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Keyword: propranolol
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Articles
Clin Sci (Lond) (2011) 121 (12): 545-554.
Published: 22 August 2011
..., sympathetic tone abnormality and vascular hyporesponsiveness in portal hypertension may impede the haemostatic effects of vasoconstrictors. Propranolol, a β-blocker binding the G-protein-coupled adrenoceptor, is a portal hypotensive agent. However, whether propranolol influences the collateral vasoresponse is...
Articles
Clin Sci (Lond) (1990) 78 (4): 403-407.
Published: 01 April 1990
...Hiroyuki Shimamoto; Yoriko Shimamoto; Shogo Sakata 1. The influence of long-acting propranolol and of atenolol on the circadian rhythm of heart rate was assessed using 24 h electrocardiographic recordings in elderly patients with essential hypertension. Eighteen elderly patients were investigated...
Articles
Clin Sci (Lond) (1988) 75 (5): 543-549.
Published: 01 November 1988
... secondary to the elevated blood pressure. 2. Indices of systemic calcium metabolism were followed prospectively during 6 months' treatment with either propranolol, bendroflumethiazide or verapamil in 35 patients with essential hypertension. Multivariate statistical methods were employed to study the effects...
Articles
Clin Sci (Lond) (1987) 73 (1): 47-52.
Published: 01 July 1987
...–effect analysis to determine whether pregnancy influences the action of propranolol. 2. Twelve women with pregnancy induced hypertension were studied during the third trimester and again 2–3 months post partum. On each occasion propranolol (10 mg) was given intravenously and measurements of heart rate...
Articles
Clin Sci (Lond) (1987) 72 (6): 679-682.
Published: 01 June 1987
...P. E. Hall; S. R. Smith; M. J. Kendall 1. Plasma ammonia and heart rate were measured in normal volunteers before, during and after an exercise test following administration of placebo, propranolol, pindolol, metoprolol and nadolol. 2. Small changes in plasma ammonia occurred during exercise after...
Articles
Clin Sci (Lond) (1987) 72 (5): 549-556.
Published: 01 May 1987
... lipoproteins during chronic β-adrenoceptor blockade in patients with stable angina pectoris treated with propranolol (without ISA) (n = 21) or pindolol (with ISA) ( n = 19). 2. No significant changes occurred in the lipoprotein profile of the patients taking pindolol. In those taking propranolol, very low...
Articles
Clin Sci (Lond) (1986) 71 (4): 457-460.
Published: 01 October 1986
... dynamic exercise was performed on a bicycle ergometer at work loads of 25, 50 and 100 W, before and after pharmacological blockade with atropine (13 individuals) or propranolol (10 individuals). 3. Parasympathetic blockade significantly depressed the rapid HR response at the beginning of the exercise...
Articles
Clin Sci (Lond) (1984) 67 (4): 427-431.
Published: 01 October 1984
... intervals and analysed in vitro for plasma potassium. 3. Arterial plasma potassium rose rapidly at the start of exercise from 3.8 ± 0.3 mmol/l (mean ± sd) to plateau levels of 5.4 ± 0.1 mmol/l. 4. One of the above subjects and a further subject were studied after β-blockade with propranolol. This resulted...
Articles
Clin Sci (Lond) (1984) 67 (2): 243-248.
Published: 01 August 1984
...Boothur J. Z. Danesh; Joyce Brunton; David J. Sumner 1. The effect of 4-6 weeks’ treatment with propranolol and nadolol on effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) was studied, in 14 patients with essential hypertension, in single blind, random and cross-over design...
Articles
Clin Sci (Lond) (1984) 66 (1): 79-85.
Published: 01 January 1984
...J. B. Warren; S. J. Jennings; T. J. H. Clark 1. Ten normal, non-asthmatic subjects performed an 18 min graduated exercise test on a static exercise bicycle on 3 separate days. They received either no medication, or propranolol 80 mg orally 2 h before, or ipratropium bromide 0.216 mg by inhalation...
Articles
Clin Sci (Lond) (1983) 65 (5): 463-468.
Published: 01 November 1983
...Yoseph Assen Mengesha; Ambachew Woreta; Belay Tesfa Mariam 1. The forearm blood flow responses to hypoxia obtained from ten subjects (ages 26–37 years) before and after propranolol showed no relation with either plasma osmolality or plasma concentrations of K + , Na + , Ca 2+ , P i and Cl − . The...
Articles
Clin Sci (Lond) (1983) 65 (1): 91-93.
Published: 01 July 1983
... propranolol, 2–5 mg, over 10–15 min each, with return to baseline between drugs. 3. After hydralazine, the occurrence of abnormal high velocity flow patterns increased in 17 of 20 patients; there was no change in three patients. Propranolol reduced the occurrence of abnormal high velocity flow patterns in 19...
Articles
Clin Sci (Lond) (1982) 63 (4): 373-380.
Published: 01 October 1982
...G. Kitis; M. L. Lucas; H. Bishop; A. Sargent; R. E. Schneider; J. A. Blair; R. N. Allan 1. Propranolol and folic acid absorption were studied separately in healthy subjects, non-coeliac patients and patients with treated and untreated coeliac disease. 2. The surface pH of jejunal biopsy samples was...
Articles
Clin Sci (Lond) (1982) 63 (s8): 451s-453s.
Published: 01 October 1982
...W. Kirch; H. Spahn; H. Köhler; E. Mutschler 1. Pharmacokinetics of metoprolol, propranolol and atenolol were investigated in six healthy volunteers after 7 days of oral monotherapy with these drugs and after 7 days concurrent administration, with each of these β-adrenoceptor antagonists with...
Articles
Clin Sci (Lond) (1982) 63 (s8): 459s-460s.
Published: 01 October 1982
..., pindolol or slow-release propranolol. 3. Drugs were administered in a once-daily variable dose regimen for a period of 3–8 months (mean 5.0 ± sd 1.4). 4. All four drugs reduced blood pressure significantly 24 h after the last dose but there were considerable differences in control when each intervening...
Articles
Clin Sci (Lond) (1982) 63 (3): 301-310.
Published: 01 September 1982
...I. A. Macdonald; T. Bennett; E. A. M. Gale; J. Hilary Green; S. Walford 1. The effects of metoprolol and propranolol on heat production and body temperature have been studied in six male subjects during insulin-induced hypoglycaemia in a thermoneutral environment. Hypoglycaemia was induced by...
Articles
Clin Sci (Lond) (1982) 63 (1): 29-32.
Published: 01 July 1982
...P. Hillon; L. Blanchet; D. Lebrec 1. The effects of propranolol on heart rate, arterial pressure, portal venous pressure and fractional hepatic blood flow were studied in rats with hepatic artery ligature or with portal vein stenosis, and in sham-operated rats. The effect of propranolol on cardiac...
Articles
Clin Sci (Lond) (1982) 63 (1): 81-85.
Published: 01 July 1982
...G. I. Sandle; A. Ward; M. D. Rawlins; C. O. Record 1. To compare the bioavailability and the elimination of propranolol in seven untreated coeliac patients and six normal subjects, plasma concentrations were measured after oral and intravenous propranolol. The bioavailability and clearance of...
Articles
Clin Sci (Lond) (1982) 62 (6): 581-588.
Published: 01 June 1982
...Massimo Volpe; Bruno Trimarcoy; Bruno Ricciardelli; Carlo Vigorito; Nicola De Luca; Franco Rengo; Mario Condorelli 1. The effects of intravenous administration of neostigmine and propranolol, individually or in combination, on baroreflex responsiveness have been evaluated in 18 borderline...
Articles
Clin Sci (Lond) (1981) 61 (1): 107-110.
Published: 01 July 1981
...M. S. Golub; M. L. Tuck; D. B. Fittingoff 1. The plasma aldosterone responses to exogenous angiotensin II and adrenocorticotropic hormone (ACTH) were studied before and after 1 month of propranolol therapy (120–240 mg/day) in eight patients with essential hypertension. 2. Basal supine plasma renin...
Articles
Clin Sci (Lond) (1981) 61 (s7): 437s-439s.
Published: 01 January 1981
... Society 1981 chlorthalidone clopamide diuretics lipoproteins pindolol propranolol β-receptor blockade Clinical Science (1981) 61,437~439s 437s P-Receptor-blocking agents may reverse or prevent diuretic-induced increases in serum low-density lipoprotein cholesterol A. M E I E R , H . S C H I...
Articles
Clin Sci (Lond) (1981) 61 (s7): 441s-444s.
Published: 01 January 1981
...J. Staessen; R. Fagard; P. Lijnen; L. J. Verschueren; A. Amery 1. With a double-blind cross-over protocol, 20 hypertensive captopril-treated patients were studied by adding in a variable sequence a placebo and propranolol (80 mg three times a day) to their captopril regimen (200 mg three times a...
Articles
Clin Sci (Lond) (1981) 61 (s7): 445s-448s.
Published: 01 January 1981
...F. W. Amann; P. Bolli; L. Hulthén; W. Kiowski; F. R. Bühler 1. α 1 -Adrenoceptor-mediated vasoconstriction was studied before and during propranolol therapy in eight normal renin essential hypertensive patients; four were known ‘responders’ and four, age-matched ‘non-responders’ to previous β...
Articles
Clin Sci (Lond) (1981) 61 (s7): 121s-123s.
Published: 01 January 1981
..., and ornithine decarboxylase (ODC) activity of SMC were increased in SHR and SHRSP in comparison with WKY rats. 4. The application of isoprenaline but not noradrenaline to the culture media increased ODC activity acutely in SMC from WKY rats and this increase was blocked by propranolol. 5. These...
Articles
Clin Sci (Lond) (1981) 60 (1): 33-40.
Published: 01 January 1981
...K. L. Evemy; P. Cummins; W. A. Littler 1. The effect of prolonged administration of β-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate...
Articles
Clin Sci (Lond) (1980) 59 (4): 251-256.
Published: 01 October 1980
... pressure, heart rate and concentrations of plasma noradrenaline, plasma adrenaline and plasma renin activity were measured during head-up tilt to 45° before and after acute β-adrenoreceptor blockade with intravenous propranolol. 2. In the normal subjects there were minimal changes in blood pressure during...
Articles
Clin Sci (Lond) (1980) 59 (4): 231-236.
Published: 01 October 1980
... 165 ± 4 mmHg, and plasma concentration of noradrenaline from 2.07 ± 0.21 to 5.02 ± 0.26 nmol/l. The maximum heart rate did not occur until after the peak in blood pressure. 3. Propranolol had no effect on the power expended during coitus, but there was a dose dependent fall in the changes in heart...
Articles
Clin Sci (Lond) (1980) 58 (4): 271-277.
Published: 01 April 1980
... dobutamine, 1.56 × 10 −8 mol min −1 kg −1 , intravenously for a 7 day period and seven conscious dogs were given dobutamine, 1.51 × 10 −8 mol min −1 kg −1 , into the left coronary artery under oral propranolol treatment for the same period while arterial pressure, cardiac output (electromagnetic flowmeter...
Articles
Clin Sci (Lond) (1980) 59 (s6): 453s-455s.
Published: 01 January 1980
...J. M. Cruickshank; G. Neil-Dwyer; M. M. Cameron; J. McAinsh 1. Sixteen neurosurgical patients received (oral) β-adrenoreceptor-blocking agents (β-receptor blockers) for 3–22 days. 2. Lipophilic β-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations...
Articles
Clin Sci (Lond) (1980) 59 (s6): 477s-478s.
Published: 01 January 1980
...P. W. De Leeuw; R. Punt; W. H. Birkenhager 1. Fifty-five patients with uncomplicated essential hypertension were admitted to hospital, where 25 of them were treated with propranolol (average daily dose 240 mg) and 30 were left untreated. 2. In all of them renal arteriography was carried out, after...
Articles
Clin Sci (Lond) (1979) 57 (5): 465-468.
Published: 01 November 1979
...P. W. Trembath; Elizabeth A. Taylor; J. Varley; P. Turner 1. The effect of a single oral dose of propranolol on the ventilatory response to hypercapnia has been studied in five healthy subjects. 2. Propranolol produced a small but significant reduction in the slope of the ventilation/end-tidal P co...
Articles
Clin Sci (Lond) (1979) 56 (2): 163-167.
Published: 01 February 1979
...H. A. J. Struyker-Boudier; J. F. Smits; H. Van Essen 1. The role of baroreceptors in the cardiovascular mechanism of action of dl-propranolol has been studied by comparing the acute effects of subcutaneous injection of 1 and 5 mg/kg (3·3 × 10 −6 and 16·5 × 10 −6 mol/kg) of this drug in conscious...
Articles
Clin Sci (Lond) (1979) 56 (2): 115-120.
Published: 01 February 1979
... different from arterial values both before and after diazoxide. 2. Sixteen patients with EHT received propranolol, 80 mg, four times a day. Six of them had a first injection of diazoxide the day before propranolol was started and a second one after 10–14 days of propranolol treatment. Peripheral vein active...
Articles
Clin Sci (Lond) (1979) 57 (s5): 145s-148s.
Published: 01 January 1979
...G. A. MacGregor; N. D. Markandu; J. E. Roulston 1. Propranolol, saralasin and captopril changed blood pressure in normotensive as well as hypertensive subjects. 2. The percentage change in blood pressure with these three drugs for a given plasma renin activity was similar in normotensive and...
Articles
Clin Sci (Lond) (1979) 57 (s5): 39s-41s.
Published: 01 January 1979
...S.-L. Boström; J. Fryklund 1. Propranolol and metoprolol were given in the diet of spontaneously hypertensive (SH) rats during the development of hypertension. 2. At the early established phase of hypertension, protein synthesis and protein composition of the left ventricle, aorta, mesenteric...
Articles
Clin Sci (Lond) (1979) 57 (s5): 393s-396s.
Published: 01 January 1979
...L. A. Salako; A. O. Falase; A. Fadeke Aderounmu 1. The β-adrenoreceptor-blocking effects of pindolol were compared with those of propranolol and a placebo in a double-blind cross-over trial involving nine hypertensive African patients. 2. Heart rate, systolic blood pressure and diastolic blood...
Articles
Clin Sci (Lond) (1979) 57 (s5): 397s-399s.
Published: 01 January 1979
...H. Houben; TH. Thien; TH. De Boo; W. Lemmens; C. L. A. Van Herwaarden; J. F. M. Fennis; A. Van 'T Laar 1. Haemodynamic effects of adrenaline were studied in 27 hypertensive patients, successively during treatment with propranolol and metoprolol. In 12 patients β-adrenoreceptor blockade was combined...
Articles
Clin Sci (Lond) (1979) 57 (s5): 409s-411s.
Published: 01 January 1979
...R. G. Shanks; J. D. Neill; W. J. Leahey; M. P. S. Varma 1. The effects of 160 mg of propranolol and 160 mg of a long-acting (LA) formulation of propranolol were studied in healthy subjects. 2. Both drugs reduced an exercise tachycardia but the peak was less and the 24 h effect greater after long...
Articles
Clin Sci (Lond) (1979) 57 (s5): 413s-415s.
Published: 01 January 1979
...F. G. Dunn; A. R. Lorimer; T. D. V. Lawrie 1. A standardized method of objectively measuring performance during simulated car driving is described. 2. The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension...
Articles
Clin Sci (Lond) (1979) 57 (s5): 417s-420s.
Published: 01 January 1979
...B. Ø. Kristensen; EVA Steiness; J. Weeke 1. In hypertension, the β-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis. 2. The effect of abrupt cessation of propranolol on serum concentrations of thyroxine (T 4...
Articles
Clin Sci Mol Med (1978) 55 (5): 491-497.
Published: 01 November 1978
...J. M. Patrick; Janice Tutty; S. B. Pearson 1. The effect on respiration of a single dose of propranolol has been studied in normal subjects. 2. The degree of β-adrenoreceptor blockade was assessed in terms of the impaired heart-rate response to progressive exercise and the plasma propranolol...
Articles
Clin Sci Mol Med (1978) 54 (6): 603-607.
Published: 01 June 1978
...-adrenergic blockade on sodium excretion in dogs with bile-duct ligation during extracellular hypotonic volume expansion. 3. Urinary excretion of sodium and fractional excretion of sodium rose significantly after 5 days of oral dl-propranolol administration to dogs with bile-duct ligation. 4. The...
Articles
Clin Sci Mol Med (1978) 54 (3): 283-289.
Published: 01 March 1978
... 1978 α-adrenoreceptor agonists β-adrenoreceptor blockade asthma atropine bronchi isoprenaline methoxamine propranolol Clinical Science and Molecular Medicine, (1978), 54, 283-289 The effect of -adrenoreceptor stimulation on the airways of normal and asthmatic man P. D. SNASHALL, FRANCES...
Articles
Clin Sci Mol Med (1978) 55 (s4): 151s-153s.
Published: 01 January 1978
...J. K. McKenzie; E. Reisin 1. Six essential hypertensive patients (five with low renin) were treated in successive weeks with placebo; hydrochlorothiazide 100 mg (382 μmol)/day; hydrochlorothiazide and 50 mmol of sodium/day diet; hydrochlorothiazide, 50 mmol of sodium diet and propranolol 160 mg...
Articles
Clin Sci Mol Med (1978) 55 (s4): 287s-290s.
Published: 01 January 1978
...D. L. Clement 1. Dose—response curves of isoprenaline were constructed in nine hypertensive patients before and after either propranolol or metoprolol. 2. The decrease of diastolic blood pressure and increase of heart rate with isoprenaline were significantly more inhibited by propranolol than by...
Articles
Clin Sci Mol Med (1978) 55 (s4): 237s-241s.
Published: 01 January 1978
... intravenous injection, blood pressure was increased by methionine—enkephalin and leucine—enkephalin, but heart rate was increased by methionine—enkephalin only. 3. Propranolol treatment reduced the increases in blood pressure following intraventricular methionine—enkephalin and leucine—enkephalin, while only...
Articles
Clin Sci Mol Med (1978) 55 (s4): 323s-324s.
Published: 01 January 1978
...J. D. F. England; A. S. P. Hua; J. Shaw 1. Chlorothiazide twice a day plus atenolol, metoprolol, pindolol and propranolol in single daily doses administered to patients with essential hypertension achieved effective control of blood pressure. 2. Each β-adrenoreceptor-blocking drug was associated...
Articles
Clin Sci Mol Med (1978) 55 (s4): 97s-100s.
Published: 01 January 1978
... with control subjects, either in supine or in upright positions, whereas no significant differences were found in plasma noradrenaline. 3. Six hypertensive patients were chronically treated with β-adrenoreceptor-blocking agents (five with propranolol and one with pindolol). Plasma noradrenaline was not...
Articles
Clin Sci Mol Med (1977) 52 (2): 171-182.
Published: 01 February 1977
...-propranolol or by a bilateral ureterovenous anastomosis which prevents salt and water loss. 3. Clopamide, metolazone and indapamide do not cause an immediate rise in renin secretion. Renin hypersecretion is induced only 1 h after intravenous injection of these diuretics. 4. Renin secretion was studied for 6 h...
Articles
Clin Sci Mol Med (1977) 52 (1): 107-109.
Published: 01 January 1977
...M. Fernandes; G. Onesti; R. Fiorentini; A. B. Gould; K. E. Kim; C. Swartz 1. Propranolol was administered to groups of mature rats before and during the development of renal hypertension induced by ligation of the aorta between the renal arteries. 2. At a dose 10 μmol (3 mg) of propranolol/kg...