...Guangyu Zhou; Jie Wu; Chunyan Gu; Bin Wang; E. Dale Abel; Alfred K. Cheung; Yufeng Huang Plasma prorenin is commonly elevated in diabetic patients and appears to predict the development of diabetic nephropathy. However, the pathological role of prorenin is unclear. In the present study...

... hypertension brain prorenin up-regulation has been claimed, which would generate angiotensin following its binding to the (pro)renin receptor. However, recent studies reported no evidence for prorenin expression in the brain, nor for its selective up-regulation in neurogenic hypertension, and the (pro)renin...

... and the prevention of seizures when pre-eclampsia progresses to eclampsia, but there is no definite cure other than delivery [ 1 ]. © The Authors Journal compilation © 2014 Biochemical Society 2014 aldosterone autoantibody pre-eclampsia prorenin renin renin–angiotensin–aldosterone system (RAAS...

... diabetic nephropathy prorenin renin–angiotensin system (RAS) urocortin vitamin D Some caveats of the AVOID trial, i.e. reliance on albuminuria as the main endpoint and short duration, were supposed to be addressed by the ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiorenal Disease...

...Wendy W. Batenburg; A. H. Jan Danser Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]. Since tissue renin levels are usually somewhat higher than expected based upon the amount of (renin...

... and inactive renin were not related to age, and the overall percentage of inactive renin was 79%. 14 12 1983 28 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 child prorenin renin Clinical Science (1984) 67, 383-387 383 The basal levels of active...

...C. F. Brown; D. H. Osmond 1. Cryoactivation of human plasma ‘prorenin’ was followed for 24 h at −4°C. Chromogenic assays were used to determine factor XII (FXII), FXIIa, prekallikrein and kallikrein in relation to the observed cold-induced increase in plasma renin activity (PRA). Bradykinin...

... with the hypothesis that acid pH induces a conformational change in a single polypeptide chain. antibody inhibition enzyme kinetics kallikrein molecular conformation plasmin prorenin renin trypsin ClinicalScience (1982) 63,167s-170s 167s Reversible acid-activation of inactive renin: evidence favouring...

... Society 1981 kallikrein prorenin renin Clinical Science (1981) 61,295~298s 295s Two forms of plasma renin after activation in vitro and their relation to natural plasma renin F. H . M. D E R K X , M. P. A. S C H A L E K A M P AND M. A. D . H . S C H A L E K A M P Department of Internal Medicine...

...S. A. Atlas; J. H. Laragh; Jean E. Sealey; T. E. Hesson 1. Plasma prorenin (inactive renin), which accounts for about 70% of the total renin in human plasma, was almost completely separated from active renin by affinity chromatography on Cibacron blue F3G-A-agarose. The slight residual renin...

...Jean E. Sealey; S. A. Atlas; J. H. Laragh; M. Silverberg; A.P. Kaplan 1. Plasma prorenin is an inactive form of renin that is converted into active renin at alkaline pH in previously acidified plasma; this conversion of prorenin into renin is mediated by Hageman factor-dependent activation...