1-50 of 113
Keyword: pregnancy
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2019) 133 (23): 2379-2400.
Published: 04 December 2019
...-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (12): 1341-1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (10): 1185-1196.
Published: 30 May 2019
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2451-2467.
Published: 30 November 2018
..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (21): 2369-2381.
Published: 13 November 2018
...Floor Spaans; Anita Quon; Stewart R. Rowe; Jude S. Morton; Raven Kirschenman; Tatsuya Sawamura; Dionne S. Tannetta; Ian L. Sargent; Sandra T. Davidge Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular...
Articles
Clin Sci (Lond) (2018) 132 (2): 295-312.
Published: 25 January 2018
...-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (24): 2911-2917.
Published: 08 December 2017
...Erin B. Taylor; Jennifer M. Sasser Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have...
Articles
Clin Sci (Lond) (2017) 131 (23): 2795-2805.
Published: 28 November 2017
...Katrina M. Mirabito Colafella; Chrishan S. Samuel; Kate M. Denton Relaxin is increasingly being recognized as a potent vasodilatory and antifibrotic hormone. Given that relaxin is present in the circulation during the luteal phase of the menstrual cycle and during pregnancy, when arterial pressure...
Articles
Clin Sci (Lond) (2017) 131 (23): 2753-2762.
Published: 23 November 2017
... © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Hypertension Intrauterine growth restriction Inflammation Natural Killer Cells Pregnancy Preeclampsia Preeclampsia (PE) is a pregnancy specific multisystem hypertensive disorder that is...
Articles
Clin Sci (Lond) (2017) 131 (17): 2223-2240.
Published: 10 August 2017
...Rachel J. Skow; Emily C. King; Craig D. Steinback; Margie H. Davenport During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume and...
Articles
Clin Sci (Lond) (2017) 131 (13): 1529-1540.
Published: 28 June 2017
...-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n =13) and PE ( n =13) mothers. Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. Adipose tissue cell densities of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (16): 1417-1434.
Published: 07 July 2016
...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...
Articles
Clin Sci (Lond) (2016) 130 (9): 651-665.
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
Articles
Clin Sci (Lond) (2016) 130 (7): 491-497.
Published: 17 February 2016
...Wan N. Wan Sulaiman; Muriel J. Caslake; Christian Delles; Helen Karlsson; Monique T. Mulder; Delyth Graham; Dilys J. Freeman The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated...
Articles
Clin Sci (Lond) (2016) 130 (6): 409-419.
Published: 04 February 2016
...Ashlyn C. Harmon; Denise C. Cornelius; Lorena M. Amaral; Jessica L. Faulkner; Mark W. Cunningham, Jr; Kedra Wallace; Babbette LaMarca Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated with...
Articles
Clin Sci (Lond) (2015) 129 (12): 1131-1141.
Published: 22 October 2015
... from women with pregnancies complicated by IUGR ( n =25) and gestational age-matched women with appropriately grown control infants ( n =19, birth weights between the twenty-fifth to seventy-fifth percentiles). The activity of mTORC1 and mTORC2 was decreased whereas the protein expression of the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (5): 347-354.
Published: 01 November 2013
...David Lissauer; Oliver Goodyear; Rahela Khanum; Paul A. H. Moss; Mark D. Kilby The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite...
Articles
Clin Sci (Lond) (2013) 124 (1): 27-40.
Published: 07 September 2012
...Pengfei Li; Wei Guo; Leilei Du; Junli Zhao; Yaping Wang; Liu Liu; Yali Hu; Yayi Hou PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral arteries. The present...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (7): 429-435.
Published: 07 June 2012
... mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...
Articles
Clin Sci (Lond) (2012) 123 (2): 53-72.
Published: 23 March 2012
...Esther F. Davis; Laura Newton; Adam J. Lewandowski; Merzaka Lazdam; Brenda A. Kelly; Theodosios Kyriakou; Paul Leeson Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of...
Articles
Clin Sci (Lond) (2012) 122 (2): 53-61.
Published: 20 September 2011
...Moulinath Banerjee; Simon G. Anderson; Rayaz A. Malik; Clare E. Austin; J. Kennedy Cruickshank; J. Kennedy Cruickshank GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small...
Articles
Clin Sci (Lond) (2011) 121 (8): 355-365.
Published: 24 June 2011
...Tracey L. Weissgerber; Gregory A. L. Davies; Michael E. Tschakovsky Whether brachial artery FMD (flow-mediated dilation) is altered in pregnancy by 28–35 weeks compared with non-pregnant women remains controversial. The controversy may be due to limitations of previous studies that include failing...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (3): 123-129.
Published: 28 April 2010
... pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and increased risk of adverse pregnancy outcome. We hypothesize that the preferential storage of fat in central rather than ‘safer’ lower-body depots in obese pregnancy leads to lipotoxicity. The combination of excess...
Articles
Clin Sci (Lond) (2010) 118 (5): 351-358.
Published: 23 November 2009
...Henar Ortega-Senovilla; Gioia Alvino; Emanuela Taricco; Irene Cetin; Emilio Herrera IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR, the...
Articles
Clin Sci (Lond) (2009) 117 (2): 85-93.
Published: 15 June 2009
... investigates the potential underlying mechanisms of these observations. Rats were established as follows: (i) control animals [offspring of control dams fed a 20% (w/v) protein diet], (ii) recuperated animals [offspring of dams fed an isocaloric low-protein (8%, w/v) diet during pregnancy and nursed by control...
Articles
Clin Sci (Lond) (2009) 116 (7): 599-606.
Published: 02 March 2009
...Dominica Zentner; Moira du Plessis; Shaun Brennecke; James Wong; Leeanne Grigg; Stephen B. Harrap The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women...
Articles
Clin Sci (Lond) (2008) 115 (7): 219-224.
Published: 03 September 2008
... alterations in adiponectin and leptin levels predate the development of PE and FGR (fetal growth restriction) in women at increased risk of these complications, as assessed by Doppler examination of the uterine arteries during the second trimester of pregnancy. We also sought to investigate the circulating...
Articles
Clin Sci (Lond) (2007) 113 (1): 1-13.
Published: 01 June 2007
... placenta in order to affect the fetus. Here, we review recent insights into how the placenta responds to changes in the maternal environment and discuss possible mechanisms by which the placenta mediates fetal programming. In IUGR (intrauterine growth restriction) pregnancies, the increased placental...
Articles
Clin Sci (Lond) (2007) 112 (1): 51-57.
Published: 01 December 2006
... pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein, the...
Articles
Clin Sci (Lond) (2006) 111 (4): 289-294.
Published: 13 September 2006
... pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune...
Articles
Clin Sci (Lond) (2006) 110 (5): 605-609.
Published: 11 April 2006
... are limited. To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and in healthy pregnant controls. Furthermore, visfatin concentrations were investigated longitudinally during pregnancy and after delivery in a subgroup of women with...
Articles
Clin Sci (Lond) (2006) 110 (4): 459-465.
Published: 15 March 2006
...Gustavo Castaño; Silvia Lucangioli; Silvia Sookoian; Marcelo Mesquida; Abraham Lemberg; Mirta Di Scala; Paula Franchi; Clyde Carducci; Valeria Tripodi ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids) and...
Articles
Clin Sci (Lond) (2006) 110 (4): 443-458.
Published: 15 March 2006
... 2006 16 1 2006 The Biochemical Society 2006 fetal genotype genome-wide screen hypertension maternal genotype pre-eclampsia pregnancy susceptibility gene Pre-eclampsia is a potentially life-threatening multisystem disorder which affects approx. 3% of pregnant women in the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 110 (3): 337-342.
Published: 10 February 2006
...@rwh.org.au ). 6 10 2005 21 11 2005 29 11 2005 29 11 2005 The Biochemical Society 2006 adrenomedullin gestational tissue parturition placenta pregnancy We have shown previously [ 1 ] that AdM (adrenomedullin) content of fetal membranes is increased in both term...
Articles
Clin Sci (Lond) (2005) 109 (3): 287-295.
Published: 24 August 2005
...Nassima A. Soulimane-Mokhtari; Baya Guermouche; Akadiri Yessoufou; Myrieum Saker; Kebirou Moutairou; Aziz Hichami; Hafida Merzouk; Naim A. Khan The time course of changes in lipid metabolism by dietary n −3 PUFAs (polyunsaturated fatty acids) in streptozotocin-induced diabetic rats during pregnancy...
Articles
Clin Sci (Lond) (2005) 109 (2): 209-215.
Published: 25 July 2005
... 2005 28 4 2005 The Biochemical Society 2005 arterial pressure endothelin-1 (ET-1) pre-eclampsia pregnancy uterus Pre-eclampsia, a disorder unique to pregnancy, is one of the leading causes of maternal and fetal mortality and morbidity worldwide [ 1 , 2 ]. Hypertension...
Articles
Clin Sci (Lond) (2005) 109 (1): 103-107.
Published: 23 June 2005
...Beatrix MERSICH; János RIGÓ, Jr; Csilla BESENYEI; Zsuzsanna LÉNÁRD; Péter STUDINGER; Márk KOLLAI Systemic arterial compliance has been known to increase during healthy pregnancy, whereas, recently, the carotid artery has been reported to stiffen. To clarify this controversy, we simultaneously...
Articles
Clin Sci (Lond) (2005) 108 (1): 81-84.
Published: 15 December 2004
...Danqing CHEN; Minyue DONG; Qin FANG; Jing HE; Zhengping WANG; Xiaofu YANG Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia...
Articles
Clin Sci (Lond) (2004) 107 (4): 407-413.
Published: 24 September 2004
.... Correspondence: Dr Mark Kollai (email kollai@elet2.sote.hu ). 5 5 2004 17 6 2004 23 6 2004 23 6 2004 The Biochemical Society 2004 baroreceptor carotid artery hypertension pre-eclampsia pregnancy Hypertension is associated with impaired arterial baroreflex...
Articles
Clin Sci (Lond) (2004) 106 (5): 449-450.
Published: 01 May 2004
...Annemarie HENNESSY One of the fundamental issues in pre-eclampsia (hypertension in pregnancy) research is to find serum proteins that can act as markers of disease predisposition, remote disease onset, imminent disease onset or disease activity at the height of its destructive powers. We make...
Articles
Clin Sci (Lond) (2004) 106 (4): 377-382.
Published: 01 April 2004
...M. W. AARDEMA; M. C. S. SARO; M. LANDER; B. T. H. M. DE WOLF; H. OOSTERHOF; J. G. AARNOUDSE The ‘classical’ concept that pregnancy-induced hypertension (PIH) and pre-eclampsia (PE) primarily originate from defective placentation in early pregnancy has been challenged recently. There is growing...
Articles
Clin Sci (Lond) (2004) 106 (3): 307-313.
Published: 01 March 2004
...Dan DROBIN; Robert G. HAHN Pre-eclampsia (PE) is a disease of pregnancy associated with peripheral oedema and hypovolaemia, but few details are known about how women with PE handle a volume load of crystalloid fluid compared with healthy pregnant women. To study this issue, Ringer's acetate...
Articles
Clin Sci (Lond) (2004) 106 (1): 93-98.
Published: 01 January 2004
...V. TOESCU; S. L. NUTTALL; U. MARTIN; P. NIGHTINGALE; M. J. KENDALL; P. BRYDON; F. DUNNE The purpose of the present study was to determine changes in plasma lipids and markers of oxidative stress longitudinally in pregnancy complicated by diabetes compared with non-diabetic pregnancy. This was...
Articles
Clin Sci (Lond) (2003) 104 (2): 103-107.
Published: 09 January 2003
...Jason WAUGH; Stephen C. BELL; Mark D. KILBY; Paul C. LAMBERT; Claire N. BLACKWELL; Andrew SHENNAN; Aidan HALLIGAN During uncomplicated pregnancy, the development of proteinuria is accepted as a poor prognostic sign and is associated with increasing maternal and perinatal mortality and morbidity...
Articles
Clin Sci (Lond) (2002) 103 (6): 633-639.
Published: 19 November 2002
...Alan A. JACKSON; Rebecca L. DUNN; Michael C. MARCHAND; Simon C. LANGLEY-EVANS When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained...
Articles
Clin Sci (Lond) (2002) 102 (5): 553-560.
Published: 18 April 2002
...Angeliki KOUMENTAKI; Frederick ANTHONY; Lucilla POSTON; Timothy WHEELER Pregnancy is associated with increases in maternal cardiac output and plasma volume and a reduction in peripheral vascular resistance. Cardiac output and plasma volume are substantially reduced in pregnant rats fed a low...
Articles
Clin Sci (Lond) (2001) 101 (6): 719-729.
Published: 21 November 2001
... during pregnancy, resulting in a higher incidence of adverse pregnancy outcomes such as pre-eclampsia, placental insufficiency and stillbirth than in non-diabetics. Vascular dysfunction is thought to underlie many of these complications, with the greatest impact occurring at the level of the resistance...
Articles
Clin Sci (Lond) (2001) 101 (1): 65-72.
Published: 29 May 2001
... turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [ 15 N]glycine and the...
Articles
Clin Sci (Lond) (2001) 100 (6): 667-671.
Published: 14 May 2001
...Eduardo PODJARNY; Michael BURSZTYN; Gloria RASHED; Sidney BENCHETRIT; Bernard KATZ; Janice GREEN; Fanny KARMELI; Edna PELEG; Jacques BERNHEIM Recent studies have shown that maternal hyperinsulinaemia is a risk factor for the development of hypertension in pregnancy. Experimentally, pregnant rats...
Articles
Clin Sci (Lond) (2001) 100 (3): 319-326.
Published: 21 February 2001
...Y. YANG; G. J. MACDONALD; K. A. DUGGAN Endothelial dysfunction and a consequent decrease in nitric oxide production have been implicated in the pathogenesis of pre-eclampsia. A prominent feature of the pre-eclamptic syndrome is a loss of the pregnancy-induced refractoriness to infused pressor...