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Keywords: prorenin
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Clin Sci (Lond) (2018) 132 (8): 839–850.
Published: 30 April 2018
... hypertension brain prorenin up-regulation has been claimed, which would generate angiotensin following its binding to the (pro)renin receptor. However, recent studies reported no evidence for prorenin expression in the brain, nor for its selective up-regulation in neurogenic hypertension, and the (pro)renin...
Clin Sci (Lond) (2014) 126 (8): 537–544.
Published: 17 December 2013
... stages of the disease. Importantly, it is generally believed that some RAAS components, prorenin in particular, are synthesized in the uteroplacental unit, thus allowing local AngII (angiotensin II) production independently of AngII production in the systemic circulation (for an extensive overview see...
Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
... nephropathy prorenin renin–angiotensin system (RAS) urocortin vitamin D Several reports indicating the nephroprotective effects of aliskiren are available in models expressing mouse renin (mRen2). The mechanisms of the effects of aliskiren in this model of nephropathy have been reported by Feldman...
Clin Sci (Lond) (2012) 123 (3): 121–133.
Published: 05 April 2012
...Wendy W. Batenburg; A. H. Jan Danser Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]. Since tissue renin levels are usually somewhat higher than expected based upon the amount of (renin...
Clin Sci (Lond) (1984) 67 (4): 383–387.
Published: 01 October 1984
... and inactive renin were not related to age, and the overall percentage of inactive renin was 79%. 14 12 1983 28 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 child prorenin renin Clinical Science (1984) 67, 383-387 383 The basal levels of active...
Clin Sci (Lond) (1984) 66 (5): 533–539.
Published: 01 May 1984
...C. F. Brown; D. H. Osmond 1. Cryoactivation of human plasma ‘prorenin’ was followed for 24 h at −4°C. Chromogenic assays were used to determine factor XII (FXII), FXIIa, prekallikrein and kallikrein in relation to the observed cold-induced increase in plasma renin activity (PRA). Bradykinin...
Clin Sci (Lond) (1982) 63 (s8): 167s–170s.
Published: 01 October 1982
... with the hypothesis that acid pH induces a conformational change in a single polypeptide chain. © 1982 The Biochemical Society and the Medical Research Society 1982 antibody inhibition enzyme kinetics kallikrein molecular conformation plasmin prorenin renin trypsin ClinicalScience (1982) 63,167s...
Clin Sci (Lond) (1981) 61 (s7): 295s–298s.
Published: 01 December 1981
... Society 1981 kallikrein prorenin renin Clinical Science (1981) 61,295~298s 295s Two forms of plasma renin after activation in vitro and their relation to natural plasma renin F. H . M. D E R K X , M. P. A. S C H A L E K A M P AND M. A. D . H . S C H A L E K A M P Department of Internal Medicine...
Clin Sci (Lond) (1980) 59 (s6): 29s–33s.
Published: 01 December 1980
...S. A. Atlas; J. H. Laragh; Jean E. Sealey; T. E. Hesson 1. Plasma prorenin (inactive renin), which accounts for about 70% of the total renin in human plasma, was almost completely separated from active renin by affinity chromatography on Cibacron blue F3G-A-agarose. The slight residual renin...
Clin Sci (Lond) (1979) 57 (s5): 97s–99s.
Published: 01 December 1979
...Jean E. Sealey; S. A. Atlas; J. H. Laragh; M. Silverberg; A.P. Kaplan 1. Plasma prorenin is an inactive form of renin that is converted into active renin at alkaline pH in previously acidified plasma; this conversion of prorenin into renin is mediated by Hageman factor-dependent activation...