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Keywords: pregnancy
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Articles

Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy

Anna Liu, Natalia Ruetalo, Janet P. Raja Xavier, Aditya Kumar Lankapalli, Jakob Admard, Miguel Camarena-Sainz, Sara Y. Brucker, Yogesh Singh, Michael Schindler, Madhuri S. Salker
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (04): 287–307.
https://doi.org/10.1042/CS20241215
Published: 19 February 2025
...Anna Liu; Natalia Ruetalo; Janet P. Raja Xavier; Aditya Kumar Lankapalli; Jakob Admard; Miguel Camarena-Sainz; Sara Y. Brucker; Yogesh Singh; Michael Schindler; Madhuri S. Salker Vertical transmission of SARS-CoV-2 during human pregnancy remains highly controversial as most studies have focused...
View articletitled, Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
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Includes: Supplementary data
Articles

Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells

Faheem Seedat, Neva Kandzija, Michael J. Ellis, Shuhan Jiang, Asselzhan Sarbalina, James Bancroft, Edward Drydale, Svenja S. Hester, Roman Fischer, Alisha N. Wade, M. Irina Stefana, John A. Todd, Manu Vatish
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (22): 1481–1502.
https://doi.org/10.1042/CS20241782
Published: 20 November 2024
...Faheem Seedat; Neva Kandzija; Michael J. Ellis; Shuhan Jiang; Asselzhan Sarbalina; James Bancroft; Edward Drydale; Svenja S. Hester; Roman Fischer; Alisha N. Wade; M. Irina Stefana; John A. Todd; Manu Vatish Insulin secretion increases progressively during pregnancy to maintain normal maternal...
View articletitled, Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells
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Includes: Supplementary data
Articles

Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency

Ronan M.N. Noble, Shubham Soni, Si Ning Liu, Jad-Julian Rachid, Heather E. Mast, Alyssa Wiedemeyer, Claudia D. Holody, Richard Mah, Andrew G. Woodman, Mourad Ferdaoussi, Helene Lemieux, Jason R.B. Dyck, Stephane L. Bourque
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (19): 1249–1264.
https://doi.org/10.1042/CS20241386
Published: 01 October 2024
... gestation would mitigate cardiac dysfunction in ID neonates. Female Sprague-Dawley rats were fed an iron-restricted or iron-replete diet before and throughout pregnancy. Throughout gestation, iron-restricted dams were given either a daily subcutaneous injection of ketone solution (containing β...
View articletitled, Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency
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Includes: Supplementary data
Articles

Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4

Amanda A. de Oliveira, Emma Elder, Floor Spaans, Murilo E. Graton, Anita Quon, Raven Kirschenman, Amy L. Wooldridge, Christy-Lynn M. Cooke, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (4): 137–151.
https://doi.org/10.1042/CS20231442
Published: 14 February 2024
...Amanda A. de Oliveira; Emma Elder; Floor Spaans; Murilo E. Graton; Anita Quon; Raven Kirschenman; Amy L. Wooldridge; Christy-Lynn M. Cooke; Sandra T. Davidge Hypercholesterolemia in pregnancy is a physiological process required for normal fetal development. In contrast, excessive pregnancy-specific...
View articletitled, Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4
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Includes: Supplementary data
Articles

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H David McIntyre, Carlos Salomon
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1311–1332.
https://doi.org/10.1042/CS20220150
Published: 31 August 2023
... sensitivity in both healthy and gestational diabetes mellitus (GDM) pregnancies. The ability of EVs to transfer molecular cargo between cells imbues them with potential as therapeutic agents. During pregnancy, the placenta assumes a vital role in metabolic regulation, with multiple mechanisms of placenta...
View articletitled, Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes
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Articles

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

In Collection
Reproductive Physiology and Disease
Matthew Kang, Cherie Blenkiron, Lawrence W. Chamley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 385–399.
https://doi.org/10.1042/CS20220301
Published: 15 March 2023
...Matthew Kang; Cherie Blenkiron; Lawrence W. Chamley Human pregnancy is a highly orchestrated process requiring extensive cross-talk between the mother and the fetus. Extracellular vesicles released by the fetal tissue, particularly the placenta, are recognized as important mediators of this process...
View articletitled, The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation
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Articles

The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

In Collection
Reproductive Physiology and Disease
Kyle M. Siemers, Michelle L. Baack
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 31–34.
https://doi.org/10.1042/CS20220657
Published: 03 January 2023
... . Prog. Lipid Res. 48 , 52 – 61 19041341 10.1016/j.plipres.2008.11.001 3. Brett K.E. , Ferraro Z.M. , Yockell-Lelievre J. , Gruslin A. and Adamo K.B. ( 2014 ) Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta . Int. J. Mol...
View articletitled, The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies
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Articles

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

In Collection
Reproductive Physiology and Disease
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1591–1614.
https://doi.org/10.1042/CS20220491
Published: 14 November 2022
...-eclampsia, placental abruption, fetal growth restriction, gestational diabetes, Group B streptococcus carrier status, history of treatment for a urinary tract infection during pregnancy, sexually transmitted infections during pregnancy, chronic infections such as HIV and hepatitis, or a history of cigarette...
View articletitled, Stress signaler p38 mitogen-activated kinase activation: a cause for concern?
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Articles

Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier
Journal: Clinical Science
Clin Sci (Lond) (2022) 1117–1137.
https://doi.org/10.1042/CS20220245
Published: 05 August 2022
...Hager M. Kowash; Harry G. Potter; Rebecca M. Woods; Nick Ashton; Reinmar Hager; Joanna C. Neill; Jocelyn D. Glazier Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain...
View articletitled, Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth
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Includes: Supplementary data
Articles

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

In Collection
Coronavirus
Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
https://doi.org/10.1042/CS20210284
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
View articletitled, Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility
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Articles

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry, Franchesca D. Houghton, Nick Ashton, Jocelyn D. Glazier
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1445–1466.
https://doi.org/10.1042/CS20210137
Published: 11 June 2021
... during rat pregnancy leads to diminished fetal weight [ 30 ], arguing for its integral involvement in supporting normal fetal growth. The potential global impacts of Ramadan fasting while pregnant are considerable, with well in excess of 0.5 billion babies in each generation likely to be exposed...
View articletitled, Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat
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Articles

Maternal microvascular dysfunction during preeclamptic pregnancy

Anna E. Stanhewicz, Virginia R. Nuckols, Gary L. Pierce
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1083–1101.
https://doi.org/10.1042/CS20200894
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
View articletitled, Maternal microvascular dysfunction during preeclamptic pregnancy
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Articles

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Sarah L. Walton, Katrina M. Mirabito Colafella, Aneesa Ansari, Siew Yeen Chai, Kate M. Denton
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
https://doi.org/10.1042/CS20201233
Published: 11 December 2020
...Sarah L. Walton; Katrina M. Mirabito Colafella; Aneesa Ansari; Siew Yeen Chai; Kate M. Denton Insulin-regulated aminopeptidase (IRAP), an enzyme that cleaves vasoactive peptides including oxytocin and vasopressin, is suggested to play a role in pregnancy and the onset of preeclampsia. Our aim...
View articletitled, Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
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Articles

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3123–3136.
https://doi.org/10.1042/CS20201050
Published: 07 December 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 fetal development Fetal programming neurodevelopmental disorders pregnancy serotonin (5-HT) trophoblast It is well established that a suboptimal intrauterine environment results...
View articletitled, Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta
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Articles

From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

Sonya Frazier, Martin W. McBride, Helen Mulvana, Delyth Graham
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
https://doi.org/10.1042/CS20200023
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
View articletitled, From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia
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Articles

Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

In Collection
Clinical and translational research highlights
Ratana Lim, Caitlyn Nguyen-Ngo, Martha Lappas
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
https://doi.org/10.1042/CS20190919
Published: 04 December 2019
...-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human...
View articletitled, Targeting bromodomain-containing proteins to prevent spontaneous preterm birth
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Articles

Endothelin receptor antagonism during preeclampsia: a matter of timing?

Emilie Hitzerd, Rugina I. Neuman, Katrina M. Mirabito Colafella, Irwin K.M. Reiss, Anton H. van den Meiracker, A.H. Jan Danser, Willy Visser, Jorie Versmissen, Langeza Saleh
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (12): 1341–1352.
https://doi.org/10.1042/CS20190464
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
View articletitled, Endothelin receptor antagonism during preeclampsia: a matter of timing?
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Articles

Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE −/− mice

Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, David P. Burgner, Timothy J. Moss
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
https://doi.org/10.1042/CS20190141
Published: 30 May 2019
.... Human and mechanistic studies are warranted to guide preventative strategies. cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic...
View articletitled, Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE −/− mice
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Articles

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2451–2467.
https://doi.org/10.1042/CS20180487
Published: 30 November 2018
..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...
View articletitled, Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity
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Articles

Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries

Floor Spaans, Anita Quon, Stewart R. Rowe, Jude S. Morton, Raven Kirschenman, Tatsuya Sawamura, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2369–2381.
https://doi.org/10.1042/CS20180639
Published: 13 November 2018
...Floor Spaans; Anita Quon; Stewart R. Rowe; Jude S. Morton; Raven Kirschenman; Tatsuya Sawamura; Dionne S. Tannetta; Ian L. Sargent; Sandra T. Davidge Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular...
View articletitled, Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries
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Articles

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Redin A. Spann, William J. Lawson, Gene L. Bidwell, III, C. Austin Zamarripa, Rodrigo O. Maranon, Sibali Bandyopadhyay, Erin R. Taylor, Jane F. Reckelhoff, Michael R. Garrett, Bernadette E. Grayson
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 295–312.
https://doi.org/10.1042/CS20171416
Published: 25 January 2018
...-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal...
View articletitled, Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development
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Includes: Supplementary data
Articles

Natural killer cells and T lymphocytes in pregnancy and pre-eclampsia

Erin B. Taylor, Jennifer M. Sasser
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2911–2917.
https://doi.org/10.1042/CS20171070
Published: 08 December 2017
...Erin B. Taylor; Jennifer M. Sasser Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have...
View articletitled, Natural killer cells and T lymphocytes in pregnancy and pre-eclampsia
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Articles

Relaxin contributes to the regulation of arterial pressure in adult female mice

Katrina M. Mirabito Colafella, Chrishan S. Samuel, Kate M. Denton
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2795–2805.
https://doi.org/10.1042/CS20171225
Published: 28 November 2017
...Katrina M. Mirabito Colafella; Chrishan S. Samuel; Kate M. Denton Relaxin is increasingly being recognized as a potent vasodilatory and antifibrotic hormone. Given that relaxin is present in the circulation during the luteal phase of the menstrual cycle and during pregnancy, when arterial pressure...
View articletitled, Relaxin contributes to the regulation of arterial pressure in adult female mice
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Articles

Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure

Jamil Elfarra, Lorena M. Amaral, Maggie McCalmon, Jeremy D. Scott, Mark W. Cunningham, Jr, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C. Cornelius
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2753–2762.
https://doi.org/10.1042/CS20171118
Published: 23 November 2017
... of the Biochemical Society 2017 Hypertension Intrauterine growth restriction Inflammation Natural Killer Cells Pregnancy Preeclampsia Preeclampsia (PE) is a pregnancy specific multisystem hypertensive disorder that is associated with new onset hypertension and proteinuria. It is usually...
View articletitled, Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure
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Articles

The influence of prenatal exercise and pre-eclampsia on maternal vascular function

Rachel J. Skow, Emily C. King, Craig D. Steinback, Margie H. Davenport
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
https://doi.org/10.1042/CS20171036
Published: 10 August 2017
...Rachel J. Skow; Emily C. King; Craig D. Steinback; Margie H. Davenport During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume...
View articletitled, The influence of prenatal exercise and pre-eclampsia on maternal vascular function
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Articles

Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys

Shahzya S. Huda, Fiona Jordan, Jack Bray, Gillian Love, Reba Payne, Naveed Sattar, Dilys J. Freeman
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1529–1540.
https://doi.org/10.1042/CS20160832
Published: 28 June 2017
...-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n =13) and PE ( n =13) mothers. Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. Adipose tissue cell densities...
View articletitled, Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys
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Includes: Supplementary data
Articles

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Omar C. Logue, Eric M. George, Gene L. Bidwell, III
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1417–1434.
https://doi.org/10.1042/CS20160108
Published: 07 July 2016
...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...
View articletitled, Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia
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Articles

Cerebral blood flow regulation, exercise and pregnancy: why should we care?

Michèle Bisson, Isabelle Marc, Patrice Brassard
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (9): 651–665.
https://doi.org/10.1042/CS20150694
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
View articletitled, Cerebral blood flow regulation, exercise and pregnancy: why should we care?
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Articles

Does high-density lipoprotein protect vascular function in healthy pregnancy?

Wan N. Wan Sulaiman, Muriel J. Caslake, Christian Delles, Helen Karlsson, Monique T. Mulder, Delyth Graham, Dilys J. Freeman
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (7): 491–497.
https://doi.org/10.1042/CS20150475
Published: 17 February 2016
...Wan N. Wan Sulaiman; Muriel J. Caslake; Christian Delles; Helen Karlsson; Monique T. Mulder; Delyth Graham; Dilys J. Freeman The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated...
View articletitled, Does high-density lipoprotein protect vascular function in healthy pregnancy?
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Articles

The role of inflammation in the pathology of preeclampsia

Ashlyn C. Harmon, Denise C. Cornelius, Lorena M. Amaral, Jessica L. Faulkner, Mark W. Cunningham, Jr, Kedra Wallace, Babbette LaMarca
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (6): 409–419.
https://doi.org/10.1042/CS20150702
Published: 04 February 2016
...Ashlyn C. Harmon; Denise C. Cornelius; Lorena M. Amaral; Jessica L. Faulkner; Mark W. Cunningham, Jr; Kedra Wallace; Babbette LaMarca Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated...
View articletitled, The role of inflammation in the pathology of preeclampsia
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Articles

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

Yi-Yung Chen, Fredrick J. Rosario, Majida Abu Shehab, Theresa L. Powell, Madhulika B. Gupta, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1131–1141.
https://doi.org/10.1042/CS20150511
Published: 22 October 2015
... from women with pregnancies complicated by IUGR ( n =25) and gestational age-matched women with appropriately grown control infants ( n =19, birth weights between the twenty-fifth to seventy-fifth percentiles). The activity of mTORC1 and mTORC2 was decreased whereas the protein expression...
View articletitled, Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
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Includes: Supplementary data
Articles

Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage

David Lissauer, Oliver Goodyear, Rahela Khanum, Paul A. H. Moss, Mark D. Kilby
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (5): 347–354.
https://doi.org/10.1042/CS20130247
Published: 01 November 2013
...David Lissauer; Oliver Goodyear; Rahela Khanum; Paul A. H. Moss; Mark D. Kilby The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite...
View articletitled, Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage
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Articles

microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells

Pengfei Li, Wei Guo, Leilei Du, Junli Zhao, Yaping Wang, Liu Liu, Yali Hu, Yayi Hou
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (1): 27–40.
https://doi.org/10.1042/CS20120121
Published: 07 September 2012
...Pengfei Li; Wei Guo; Leilei Du; Junli Zhao; Yaping Wang; Liu Liu; Yali Hu; Yayi Hou PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral arteries. The present...
View articletitled, microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells
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Includes: Supplementary data
Articles

Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

Styliani Goulopoulou, Takayuki Matsumoto, Gisele F. Bomfim, R. Clinton Webb
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (7): 429–435.
https://doi.org/10.1042/CS20120130
Published: 07 June 2012
... and mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...
View articletitled, Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia
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Articles

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Esther F. Davis, Laura Newton, Adam J. Lewandowski, Merzaka Lazdam, Brenda A. Kelly, Theodosios Kyriakou, Paul Leeson
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (2): 53–72.
https://doi.org/10.1042/CS20110627
Published: 23 March 2012
...Esther F. Davis; Laura Newton; Adam J. Lewandowski; Merzaka Lazdam; Brenda A. Kelly; Theodosios Kyriakou; Paul Leeson Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk...
View articletitled, Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
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Articles

Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy

Moulinath Banerjee, Simon G. Anderson, Rayaz A. Malik, Clare E. Austin, J. Kennedy Cruickshank
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (2): 53–61.
https://doi.org/10.1042/CS20110033
Published: 20 September 2011
...Moulinath Banerjee; Simon G. Anderson; Rayaz A. Malik; Clare E. Austin; J. Kennedy Cruickshank GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small artery function...
View articletitled, Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy
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Articles

Brachial artery flow-mediated dilation is not affected by pregnancy or regular exercise participation

Tracey L. Weissgerber, Gregory A. L. Davies, Michael E. Tschakovsky
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (8): 355–365.
https://doi.org/10.1042/CS20110008
Published: 24 June 2011
...Tracey L. Weissgerber; Gregory A. L. Davies; Michael E. Tschakovsky Whether brachial artery FMD (flow-mediated dilation) is altered in pregnancy by 28–35 weeks compared with non-pregnant women remains controversial. The controversy may be due to limitations of previous studies that include failing...
View articletitled, Brachial artery flow-mediated dilation is not affected by pregnancy or regular exercise participation
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Includes: Supplementary data
Articles

Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring

Eleanor Jarvie, Sylvie Hauguel-de-Mouzon, Scott M. Nelson, Naveed Sattar, Patrick M. Catalano, Dilys J. Freeman
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (3): 123–129.
https://doi.org/10.1042/CS20090640
Published: 28 April 2010
... pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and increased risk of adverse pregnancy outcome. We hypothesize that the preferential storage of fat in central rather than ‘safer’ lower-body depots in obese pregnancy leads to lipotoxicity. The combination of excess...
View articletitled, Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
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Articles

Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction

Henar Ortega-Senovilla, Gioia Alvino, Emanuela Taricco, Irene Cetin, Emilio Herrera
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (5): 351–358.
https://doi.org/10.1042/CS20090292
Published: 23 November 2009
...Henar Ortega-Senovilla; Gioia Alvino; Emanuela Taricco; Irene Cetin; Emilio Herrera IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR...
View articletitled, Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction
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Articles

Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation

Roselle L. Cripps, Malgorzata S. Martin-Gronert, Zoe A. Archer, C. Nick Hales, Julian G. Mercer, Susan E. Ozanne
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (2): 85–93.
https://doi.org/10.1042/CS20080393
Published: 15 June 2009
... investigates the potential underlying mechanisms of these observations. Rats were established as follows: (i) control animals [offspring of control dams fed a 20% (w/v) protein diet], (ii) recuperated animals [offspring of dams fed an isocaloric low-protein (8%, w/v) diet during pregnancy and nursed by control...
View articletitled, Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation
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Articles

Deterioration in cardiac systolic and diastolic function late in normal human pregnancy

Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen B. Harrap
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (7): 599–606.
https://doi.org/10.1042/CS20080142
Published: 02 March 2009
...Dominica Zentner; Moira du Plessis; Shaun Brennecke; James Wong; Leeanne Grigg; Stephen B. Harrap The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women...
View articletitled, Deterioration in cardiac systolic and diastolic function late in normal human pregnancy
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Articles

Circulating levels of adiponectin and leptin at 23–25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction

Makrina D. Savvidou, Alexandros Sotiriadis, Christine Kaihura, Kypros H. Nicolaides, Naveed Sattar
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (7): 219–224.
https://doi.org/10.1042/CS20070409
Published: 03 September 2008
... alterations in adiponectin and leptin levels predate the development of PE and FGR (fetal growth restriction) in women at increased risk of these complications, as assessed by Doppler examination of the uterine arteries during the second trimester of pregnancy. We also sought to investigate the circulating...
View articletitled, Circulating levels of adiponectin and leptin at 23–25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction
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Articles

Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches

Thomas Jansson, Theresa L. Powell
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (1): 1–13.
https://doi.org/10.1042/CS20060339
Published: 01 June 2007
... the placenta in order to affect the fetus. Here, we review recent insights into how the placenta responds to changes in the maternal environment and discuss possible mechanisms by which the placenta mediates fetal programming. In IUGR (intrauterine growth restriction) pregnancies, the increased placental...
View articletitled, Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches
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Articles

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction

Wenzel Wallner, Ruth Sengenberger, Reiner Strick, Pamela L. Strissel, Britta Meurer, Matthias W. Beckmann, Dietmar Schlembach
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (1): 51–57.
https://doi.org/10.1042/CS20060161
Published: 01 December 2006
... pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein...
View articletitled, Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction
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Articles

n − 3 Fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids

Anne E. Barden, Janet A. Dunstan, Lawrence J. Beilin, Susan L. Prescott, Trevor A. Mori
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (4): 289–294.
https://doi.org/10.1042/CS20060096
Published: 13 September 2006
... pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune...
View articletitled, n − 3 Fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids
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Articles

Increased visfatin concentrations in women with gestational diabetes mellitus

Katarzyna Krzyzanowska, Walter Krugluger, Friedrich Mittermayer, Rupa Rahman, Dominik Haider, Nadja Shnawa, Guntram Schernthaner
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (5): 605–609.
https://doi.org/10.1042/CS20050363
Published: 11 April 2006
... are limited. To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and in healthy pregnant controls. Furthermore, visfatin concentrations were investigated longitudinally during pregnancy and after delivery in a subgroup of women with GDM...
View articletitled, Increased visfatin concentrations in women with gestational diabetes mellitus
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Articles

Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy

Gustavo Castaño, Silvia Lucangioli, Silvia Sookoian, Marcelo Mesquida, Abraham Lemberg, Mirta Di Scala, Paula Franchi, Clyde Carducci, Valeria Tripodi
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (4): 459–465.
https://doi.org/10.1042/CS20050302
Published: 15 March 2006
...Gustavo Castaño; Silvia Lucangioli; Silvia Sookoian; Marcelo Mesquida; Abraham Lemberg; Mirta Di Scala; Paula Franchi; Clyde Carducci; Valeria Tripodi ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids...
View articletitled, Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy
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Articles

Searching for genetic clues to the causes of pre-eclampsia

Sally Chappell, Linda Morgan
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (4): 443–458.
https://doi.org/10.1042/CS20050323
Published: 15 March 2006
... genome-wide screen hypertension maternal genotype pre-eclampsia pregnancy susceptibility gene Pre-eclampsia is a potentially life-threatening multisystem disorder which affects approx. 3% of pregnant women in the Western world [ 1 ]. Recognized clinically by the onset of hypertension...
View articletitled, Searching for genetic clues to the causes of pre-eclampsia
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Includes: Supplementary data
Articles

Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes

Alfia Al-Ghafra, Shaun P. Brennecke, Roger G. King, Neil M. Gude
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 337–342.
https://doi.org/10.1042/CS20050303
Published: 10 February 2006
[email protected] ). 6 10 2005 21 11 2005 29 11 2005 29 11 2005 The Biochemical Society 2006 adrenomedullin gestational tissue parturition placenta pregnancy We have shown previously [ 1 ] that AdM (adrenomedullin) content of fetal membranes is increased in both term...
View articletitled, Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes
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Articles

Modulation of lipid metabolism by n −3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring

Nassima A. Soulimane-Mokhtari, Baya Guermouche, Akadiri Yessoufou, Myrieum Saker, Kebirou Moutairou, Aziz Hichami, Hafida Merzouk, Naim A. Khan
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (3): 287–295.
https://doi.org/10.1042/CS20050028
Published: 24 August 2005
...Nassima A. Soulimane-Mokhtari; Baya Guermouche; Akadiri Yessoufou; Myrieum Saker; Kebirou Moutairou; Aziz Hichami; Hafida Merzouk; Naim A. Khan The time course of changes in lipid metabolism by dietary n −3 PUFAs (polyunsaturated fatty acids) in streptozotocin-induced diabetic rats during pregnancy...
View articletitled, Modulation of lipid metabolism by n −3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring
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