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1-28 of 28
Keywords: preeclampsia
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Articles
Amanda A. de Oliveira, Emma Elder, Floor Spaans, Murilo E. Graton, Anita Quon, Raven Kirschenman, Amy L. Wooldridge, Christy-Lynn M. Cooke, Sandra T. Davidge
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (4): 137–151.
Published: 14 February 2024
... hypercholesterolemia increases the risk of complications, such as preeclampsia. However, the underlying mechanisms are unclear. Toll-like receptor 4 (TLR4) is a membrane receptor modulated by high cholesterol levels, leading to endothelial dysfunction; but whether excessive hypercholesterolemia in pregnancy activates...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (22): 1699–1719.
Published: 21 November 2023
...Yangyang Chen; Gui Wan; Zeyun Li; Xiaoxia Liu; Yin Zhao; Li Zou; Weifang Liu Placental neovascularization plays a crucial role in fetomaternal circulation throughout pregnancy and is dysregulated in several pregnancy-related diseases, including preeclampsia, gestational diabetes mellitus, and fetal...
Articles
In Collection
Reproductive Physiology and Disease
Renata Lúcia Vieira Pimentel, Janaína Félix Braga, Elizabeth Portugal Pimenta Velloso, Roberto Queiroga Lautner, Marilene Luzia de Oliveira, Mihail Todiras, Natalia Alenina, Michael Bader, Felipe Gaia de Sousa, Suzane Lilian Beier, RAS Santos
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1249–1263.
Published: 22 August 2023
...) system (RAS) between the Ang II/AT 1 and Ang-(1-7)/ Mas axis appears to be involved in preeclampsia (PE), in which a reduction in Ang-(1-7) was observed. Here, we tested whether the reduction in the activity of the Ang-(1-7)/ Mas axis could be a contributing factor for the development of PE, using Mas...
Articles
Helen Casey, Natalie Dennehy, Abigail Fraser, Christoph Lees, Carmel M. McEniery, Kayley Scott, Ian B. Wilkinson, Christian Delles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1211–1224.
Published: 22 August 2023
...Helen Casey; Natalie Dennehy; Abigail Fraser; Christoph Lees; Carmel M. McEniery; Kayley Scott; Ian B. Wilkinson; Christian Delles The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (3): 265–279.
Published: 10 February 2023
... shows all CpG sites. DNA methylation epigenetics linkage disequilibrium preeclampsia Pre-eclampsia (PE) is a complex syndrome characterized by new-onset of hypertension, proteinuria, and other signs of maternal vascular damage after 20 weeks of gestation [ 1 ]. It affects approximately 8...
Includes: Supplementary data
Articles
In Collection
Reproductive Physiology and Disease
Toluwalase Awoyemi, Ana Sofia Cerdeira, Wei Zhang, Shuhan Jiang, Maryam Rahbar, Prassana Logenthiran, Christopher Redman, Manu Vatish
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1793–1807.
Published: 13 December 2022
...Toluwalase Awoyemi; Ana Sofia Cerdeira; Wei Zhang; Shuhan Jiang; Maryam Rahbar; Prassana Logenthiran; Christopher Redman; Manu Vatish Preeclampsia (PE) is a hypertensive complication of pregnancy that affects 2–8% of women worldwide and is one of the leading causes of maternal deaths and premature...
Articles
Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (4): 257–272.
Published: 14 February 2022
... in preeclampsia, but its origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental chemerin expression and release in human pregnancy, and (2) the consequences of chemerin overexpression via lentivirus-mediated trophoblast-specific gene manipulation in both mice and immortalized...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2307–2327.
Published: 13 October 2021
...Usman M. Ashraf; Dalton L. Hall; Adam Z. Rawls; Barbara T. Alexander Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight (LBW). Offspring of women who had PE...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 heart failure hypertension leptin Obesity preeclampsia Women's Health Both adolescent and adult obesity prevalence has reached proportions of >30% in the United States...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1083–1101.
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2295–2313.
Published: 04 September 2020
...Tamara Sáez; Floor Spaans; Raven Kirschenman; Tatsuya Sawamura; Sandra T. Davidge The lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) has been shown to induce angiotensin II (AngII) type 1 receptor (AT 1 ) activation, contributing to vascular dysfunction. Preeclampsia...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
Articles
Suchismita Dutta, Andrew Lai, Katherin Scholz-Romero, Muhammad J. A. Shiddiky, Yusuke Yamauchi, Jay S. Mishra, Gregory E. Rice, Jon Hyett, Sathish Kumar, Carlos Salomon
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 593–607.
Published: 24 March 2020
... remodeling during early pregnancy. The bioactivity and release of these sEVs differ under differing oxygen tensions and in aberrant pregnancy conditions. Whether the placental cell-derived sEVs released from the hypoxic placenta contribute to the pathophysiology of preeclampsia is not known. We hypothesize...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 459–472.
Published: 04 March 2020
...Yunhui Tang; Yan Chen; Yohanes Nursalim; Katie Groom; Anthony Hickey; Larry Chamley; Qi Chen Antiphospholipid autoantibodies (aPLs), a major maternal risk factor for preeclampsia, are taken into the syncytiotrophoblast where they bind intracellular vesicles and mitochondria. Subsequently, large...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 289–302.
Published: 30 January 2020
...Yanling Chang; Yunyan Chen; Qiong Zhou; Chuan Wang; Lei Chen; Wen Di; Yu Zhang Preeclampsia (PE) is regarded as a pregnancy-associated hypertension disorder that is related to excessive inflammatory responses. Although the gut microbiota (GM) and short-chain fatty acids (SCFAs) have been related...
Includes: Supplementary data
Articles
In Collection
Clinical and translational research highlights
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 87–101.
Published: 21 January 2020
...Kenny Schlosser; Amanpreet Kaur; Natalie Dayan; Duncan J. Stewart; Louise Pilote; Christian Delles Women with a history of preeclampsia (PE) have increased risk of cardiovascular disease (CVD) later in life. However, the molecular determinants underlying this risk remain unclear. We sought...
Includes: Supplementary data
Articles
Emilie Hitzerd, Rugina I. Neuman, Katrina M. Mirabito Colafella, Irwin K.M. Reiss, Anton H. van den Meiracker, A.H. Jan Danser, Willy Visser, Jorie Versmissen, Langeza Saleh
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
..., most prominent being marinobufagenin (MBG). A synthetic pathway for MBG has been identified in mammalian placental tissue. Elevated maternal and fetal EDLF, O and MBG have been demonstrated in preeclampsia (PE), and inhibition of red cell membrane sodium, potassium ATPase (Na, K ATPase (NKA)) by EDLF...
Articles
Sabrina M. Scroggins, Donna A. Santillan, Jenna M. Lund, Jeremy A. Sandgren, Lindsay K. Krotz, Wendy S. Hamilton, Eric J. Devor, Heather A. Davis, Gary L. Pierce, Katherine N. Gibson-Corley, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (3): 419–436.
Published: 14 February 2018
...Sabrina M. Scroggins; Donna A. Santillan; Jenna M. Lund; Jeremy A. Sandgren; Lindsay K. Krotz; Wendy S. Hamilton; Eric J. Devor; Heather A. Davis; Gary L. Pierce; Katherine N. Gibson-Corley; Curt D. Sigmund; Justin L. Grobe; Mark K. Santillan The pathogenesis of preeclampsia (PreE), a hypertensive...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... endothelins preeclampsia Correspondence: Katrina M. Mirabito Colafella ( [email protected] ) K.M.MC. is supported by the National Health and Medical Research Council (NHMRC) of Australia CJ Martin Early Career Fellowship [grant number GNT1112125]. Activation of the endothelin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2911–2917.
Published: 08 December 2017
... I.L. , Borzychowski A.M. and Redman C.W. ( 2007 ) NK cells and pre-eclampsia . J. Reprod. Immunol. 76 , 40 – 44 10 Fukui A. , Yokota M. , Funamizu A. , Nakamua R. , Fukuhara R. , Yamada K. ( 2012 ) Changes of NK cells in preeclampsia . Am...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... of postpartum women who had preeclampsia (PrEC, n =12) and control women who had a healthy pregnancy (HC, n =12). We hypothesized that (1) PrEC would have a greater vasoconstrictor response to ET-1, and (2) reduced ET B R-mediated dilation. We further hypothesized that ET B R-blockade would attenuate...
Articles
Jamil Elfarra, Lorena M. Amaral, Maggie McCalmon, Jeremy D. Scott, Mark W. Cunningham, Jr, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C. Cornelius
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2753–2762.
Published: 23 November 2017
...Jamil Elfarra; Lorena M. Amaral; Maggie McCalmon; Jeremy D. Scott; Mark W. Cunningham, Jr; Ashley Gnam; Tarek Ibrahim; Babbette LaMarca; Denise C. Cornelius Preeclampsia is associated with hypertension, small-for-gestational-age babies, and increased cytolytic natural killer (NK) cells...
Articles
Piyali Chatterjee, Valorie L. Chiasson, Geetha Seerangan, Eugene De Guzman, Moheb Milad, Kelsey R. Bounds, Olga Gasheva, Richard P. Tobin, Mohamad Hatahet, Shelley Kopriva, Kathleen A. Jones, M. Karen Newell-Rogers, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2047–2058.
Published: 17 July 2017
... pregnancy can lead to organ injury and dysfunction and preeclampsia (PE); however, the molecular mechanisms involved are unknown. We tested the hypothesis that Toll-like receptor (TLR) activation induces major histocompatibility complex (MHC) class II invariant chain peptide (CLIP) expression on immune...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1529–1540.
Published: 28 June 2017
... 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adipocytes adipokines pregnancy preeclampsia Healthy...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1417–1434.
Published: 07 July 2016
...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 239–246.
Published: 14 January 2016
...Nina D. Paauw; Kim Luijken; Arie Franx; Marianne C. Verhaar; A. Titia Lely Preeclampsia (PE) is a hypertensive pregnancy disorder complicating up to 1–5% of pregnancies, and a major cause of maternal and fetal morbidity and mortality. In recent years, observational studies have consistently shown...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (4): 477–482.
Published: 01 October 1985
...-eclampsia, 10 normotensive pregnant women and eight normotensive nonpregnant women were determined. 2. In vessels from the women with preeclampsia, the ratio of media thickness to lumen diameter was increased, compared with that in vessels from the other two groups. 3. The vessels from the women...
