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Keywords: protective immunity
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Articles

Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine

Rachelle Babb, Austen Chen, Abiodun D. Ogunniyi, Timothy R. Hirst, Ervin E. Kara, Shaun R. McColl, Mohammed Alsharifi, James C. Paton
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (2): 169–180.
https://doi.org/10.1042/CS20160475
Published: 23 December 2016
... A virus (γ-FLU) vaccine that provides cross-protective immunity against heterosubtypic infections. More recently, we reported a novel non-adjuvanted γ-irradiated S . pneumoniae (γ-PN) vaccine that elicits serotype-independent protection. Considering the clinical synergism of both pathogens, combination...
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Articles

Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses

Rachelle Babb, Austen Chen, Timothy R. Hirst, Ervin E. Kara, Shaun R. McColl, Abiodun D. Ogunniyi, James C. Paton, Mohammed Alsharifi
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (9): 697–710.
https://doi.org/10.1042/CS20150699
Published: 18 March 2016
... generated a killed Streptococcus pneumoniae whole bacterial cell vaccine, by exposing the bacteria to γ-irradiation. The non-adjuvanted γ-irradiated pneumococcal vaccine provides protection against lethal infection by S. pneumoniae strains of different capsular serotypes. protective immunity...
View article titled, Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses
Open the PDF for Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses in another window
Includes: Supplementary data