...Jianmin Liu; Daoquan Liu; Xueneng Zhang; Yan Li; Xun Fu; Weixiang He; Mingzhou Li; Ping Chen; Guang Zeng; Michael E. DiSanto; Xinghuan Wang; Xinhua Zhang Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like...

...Ping Chen; De-qiang Xu; Sheng-li Xu; He Xiao; Sheng-hong Wan; Xing-huan Wang; Michael E. DiSanto; Xin-hua Zhang To investigate the effect of blebbistatin (BLEB, a selective myosin inhibitor) on regulating contractility and growth of prostate cells and to provide insight into possible mechanisms...

...Daniel GIOELI Prostate cancer is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths in the United States. When prostate cancer initially presents in the clinic, the tumour is dependent on androgen for growth and, therefore, responsive to the surgical...

...Badar A. USMANI; Ben HARDEN; Norman J. MAITLAND; Anthony J. TURNER Neutral endopeptidase-24.11 (neprilysin; NEP/CD10) is a cell surface metallopeptidase expressed by prostatic epithelial cells that degrades various bioactive peptides including endothelin. Endothelin-converting enzyme (ECE), the key...

... refractory prostate cancer who have undergone aggressive hormone ablation therapy. It is not known how hormone ablation affects ET-binding sites, although ET-1 and ET A expression are found to be elevated in prostate cancer patients. In this study, we examined the effect of castration on ET receptor binding...