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1-7 of 7
Keywords: pressure overload
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Articles
Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (2): 181–196.
Published: 28 January 2022
... activation and mitochondrial depolarization. Thus, our results demonstrate that NRK-2 plays protective roles in pressure overload (PO)-induced dilatative cardiac remodeling and, genetic ablation exacerbates dilated cardiomyopathy (DCM), interstitial collagen deposition, and cardiac dysfunction post-TAC due...
Includes: Supplementary data
Articles
A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis
Available to PurchaseVanessa Arrieta, Ernesto Martinez-Martinez, Jaime Ibarrola, Virginia Alvarez, Rafael Sádaba, Amaia Garcia-Peña, Amaya Fernández-Celis, Victoria Cachofeiro, Patrick Rossignol, Natalia López-Andrés
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (10): 935–949.
Published: 04 May 2017
...Vanessa Arrieta; Ernesto Martinez-Martinez; Jaime Ibarrola; Virginia Alvarez; Rafael Sádaba; Amaia Garcia-Peña; Amaya Fernández-Celis; Victoria Cachofeiro; Patrick Rossignol; Natalia López-Andrés Aortic stenosis (AS) is characterized by pressure overload and causes left ventricular (LV) fibrosis...
Includes: Supplementary data
Articles
OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4 + T-cells
Available to PurchaseQing-Qing Wu, Yuan Yuan, Xiao-Han Jiang, Yang Xiao, Zheng Yang, Zhen-Guo Ma, Hai-Han Liao, Yuan Liu, Wei Chang, Zhou-Yan Bian, Qi-Zhu Tang
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2061–2071.
Published: 14 October 2016
... + T-lymphocytes. 2 2 2016 16 8 2016 30 8 2016 31 8 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 Global loss of OX40 aids in resisting pressure overload-induced cardiac remodelling. OX40 KO mice...
Articles
Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents
Available to PurchaseLiang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Liao
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
Includes: Supplementary data
Articles
microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β 1 up-regulation
Available to PurchaseJavier Beaumont, Begoña López, Nerea Hermida, Blanche Schroen, Gorka San José, Stephane Heymans, Félix Valencia, Juan José Gómez-Doblas, Eduardo De Teresa, Javier Díez, Arantxa González
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (7): 497–506.
Published: 11 December 2013
...-regulation with myocardial fibrosis in AS patients, probably through TGF-β 1 up-regulation and stimulation of the enzymatic systems involved in extracellular collagen type I synthesis and deposition. cardiac remodelling miR-122 myocardial fibrosis pressure overload procollagen C-terminal...
Articles
Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis
Available to PurchaseMaría U. Moreno, Idoia Gallego, Begoña López, Arantxa González, Ana Fortuño, Gorka San José, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Ajay M. Shah, Javier Díez, Guillermo Zalba
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (6): 291–300.
Published: 22 May 2013
... differentially contribute to cardiac pathophysiology. Animal studies show uncertain results regarding the regulation of cardiac Nox4 by pressure overload and no data are available on human myocardial Nox4. In the present study, we evaluated Nox4 expression and its relationship with myocardial remodelling and LV...
Articles
The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension
Available to PurchaseXiaojian Wang, Xu Yang, Kai Sun, Jingzhou Chen, Xiaodong Song, Hu Wang, Zhe Liu, Changxin Wang, Channa Zhang, Rutai Hui
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (2): 137–145.
Published: 19 October 2009
...Xiaojian Wang; Xu Yang; Kai Sun; Jingzhou Chen; Xiaodong Song; Hu Wang; Zhe Liu; Changxin Wang; Channa Zhang; Rutai Hui GDF15 (growth-differentiation factor 15) is a novel antihypertrophic factor which is induced in the heart in response to pressure overload and plays an important regulatory role...
Includes: Supplementary data
