... compilation © 2010 Biochemical Society 2010 endotoxin phenylalanine protein turnover sepsis skeletal muscle Both surgical stress and critical illness are characterized by changes in protein metabolism, resulting in a net loss of proteins on a whole-body basis. This loss of proteins...

... turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [ 15 N]glycine...

...I. M. NAKSHABENDI; S. DOWNIE; R. I. RUSSELL; M. J. RENNIE We used stable-isotope-labelled amino acids to measure the effects of alcoholic liver disease (ALD) on whole-body protein turnover and small-intestinal mucosal protein synthesis. Groups comprising eight patients with ALD and eight healthy...

..., the German physiologist Von Liebig hypothesized that muscle protein is the main fuel used to achieve muscular contraction [1]. Fick and Wislecenus, in their classic study [2], raised considerable doubts about Key words : amino acids, knee-extensor, protein turnover. Abbreviations : BCAA, branched-chain amino...

...G. E. A. Bettany; B. C. Ang; S. N. Georgiannos; D. Halliday; J. Powell-Tuck 1. Whole-body protein turnover was measured using the [ 15 N]glycine tracer technique in 10 post-absorptive healthy volunteers during normal daily activities and a period of bed rest. 2. Bed rest reduced whole-body protein...

... and the Medical Research Society 1995 acute-phase protein protein turnover vaccination Clinical Science (1995) 89, 389-396 (Printed in Great Britain) Whole-body protein turnover and hepatic protein synthesis are increased by vaccination in man M. CAYOll, I.TAUVERONI,2, F. RAMBOURDIN', J. PRUGNAUD', P...

...D. Joe Millward; Paul J. Pacy diurnal cycling fasting feeding indispensable amino acid requirements leucine nitrogen balance protein turnover stable isotopes © 1995 The Biochemical Society and the Medical Research Society 1995 Clinical Science (1995) 88, 5 9 7 4 6 (Printed...

... characterized in man by a marked negative nitrogen balance and an increased rate of protein turnover C1-41. Different animal models have been used to study changes in protein metabolism. Studies after administration of endotoxins [ 5 , 61, turpentine [7, 81 or induction of abdominal sepsis 663 [9-13] showed...

... on the day of study. The objective of the present study was therefore to control for the dietary intake during the measurement of whole body protein turnover. 3. In the present study dietary intakes were equated on a body weight basis; however, expressed per kg fat-free mass, the normal weight subjects had...

...Paul J. Pacy; Gill M. Price; David Halliday; Marcello R. Quevedo; D. Joe Millward 1. The diurnal changes in whole body protein turnover associated with the increasing fasting body nitrogen (N) losses and feeding gains with increasing protein intake were investigated in normal adults. [ 13 C]Leucine...

...-nourished Indian control subjects. 2. The object of the present study was to find out whether a reduced rate of protein turnover, measured after a single dose of [ 15 N]glycine, contributed to a lower basal metabolic rate. It was found, however, that after adjusting for body weight and fat-free mass...

.... Sequential post-operative (2, 4 and 6 days) changes in whole-body protein turnover, forearm arteriovenous difference of plasma amino acids, glucose, lactate and free fatty acids, muscle concentration of free amino acids, RNA and protein, urinary nitrogen and 3-methylhistidine, plasma concentrations...

... with cirrhosis and in 11 healthy control subjects. Whole-body protein turnover was also measured using l -[1- 13 C]leucine. 2. Leg efflux of tyrosine was 45% greater in cirrhotic patients than in normal control subjects [−6.5(1.4 to −19.1) vs −4.2 (−2.2 to −7.7) μmol min −1 100 mg −1 of leg, median (range), P...

...Asha Badaloo; Alan A. Jackson; Farook Jahoor 1. Whole body protein turnover and resting metabolic rate were measured in six adults with homozygous sickle cell disease (genotype HbSS ) and in six normal adults (genotype HbAA ) of similar age. 2. Turnover was measured with prime/intermittent oral...

... synthesis. 15 8 1988 23 8 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 amino acids leucine muscle protein synthesis protein turnover Clinical Science (1989) 76, 447-454 447 Increase in anterior tibialis muscle protein synthesis in healthy man during...

... patients with emphysema and in 11 healthy controls. Whole-body protein turnover was measured using l -[1- 13 C]leucine. 2. Leg efflux of tyrosine was increased by 47% in emphysematous patients compared with normal control subjects, but 3-methylhistidine efflux was not significantly altered. 3. In emphysema...

... requirement protein turnover whole body Clinical Science (1988) 75, 101-107 101 Elevated protein requirements in cirrhosis of the liver investigated by whole body protein turnover studies G. R. SWART, J. W. 0. VAN DEN BERG, J. L. D. WATTIMENA, T. RIETVELD, J. K. VAN VUuRE AND M. FRENKEL Department...

... chloride solutions or balanced amino acid intakes. 13 12 1982 28 4 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 albumin synthesis leucine protein turnover tyrosine Clinical Science (1983) 65, 499-505 499 Amino acid and protein metabolism...

... © 1983 The Biochemical Society and the Medical Research Society 1983 carbon dioxide [ 14 C]bicarbonate leucine oxidation protein turnover Clinical Science (1983) 64,23 1-233 SHORT COMMUNICATION 23 1 Recovery of infused [14C]bicarbonate as respiratory 14C02 in man GRAEME A. CLUGSTON...

... turnover, measured from the urinary [ 15 N]ammonia enrichment, was 30.3 ± 7.7 g of N/day (2.8 g of protein day −1 kg −1 ). 1 5 1981 13 10 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 ammonia ammoniagenesis glutamine nitrogen protein turnover...

...M. J. Rennie; R. H. T. Edwards; S. Krywawych; C. T. M. Davies; D. Halliday; J. C. Waterlow; D. J. Millward 1. We have investigated the effects of moderate long-term exercise on protein turnover in fed man by measuring the extent of whole-body nitrogen production, the labelling of urinary ammonia...

...M. Taruvinga; A. A. Jackson; M. H. N. Golden 1. Whole-body protein turnover was measured in rats by constant infusion of 15 N-labelled glycine, aspartate, valine and leucine and measuring the enrichment of hepatic and renal urea and ammonia nitrogen. 2. The values obtained with [ 15 N]glycine were...

...M. H. N. Golden; J. C. Waterlow 1. Total body protein turnover was studied in six elderly patients. 2. During the study they were fed by continuous infusion of a liquid formula through a nasogastric tube. l-[1- 14 C]Leucine and [ 15 N]glycine were infused at a constant rate for 30 h. The labelled...