... of the core components of cytoskeleton, in this process is only beginning to be revealed. Here, we find that the MT dynamics regulator end-binding protein 2 (EB2) is highly expressed in HCC and predicts poor prognosis of HCC patients. Functional studies show that EB2 overexpression promotes HCC proliferation...

... respective formaldehyde-fixed and paraffin-embedded (FFPE) blocks in order to capture the contextual heterogeneity. PD-1 prognosis T cell exhaustion triple-negative breast cancer Breast cancer (BC) is the most commonly occurring cancer in women worldwide, estimated over 2 million new cases...

... clinicopathological features. Patients with high HEG1 expression had shorter overall survival (OS) and disease-free survival (DFS) than those with low HEG1 expression, which indicated that HEG1 is an independent factor for poor prognosis. Lentivirus-mediated HEG1 overexpression significantly promotes HCC cell...

... on the expression, function and mechanisms of miR-92b in osteosarcoma development. The miRNA miR-92b was up-regulated in osteosarcoma cell lines and tissues; miR-92b up-regulation correlated with poor prognosis in osteosarcoma. Overexpression of miR-92b promoted osteosarcoma cell proliferation, migration...

... Society 2015 diagnosis individualized treatment miRNA non-small-cell lung cancer (NSCLC) post-transcriptional regulation prognosis Lung cancer remains the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) accounts for approximately 80–85% of cases...

... prognosis, we performed ROC analyses on the cohort of clinical samples ( Figure 1 C) and computed the Youden index (J) to stratify the patients. miR-296 was able to significantly discriminate between pathological and normal mammary glands with an area under the ROC curve of 0.73 ( P <0.001; Figure 1 C...

...: Dr Hui Chen (email [email protected] ). 10 6 2013 4 9 2013 11 9 2013 11 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 acute ischaemic stroke Chinese population 25-hydroxyvitamin D [25(OH)D] prognosis stroke • Low vitamin D...

... prognosis survival • DM is very common in patients with liver cirrhosis, and may increase mortality, either by accelerating deterioration of liver function, or by predisposing to serious infections, such as SBP. • In the present study, the presence of DM at baseline was associated...

... that induction of autophagy promotes VPRBP–LC3/p62 interaction. Immunohistochemical examination of human NSCLC (non-small cell lung cancer) tissues showed that VPRBP was positively correlated with p62 and negatively correlated with LC3B. Moreover, p62 and VPRBP were associated with poor prognosis in lung ADC...

... therapy. acute dyspnoea diagnosis latent transforming-growth-factor-binding protein (LTBP) prognosis pulmonary death Acute dyspnoea is one of the most common chief complaints of patients presenting to the emergency department [ 1 ], with the array of possible underlying pathologies ranging...

... Journal compilation © 2012 Biochemical Society 2012 nitric oxide prognosis renal function risk factor symmetric dimethylarginine stroke Dimethylarginines are endogenously occurring structural analogues of the amino acid L -arginine that contain two methyl groups. ADMA (asymmetric...

... an ROC (receiver operating characteristic) AUC (area under the curve) of 0.902 [95% CI (confidence interval), 0.857–0.936] in the discovery group and a similar result in the validation group [ROC AUC, 0.888 (95% CI, 0.819–0.939)]. Patients with high-levels of serum miR-31 also had a poorer prognosis...

... PR3 in determining mortality and incidence of heart failure following AMI, independent of established conventional risk factors. PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. Blood samples were drawn at 2–5 days after the onset of chest...

... troponin T (hsTnT) prognosis pulmonary arterial hypertension 6-min walk test At the dawn of the new century, the discovery of the cardiac-specific biomarkers cTnI (cardiac troponin I) and cTnT (cardiac troponin T) led to the new definition of AMI (acute myocardial infarction) [ 1 , 2...

... biomarker cardiac troponin T (cTnT) echocardiography high-sensitive cardiac troponin T (hsTnT) prognosis pulmonary arterial hypertension (PAH) Chronic PAH (pulmonary arterial hypertension), a potential consequence of many distinct disease mechanisms, is characterized by progressive dyspnoea...

... 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse prognosis for patients with coronary...

... is known as remodelling [ 4 ]. These changes in geometry contribute to the development of congestive HF (heart failure) and predict prognosis [ 5 ]. Rohde and co-workers [ 6 ] were the first to show that administration of an MMP inhibitor attenuated early LV (left ventricular) dilation 4 days after MI...

... demonstrating that variables of interest are independently associated with outcome in multivariable Cox or logistic regression models. acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis...

... compilation © 2009 Biochemical Society 2009 acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis Risk stratification is an important and integral part of the management of patients...

... 2006 2 10 2006 2 10 2006 acute coronary syndrome major adverse cardiac event myocardial infarction myotrophin N-terminal pro-B-type natriuretic peptide (NTproBNP) prognosis ACI [acute MI (myocardial infarction)] is a leading cause of mortality and morbidity. Recent...

... diagnosed with HF has improved over the past decade due to advances in anti-HF therapy, the prognosis remains poor [ 8 ]. On this background and in light of evidence from clinical trials demonstrating marked benefits in treating asymptomatic patients [ 9 ], it is clear that early detection of LV (left...

... myocardial infarction natriuretic peptide prognosis Circulating natriuretic peptide levels provide prognostic information in patients following AMI (acute myocardial infarction) [ 1 – 10 ]. Elevated plasma levels of ANP (atrial natriuretic peptide) [ 1 ] and BNP (B-type natriuretic peptide) [ 3...

... body composition human immunodeficiency virus interleukin-6 malnutrition nutritional status prognosis soluble tumour necrosis factor receptors tumour necrosis factor wasting Clinical Science (1994) 86, 461467 (Printed in Great Britain) 461 Tumour necrosis factor receptor levels are linked...

... The Biochemical Society and the Medical Research Society 1994 hypertension renal artery stenosis renal parenchyma renin activity renal veins prognosis Clinical Science and Molecular Medicine (1973) 45, 31 1s-314s. DIVIDED RENAL A N D PERIPHERAL VENOUS RENIN AS A MEANS OF PREDICTING OPERATIVE...