose of prazosin was greater in a group of patients with chronic renal failure than in a group with normal renal function. 2. This difference could not be attributed to increased reactivity...

...J. Rosenthal; H. Jaeger; I. Arlart 1. The effects of oral administration of 4·5 mg of prazosin/day on blood pressure and on plasma renin activity were assessed in patients with essential hypertension and in healthy normotensive volunteer subjects. 2. Mean blood pressure in the hypertensive group...

...P. A. Van Zwieten; E. Lam; P. B. M. W. M. Timmermans 1. The interaction between prazosin and clonidine was studied in anaesthetized rats, pithed rats and in anaesthetized cats. 2. Prazosin diminished the clonidine-induced hypotensive effect in anaesthetized rats, probably via an antagonism...

...I. Cavero 1. In pentobarbitone-anaesthetized dogs, prazosin (2×1·3 μmol day —1 kg —1 ; 2×0·5 mg day —1 kg —1 ) administered orally for 3 days reduced resting aortic blood pressure as well as the pressor response to bilateral carotid occlusion. Prazosin neither affected resting heart rate nor...

...J. S. Kim 1. The effects of prazosin administered alone or in combination were studied in thirty patients between August 1974 and March 1975. 2. All patients had previously received treatment for hypertension with other agents, for from 2 months to 10 years. All thirty patients had refractory...

...K. Rasmussen; H. Æ. Jensen 1. In a cross-over study between hydrallazine and prazosin in fifteen patients, also treated with the β-receptor-blocking agent propranolol, 1 mg of prazosin was found to be equipotent with 30 mg of hydrallazine. 2. All patients were known to tolerate hydrallazine. In one...

...P. Bolli; A. J. Wood; E. L. Phelan; D. R. Lee; F. O. Simpson 1. Prazosin had a considerable anti-hypertensive effect in both lying and standing posture in a mixed group of twenty-four patients in an open clinical trial. The drug was well tolerated and side-effects were few. 2. Tested on rat blood...

...M. Fernandes; I. Sanford Smith; A. Weder; K. E. Kim; Anne B. Gould; Patricia Busby; C. Swartz; G. Onesti 1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats...

.... An increasing effect on the blood pressure was demonstrated with doses between 1 and 2 g per day. 4. A new drug, prazosin hydrochloride, with properties somewhat similar to hydrallazine but with few side effects promises to be useful in the control of severe refractory hypertension particularly in combination...