..., we investigated whether muscle protein degradation is increased in critically ill patients with sepsis and which proteolytic enzyme systems are involved in this degradation. Eight patients and seven healthy volunteers were studied. In vivo muscle protein kinetics was measured using arteriovenous...

... dysfunction proteasome protein degradation sepsis skeletal muscle Patients with septic shock in the ICU (intensive care unit) are prone to develop muscle wasting, a condition that is mainly manifested in skeletal muscle. The net loss of muscle proteins could depend on decreased protein synthesis...

... kinetics. Correspondence: Dr N. E. P. Deutz. The Biochemical Society and the Medical Research Society © 1999 1999 amino acid glutamine glutamine synthetase muscle protein degradation tracer 639Clinical Science (1999) 96, 639ñ646 (Printed in Great Britain) Effects in vivo of decreased...

... to amino acid supply. INTRODUCTION Protein deposition in individuals requires amino acid substrates, energy and an appropriate regulatory response to feeding by pathways of amino acid metabolism which Key words : insulin, leucine, protein degradation, protein requirement, protein synthesis, protein...

... pool [7, 101. A recent comparison of the results in the literature, obtained using the precursor and end-product methods, showed remarkable Key words: circadian rhythm, life-time kinetics, nitrogen flux, protein degradation, protein synthesis. Abbreviations: BMR basal metabolic rate; CV, coefficient...

... The Biochemical Society and the Medical Research Society 1996 amino acid membrane transport phenylalanine protein degradation tracer Clinical Science (1996) W, 457466 (Printed in Great Britain) Muscle protein and amino acid turnover in rats in v iva effects of short-term and prolonged starvation 1...

... rate. 20 7 1992 19 10 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 amino acids constant infusion flooding dose fractional synthesis rate leucine metabolism modelling muscle protein degradation protein synthesis tracer Clinical Science...

... rates ( k s ), the whole-body fractional protein degradation rate ( k d ), the capacity for protein synthesis ( C s ) and the efficiency of protein synthesis ( k RNA ) in vivo in fed and fasted (1, 5 and about 9 days) 400 g rats. 2. One day of starvation resulted in a reduced k s and an increased k d...

...S. B. Ireland; P. M. Stewart 1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham...

... The Biochemical Society and the Medical Research Society 1970 feeding indomethacin protein degradation protein metabolism protein synthesis 10 12 1986 21 1 1987 ...

...K. Lundholm; S. Edström; L. Ekman; I. Karlberg; P. Walker; T. Scherstén 1. The protein degradation rate of human skeletal muscle was evaluated in vitro in isolated fibre bundles from the rectus abdominus muscle by measuring the tyrosine released from muscle tissue proteins. Protein metabolism...

...F. J. Ballard; F. M. Tomas; L. M. Pope; P. G. Hendry; B. E. James; R. A. MacMahon 1. Myofibrillar protein degradation has been measured by the rate of 3-methylhistidine excretion in premature infants weighing between 635 g and 1295 g. Analyses were made in conjunction with 1–3 day nitrogen balance...

...F. J. Ballard; F. M. Tomas; L. M. Stern 1. Myofibrillar protein degradation has been measured in patients with Duchenne muscular dystrophy, normal boys, adult males and Duchenne carriers by the rate of 3-methylhistidine excretion after transfer of subjects to a meat-free diet. 2. Although absolute...

...F. M. Tomas; F. J. Ballard; L. M. Pope 1. Urinary excretion of 3-methylhistidine and creatinine have been measured in normal male and female humans ranging in age from pre-term neonates to 68 years to assess changes in the rate of muscle protein degradation and in muscle mass. 2. The 3...