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Kenshi HAYASHI, Masami SHIMIZU, Hidekazu INO, Masato YAMAGUCHI, Hidenobu TERAI, Naoto HOSHI, Haruhiro HIGASHIDA, Nariaki TERASHIMA, Yoshihide UNO, Honin KANAYA, Hiroshi MABUCHI
Clin Sci (Lond) (2004) 107 (2): 175–182.
Published: 27 July 2004
... dysfunction, may manifest marked QT prolongation or torsade de pointes only upon an additional stressor. A 59-year-old woman had marked QT prolongation and repeated torsade de pointes 3 months after initiation of probucol, a cholesterol-lowering drug. We identified a single base substitution in the HERG gene...
Clin Sci (Lond) (1996) 90 (6): 517–523.
Published: 01 June 1996
...Takeshi Ishizaki; Youichi Kishi; Fumihiko Sasaki; Shingo Ameshima; Tsuguhiko Nakai; Susumu Miyabo 1. We hypothesized that probucol, an oral hypocholesterolaemic agent, can suppress the oxidant stress induced by acute tobacco smoke inhalation in rats. We determined lung tissue glutathione (reduced...
Clin Sci (Lond) (1981) 61 (5): 615–619.
Published: 01 November 1981
...S. Balasubramaniam; D. M. Beins; L. A. Simons 1. The effects of the cholesterol-lowering drug probucol on lipoprotein metabolism and on the key enzymes that regulate hepatic cholesterol metabolism in the rat were studied. 2. Probucol given for 2 weeks was accompanied by a significant reduction in...