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Keywords: proliferation
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Articles
Clin Sci (Lond) (2021) 135 (7): 847–864.
Published: 06 April 2021
... of the core components of cytoskeleton, in this process is only beginning to be revealed. Here, we find that the MT dynamics regulator end-binding protein 2 (EB2) is highly expressed in HCC and predicts poor prognosis of HCC patients. Functional studies show that EB2 overexpression promotes HCC proliferation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1567–1579.
Published: 18 July 2019
... the proliferation, migration, and invasion ability of NSCLC cells both in vivo and in vitro . Mechanically, it was indicated that XIST could serve as an endogenous competitive RNA modulating miR-744, leading to the miR-744/RING1 signaling pathway inhibition and Wnt/β-catenin signaling pathway activation. Taken...
Articles
Clin Sci (Lond) (2019) 133 (13): 1439–1455.
Published: 15 July 2019
... ten (PTEN), has been implicated in smooth muscle cell (SMC) proliferation and apoptosis. PTENP1 is the pseudogene of PTEN. However, it is unclear whether and how PTENP1 functions in the proliferation and apoptosis of human aortic SMCs (HASMCs). Here, we hypothesised that PTENP1 inhibits HASMC...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (11): 1229–1253.
Published: 07 June 2019
... is increasing presenting a major socio-economic burden. Thus, there is a great need for novel therapies that can reverse damage inflicted to the heart. In recent years, data have accumulated suggesting that induction of cardiomyocyte proliferation might be a future option for cardiac regeneration. Here, we...
Articles
Clin Sci (Lond) (2019) 133 (2): 381–392.
Published: 30 January 2019
..., as well as poorer overall survival. Moreover, ZEB1-AS1 knockdown inhibited NSCLC cell proliferation and migration, and promoted cell apoptosis. In addition, a chromatin immunoprecipitation assay revealed that ZEB1-AS1 interacted with STAT3, thereby repressing ID1 expression. Furthermore, rescue...
Articles
Clin Sci (Lond) (2017) 131 (22): 2721–2735.
Published: 13 November 2017
... increased BMSCs proliferation through H19/miR-675 axis. We found that BMSCs derived from the TDO patient (TDO-BMSCs) had stronger proliferation ability than controls by clonogenic and CCK-8 assays. Next, experiments of overexpression and knockdown of wild-type DLX3 via lentiviruses in normal BMSCs confirmed...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1125–1136.
Published: 23 May 2016
.... Phospholipase D (PD) is involved in cell proliferation and migration, but its role in HCC remains unclear. In the present study, we show that PLD1, but not PLD2, was overexpressed in HCC cell lines (HepG2, Bel-7402 and Bel-7404) compared with the normal human L-02 hepatocytes. PLD1 was required...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (11): 921–930.
Published: 29 April 2016
... on the expression, function and mechanisms of miR-92b in osteosarcoma development. The miRNA miR-92b was up-regulated in osteosarcoma cell lines and tissues; miR-92b up-regulation correlated with poor prognosis in osteosarcoma. Overexpression of miR-92b promoted osteosarcoma cell proliferation, migration...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
... artery (LCA). Neointimal and medial composition was assessed using immunohistochemistry and ESI–MS. Primary rabbit aortic SMCs (smooth muscle cells) were utilized to examine the effects of modified lipids on VSMC proliferation, viability and migration at a cellular level. Neointimal area, measured...
Articles
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
...) transactivation is probably responsible for aldosterone-induced mesangial mitosis and proliferation. In podocytes, mitochondrial dysfunction elicited by oxidative stress is an early event associated with aldosterone-induced podocyte injury. Both the p38 MAPK (p38 mitogen-activated protein kinase) signalling...
Articles
Clin Sci (Lond) (2014) 127 (9): 571–579.
Published: 09 July 2014
...Wei Gao; Jimmy Yu-Wai Chan; Thian-Sze Wong Curcumin suppresses proliferation, migration, invasion, metastasis and angiogenesis and induces apoptosis by regulating multiple signalling pathways and miRNAs in a wide variety of human malignancies. miRNAs play crucial roles in various steps...
Articles
Clin Sci (Lond) (2014) 126 (7): 517–527.
Published: 11 December 2013
...) and ELISA, and examined in vitro how UCN2 affects human aortic VSMC (vascular smooth muscle cell) Akt phosphorylation, pro-inflammatory cytokine IL (interleukin)-6 secretion, proliferation, cell cycle and apoptosis. UCN2 and CRFR2 expression were significantly up-regulated in biopsies from the AAA body. AAA...
Articles
Clin Sci (Lond) (2010) 118 (7): 473–485.
Published: 12 January 2010
... expression of DNA damage markers and of DNA repair genes, together with the assessment of proliferation and apoptosis indexes. The expression of the oxidative DNA damage marker 7,8-dihydro-8-oxo-2′-deoxyguanosine was increased at 3 and 7 days after arteriotomy, with immunostaining distributed in the injured...
Articles
Clin Sci (Lond) (2008) 115 (8): 245–253.
Published: 12 September 2008
... to be involved in the regulation of vital cell functions, such as proliferation, differentiation, apoptosis and cell–cell interaction. In airways, most cells express the non-neuronal cholinergic system, each containing a specific set of components required for synthesis, signal transduction and ACh hydrolysis...
Articles
Clin Sci (Lond) (2006) 111 (6): 389–399.
Published: 14 November 2006
...Neil Ashman; Tatiana M. Brunini; Giovanni E. Mann; A. Claudio Mendes Ribeiro; Muhammad M. Yaqoob Albumin has complex effects on PTECs (proximal tubular epithelial cells) and is able to stimulate growth or injury depending on its bound moieties. Albumin itself is a mitogen, inducing proliferation...
Articles
Clin Sci (Lond) (2005) 109 (5): 457–463.
Published: 24 October 2005
...-oestradiol. Finally, the expression of PDI isoforms was reduced by 17β-oestradiol. In summary, 17β-oestradiol modified the expression of isoforms of proteins associated with smooth muscle cell proliferation (α-enolase, vimentin and HSP-60), cell contraction (vimentin and caldesmon) and cell redox modulation...
Articles
Clin Sci (Lond) (2003) 105 (3): 323–330.
Published: 01 September 2003
... littermates ( n =26) received saline or EGF (223 μg of EGF/kg per day) for 4 weeks using subcutaneous osmotic mini-pumps. Cell proliferation and crypt fission were analysed using microdissection techniques and the number and size of polyps in the small and large intestines were determined. EGF increased wet...
Articles
Clin Sci (Lond) (2003) 104 (5): 467–481.
Published: 01 May 2003
... of hormone release, pituitary cell proliferation and cytokine/growth factor expression. In this review, we discuss these advances and examine some implications for pituitary growth control and the response of the hypothalamic–pituitary–adrenal axis to stress and inflammation. Correspondence: Dr D.A...
Articles
Clin Sci (Lond) (2000) 98 (3): 295–301.
Published: 09 February 2000
... in tubular cell growth and proliferation. We have used the opossum kidney proximal tubular cell line to investigate the effects of albumin on cell growth. The effect of albumin on cell proliferation was investigated by cell counting and measurement of [ 3 H]thymidine incorporation. We studied the effect...
Articles
Clin Sci (Lond) (1995) 88 (2): 119–130.
Published: 01 February 1995
...Ralph A. Boulton; Humphrey J. F. Hodgson © 1995 The Biochemical Society and the Medical Research Society 1995 5-bromodeoxyuridine cell cycle flow cytometry Ki-67 polyamine proliferating cell nuclear antigen proliferation thymidine Clinical Science (1995) 88, 119-130 (Printed...
Articles
Clin Sci (Lond) (1989) 76 (6): 595–598.
Published: 01 June 1989
...R. A. Goodlad; H. Gregory; N. A. Wright 1. Intestinal epithelial cell proliferation was measured in rats maintained on total parenteral nutriton (TPN), in TPN rats given 300 μg of recombinant human epidermal growth factor (urogastrone-epidermal growth factor, URO-EGF) day −1 kg −1 , and in further...
Articles
Clin Sci (Lond) (1988) 74 (3): 301–306.
Published: 01 March 1988
... migration food intake gastrointestinal tract intestine proliferation starvation 28 7 1987 8 9 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 Clinical Science ( 1988) 74, 30 1-306 30 1 Epithelial cell proliferation and intestinal absorptive function...
Articles
Clin Sci (Lond) (1987) 72 (3): 297–304.
Published: 01 March 1987
... in microdissected intestinal crypts to determine the crypt cell production rate (CCPR), is one of the most effective methods of estimating intestinal epithelial cell proliferation which is robust enough to withstand scrutiny. However, studies in the field of intestinal adaptation could be much more informative...