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Keywords: prostacyclin
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Clin Sci (Lond) (2007) 112 (12): 607–616.
Published: 14 May 2007
... investigated the effect of ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase-inhibitory activity, on expression of endogenous growth factors and angiogenesis. ONO-1301 induced secretion of HGF (hepatocyte growth factor) and VEGF (vascular endothelial growth factor) from cultured normal human...
Clin Sci (Lond) (2007) 112 (7): 393–401.
Published: 01 March 2007
...- L -arginine)], after a single oral administration of telmisartan (80 mg) or placebo, using a randomized double-blind cross-over design. In six volunteers, we also assessed the roles of prostacyclin and EDHF (endothelium-derived hyperpolarizing factor) during radial FMD after AT 1 receptor blockade...
Clin Sci (Lond) (2002) 103 (s2002): 128S–131S.
Published: 01 September 2002
...) inhibitor, thiorphan, we determined the involvement of this enzyme on ET-1 (1–31) effects. Infusion of ET-1 (1–31) (50nM) stimulates a marked release of thromboxane A 2 and prostacyclin equivalent to that observed with a ten times lower concentration of ET-1 (5nM). BQ-788 (5nM and 10nM), but not BQ-123 (1 µ...
Clin Sci (Lond) (1999) 97 (6): 697–706.
Published: 15 November 1999
... lipoprotein (LDL) and high-density lipoprotein (HDL), isolated from women with pre-eclampsia and matched controls, on the endothelial synthesis of 6-oxo-prostaglandin F 1α (6-oxo-PGF 1α ; a metabolite of prostacyclin) and endothelin 1, and on the expression of nitric oxide synthase 3 (NOS3) mRNA. VLDL, LDL...
Clin Sci (Lond) (1999) 97 (1): 99–102.
Published: 01 June 1999
...Ian A. FORREST; Therese SMALL; Paul A. CORRIS Inhaled epoprostenol (prostacyclin) may be used in the treatment of severe pulmonary hypertension, improving oxygenation and reducing pulmonary artery pressures. We have observed symptomatic benefits of epoprostenol in patients with congenital heart...
Clin Sci (Lond) (1996) 90 (2): 87–89.
Published: 01 February 1996
... © 1996 The Biochemical Society and the Medical Research Society 1996 atrial natriuretic peptide epoprostenol heart rate mean blood pressure prostacyclin Clinical Science (1996) 90, 87-a9 (Printed in Great Britain) Rapid Communication Epoprostenol increases plasma level of atrial...
Clin Sci (Lond) (1993) 84 (4): 427–433.
Published: 01 April 1993
...William G. Haynes; David J. Webb 1. We have investigated whether local vascular production of nitric oxide or prostacyclin regulates venoconstriction induced by the endothelium-derived peptide, endothelin-1, in vivo in man. 2. Six healthy subjects received local dorsal hand vein infusion...
Clin Sci (Lond) (1992) 83 (4): 461–465.
Published: 01 October 1992
...Å. Wennmalm; G. Benthin; E.F. Granström; L. Persson; S. Winell 1. Urinary levels of the 2,3-dinor metabolites of thromboxane A 2 (2,3-dinor-thromboxane A 2 , Tx-M) and prostacyclin (2,3-dinor-6-keto-prostaglandin F 1α , PGI-M) are frequently analysed as indices of platelet and endothelial activity...
Clin Sci (Lond) (1992) 83 (3): 301–306.
Published: 01 September 1992
... synthesis in the ageing kidney. Increased prostacyclin and prostaglandin E 2 synthesis may be an attempt to counteract enhanced thromboxane production. Blunting of this tendency in medulla and papilla could contribute to the conservation of medullary solute concentration, whereas inappropriate stimulation...
Clin Sci (Lond) (1992) 82 (4): 383–388.
Published: 01 April 1992
...-induced hypertension has been reported by others to be cytotoxic to endothelial cells in vitro. We hypothesized that such serum contains a factor that limits the ability of endothelial cells to produce and/ or release prostacyclin. 2. Prostacyclin production by intact and damaged cultured human umbilical...
Clin Sci (Lond) (1991) 81 (s25): 499–507.
Published: 01 October 1991
... was positively related to the prostaglandin E 2 excretion. 3. Basal release of prostaglandin E 2 from the sliced renal cortex was enhanced by the atenolol treatment. Prostacyclin-generating capacity in the aortic wall was also significantly increased. 4. Atenolol treatment stimulated prostaglandin synthesis...
Clin Sci (Lond) (1991) 81 (1): 11–15.
Published: 01 July 1991
...-thromboxane B 2 (an index of platelet activation) and of the prostacyclin metabolite 2,3-dinor-6-keto-prostaglandin F 1α (an index of platelet/vessel wall interaction) were analysed by g.c.-m.s. in samples collected on days 3, 10 and 20 of their respective menstrual cycles. 3. The urinary excretion of 2,3...
Clin Sci (Lond) (1990) 79 (6): 639–645.
Published: 01 December 1990
... wall prostacyclin formation, as reflected non-invasively by the urinary excretion of the 2,3-dinor-metabolites of thromboxane A 2 (2,3-dinor-thromboxane B 2 , Tx-M) and prostacyclin (2,3-dinor-6-keto-prostaglandin F 1α , PGI-M), respectively. 2. Fathers of young men with high platelet activity did...
Clin Sci (Lond) (1989) 76 (5): 529–534.
Published: 01 May 1989
...F. Broughton Pipkin; R. Morrison; P. M. S. O'Brien 1. The effects of angiotensin II (ANG II) infusion without and with simultaneous infusion of prostacyclin (PGI 2 ; 1.4 pmol min −1 kg −1 ; 5 ng min −1 kg −1 ) have been studied in 16 women in second-trimester pregnancy. Ten received one infusion...
Clin Sci (Lond) (1988) 75 (3): 263–269.
Published: 01 September 1988
... that in rats with CCl 4 -induced cirrhosis, the increased renal production of prostacyclin and TXA 2 is a consequence of the stimulation of endogenous vasoconstrictor systems. The impaired urinary excretion of PGE 2 and PGF 2α in CCl 4 rats may be secondary to an inhibitory effect of CCl 4 on PG synthesis...
Clin Sci (Lond) (1987) 73 (3): 277–283.
Published: 01 September 1987
...Ulrich Förstermann; Thomas J. Feuerstein 1. The rates of secretion into the circulation of prostaglandin E, prostacyclin, and thromboxane A 2 were estimated in male alcoholics on the third day of withdrawal and in control subjects by measuring appropriate metabolites in urine. 2. Urinary levels...
Clin Sci (Lond) (1987) 73 (1): 99–103.
Published: 01 July 1987
... aggregation in response to adenosine 5′-pyrophosphate, thrombin, adrenaline and collagen. Platelet sensitivity to prostacyclin was also examined. 3. Platelet noradrenaline showed a positive correlation with extent of aggregation induced by ‘low-dose’ collagen (1 μg/ml). No correlation was seen at the higher...
Clin Sci (Lond) (1986) 71 (6): 743–747.
Published: 01 December 1986
...J. M. Ritter; G. Hamilton; S. E. Barrow; D. J. Heavey; N. E. Hickling; K. M. Taylor; K. E. F. Hobbs; C. T. Dollery 1. The object of this study was to investigate clinical conditions in which increased production of prostacyclin (PGI 2 ) has been reported. 6-Oxo-prostaglandin F 1α (6-oxo-PGF 1α...
Clin Sci (Lond) (1984) 67 (6): 633–638.
Published: 01 December 1984
... respectively. 2. Attempts to elicit peripheral vascular prostacyclin biosynthesis in volunteers by using forearm ischaemia produced no increase in plasma 6-oxo-PGF 1α levels. Measurement of the combined plasma levels of 6-oxo-PGF 1α , 13,14-dihydro-6-oxo-PGF 1α , 13,14-dihydro-6,15-dioxo-PGF 1α and 6-oxo-PGE 1...
Clin Sci (Lond) (1984) 66 (4): 453–457.
Published: 01 April 1984
...D. Benzoni; M. Vincent; J. Sassard 1. In order to assess the pathophysiological role of renal prostacyclin in genetic hypertension, the urinary excretion of its main stable metabolite, 6-ketoprostaglandin F 1α , was followed in 12 hypertensive, normotensive and low blood pressure female rats...
Clin Sci (Lond) (1984) 66 (1): 33–37.
Published: 01 January 1984
...Isamu Miyamori; Toshio Morise; Masatoshi Ikeda; Hideo Koshida; Yoshiyu Takeda; Shuichiro Yasuhara; Hiroaki Takimoto; Ryoyu Takeda 1. The effects of subdepressor infusion of prostacyclin (PGI 2 , 5.3 pmol min −1 kg −1 ) on arterial pressure and aldosterone production induced by angiotensin II (ANG...
Clin Sci (Lond) (1983) 65 (1): 43–46.
Published: 01 July 1983
..., are due to overproduction of prostacyclin, the principal prostaglandin (PG) synthesized by the vascular endothelium, we studied the effect of experimental hypokalaemia on the urinary excretion of immunoreactive 6-keto-prostaglandin F 1α , a stable metabolite of prostacyclin, in the rat. 2. The animals...
Clin Sci (Lond) (1983) 64 (4): 395–398.
Published: 01 April 1983
...P. B. B. Jones; R. G. G. Russell 1. We studied the effect of oral administration of acetylsalicylic acid (1200 mg/day for 3 days) on the urinary excretion of 6-ketoprostaglandin F 1α in normal human subjects as an index of prostacyclin production in vivo. 2. The concentrations and excretion rate...
Clin Sci (Lond) (1983) 64 (4): 387–394.
Published: 01 April 1983
...J. M. Seid; P. B. B. Jones; R. G. G. Russell 1. The effect of plasma and serum from normal subjects on the production of prostacyclin by cultured porcine endothelial cells was investigated. 2. Both plasma and serum from all subjects studied significantly stimulated the production of prostacyclin...
Clin Sci (Lond) (1982) 62 (2): 177–181.
Published: 01 February 1982
...D. P. Mikhailidis; A. M. Mikhailidis; M. L. Woollard; P. Dandona 1. The rate of decay of the platelet anti-aggregatory activity of prostacyclin in plasma and buffer solutions was investigated. 2. Platelet anti-aggregatory activity of prostacyclin was more stable in plasma than in buffer solutions...
Clin Sci (Lond) (1980) 59 (s6): 121s–123s.
Published: 01 December 1980
...J. H. Grose; M. Lebel; F. M. Gbeassor 1. Urinary excretion rate of 6-keto-prostaglandin F 1α (6-keto-PGF 1α ), a stable non-enzymatic transformation product of prostacyclin (PGI 2 ), was measured in 13 patients with sustained essential hypertension and in nine normotensive control subjects...
Clin Sci (Lond) (1980) 59 (s6): 125s–128s.
Published: 01 December 1980
... weeks treatment with bendrofluazide (10 mg daily). 2. Plasma levels of 6-oxo-prostaglandin F 1α , the chemical hydrolysis product of prostacyclin, were significantly increased by both 3 days and 10 weeks therapy with bendrofluazide. This raises the possibility that thiazides may reduce peripheral...
Clin Sci (Lond) (1980) 59 (s6): 105s–116s.
Published: 01 December 1980
... stimuli enhances prostaglandin synthesis, which protects organ function from excessive effects of angiotensins and catecholamines. 5. Several findings preclude unqualified acceptance of prostacyclin as the only important vascular prostaglandin: first, in some blood vessels prostacyclin...
Clin Sci (Lond) (1980) 59 (5): 369–372.
Published: 01 November 1980
...L. Karpati; F. P. R. Chow; M. L. Woollard; R. A. Hutton; P. Dandona 1. Female rats were injected with ethinyloestradiol, norethisterone or both compounds for 30 days. Prostacyclin-like activity was measured in the thoracic aorta and inferior vena cava. 2. In the thoracic aorta of rats injected...
Clin Sci Mol Med (1978) 55 (s4): 199s–202s.
Published: 01 December 1978
... vessels able to convert arachidonic acid into prostaglandins (primarily prostacyclin). In contrast, convoluted tubules showed a low capacity to metabolize arachidonic acid. 3. The failure to demonstrate prostaglandin synthesis by renal cortical slices is related to the presence of an inhibitor of cyclo...
Clin Sci Mol Med (1978) 55 (s4): 207s–210s.
Published: 01 December 1978
...C. M. Markov 1. Biosynthesis of PGE 2 from [ 14 C]arachidonic acid has been found to be lower and PGF 2α higher in the renal medulla of spontaneously hypertensive (SH) rats than in normal Wistar (NW) rats. 2. Biosynthesis of prostacyclin (PGF 1α ) from [ 14 C]arachidonic acid was decreased in lungs...