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Keyword: prostaglandins
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Articles
Clin Sci (Lond) (2000) 99 (6): 511–516.
Published: 07 November 2000
... the anti-tumorigenic effects of this agent. The present study investigates the urinary levels of 8-iso-prostaglandin F 2α (8-iso-PGF 2α ), a major isoprostane, and of 15-oxo-dihydro-PGF 2α , a major metabolite of PGF 2α , as indicators of non-enzymic and enzymic arachidonic acid oxidation respectively...
Articles
Clin Sci (Lond) (2000) 99 (5): 383–392.
Published: 03 October 2000
... (e-mail ian.meredith@med.monash.edu.au ). 17 12 1999 27 3 2000 28 6 2000 The Biochemical Society and the Medical Research Society © 2000 2000 artery blood flow diabetes mellitus nitric oxide prostaglandins 383Clinical Science (2000) 99, 383 392 (Printed in Great...
Articles
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
..., arterial blood pressure, cardiac output and plasma catecholamines at rest and during exercise were not altered by indomethacin or nabumetone. Indomethacin decreased urinary rates of excretion of 6-oxo-prostaglandin F 1α (6-oxo-PGF 1α ) and thromboxane B 2 in all study periods. Nabumetone decreased 6-oxo...
Articles
Clin Sci (Lond) (1998) 95 (5): 603–609.
Published: 01 November 1998
... 70-fold increase of naproxen accumulation in the kidney with a subsequent renal release of the active metabolite naproxen–lysine. 2. In the present study we questioned whether naproxen–lysozyme is active in the rat kidney, inhibiting the urinary excretion of prostaglandin E 2 and renal sodium and...
Articles
Clin Sci (Lond) (1998) 95 (1): 73–81.
Published: 01 July 1998
...) ml/min to 17 (10/21) ml/min ( P = 0.008). Calculated absolute proximal reabsorption rate of water increased from 63 (40/69) ml/min to 71 (47/82) ml/min ( P = 0.04). The urinary excretion rate of thromboxane B 2 and the ratio between excretion rates of thromboxane B 2 and 6-keto-prostaglandin-F 1α...
Articles
Clin Sci (Lond) (1997) 92 (4): 409–414.
Published: 01 April 1997
...G. S. Stokes; J. C. Monaghan; D. N. Pillai 1. Dopamine and prostaglandins are putative endogenous natriuretic hormones. The role of each in facilitating natriuresis induced by intravenous saline infusion was examined in normal volunteers in relation to administration of carbidopa, a...
Articles
Clin Sci (Lond) (1995) 88 (2): 211–217.
Published: 01 February 1995
... described for other types of macrophages, although the pattern was specific for Kupffer cells. 4. Eicosanoids, predominantly prostaglandin D 2 and prostaglandin F 2α , were produced mainly during the first hour after exposure to lipopolysaccharide. Endotoxin stimulated synthesis of mRNAs of interleukin 1...
Articles
Clin Sci (Lond) (1994) 87 (4): 453–458.
Published: 01 October 1994
... ml/min, and was recovered 30 cm distally by siphonage. Effluents were assayed for tumour necrosis factor by a specific e.l.i.s.a. and for prostaglandin E 2 and leukotriene B 4 by specific r.i.a.s. 3. The intracolonic release of tumour necrosis factor was undetectable in patients with irritable bowel...
Articles
Clin Sci (Lond) (1994) 86 (1): 1–9.
Published: 01 January 1994
...Nigel D.C. Sturrock; A.D. Struthers © 1994 The Biochemical Society and the Medical Research Society 1994 calcium cyclosporin hypertension nephrotoxicity prostaglandins renin-angiotensin system sodium Clinical Science (1994) 86, 1-9 (Printed in Great Britain) I Editorial Review...
Articles
Clin Sci (Lond) (1993) 85 (6): 679–685.
Published: 01 December 1993
... Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...
Articles
Clin Sci (Lond) (1993) 85 (5): 569–575.
Published: 01 November 1993
...Weng S. Leong; R. Graham; G. Russell; Alison M. Caswell 1. We have observed previously that extracellular ATP acting at P 2 -purinoceptors promotes the production of prostaglandin E 2 by human articular chondrocytes, and that this response is enhanced synergistically by interleukin-1β. Since other...
Articles
Clin Sci (Lond) (1993) 84 (5): 525–529.
Published: 01 May 1993
...-oxygenase inhibitor indomethacin (3 mg/kg intravenously) restored pressor sensitivity to angiotensin II to normal, suggesting that cyclo-oxygenase products, possibily vasodilator prostaglandins, may be involved in mediating pressor resistance to this hormone in vivo. 23 12 1992 25 1 1993...
Articles
Clin Sci (Lond) (1993) 84 (4): 427–433.
Published: 01 April 1993
... endothelin-1 for 60 min alone or, on two separate occasions, co-infused with the donator of nitric oxide, glyceryl trinitrate, or the vasodilator prostaglandin, prostacyclin. In further studies, endothelin-l was co-infused with an inhibitor of nitric oxide production, N G -monomethyl-L-arginine, or after...
Articles
Clin Sci (Lond) (1993) 84 (1): 1–10.
Published: 01 January 1993
...Ole Skøtt; Boye L. Jensen © 1993 The Biochemical Society and the Medical Research Society 1993 angiotensin II baroreceptor calcium cyclic nucleotides endothelial factors juxtaglomerular apparatus macula densa osmotic forces prostaglandins renal nerves renin biosynthesis renin...
Articles
Clin Sci (Lond) (1992) 83 (3): 347–352.
Published: 01 September 1992
...John Watson; Siew Yeam Chuah 1. A method is described for the primary culture of human breast tumour cells on feeder layers of the STO mouse embryo fibroblast cell line. 2. The secretion of the prostaglandins E 2 and F 2α from the cells was measured and the results indicate that the secretion of...
Articles
Clin Sci (Lond) (1992) 83 (1): 75–80.
Published: 01 July 1992
...C. Henríquez-la Roche; B. Rodríguez-Iturbe; G. Parra 1. Urinary excretion of prostaglandin E 2 is increased in patients with idiopathic hypercalciuria, but in order to conclude that hyperprostaglandinuria is a primary phenomenon, it must be demonstrated that high levels of urinary prostaglandin E 2...
Articles
Clin Sci (Lond) (1990) 79 (6): 657–662.
Published: 01 December 1990
...David C. Bibby; Robert F. Grimble 1. The primary aim of the study was to determine whether the stimulatory effect of tumour necrosis factor-α and endotoxin on hypothalamic prostaglandin E 2 production was influenced by dietary fats containing different amounts of linoleic acid. Rats received diets...
Articles
Clin Sci (Lond) (1989) 76 (2): 143–149.
Published: 01 February 1989
... 6 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 prostaglandins pulmonary circulation pulmonary gas exchange vasoconstriction Clinical Science (1989) 76, 143-149 143 Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a...
Articles
Clin Sci (Lond) (1988) 75 (6): 581–587.
Published: 01 December 1988
...Carlos Henríquez-La Roche; Bernardo Rodríguez-Iturbe; José Herrera; Gustavo Parra 1. Because urinary prostaglandin excretion could play a role in idiopathic hypercalciuria (IH), we studied the excretion of prostaglandin E (PGE), calcium and sodium at various urine flows in 21 patients (14 males...
Articles
Clin Sci (Lond) (1988) 74 (6): 613–619.
Published: 01 June 1988
...Antoni Rimola; Pere Ginés; Eulàlia Cusó; Jordi Camps; Joan Gaya; Vincente Arroyo; Joan Rodés 1. Functional renal failure (FRF) in cirrhosis with ascites could be related to an inappropriately low renal prostaglandin (PG) production. To investigate whether the impaired renal PG synthesis in these...
Articles
Clin Sci (Lond) (1988) 74 (5): 477–483.
Published: 01 May 1988
...J. C. W. M. Holtslag; H. J. Moshage; J. F. van Pelt; J. A. G. M. Kleuskens; F. W. J. Gribnau; S. H. Yap 1. Monocytic products, especially interleukin-1 (IL-1), play an important role in the acute-phase response. Prostaglandins have been shown to act as second messengers in several physiological...
Articles
Clin Sci (Lond) (1987) 73 (6): 641–644.
Published: 01 December 1987
...I. Gregoire; J. P. Dupouy; P. Fievet; J. D. Sraer; A. Fournier 1. An increase in glomerular prostaglandin (PG) synthesis has been reported in two experimental models of increased glomerular filtration rate (GFR). 2. Because pregnancy, in women and rats, is also associated with an increased GFR, we...
Articles
Clin Sci (Lond) (1987) 73 (4): 377–381.
Published: 01 October 1987
... © 1970 The Biochemical Society and the Medical Research Society 1970 cisplatin kidney polyuria prostaglandins vasopressin ...
Articles
Clin Sci (Lond) (1987) 73 (4): 365–370.
Published: 01 October 1987
... indomethacin prostaglandins proteinuria ...
Articles
Clin Sci (Lond) (1987) 72 (6): 717–724.
Published: 01 June 1987
... periods of 30 min (i.e. maximum time needed to generate a MPAP/CI plot) alternately at F 1 o 2 0.4 and at F 1 o 2 0.1. 6. These results suggest that pulmonary vascular reactivity to hypoxia is regulated by balanced actions of vasoconstricting leukotrienes and vasodilating prostaglandins in anaesthetized...
Articles
Clin Sci (Lond) (1987) 72 (5): 605–609.
Published: 01 May 1987
...Ahmad A. Attallah 1. The effects of chronic alterations in dietary sodium intake on urinary prostaglandin (PG) E 2 and thromboxane (TX) B 2 was investigated in the rabbit. 2. Sodium restriction, over a 15-day period, reduced daily urinary PGE 2 and TXB 2 in concordance with urinary flow ( V ) and...
Articles
Clin Sci (Lond) (1987) 72 (4): 429–436.
Published: 01 April 1987
...Margrethe E. Olsen; John E. Hall; Jean-Pierre Montani; John E. Cornell 9 7 1986 24 10 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 angiotensin II autoregulation glomerular filtration rate prostaglandins renal blood flow tubuloglomerular...
Articles
Clin Sci (Lond) (1986) 70 (5): 477–484.
Published: 01 May 1986
...C. Guarner; I. Colina; F. Guarner; J. Corzo; J. Prieto; F. Vilardell 1. Urinary prostaglandin excretion was studied in 42 patients with liver cirrhosis and in nine control subjects on restricted sodium intake and on bed rest. Creatinine clearance ( C Cr ), sodium excretion ( U Na V ), plasma renin...
Articles
Clin Sci (Lond) (1986) 70 (5): 501–505.
Published: 01 May 1986
... the 6-ketoprostaglandin F 1α (6-keto-PGF 1α ), a stable breakdown product of prostacyclin (PGI 2 ), was significantly reduced ( P < 0.02) when compared with four healthy controls, whereas prostaglandin E 2 (PGE 2 ) was unchanged. Administration of sulindac did not significantly alter the excretion...
Articles
Clin Sci (Lond) (1986) 70 (1): 13–17.
Published: 01 January 1986
..., the DOCA-induced potassium loss was enhanced. 3. Kallikrein inhibition decreased urinary prostaglandin (PG) E 2 and prevented the DOCA-induced rise in PGE 2 . Plasma renin activity was stimulated after 10 days of aprotinin administration. 4. The kallikrein-kinin system is not an important mediator of...
Articles
Clin Sci (Lond) (1985) 69 (3): 293–298.
Published: 01 September 1985
...C. Ray; S. L. Carney; A. H. B. Gillies 1. The precise role of prostaglandins in modulating urine concentration and dilution is unclear. Evidence in vitro has recently cast doubt on the accepted theory that renal prostaglandins inhibit the hydro-osmotic effect of vasopressin. 2. Urine clearance...
Articles
Clin Sci (Lond) (1985) 68 (5): 605–607.
Published: 01 May 1985
.... 25 4 1984 30 11 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 experimental portal hypertension indomethacin microspheres prostaglandins Clinical Science (1985) 68,605-607 SHORT COMMUNICATION 605 Lack of effect of indomethacin on systemic and...
Articles
Clin Sci (Lond) (1985) 68 (4): 387–393.
Published: 01 April 1985
...Herbert J. Kramer; Bruno Stinnesbeck; Georg Klautke; Jochen Kipnowski; Dietrich Klingmueller; Kilian Glaenzer; Rainer Duesing 1. In six healthy subjects the role of renal prostaglandins (PG) in modulating the actions of the renin-angiotensin and renal adrenergic nervous systems on renal function...
Articles
Clin Sci (Lond) (1985) 68 (2): 159–164.
Published: 01 February 1985
...I. G. Mackay; K. Nath; A. D. Cumming; A. L. Muir; M. L. Watson 1. Prostaglandin-dependent, frusemide-induced changes in renal plasma flow, glomerular filtration rate and plasma renin activity were measured in 14 patients with mild essential hypertension. 2. The renal haemodynamic responses to...
Articles
Clin Sci (Lond) (1984) 67 (6): 579–583.
Published: 01 December 1984
...H. Vierhapper; J. Jörg; W. Waldhäusl 1. The effect of acetylsalicylic acid (ASA, 3 g/day for 3 days) and of indomethacin (IND, 150 mg/day for 3 days) on diuresis and on the excretion of prostaglandin E 2 (PGE 2 ) was studied in six healthy, male volunteers. After overnight deprivation the subjects...
Articles
Clin Sci (Lond) (1984) 67 (4): 413–420.
Published: 01 October 1984
... pretreatment with indomethacin. 2. After frusemide administration, increases in urinary sodium excretion paralleled increases in urinary volume, and urinary prostaglandin E 2 (PGE 2 ) excretion correlated closely with sodium excretion ( y = 1.03 x −0.28; r = 0.940; P <.0001). 3. In the absence of the...
Articles
Clin Sci (Lond) (1984) 66 (4): 407–413.
Published: 01 April 1984
...Philip G. Baer; Alberto Nasjletti 1. Male Wistar rats were used to examine whether renal prostaglandins (PG) contribute to functional compensatory changes in the remaining kidney after uninephrectomy. Total urinary excretion of PGE 2 , PGF 2α and 6-keto-PGF 1α , a metabolite of PGI 2 , was measured...
Articles
Clin Sci (Lond) (1984) 66 (2): 165–171.
Published: 01 February 1984
...J. T. Whicher; A. M. Bell; M. F. R. Martin; L. A. Marshall; P. A. Dieppe 1. The prostaglandin E 1 increases the plasma concentration of acute-phase proteins in man and decreases the concentration of certain carrier proteins. 2. This response is greatly diminished in patients with systemic sclerosis...
Articles
Clin Sci (Lond) (1983) 65 (1): 43–46.
Published: 01 July 1983
..., are due to overproduction of prostacyclin, the principal prostaglandin (PG) synthesized by the vascular endothelium, we studied the effect of experimental hypokalaemia on the urinary excretion of immunoreactive 6-keto-prostaglandin F 1α , a stable metabolite of prostacyclin, in the rat. 2. The animals...
Articles
Clin Sci (Lond) (1983) 64 (5): 471–474.
Published: 01 May 1983
...R. A. Banks; L. J. Beilin; J. Soltys 1. Changes in systemic haemodynamics and organ blood flow were measured in conscious rabbits after various doses of intravenous sodium meclofenamate, an inhibitor of prostaglandin cyclo-oxygenase. 2. Meclofenamate had no effect on arterial pressure or cardiac...
Articles
Clin Sci (Lond) (1983) 64 (4): 395–398.
Published: 01 April 1983
... Medical Research Society 1983 aspirin endothelium haemostasis prostacyclin prostaglandins Clinical Science (1983) 64,395-398 395 Effect of aspirin on urinary excretion of 6-ketoprostaglandin FI, P. B. B. JONES* AND R. G. G. RUSSELL Department of Human Metabolism and Clinical Biochemistry...
Articles
Clin Sci (Lond) (1983) 64 (1): 91–99.
Published: 01 January 1983
... supplements on plasma lipid concentrations, the fatty acid composition of platelet phosphoglycerides, template bleeding time and platelet aggregation induced by collagen and the prostaglandin analogue compound U46619 were studied. 3. In the platelet lipids, the proportion of 20:5 ω3 was increased by the 20 ml...
Articles
Clin Sci (Lond) (1982) 63 (s8): 109s–112s.
Published: 01 October 1982
...P. Lijnen; R. Fagard; J. Staessen; A. Amery 1. Plasma prostaglandins (PGE and PGF α ) and catecholamine concentrations, and plasma renin activity were measured during an uninterrupted graded exercise test on the bicycle ergometer in 11 hypertensive patients. Blood was withdrawn from the brachial...
Articles
Clin Sci (Lond) (1982) 63 (s8): 247s–248s.
Published: 01 October 1982
...H. Ignatowska-Świtalska; B. Wocial; S. Filipecki; W. Januszewicz 1. Urinary excretion of prostaglandins E 2 and F 2α were determined in 11 women with phaeochromocytoma and in 23 healthy women. 2. In patients with phaeochromocytoma a significant decrease in urinary excretion of PGE 2 and a...
Articles
Clin Sci (Lond) (1982) 63 (s8): 253s–255s.
Published: 01 October 1982
... release of prostaglandins into the incubation medium was measured. 2. Compared with Wistar-Kyoto control animals, the release of prostaglandin E from renal medullary tissue in spontaneously hypertensive rats was raised at 30 days (pre-hypertensive stage) and 90 days (early hypertensive stage), but...
Articles
Clin Sci (Lond) (1982) 63 (s8): 265s–267s.
Published: 01 October 1982
... < 0.02). Heart rate did not change. Plasma renin activity (PRA) increased ( P < 0.002), and plasma and urinary aldosterone as well as plasma 18-hydroxycorticosterone (18- OH-B) decreased after captopril ( P < 0.02). Prostaglandin (PG) E 2 , kallikrein, urine volume, sodium and potassium...
Articles
Clin Sci (Lond) (1982) 62 (6): 611–615.
Published: 01 June 1982
...). Prostaglandin (PG) E 2 , sodium and potassium excretion rates remained constant after captopril. 3. Under indomethacin pretreatment, the fall in mean arterial blood pressure was less than without indomethacin at 30 and 60 min after captopril ( P < 0.05). Heart rate was constantly lower than without...
Articles
Clin Sci (Lond) (1982) 62 (4): 343–348.
Published: 01 April 1982
...W. D. W. Rees; L. A. Turnberg © 1982 The Biochemical Society and the Medical Research Society 1982 alkali secretion cytoprotection gastric mucosa prostaglandins Clinical Science (1982) 6% 343-348 343 EDITORIAL REVIEW Mechanisms of gastric mucosal protection: a role for the mucus...
Articles
Clin Sci (Lond) (1982) 62 (2): 209–213.
Published: 01 February 1982
...H.-G. Güllner; D. J. Lakatua; F. C. Bartter 1. The effect of inhibition of prostaglandin synthesis on urinary excretion of free dopamine, a catecholamine thought to act as a renal natriuretic hormone, was examined in six normal women. 2. The volunteer subjects were treated with indomethacin (2 mg...
Articles
Clin Sci (Lond) (1982) 62 (2): 169–176.
Published: 01 February 1982
...R. A. Banks; L. J. Beilin; J. Soltys; L. Davidson 1. The role of prostaglandins and angiotensin II in blood flow regulation was studied in conscious rabbits subjected to mild haemorrhage. 2. Haemorrhage caused a 13% fall in arterial pressure and a 21% fall in cardiac output, responses which were...