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Keywords: prognosis
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 847–864.
Published: 06 April 2021
... of the core components of cytoskeleton, in this process is only beginning to be revealed. Here, we find that the MT dynamics regulator end-binding protein 2 (EB2) is highly expressed in HCC and predicts poor prognosis of HCC patients. Functional studies show that EB2 overexpression promotes HCC proliferation...
Includes: Supplementary data
Articles
Liang Guo, Chunmei Cao, Shyamal Goswami, Xiaoyan Huang, Linxiaoxi Ma, Yicheng Guo, Benlong Yang, Teng Li, Yayun Chi, Xiaoming Zhang, Jiong Wu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 711–726.
Published: 03 April 2020
... respective formaldehyde-fixed and paraffin-embedded (FFPE) blocks in order to capture the contextual heterogeneity. PD-1 prognosis T cell exhaustion triple-negative breast cancer Breast cancer (BC) is the most commonly occurring cancer in women worldwide, estimated over 2 million new cases...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1645–1662.
Published: 25 July 2019
... clinicopathological features. Patients with high HEG1 expression had shorter overall survival (OS) and disease-free survival (DFS) than those with low HEG1 expression, which indicated that HEG1 is an independent factor for poor prognosis. Lentivirus-mediated HEG1 overexpression significantly promotes HCC cell...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (11): 921–930.
Published: 29 April 2016
... on the expression, function and mechanisms of miR-92b in osteosarcoma development. The miRNA miR-92b was up-regulated in osteosarcoma cell lines and tissues; miR-92b up-regulation correlated with poor prognosis in osteosarcoma. Overexpression of miR-92b promoted osteosarcoma cell proliferation, migration...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 619–634.
Published: 20 February 2015
... Society 2015 diagnosis individualized treatment miRNA non-small-cell lung cancer (NSCLC) post-transcriptional regulation prognosis Lung cancer remains the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) accounts for approximately 80–85% of cases...
Articles
Federica Savi, Irene Forno, Alice Faversani, Andrea Luciani, Sarah Caldiera, Stefano Gatti, Paolo Foa, Dario Ricca, Gaetano Bulfamante, Valentina Vaira, Silvano Bosari
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (4): 233–242.
Published: 10 April 2014
... prognosis, we performed ROC analyses on the cohort of clinical samples ( Figure 1 C) and computed the Youden index (J) to stratify the patients. miR-296 was able to significantly discriminate between pathological and normal mammary glands with an area under the ROC curve of 0.73 ( P <0.001; Figure 1 C...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (5): 339–346.
Published: 25 October 2013
...: Dr Hui Chen (email [email protected] ). 10 6 2013 4 9 2013 11 9 2013 11 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 acute ischaemic stroke Chinese population 25-hydroxyvitamin D [25(OH)D] prognosis stroke • Low vitamin D...
Articles
Nick Wlazlo, Marleen M. van Greevenbroek, Joyce Curvers, Erik J. Schoon, Pieter Friederich, Jos W. R. Twisk, Bert Bravenboer, Coen D. A. Stehouwer
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (7): 341–348.
Published: 07 June 2013
... prognosis survival • DM is very common in patients with liver cirrhosis, and may increase mortality, either by accelerating deterioration of liver function, or by predisposing to serious infections, such as SBP. • In the present study, the presence of DM at baseline was associated...
Articles
Bo-Shi Wang, Yi-Zhen Liu, Yang Yang, Yu Zhang, Jia-Jie Hao, Hai Yang, Xiao-Min Wang, Zi-Qiang Zhang, Qi-Min Zhan, Ming-Rong Wang
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (3): 203–214.
Published: 17 October 2012
... that induction of autophagy promotes VPRBP–LC3/p62 interaction. Immunohistochemical examination of human NSCLC (non-small cell lung cancer) tissues showed that VPRBP was positively correlated with p62 and negatively correlated with LC3B. Moreover, p62 and VPRBP were associated with poor prognosis in lung ADC...
Includes: Supplementary data
Articles
Tobias Breidthardt, Griet Vanpoucke, Mihael Potocki, Tamina Mosimann, Ronny Ziller, Gregoire Thomas, Wouter Laroy, Piet Moerman, Thenral Socrates, Beatrice Drexler, Alexandre Mebazaa, Koen Kas, Christian Mueller
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (9): 557–566.
Published: 13 July 2012
... therapy. acute dyspnoea diagnosis latent transforming-growth-factor-binding protein (LTBP) prognosis pulmonary death Acute dyspnoea is one of the most common chief complaints of patients presenting to the emergency department [ 1 ], with the array of possible underlying pathologies ranging...
Articles
Nicole Lüneburg, Rouven-Alexander von Holten, Rudolf F. Töpper, Edzard Schwedhelm, Renke Maas, Rainer H. Böger
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
... Journal compilation © 2012 Biochemical Society 2012 nitric oxide prognosis renal function risk factor symmetric dimethylarginine stroke Dimethylarginines are endogenously occurring structural analogues of the amino acid L -arginine that contain two methyl groups. ADMA (asymmetric...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (10): 437–447.
Published: 25 July 2011
... an ROC (receiver operating characteristic) AUC (area under the curve) of 0.902 [95% CI (confidence interval), 0.857–0.936] in the discovery group and a similar result in the validation group [ROC AUC, 0.888 (95% CI, 0.819–0.939)]. Patients with high-levels of serum miR-31 also had a poorer prognosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (6): 231–238.
Published: 03 December 2010
... PR3 in determining mortality and incidence of heart failure following AMI, independent of established conventional risk factors. PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. Blood samples were drawn at 2–5 days after the onset of chest...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (5): 203–205.
Published: 02 June 2010
... troponin T (hsTnT) prognosis pulmonary arterial hypertension 6-min walk test At the dawn of the new century, the discovery of the cardiac-specific biomarkers cTnI (cardiac troponin I) and cTnT (cardiac troponin T) led to the new definition of AMI (acute myocardial infarction) [ 1 , 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (5): 207–213.
Published: 02 June 2010
... biomarker cardiac troponin T (cTnT) echocardiography high-sensitive cardiac troponin T (hsTnT) prognosis pulmonary arterial hypertension (PAH) Chronic PAH (pulmonary arterial hypertension), a potential consequence of many distinct disease mechanisms, is characterized by progressive dyspnoea...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (8): 527–535.
Published: 02 February 2010
... 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse prognosis for patients with coronary...
Articles
Onkar S. Dhillon, Sohail Q. Khan, Hafid K. Narayan, Kelvin H. Ng, Noor Mohammed, Paulene A. Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (4): 249–257.
Published: 09 November 2009
... is known as remodelling [ 4 ]. These changes in geometry contribute to the development of congestive HF (heart failure) and predict prognosis [ 5 ]. Rohde and co-workers [ 6 ] were the first to show that administration of an MMP inhibitor attenuated early LV (left ventricular) dilation 4 days after MI...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (1): 13–15.
Published: 02 June 2009
... demonstrating that variables of interest are independently associated with outcome in multivariable Cox or logistic regression models. acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis...
Articles
Sohail Q. Khan, Hafid Narayan, Kelvin H. Ng, Onkar S. Dhillon, Dominic Kelly, Paulene Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (1): 31–39.
Published: 02 June 2009
... compilation © 2009 Biochemical Society 2009 acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis Risk stratification is an important and integral part of the management of patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (4): 251–256.
Published: 17 January 2007
... 2006 2 10 2006 2 10 2006 acute coronary syndrome major adverse cardiac event myocardial infarction myotrophin N-terminal pro-B-type natriuretic peptide (NTproBNP) prognosis ACI [acute MI (myocardial infarction)] is a leading cause of mortality and morbidity. Recent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (1): 23–36.
Published: 15 December 2004
... diagnosed with HF has improved over the past decade due to advances in anti-HF therapy, the prognosis remains poor [ 8 ]. On this background and in light of evidence from clinical trials demonstrating marked benefits in treating asymptomatic patients [ 9 ], it is clear that early detection of LV (left...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (3): 309–316.
Published: 24 August 2004
... myocardial infarction natriuretic peptide prognosis Circulating natriuretic peptide levels provide prognostic information in patients following AMI (acute myocardial infarction) [ 1 – 10 ]. Elevated plasma levels of ANP (atrial natriuretic peptide) [ 1 ] and BNP (B-type natriuretic peptide) [ 3...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (4): 461–467.
Published: 01 April 1994
... body composition human immunodeficiency virus interleukin-6 malnutrition nutritional status prognosis soluble tumour necrosis factor receptors tumour necrosis factor wasting Clinical Science (1994) 86, 461467 (Printed in Great Britain) 461 Tumour necrosis factor receptor levels are linked...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (s1): 311s–314s.
Published: 01 August 1973
... The Biochemical Society and the Medical Research Society 1994 hypertension renal artery stenosis renal parenchyma renin activity renal veins prognosis Clinical Science and Molecular Medicine (1973) 45, 31 1s-314s. DIVIDED RENAL A N D PERIPHERAL VENOUS RENIN AS A MEANS OF PREDICTING OPERATIVE...