...Dave J.P. Henderson; Miles D. Houslay; Chris H. Bangma; Ralf Hoffmann Increased PSA-based screening for prostate cancer has resulted in a growing number of diagnosed cases. However, around half of these are ‘indolent’, neither metastasizing nor leading to disease specific death. Treating non...

...Helen M. Wise; Miguel A. Hermida; Nicholas R. Leslie Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most common driving events in prostate cancer development. The observed...

...Alison K. Ramsay; Hing Y. LEUNG Prostate cancer represents a major health issue and its incidence is rising globally. In developed countries, prostate cancer is the most frequently diagnosed cancer and the second most common cause of death from cancer in men. Androgen deprivation reduces tumour...

...Ronan M. LONG; Colm MORRISSEY; John M. FITZPATRICK; R. William G. WATSON Prostate cancer is the most common malignancy in males in the western world. However, little is known about its origin and development. This review highlights the biology of the normal prostate gland and the differentiation...