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Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells

Faheem Seedat, Neva Kandzija, Michael J. Ellis, Shuhan Jiang, Asselzhan Sarbalina, James Bancroft, Edward Drydale, Svenja S. Hester, Roman Fischer, Alisha N. Wade, M. Irina Stefana, John A. Todd, Manu Vatish

Clin Sci (Lond) (2024) 138 (22): 1481–1502.

https://doi.org/10.1042/CS20241782

Published: 20 November 2024

...Faheem Seedat; Neva Kandzija; Michael J. Ellis; Shuhan Jiang; Asselzhan Sarbalina; James Bancroft; Edward Drydale; Svenja S. Hester; Roman Fischer; Alisha N. Wade; M. Irina Stefana; John A. Todd; Manu Vatish Insulin secretion increases progressively during pregnancy to maintain normal maternal...

View article titled, Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells

Includes: Supplementary data

Articles

Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency

Ronan M.N. Noble, Shubham Soni, Si Ning Liu, Jad-Julian Rachid, Heather E. Mast, Alyssa Wiedemeyer, Claudia D. Holody, Richard Mah, Andrew G. Woodman, Mourad Ferdaoussi, Helene Lemieux, Jason R.B. Dyck, Stephane L. Bourque

Clin Sci (Lond) (2024) 138 (19): 1249–1264.

https://doi.org/10.1042/CS20241386

Published: 01 October 2024

... gestation would mitigate cardiac dysfunction in ID neonates. Female Sprague-Dawley rats were fed an iron-restricted or iron-replete diet before and throughout pregnancy. Throughout gestation, iron-restricted dams were given either a daily subcutaneous injection of ketone solution (containing β...

View article titled, Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency

Includes: Supplementary data

Articles

Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4

Amanda A. de Oliveira, Emma Elder, Floor Spaans, Murilo E. Graton, Anita Quon, Raven Kirschenman, Amy L. Wooldridge, Christy-Lynn M. Cooke, Sandra T. Davidge

Clin Sci (Lond) (2024) 138 (4): 137–151.

https://doi.org/10.1042/CS20231442

Published: 14 February 2024

...Amanda A. de Oliveira; Emma Elder; Floor Spaans; Murilo E. Graton; Anita Quon; Raven Kirschenman; Amy L. Wooldridge; Christy-Lynn M. Cooke; Sandra T. Davidge Hypercholesterolemia in pregnancy is a physiological process required for normal fetal development. In contrast, excessive pregnancy-specific...

View article titled, Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4

Includes: Supplementary data

Articles

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H David McIntyre, Carlos Salomon

Clin Sci (Lond) (2023) 137 (16): 1311–1332.

https://doi.org/10.1042/CS20220150

Published: 31 August 2023

... sensitivity in both healthy and gestational diabetes mellitus (GDM) pregnancies. The ability of EVs to transfer molecular cargo between cells imbues them with potential as therapeutic agents. During pregnancy, the placenta assumes a vital role in metabolic regulation, with multiple mechanisms of placenta...

View article titled, Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Articles

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

In Collection

Reproductive Physiology and Disease

Matthew Kang, Cherie Blenkiron, Lawrence W. Chamley

Clin Sci (Lond) (2023) 137 (5): 385–399.

https://doi.org/10.1042/CS20220301

Published: 15 March 2023

...Matthew Kang; Cherie Blenkiron; Lawrence W. Chamley Human pregnancy is a highly orchestrated process requiring extensive cross-talk between the mother and the fetus. Extracellular vesicles released by the fetal tissue, particularly the placenta, are recognized as important mediators of this process...

View article titled, The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

Articles

The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

In Collection

Reproductive Physiology and Disease

Kyle M. Siemers, Michelle L. Baack

Clin Sci (Lond) (2023) 137 (1): 31–34.

https://doi.org/10.1042/CS20220657

Published: 03 January 2023

... to affect pregnancy outcomes. Kyle M. Siemers: Visualization, Writing—original draft, Writing—review & editing. Michelle L. Baack: Conceptualization, Supervision, Project administration, Writing—review & editing. FFA free fatty acids LCPUFA long chain polyunsaturated fatty...

View article titled, The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

Articles

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

In Collection

Reproductive Physiology and Disease

Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon

Clin Sci (Lond) (2022) 136 (22): 1591–1614.

https://doi.org/10.1042/CS20220491

Published: 14 November 2022

... EMT pregnancy Senescence Reactive oxygen species (ROS) generated in response to both endogenous and exogenous stimuli initiate various stress signaling responses that can determine cell fate which includes proliferation, transition, differentiation, senescence, and cell death [ 1 , 2...

View article titled, Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

Includes: Supplementary data

Articles

Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier

Clin Sci (Lond) (2022) 1117–1137.

https://doi.org/10.1042/CS20220245

Published: 05 August 2022

...Hager M. Kowash; Harry G. Potter; Rebecca M. Woods; Nick Ashton; Reinmar Hager; Joanna C. Neill; Jocelyn D. Glazier Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain...

View article titled, Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Includes: Supplementary data

Articles

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

In Collection

Coronavirus

Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli

Clin Sci (Lond) (2021) 135 (15): 1805–1824.

https://doi.org/10.1042/CS20210284

Published: 02 August 2021

...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...

View article titled, Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

Articles

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry, Franchesca D. Houghton, Nick Ashton, Jocelyn D. Glazier

Clin Sci (Lond) (2021) 135 (11): 1445–1466.

https://doi.org/10.1042/CS20210137

Published: 11 June 2021

... Fetus Nutrients Placenta Pregnancy Fasting during the month of Ramadan is one of the five pillars of Islam. During this period, it is a religious requirement that healthy adult Muslims abstain from consuming food and drink from dawn to sunset for the duration of this holy month. From sunset...

View article titled, Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Includes: Supplementary data

Articles

Maternal microvascular dysfunction during preeclamptic pregnancy

Anna E. Stanhewicz, Virginia R. Nuckols, Gary L. Pierce

Clin Sci (Lond) (2021) 135 (9): 1083–1101.

https://doi.org/10.1042/CS20200894

Published: 07 May 2021

...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...

View article titled, Maternal microvascular dysfunction during preeclamptic pregnancy

Articles

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Sarah L. Walton, Katrina M. Mirabito Colafella, Aneesa Ansari, Siew Yeen Chai, Kate M. Denton

Clin Sci (Lond) (2020) 134 (23): 3213–3228.

https://doi.org/10.1042/CS20201233

Published: 11 December 2020

...Sarah L. Walton; Katrina M. Mirabito Colafella; Aneesa Ansari; Siew Yeen Chai; Kate M. Denton Insulin-regulated aminopeptidase (IRAP), an enzyme that cleaves vasoactive peptides including oxytocin and vasopressin, is suggested to play a role in pregnancy and the onset of preeclampsia. Our aim...

View article titled, Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Includes: Supplementary data

Articles

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (23): 3123–3136.

https://doi.org/10.1042/CS20201050

Published: 07 December 2020

... of trophoblast serotonin synthesis and OGT protein expression. fetal development Fetal programming neurodevelopmental disorders pregnancy serotonin (5-HT) trophoblast All results were analyzed and plotted using PRISM (v9.0, GraphPad Software Inc, La Jolla, CA). The impact of fetal sex...

View article titled, Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Includes: Supplementary data

Articles

From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

Sonya Frazier, Martin W. McBride, Helen Mulvana, Delyth Graham

Clin Sci (Lond) (2020) 134 (8): 1001–1025.

https://doi.org/10.1042/CS20200023

Published: 27 April 2020

...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...

View article titled, From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

Articles

Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

In Collection

Clinical and translational research highlights

Ratana Lim, Caitlyn Nguyen-Ngo, Martha Lappas

Clin Sci (Lond) (2019) 133 (23): 2379–2400.

https://doi.org/10.1042/CS20190919

Published: 04 December 2019

...-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human...

View article titled, Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

Includes: Supplementary data

Articles

Endothelin receptor antagonism during preeclampsia: a matter of timing?

Emilie Hitzerd, Rugina I. Neuman, Katrina M. Mirabito Colafella, Irwin K.M. Reiss, Anton H. van den Meiracker, A.H. Jan Danser, Willy Visser, Jorie Versmissen, Langeza Saleh

Clin Sci (Lond) (2019) 133 (12): 1341–1352.

https://doi.org/10.1042/CS20190464

Published: 20 June 2019

...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...

View article titled, Endothelin receptor antagonism during preeclampsia: a matter of timing?

Includes: Supplementary data

Articles

Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE −/− mice

Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, David P. Burgner, Timothy J. Moss

Clin Sci (Lond) (2019) 133 (10): 1185–1196.

https://doi.org/10.1042/CS20190141

Published: 30 May 2019

... Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic inflammatory conditions, such as severe infections...

View article titled, Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE −/− mice

Includes: Supplementary data

Articles

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon

Clin Sci (Lond) (2018) 132 (22): 2451–2467.

https://doi.org/10.1042/CS20180487

Published: 30 November 2018

..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...

View article titled, Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Includes: Supplementary data

Articles

Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries

Floor Spaans, Anita Quon, Stewart R. Rowe, Jude S. Morton, Raven Kirschenman, Tatsuya Sawamura, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge

Clin Sci (Lond) (2018) 132 (21): 2369–2381.

https://doi.org/10.1042/CS20180639

Published: 13 November 2018

...Floor Spaans; Anita Quon; Stewart R. Rowe; Jude S. Morton; Raven Kirschenman; Tatsuya Sawamura; Dionne S. Tannetta; Ian L. Sargent; Sandra T. Davidge Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular...

View article titled, Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries

Articles

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Redin A. Spann, William J. Lawson, Gene L. Bidwell, III, C. Austin Zamarripa, Rodrigo O. Maranon, Sibali Bandyopadhyay, Erin R. Taylor, Jane F. Reckelhoff, Michael R. Garrett, Bernadette E. Grayson

Clin Sci (Lond) (2018) 132 (2): 295–312.

https://doi.org/10.1042/CS20171416

Published: 25 January 2018

...-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal...

View article titled, Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Includes: Supplementary data

Articles

Natural killer cells and T lymphocytes in pregnancy and pre-eclampsia

Erin B. Taylor, Jennifer M. Sasser

Clin Sci (Lond) (2017) 131 (24): 2911–2917.

https://doi.org/10.1042/CS20171070

Published: 08 December 2017

...Erin B. Taylor; Jennifer M. Sasser Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have...

View article titled, Natural killer cells and T lymphocytes in pregnancy and pre-eclampsia

Articles

Relaxin contributes to the regulation of arterial pressure in adult female mice

Katrina M. Mirabito Colafella, Chrishan S. Samuel, Kate M. Denton

Clin Sci (Lond) (2017) 131 (23): 2795–2805.

https://doi.org/10.1042/CS20171225

Published: 28 November 2017

...Katrina M. Mirabito Colafella; Chrishan S. Samuel; Kate M. Denton Relaxin is increasingly being recognized as a potent vasodilatory and antifibrotic hormone. Given that relaxin is present in the circulation during the luteal phase of the menstrual cycle and during pregnancy, when arterial pressure...

View article titled, Relaxin contributes to the regulation of arterial pressure in adult female mice

Articles

Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure

Jamil Elfarra, Lorena M. Amaral, Maggie McCalmon, Jeremy D. Scott, Mark W. Cunningham, Jr, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C. Cornelius

Clin Sci (Lond) (2017) 131 (23): 2753–2762.

https://doi.org/10.1042/CS20171118

Published: 23 November 2017

... 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Hypertension Intrauterine growth restriction Inflammation Natural Killer Cells Pregnancy Preeclampsia Preeclampsia (PE) is a pregnancy specific multisystem hypertensive disorder...

View article titled, Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure

Articles

The influence of prenatal exercise and pre-eclampsia on maternal vascular function

Rachel J. Skow, Emily C. King, Craig D. Steinback, Margie H. Davenport

Clin Sci (Lond) (2017) 131 (17): 2223–2240.

https://doi.org/10.1042/CS20171036

Published: 10 August 2017

...Rachel J. Skow; Emily C. King; Craig D. Steinback; Margie H. Davenport During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume...

View article titled, The influence of prenatal exercise and pre-eclampsia on maternal vascular function

Articles

Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys

Shahzya S. Huda, Fiona Jordan, Jack Bray, Gillian Love, Reba Payne, Naveed Sattar, Dilys J. Freeman

Clin Sci (Lond) (2017) 131 (13): 1529–1540.

https://doi.org/10.1042/CS20160832

Published: 28 June 2017

...-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n =13) and PE ( n =13) mothers. Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. Adipose tissue cell densities...

View article titled, Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys

Includes: Supplementary data

Articles

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Omar C. Logue, Eric M. George, Gene L. Bidwell, III

Clin Sci (Lond) (2016) 130 (16): 1417–1434.

https://doi.org/10.1042/CS20160108

Published: 07 July 2016

...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...

View article titled, Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Articles

Cerebral blood flow regulation, exercise and pregnancy: why should we care?

Michèle Bisson, Isabelle Marc, Patrice Brassard

Clin Sci (Lond) (2016) 130 (9): 651–665.

https://doi.org/10.1042/CS20150694

Published: 18 March 2016

...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...

View article titled, Cerebral blood flow regulation, exercise and pregnancy: why should we care?

Articles

Does high-density lipoprotein protect vascular function in healthy pregnancy?

Wan N. Wan Sulaiman, Muriel J. Caslake, Christian Delles, Helen Karlsson, Monique T. Mulder, Delyth Graham, Dilys J. Freeman

Clin Sci (Lond) (2016) 130 (7): 491–497.

https://doi.org/10.1042/CS20150475

Published: 17 February 2016

...Wan N. Wan Sulaiman; Muriel J. Caslake; Christian Delles; Helen Karlsson; Monique T. Mulder; Delyth Graham; Dilys J. Freeman The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated...

View article titled, Does high-density lipoprotein protect vascular function in healthy pregnancy?

Articles

The role of inflammation in the pathology of preeclampsia

Ashlyn C. Harmon, Denise C. Cornelius, Lorena M. Amaral, Jessica L. Faulkner, Mark W. Cunningham, Jr, Kedra Wallace, Babbette LaMarca

Clin Sci (Lond) (2016) 130 (6): 409–419.

https://doi.org/10.1042/CS20150702

Published: 04 February 2016

...Ashlyn C. Harmon; Denise C. Cornelius; Lorena M. Amaral; Jessica L. Faulkner; Mark W. Cunningham, Jr; Kedra Wallace; Babbette LaMarca Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated...

View article titled, The role of inflammation in the pathology of preeclampsia

Articles

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

Yi-Yung Chen, Fredrick J. Rosario, Majida Abu Shehab, Theresa L. Powell, Madhulika B. Gupta, Thomas Jansson

Clin Sci (Lond) (2015) 129 (12): 1131–1141.

https://doi.org/10.1042/CS20150511

Published: 22 October 2015

... from women with pregnancies complicated by IUGR ( n =25) and gestational age-matched women with appropriately grown control infants ( n =19, birth weights between the twenty-fifth to seventy-fifth percentiles). The activity of mTORC1 and mTORC2 was decreased whereas the protein expression...

View article titled, Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

Includes: Supplementary data

Articles

Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage

David Lissauer, Oliver Goodyear, Rahela Khanum, Paul A. H. Moss, Mark D. Kilby

Clin Sci (Lond) (2014) 126 (5): 347–354.

https://doi.org/10.1042/CS20130247

Published: 01 November 2013

...David Lissauer; Oliver Goodyear; Rahela Khanum; Paul A. H. Moss; Mark D. Kilby The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite...

View article titled, Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage

Articles

microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells

Pengfei Li, Wei Guo, Leilei Du, Junli Zhao, Yaping Wang, Liu Liu, Yali Hu, Yayi Hou

Clin Sci (Lond) (2013) 124 (1): 27–40.

https://doi.org/10.1042/CS20120121

Published: 07 September 2012

...Pengfei Li; Wei Guo; Leilei Du; Junli Zhao; Yaping Wang; Liu Liu; Yali Hu; Yayi Hou PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral arteries. The present...

View article titled, microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells

Includes: Supplementary data

Articles

Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

Styliani Goulopoulou, Takayuki Matsumoto, Gisele F. Bomfim, R. Clinton Webb

Clin Sci (Lond) (2012) 123 (7): 429–435.

https://doi.org/10.1042/CS20120130

Published: 07 June 2012

... and mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...

View article titled, Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

Articles

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Esther F. Davis, Laura Newton, Adam J. Lewandowski, Merzaka Lazdam, Brenda A. Kelly, Theodosios Kyriakou, Paul Leeson

Clin Sci (Lond) (2012) 123 (2): 53–72.

https://doi.org/10.1042/CS20110627

Published: 23 March 2012

...Esther F. Davis; Laura Newton; Adam J. Lewandowski; Merzaka Lazdam; Brenda A. Kelly; Theodosios Kyriakou; Paul Leeson Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk...

View article titled, Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Articles

Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy

Moulinath Banerjee, Simon G. Anderson, Rayaz A. Malik, Clare E. Austin, J. Kennedy Cruickshank

Clin Sci (Lond) (2012) 122 (2): 53–61.

https://doi.org/10.1042/CS20110033

Published: 20 September 2011

...Moulinath Banerjee; Simon G. Anderson; Rayaz A. Malik; Clare E. Austin; J. Kennedy Cruickshank GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small artery function...

View article titled, Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy

Articles

Brachial artery flow-mediated dilation is not affected by pregnancy or regular exercise participation

Tracey L. Weissgerber, Gregory A. L. Davies, Michael E. Tschakovsky

Clin Sci (Lond) (2011) 121 (8): 355–365.

https://doi.org/10.1042/CS20110008

Published: 24 June 2011

...Tracey L. Weissgerber; Gregory A. L. Davies; Michael E. Tschakovsky Whether brachial artery FMD (flow-mediated dilation) is altered in pregnancy by 28–35 weeks compared with non-pregnant women remains controversial. The controversy may be due to limitations of previous studies that include failing...

View article titled, Brachial artery flow-mediated dilation is not affected by pregnancy or regular exercise participation

Includes: Supplementary data

Articles

Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring

Eleanor Jarvie, Sylvie Hauguel-de-Mouzon, Scott M. Nelson, Naveed Sattar, Patrick M. Catalano, Dilys J. Freeman

Clin Sci (Lond) (2010) 119 (3): 123–129.

https://doi.org/10.1042/CS20090640

Published: 28 April 2010

... pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and increased risk of adverse pregnancy outcome. We hypothesize that the preferential storage of fat in central rather than ‘safer’ lower-body depots in obese pregnancy leads to lipotoxicity. The combination of excess...

View article titled, Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring

Articles

Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction

Henar Ortega-Senovilla, Gioia Alvino, Emanuela Taricco, Irene Cetin, Emilio Herrera

Clin Sci (Lond) (2010) 118 (5): 351–358.

https://doi.org/10.1042/CS20090292

Published: 23 November 2009

...Henar Ortega-Senovilla; Gioia Alvino; Emanuela Taricco; Irene Cetin; Emilio Herrera IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR...

View article titled, Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction

Articles

Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation

Roselle L. Cripps, Malgorzata S. Martin-Gronert, Zoe A. Archer, C. Nick Hales, Julian G. Mercer, Susan E. Ozanne

Clin Sci (Lond) (2009) 117 (2): 85–93.

https://doi.org/10.1042/CS20080393

Published: 15 June 2009

... investigates the potential underlying mechanisms of these observations. Rats were established as follows: (i) control animals [offspring of control dams fed a 20% (w/v) protein diet], (ii) recuperated animals [offspring of dams fed an isocaloric low-protein (8%, w/v) diet during pregnancy and nursed by control...

View article titled, Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation

Articles

Deterioration in cardiac systolic and diastolic function late in normal human pregnancy

Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen B. Harrap

Clin Sci (Lond) (2009) 116 (7): 599–606.

https://doi.org/10.1042/CS20080142

Published: 02 March 2009

...Dominica Zentner; Moira du Plessis; Shaun Brennecke; James Wong; Leeanne Grigg; Stephen B. Harrap The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women...

View article titled, Deterioration in cardiac systolic and diastolic function late in normal human pregnancy

Articles

Circulating levels of adiponectin and leptin at 23–25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction

Makrina D. Savvidou, Alexandros Sotiriadis, Christine Kaihura, Kypros H. Nicolaides, Naveed Sattar

Clin Sci (Lond) (2008) 115 (7): 219–224.

https://doi.org/10.1042/CS20070409

Published: 03 September 2008

... alterations in adiponectin and leptin levels predate the development of PE and FGR (fetal growth restriction) in women at increased risk of these complications, as assessed by Doppler examination of the uterine arteries during the second trimester of pregnancy. We also sought to investigate the circulating...

View article titled, Circulating levels of adiponectin and leptin at 23–25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction

Articles

Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches

Thomas Jansson, Theresa L. Powell

Clin Sci (Lond) (2007) 113 (1): 1–13.

https://doi.org/10.1042/CS20060339

Published: 01 June 2007

... the placenta in order to affect the fetus. Here, we review recent insights into how the placenta responds to changes in the maternal environment and discuss possible mechanisms by which the placenta mediates fetal programming. In IUGR (intrauterine growth restriction) pregnancies, the increased placental...

View article titled, Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches

Articles

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction

Wenzel Wallner, Ruth Sengenberger, Reiner Strick, Pamela L. Strissel, Britta Meurer, Matthias W. Beckmann, Dietmar Schlembach

Clin Sci (Lond) (2007) 112 (1): 51–57.

https://doi.org/10.1042/CS20060161

Published: 01 December 2006

... pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein...

View article titled, Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction

Articles

n − 3 Fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids

Anne E. Barden, Janet A. Dunstan, Lawrence J. Beilin, Susan L. Prescott, Trevor A. Mori

Clin Sci (Lond) (2006) 111 (4): 289–294.

https://doi.org/10.1042/CS20060096

Published: 13 September 2006

... pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune...

View article titled, n − 3 Fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids

Articles

Increased visfatin concentrations in women with gestational diabetes mellitus

Katarzyna Krzyzanowska, Walter Krugluger, Friedrich Mittermayer, Rupa Rahman, Dominik Haider, Nadja Shnawa, Guntram Schernthaner

Clin Sci (Lond) (2006) 110 (5): 605–609.

https://doi.org/10.1042/CS20050363

Published: 11 April 2006

... are limited. To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and in healthy pregnant controls. Furthermore, visfatin concentrations were investigated longitudinally during pregnancy and after delivery in a subgroup of women with GDM...

View article titled, Increased visfatin concentrations in women with gestational diabetes mellitus

Articles

Searching for genetic clues to the causes of pre-eclampsia

Sally Chappell, Linda Morgan

Clin Sci (Lond) (2006) 110 (4): 443–458.

https://doi.org/10.1042/CS20050323

Published: 15 March 2006

.... The imperative for research into pre-eclampsia is its unacceptable burden on maternal and fetal health, much of which is borne by the developing world. Globally, the hypertensive disorders of pregnancy are responsible for up to 50000 maternal deaths and as many as 900000 perinatal deaths annually [ 2 ]. Prompt...

View article titled, Searching for genetic clues to the causes of pre-eclampsia

Includes: Supplementary data

Articles

Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy

Gustavo Castaño, Silvia Lucangioli, Silvia Sookoian, Marcelo Mesquida, Abraham Lemberg, Mirta Di Scala, Paula Franchi, Clyde Carducci, Valeria Tripodi

Clin Sci (Lond) (2006) 110 (4): 459–465.

https://doi.org/10.1042/CS20050302

Published: 15 March 2006

...Gustavo Castaño; Silvia Lucangioli; Silvia Sookoian; Marcelo Mesquida; Abraham Lemberg; Mirta Di Scala; Paula Franchi; Clyde Carducci; Valeria Tripodi ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids...

View article titled, Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy

Articles

Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes

Alfia Al-Ghafra, Shaun P. Brennecke, Roger G. King, Neil M. Gude

Clin Sci (Lond) (2006) 110 (3): 337–342.

https://doi.org/10.1042/CS20050303

Published: 10 February 2006

... The Biochemical Society 2006 Placentas were collected either at elective Caesarean section without spontaneous onset of labour (not-in-labour) or after normal vaginal deliveries or at Caesarean section with spontaneous onset of labour (in-labour) from women with singleton pregnancies. Placentas were obtained...

View article titled, Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes

Articles

Modulation of lipid metabolism by n −3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring

Nassima A. Soulimane-Mokhtari, Baya Guermouche, Akadiri Yessoufou, Myrieum Saker, Kebirou Moutairou, Aziz Hichami, Hafida Merzouk, Naim A. Khan

Clin Sci (Lond) (2005) 109 (3): 287–295.

https://doi.org/10.1042/CS20050028

Published: 24 August 2005

...Nassima A. Soulimane-Mokhtari; Baya Guermouche; Akadiri Yessoufou; Myrieum Saker; Kebirou Moutairou; Aziz Hichami; Hafida Merzouk; Naim A. Khan The time course of changes in lipid metabolism by dietary n −3 PUFAs (polyunsaturated fatty acids) in streptozotocin-induced diabetic rats during pregnancy...

View article titled, Modulation of lipid metabolism by n −3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring

Articles

Increased uterine arterial pressure and contractility of perfused swine uterus after treatment with serum from pre-eclamptic women and endothelin-1

Theodoros Maltaris, Fortunato Scalera, Dietmar Schlembach, Inge Hoffmann, Andreas Mueller, Helge Binder, Tamme Goecke, Torsten Hothorn, Ralf L. Schild, Matthias W. Beckmann, Ralf Dittrich

Clin Sci (Lond) (2005) 109 (2): 209–215.

https://doi.org/10.1042/CS20040340

Published: 25 July 2005

..., 15.5 mmHg, minimum, 12.9 mmHg) ( Figure 1 ). Figure 1 Time schedule of administration of control and test substances For detailed information, see text. The arrows indicate measurements of vitality parameters. arterial pressure endothelin-1 (ET-1) pre-eclampsia pregnancy uterus...

View article titled, Increased uterine arterial pressure and contractility of perfused swine uterus after treatment with serum from pre-eclamptic women and endothelin-1

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