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Keywords: protein synthesis
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Clin Sci (Lond) (2022) 136 (19): 1425–1431.
Published: 14 October 2022
...Philip C. Calder; Nicolaas E.P. Deutz In 1982 and 2011, Clinical Science published papers that used infusion of stable isotope-labeled amino acids to assess skeletal muscle protein synthesis in the fasted and fed state and before and after a period of increased intake of omega-3 fatty acids...
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Clin Sci (Lond) (2018) 132 (1): 17–31.
Published: 02 January 2018
... (crossover design). Whole body protein synthesis (PS), breakdown (PB), net PS (PS − PB) protein efficiency (netPSPE), net protein balance (phenylalanine (PHE) intake – PHE hydroxylation) protein efficiency (netBalPE), and splanchnic PHE extraction (SPE PHE ) were assessed using stable isotope tracer...
Includes: Supplementary data
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Clin Sci (Lond) (2005) 108 (2): 179–184.
Published: 21 January 2005
.... The aim of the present study was to investigate if the immunological activation of the human palatine tonsil is reflected by a high metabolic activity, as determined by in vivo measurement of protein synthesis. The protein synthesis rate of the tonsil was also compared with that of the circulating T...
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Clin Sci (Lond) (2004) 107 (6): 601–607.
Published: 24 November 2004
...Inga TJÄDER; Pia ESSEN; Peter J. GARLICK; Margaret A. McMNURLAN; Olav ROOYACKERS; Jan WERNERMAN Muscle protein catabolism is a considerable clinical problem following surgery. However, the impact of surgical trauma on muscle protein synthesis is not well characterized. In this pilot study, we...
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Clin Sci (Lond) (2004) 107 (4): 371–379.
Published: 24 September 2004
... investigated the arginine requirements of tumour cells for optimal protein synthesis and growth, and the metabolic pathway responsible for the arginine-dependent growth. The results showed that MCF-7 cells are highly dependent on arginine for growth and that the requirement for arginine is much higher than...
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Clin Sci (Lond) (2003) 105 (6): 691–698.
Published: 01 December 2003
... for 18 h and then received intravenous infusions of saline or parenteral nutrition (PN) with or without glutamine for 6 h. In animals receiving PN, parenteral injections of growth hormone (GH) or saline vehicle were also administered. Fractional rate of liver total protein synthesis was elevated...
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Clin Sci (Lond) (2001) 101 (1): 65–72.
Published: 29 May 2001
... who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake...
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Clin Sci (Lond) (1998) 94 (4): 413–423.
Published: 01 April 1998
...), in a chronic septic phase (day 6) and in a late septic phase (day 10). Protein synthesis rates were measured in vivo after administration of a flooding dose of l[1- 13 C]valine. 2. During the acute phase, muscle protein loss associated with infection resulted from both a decrease in protein synthesis...
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Clin Sci (Lond) (1997) 93 (3): 265–271.
Published: 01 September 1997
... turnover of the urea pool. 3. Protein synthesis, derived from the first ammonia plateau, 179 mg h −1 kg −1 , was significantly higher than that derived from the second plateau, 118 mg h −1 kg −1 . Using the plateau in urea towards the end of the 36 h, the estimate of protein synthesis was 153 mg h −1 kg −1...
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Clin Sci (Lond) (1996) 91 (1): 99–106.
Published: 01 July 1996
..., it is difficult to interpret these in vitro findings. Therefore, an in vivo technique has been established for determination of the fractional protein synthesis rate, as an index of metabolic activity in human peripheral blood lymphocytes, by using a stable isotope technique. 2. The rate of protein synthesis...
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Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
..., in total fat, to avoid essential fatty acid deficiency. 3. Rats subsequently received 800 μg/kg Escherichia coli endotoxin or sterile saline subcutaneously. Twenty-four hours after injection, the rate of tissue protein synthesis was measured in liver, lung, kidney, tibialis muscle and spleen...
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Clin Sci (Lond) (1994) 87 (5): 539–546.
Published: 01 November 1994
...D. C. Macallan; G. E. Griffin 1. Sepsis is associated with marked changes in cardiac muscle protein synthesis. Such changes may be the result of altered transcription of specific myofibrillar protein mRNAs. 2. In order to investigate myofibrillar protein gene expression, a rat model of sepsis...
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Clin Sci (Lond) (1994) 86 (6): 671–675.
Published: 01 June 1994
...Kenneth G. M. Park; Steven D. Heys; Margaret A. McNurlan; Peter J. Garlick; Oleg Eremin 1. The ‘flooding’ dose technique was used to measure rates of lymphocyte protein synthesis after infusion of [1- 13 C]leucine (20 atoms% enrichment, 4 g/70 kg body weight). Lymphocyte protein synthesis...
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Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... is that the protein synthesis rate is not stimulated by the flooding dose. A new formula for calculation of the fractional synthesis rate is derived with the alternative assumption that the protein synthesis rate is stimulated by an amount proportional to the change in the intracellular concentration of the infused...
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Clin Sci (Lond) (1992) 82 (4): 413–417.
Published: 01 April 1992
... have been reproduced in man there have been few studies of its effects on human tumours. In this study the effects of arginine on human breast cancers were determined by measuring tumour protein synthesis and comparing this with immunohistochemical assessments of cell proliferation. 2. Patients...
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Clin Sci (Lond) (1990) 79 (5): 537–542.
Published: 01 November 1990
...S. B. Ireland; P. M. Stewart 1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham...
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Clin Sci (Lond) (1989) 77 (6): 651–655.
Published: 01 December 1989
...S. D. Heys; A. C. Norton; C. R. Dundas; O. Eremin; K. Ferguson; P. J. Garlick 1. Rates of protein synthesis were measured, in vivo , in lung, liver, heart and skeletal muscle of young male rats. Groups of rats were exposed for 1 h duration to one of the following anaesthetic regimens: 1.4...
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Clin Sci (Lond) (1987) 72 (4): 503–509.
Published: 01 April 1987
..., with the decrement in muscle mass being due mainly to a substantial (25%) depression of muscle protein synthesis. 17 9 1986 20 11 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 fractured tibia immobilization protein breakdown protein synthesis skeletal muscle...
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Clin Sci (Lond) (1984) 66 (3): 337–342.
Published: 01 March 1984
...Marc Yudkoff; Itzhak Nissim; Mark Glassman; Stanton Segal 1. Whole body nitrogen turnover and protein synthesis were calculated by the method of D. Picou & T. Taylor-Roberts [ Clinical Science and Molecular Medicine (1969) 36, 283–296] except that plateau plasma enrichment of [ guanidino - 15 N...
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Clin Sci Mol Med (1976) 50 (5): 425–429.
Published: 01 May 1976
... DNA synthesis jejunum protein synthesis radioautography tissue culture Clinical Science and Molecular Medicine (1976) 50, 425-429. Biochemical and morphological studies on human jejunal mucosa maintained in culture C. L HIRONDEL, W. F. DOE AND T. J. PETERS Royal Postgraduate Medical School...
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Clin Sci Mol Med (1975) 48 (5): 373–378.
Published: 01 May 1975
... and the Medical Research Society 1975 bound and free ribosomes parathyroid gland protein synthesis Clinical Science and Molecular Medicine (1975) 48, 373-378. Protein synthetic activity of membrane-bound and free ribosomes from parathyroid glands of dogs F. P. ALFORD,(i) P. S. COOK, R. S. SWENSON AND G...
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Clin Sci Mol Med (1974) 47 (6): 531–545.
Published: 01 December 1974
.... Cooksley et al. factors other than the synthesis of TCII and the concentration of vitamin B,, or unsaturated transcobalamin in the plasma. Key words : bile secretion, liver perfusion, protein synthesis, transcobalamin 11, vitamin B Protein-binding of vitamin B,, has been shown to play a role in its...
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Clin Sci Mol Med (1973) 44 (1): 1–8.
Published: 01 January 1973
... hormone cell culture protein synthesis affinity chromatography Clinical Science (1973) 44, 1-8. SYNTHESIS O F HUMAN PARATHYROID HORMONE BY CULTURED CELLS: EVIDENCE FOR RELEASE OF PROHORMONE BY SOME ADENOMATA T. J. MARTIN, P. B. GREENBERG AND V. MICHELANGELI University of Melbourne Department...