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Keywords: prognosis
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Articles
Clin Sci (Lond) (2021) 135 (7): 847–864.
Published: 06 April 2021
... core components of cytoskeleton, in this process is only beginning to be revealed. Here, we find that the MT dynamics regulator end-binding protein 2 (EB2) is highly expressed in HCC and predicts poor prognosis of HCC patients. Functional studies show that EB2 overexpression promotes HCC proliferation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (7): 711–726.
Published: 03 April 2020
... Portland Press Limited on behalf of the Biochemical Society 2020 PD-1 prognosis T cell exhaustion triple-negative breast cancer Breast cancer (BC) is the most commonly occurring cancer in women worldwide, estimated over 2 million new cases in 2018 [ 1 ]. Classically, BC can be categorized...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1645–1662.
Published: 25 July 2019
... clinicopathological features. Patients with high HEG1 expression had shorter overall survival (OS) and disease-free survival (DFS) than those with low HEG1 expression, which indicated that HEG1 is an independent factor for poor prognosis. Lentivirus-mediated HEG1 overexpression significantly promotes HCC cell...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (11): 921–930.
Published: 29 April 2016
... expression, function and mechanisms of miR-92b in osteosarcoma development. The miRNA miR-92b was up-regulated in osteosarcoma cell lines and tissues; miR-92b up-regulation correlated with poor prognosis in osteosarcoma. Overexpression of miR-92b promoted osteosarcoma cell proliferation, migration and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (10): 619–634.
Published: 20 February 2015
...@163.com ) 29 8 2014 24 11 2014 9 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 diagnosis individualized treatment miRNA non-small-cell lung cancer (NSCLC) post-transcriptional regulation prognosis Lung cancer remains the leading...
Articles
Clin Sci (Lond) (2014) 127 (4): 233–242.
Published: 10 April 2014
... a role in breast carcinogenesis and metastatic dissemination. Furthermore, an miR-296-5p -based therapeutic approach hampers breast cancer tumour growth in vivo . breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being a...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (5): 339–346.
Published: 25 October 2013
... population 25-hydroxyvitamin D [25(OH)D] prognosis stroke • Low vitamin D levels have been reported to contribute to the risk of cardiovascular events and mortality, especially stroke. • In the present study, we found that that 25(OH)D is an independent prognostic marker for death and...
Articles
Clin Sci (Lond) (2013) 125 (7): 341–348.
Published: 07 June 2013
... prognosis survival • DM is very common in patients with liver cirrhosis, and may increase mortality, either by accelerating deterioration of liver function, or by predisposing to serious infections, such as SBP. • In the present study, the presence of DM at baseline was associated with...
Articles
Clin Sci (Lond) (2013) 124 (3): 203–214.
Published: 17 October 2012
... that induction of autophagy promotes VPRBP–LC3/p62 interaction. Immunohistochemical examination of human NSCLC (non-small cell lung cancer) tissues showed that VPRBP was positively correlated with p62 and negatively correlated with LC3B. Moreover, p62 and VPRBP were associated with poor prognosis in...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (9): 557–566.
Published: 13 July 2012
...) prognosis pulmonary death Acute dyspnoea is one of the most common chief complaints of patients presenting to the emergency department [ 1 ], with the array of possible underlying pathologies ranging from anxiety and hyperventilation to life-threatening pulmonary, cardiac and metabolic causes...
Articles
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
... Journal compilation © 2012 Biochemical Society 2012 nitric oxide prognosis renal function risk factor symmetric dimethylarginine stroke Dimethylarginines are endogenously occurring structural analogues of the amino acid L -arginine that contain two methyl groups. ADMA (asymmetric...
Articles
Clin Sci (Lond) (2011) 121 (10): 437–447.
Published: 25 July 2011
... ROC (receiver operating characteristic) AUC (area under the curve) of 0.902 [95% CI (confidence interval), 0.857–0.936] in the discovery group and a similar result in the validation group [ROC AUC, 0.888 (95% CI, 0.819–0.939)]. Patients with high-levels of serum miR-31 also had a poorer prognosis in...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (6): 231–238.
Published: 03 December 2010
... PR3 in determining mortality and incidence of heart failure following AMI, independent of established conventional risk factors. PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. Correspondence: Professor Leong L. Ng (email lln1@le.ac.uk...
Articles
Clin Sci (Lond) (2010) 119 (5): 203–205.
Published: 02 June 2010
...-sensitive cardiac troponin T (hsTnT) prognosis pulmonary arterial hypertension 6-min walk test At the dawn of the new century, the discovery of the cardiac-specific biomarkers cTnI (cardiac troponin I) and cTnT (cardiac troponin T) led to the new definition of AMI (acute myocardial infarction) [ 1...
Articles
Clin Sci (Lond) (2010) 119 (5): 207–213.
Published: 02 June 2010
... 2010 biomarker cardiac troponin T (cTnT) echocardiography high-sensitive cardiac troponin T (hsTnT) prognosis pulmonary arterial hypertension (PAH) Chronic PAH (pulmonary arterial hypertension), a potential consequence of many distinct disease mechanisms, is characterized by...
Articles
Clin Sci (Lond) (2010) 118 (8): 527–535.
Published: 02 February 2010
... 2009 28 9 2009 13 10 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse...
Articles
Clin Sci (Lond) (2010) 118 (4): 249–257.
Published: 09 November 2009
...-proBNP) prognosis MMPs (matrix metalloproteinases) are a family of zinc-containing endoproteinases which, along with their inhibitors [TIMPs (tissue inhibitors of metalloproteinases)] are vital in ensuring a balanced turnover of the cardiac ECM (extracellular matrix). MMPs have been classified...
Articles
Clin Sci (Lond) (2009) 117 (1): 13–15.
Published: 02 June 2009
... Society 2009 acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis In the present issue of Clinical Science , Khan et al. [ 1 ] have compared the prognostic value of the GRACE...
Articles
Clin Sci (Lond) (2009) 117 (1): 31–39.
Published: 02 June 2009
... compilation © 2009 Biochemical Society 2009 acute coronary syndrome Global Registry of Acute Coronary Events (GRACE) score myocardial infarction N-terminal pro-B-type natriuretic peptide (NT-proBNP) prognosis Risk stratification is an important and integral part of the management of patients...
Articles
Clin Sci (Lond) (2007) 112 (4): 251–256.
Published: 17 January 2007
... 2006 2 10 2006 2 10 2006 The Biochemical Society 2007 acute coronary syndrome major adverse cardiac event myocardial infarction myotrophin N-terminal pro-B-type natriuretic peptide (NTproBNP) prognosis ACI [acute MI (myocardial infarction)] is a leading cause of...
Articles
Clin Sci (Lond) (2005) 108 (1): 23–36.
Published: 15 December 2004
... heart failure prognosis management treatment The cardiac natriuretic peptides, ANP and BNP (atrial and brain natriuretic peptides respectively), are hormones secreted predominantly by the heart. ANP is synthesized most abundantly in the atria where it is stored in specific intramyocyte...
Articles
Clin Sci (Lond) (2004) 107 (3): 309–316.
Published: 24 August 2004
... failure than either peptide alone. Correspondence: Dr Iain Squire (email is11@le.ac.uk ). 17 3 2004 28 4 2004 7 6 2004 7 6 2004 The Biochemical Society 2004 heart failure myocardial infarction natriuretic peptide prognosis Circulating natriuretic peptide...
Articles
Clin Sci (Lond) (1994) 86 (4): 461–467.
Published: 01 April 1994
... impedance analysis body composition human immunodeficiency virus interleukin-6 malnutrition nutritional status prognosis soluble tumour necrosis factor receptors tumour necrosis factor wasting Clinical Science (1994) 86, 461467 (Printed in Great Britain) 461 Tumour necrosis factor receptor...
Articles
Clin Sci Mol Med (1973) 45 (s1): 311s–314s.
Published: 01 August 1973
... curable. A similar pattern was found in four controls. (PI. Key words: hypertension, renal artery stenosis, renal parenchyma, renin activity, renal veins, prognosis. A number of criteria have been proposed for selecting renovascular hypertensive patients who are likely to benefit from surgery. Recently, a...