... of the core components of cytoskeleton, in this process is only beginning to be revealed. Here, we find that the MT dynamics regulator end-binding protein 2 (EB2) is highly expressed in HCC and predicts poor prognosis of HCC patients. Functional studies show that EB2 overexpression promotes HCC proliferation...

... by Portland Press Limited on behalf of the Biochemical Society 2020 PD-1 prognosis T cell exhaustion triple-negative breast cancer Breast cancer (BC) is the most commonly occurring cancer in women worldwide, estimated over 2 million new cases in 2018 [ 1 ]. Classically, BC can be categorized...

... clinicopathological features. Patients with high HEG1 expression had shorter overall survival (OS) and disease-free survival (DFS) than those with low HEG1 expression, which indicated that HEG1 is an independent factor for poor prognosis. Lentivirus-mediated HEG1 overexpression significantly promotes HCC cell...

... on the expression, function and mechanisms of miR-92b in osteosarcoma development. The miRNA miR-92b was up-regulated in osteosarcoma cell lines and tissues; miR-92b up-regulation correlated with poor prognosis in osteosarcoma. Overexpression of miR-92b promoted osteosarcoma cell proliferation, migration...

... treatment miRNA non-small-cell lung cancer (NSCLC) post-transcriptional regulation prognosis Lung cancer remains the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) accounts for approximately 80–85% of cases, with squamous cell carcinoma (SCC...

... (email silvano.bosari@unimi.it or). 12 9 2013 11 2 2014 17 2 2014 17 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being...

... 25-hydroxyvitamin D [25(OH)D] prognosis stroke • Low vitamin D levels have been reported to contribute to the risk of cardiovascular events and mortality, especially stroke. • In the present study, we found that that 25(OH)D is an independent prognostic marker for death...

... patients. Two small studies have also shown that DM was associated with increased 1-year [ 7 ] and 2-year mortality [ 8 ]. In contrast, in two other prospective studies, DM did not influence the prognosis [ 1 ], or was no longer significantly associated with 2-year mortality after adjustment for Child–Pugh...

... that induction of autophagy promotes VPRBP–LC3/p62 interaction. Immunohistochemical examination of human NSCLC (non-small cell lung cancer) tissues showed that VPRBP was positively correlated with p62 and negatively correlated with LC3B. Moreover, p62 and VPRBP were associated with poor prognosis in lung ADC...

...-binding protein (LTBP) prognosis pulmonary death Acute dyspnoea is one of the most common chief complaints of patients presenting to the emergency department [ 1 ], with the array of possible underlying pathologies ranging from anxiety and hyperventilation to life-threatening pulmonary, cardiac...

... Journal compilation © 2012 Biochemical Society 2012 nitric oxide prognosis renal function risk factor symmetric dimethylarginine stroke Dimethylarginines are endogenously occurring structural analogues of the amino acid L -arginine that contain two methyl groups. ADMA (asymmetric...

... an ROC (receiver operating characteristic) AUC (area under the curve) of 0.902 [95% CI (confidence interval), 0.857–0.936] in the discovery group and a similar result in the validation group [ROC AUC, 0.888 (95% CI, 0.819–0.939)]. Patients with high-levels of serum miR-31 also had a poorer prognosis...

... PR3 in determining mortality and incidence of heart failure following AMI, independent of established conventional risk factors. PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. Blood samples were drawn at 2–5 days after the onset of chest...

... be helpful not only in risk assessment, but also in the selection of treatment modalities and care intensity. Moreover, reliable indicators of clinical worsening and disease severity may be useful to delineate the disease severity and prognosis, as well as to monitor the clinical course and response...

... biomarker cardiac troponin T (cTnT) echocardiography high-sensitive cardiac troponin T (hsTnT) prognosis pulmonary arterial hypertension (PAH) Chronic PAH (pulmonary arterial hypertension), a potential consequence of many distinct disease mechanisms, is characterized by progressive dyspnoea...

... infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse prognosis for patients with coronary heart disease. In the setting of AMI (acute myocardial infarction), the diagnosis of diabetes is associated with adverse outcome [ 1 , 2 ]. In addition, elevated blood...

...) prognosis MMPs (matrix metalloproteinases) are a family of zinc-containing endoproteinases which, along with their inhibitors [TIMPs (tissue inhibitors of metalloproteinases)] are vital in ensuring a balanced turnover of the cardiac ECM (extracellular matrix). MMPs have been classified into four...

... Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis Alternatively, improvement in risk classification can be evaluated by the use of event-specific re-classification tables. Predicted probabilities for the outcome in question can...

... compilation © 2009 Biochemical Society 2009 acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis Risk stratification is an important and integral part of the management of patients...

... cardiac event myocardial infarction myotrophin N-terminal pro-B-type natriuretic peptide (NTproBNP) prognosis ACI [acute MI (myocardial infarction)] is a leading cause of mortality and morbidity. Recent advances in the treatment of AMI have improved patient survival; however, despite...

... peptide diagnosis heart failure prognosis management treatment The cardiac natriuretic peptides, ANP and BNP (atrial and brain natriuretic peptides respectively), are hormones secreted predominantly by the heart. ANP is synthesized most abundantly in the atria where it is stored in specific...

... either peptide alone. heart failure myocardial infarction natriuretic peptide prognosis Circulating natriuretic peptide levels provide prognostic information in patients following AMI (acute myocardial infarction) [ 1 – 10 ]. Elevated plasma levels of ANP (atrial natriuretic peptide) [ 1...

... body composition human immunodeficiency virus interleukin-6 malnutrition nutritional status prognosis soluble tumour necrosis factor receptors tumour necrosis factor wasting Clinical Science (1994) 86, 461467 (Printed in Great Britain) 461 Tumour necrosis factor receptor levels are linked...

... The Biochemical Society and the Medical Research Society 1994 hypertension renal artery stenosis renal parenchyma renin activity renal veins prognosis Clinical Science and Molecular Medicine (1973) 45, 31 1s-314s. DIVIDED RENAL A N D PERIPHERAL VENOUS RENIN AS A MEANS OF PREDICTING OPERATIVE...