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Articles

Mechanisms of podocyte injury and implications for diabetic nephropathy

Federica Barutta, Stefania Bellini, Gabriella Gruden

Clin Sci (Lond) (2022) 136 (7): 493–520.

https://doi.org/10.1042/CS20210625

Published: 13 April 2022

... ( [email protected] ) 31 10 2021 25 02 2022 25 03 2022 diabetic nephropathy podocytes proteinuria The kidneys filter approximately 180 l of fluids everyday; however, there is no loss of proteins into urine as the glomerular filtration barrier (GFB) retains 99.99% of plasma...

View articletitled, Mechanisms of podocyte injury and implications for diabetic nephropathy

Articles

First identification of PODXL nonsense mutations in autosomal dominant focal segmental glomerulosclerosis

Fu-Jun Lin, Lei Yao, Xue-Qing Hu, Fan Bian, Gang Ji, Geng-Ru Jiang, Daniel P. Gale, Hong-Qi Ren

Clin Sci (Lond) (2019) 133 (1): 9–21.

https://doi.org/10.1042/CS20180676

Published: 03 January 2019

... pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES). Total mRNA and PODXL protein abundance were decreased in available peripheral blood cell samples of two affected patients undergoing hemodialysis, compared with those in healthy controls...

View articletitled, First identification of PODXL nonsense mutations in autosomal dominant focal segmental glomerulosclerosis

Includes: Supplementary data

Articles

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Sandra Villanueva, Juan E. Carreño, Lorena Salazar, César Vergara, Rocío Strodthoff, Francisca Fajre, Carlos Céspedes, Pablo J. Sáez, Carlos Irarrázabal, Jorge Bartolucci, Fernando Figueroa, Carlos P. Vio

Clin Sci (Lond) (2013) 125 (4): 199–210.

https://doi.org/10.1042/CS20120644

Published: 01 May 2013

...Sandra Villanueva; Juan E. Carreño; Lorena Salazar; César Vergara; Rocío Strodthoff; Francisca Fajre; Carlos Céspedes; Pablo J. Sáez; Carlos Irarrázabal; Jorge Bartolucci; Fernando Figueroa; Carlos P. Vio Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce proteinuria...

View articletitled, Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Articles

Angiotensin-(1–7) in kidney disease: a review of the controversies

Danielle Zimmerman, Kevin D. Burns

Clin Sci (Lond) (2012) 123 (6): 333–346.

https://doi.org/10.1042/CS20120111

Published: 29 May 2012

... Society 2012 angiotensin angiotensin-converting enzyme 2 (ACE2) diabetes kidney nephropathy proteinuria The formation of Ang-(1–7) in the kidney was considered for years to be primarily the result of hydrolysis of the substrate decapeptide AngI (angiotensin I), mediated by tissue...

View articletitled, Angiotensin-(1–7) in kidney disease: a review of the controversies

Articles

The cellular basis of albuminuria

Peter W. MATHIESON

Clin Sci (Lond) (2004) 107 (6): 533–538.

https://doi.org/10.1042/CS20040168

Published: 24 November 2004

..., targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding of the cellular and molecular basis of albuminuria. This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states...

View articletitled, The cellular basis of albuminuria

Articles

Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat

Marijke HAAS, Eric De BOER, Paul E. De JONG, Frits MOOLENAAR, Dirk K. F. MEIJER, Dick De ZEEUW

Clin Sci (Lond) (2003) 105 (1): 51–57.

https://doi.org/10.1042/CS20020205

Published: 01 July 2003

... 13 3 2003 13 3 2003 © 2003 The Biochemical Society 2003 adriamycin-induced nephrotic rat angiotensin-converting-enzyme (ACE) inhibition low-molecular-weight protein protein catabolism proteinuria Clinical Science (2003) 105, 51 57 (Printed in Great Britain) 51 Effects...

View articletitled, Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat

Articles

Albumin stimulates p44/p42 extracellular-signal-regulated mitogen-activated protein kinase in opossum kidney proximal tubular cells

Richard DIXON, Nigel J. BRUNSKILL

Clin Sci (Lond) (2000) 98 (3): 295–301.

https://doi.org/10.1042/cs0980295

Published: 09 February 2000

...Richard DIXON; Nigel J. BRUNSKILL The presence of protein in the urine of patients with renal disease is an adverse prognostic feature. It has therefore been suggested that proteinuria per se may be responsible for the development of renal tubulo-interstitial scarring and fibrosis, and disturbances...

View articletitled, Albumin stimulates p44/p42 extracellular-signal-regulated mitogen-activated protein kinase in opossum kidney proximal tubular cells

Articles

Is proteinuric pre-eclampsia a different disease in primigravida and multigravida?

Anne E. BARDEN, Lawrence J. BEILIN, Jackie RITCHIE, Barry N. WALTERS, Dorothy GRAHAM, Constantine A. MICHAEL

Clin Sci (Lond) (1999) 97 (4): 475–483.

https://doi.org/10.1042/cs0970475

Published: 01 September 1999

... to parity in a direction that would suggest a different pathophysiology. Groups of 27 primigravid and 35 multigravid women with pre-eclampsia (defined as blood pressure > 140/90 mmHg and 2+ proteinuria) were studied ante-partum, and at 6 weeks and 6 months post-partum. Clinical markers of severity of pre...

View articletitled, Is proteinuric pre-eclampsia a different disease in primigravida and multigravida?

Articles

Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant

Catheryne WHITTLE, Kathleen GILLESPIE, Rebecca HARRISON, Peter W. MATHIESON, Steve J. HARPER

Clin Sci (Lond) (1999) 97 (3): 303–312.

https://doi.org/10.1042/cs0970303

Published: 21 July 1999

...Catheryne WHITTLE; Kathleen GILLESPIE; Rebecca HARRISON; Peter W. MATHIESON; Steve J. HARPER Vascular endothelial growth factor (VEGF) mediates increased vascular permeability and endothelial mitogenesis, and may orchestrate normal glomerular permselectivity and proteinuria. Distinct isoforms...

View articletitled, Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant

Articles

Proximal Renal Tubular Peptide Catabolism, Ammonia Excretion and Tubular Injury in Patients with Proteinuria: Before and after Lisinopril

Rana Rustom, J. Steve Grime, Michael Costigan, Paul Maltby, Anthony Hughes, Alan Shenkin, Mair Critchley, J. Michael Bone

Clin Sci (Lond) (1998) 94 (4): 425–430.

https://doi.org/10.1042/cs0940425

Published: 01 April 1998

...Rana Rustom; J. Steve Grime; Michael Costigan; Paul Maltby; Anthony Hughes; Alan Shenkin; Mair Critchley; J. Michael Bone 1. Progression to renal failure may be linked to the degree of proteinuria through tubulo-interstitial mechanisms. However, there are no data in man on the kinetics of proximal...

View articletitled, Proximal Renal Tubular Peptide Catabolism, Ammonia Excretion and Tubular Injury in Patients with Proteinuria: Before and after Lisinopril

Articles

Elevated Renal Endothelin-1 Clearance and mRNA Levels Associated with Albuminuria and Nephropathy in Non-Insulin-Dependent Diabetes Mellitus: Studies in Obese fa/fa Zucker Rats

N. C. Turner, P. J. Morgan, A. C. Haynes, M. Vidgeon-Hart, N. Toseland, J. C. Clapham

Clin Sci (Lond) (1997) 93 (6): 565–571.

https://doi.org/10.1042/cs0930565

Published: 01 December 1997

...N. C. Turner; P. J. Morgan; A. C. Haynes; M. Vidgeon-Hart; N. Toseland; J. C. Clapham 1. The obese fa/fa Zucker rat is a genetic model of obesity and insulin resistance which develops a number of metabolic and endocrine features of non-insulin-dependent diabetes, including hypertension, proteinuria...

View articletitled, Elevated Renal Endothelin-1 Clearance and mRNA Levels Associated with Albuminuria and Nephropathy in Non-Insulin-Dependent Diabetes Mellitus: Studies in Obese fa/fa Zucker Rats

Articles

Antiproteinuric Effect Predicts Renal Protection by Angiotensin-Converting Enzyme Inhibition in Rats with Established Adriamycin Nephrosis

Frits H. Wapstra, Harry Van Goor, Gerjan Navis, Paul E. De Jong, Dick De Zeeuw

Clin Sci (Lond) (1996) 90 (5): 393–401.

https://doi.org/10.1042/cs0900393

Published: 01 May 1996

...Frits H. Wapstra; Harry Van Goor; Gerjan Navis; Paul E. De Jong; Dick De Zeeuw 1. The mechanism of renal protection by angiotensin-converting enzyme inhibition is still the subject of debate. Inhibition of proteinuria might play a role. If so, a good antiproteinuric response to angiotensin...

View articletitled, Antiproteinuric Effect Predicts Renal Protection by Angiotensin-Converting Enzyme Inhibition in Rats with Established Adriamycin Nephrosis

Articles

Metabolic Acidosis Does Not Contribute to Chronic Renal Injury in the Rat

D. Throssell, J. Brown, K. P. G. Harris, J. Walls

Clin Sci (Lond) (1995) 89 (6): 643–650.

https://doi.org/10.1042/cs0890643

Published: 01 December 1995

...D. Throssell; J. Brown; K. P. G. Harris; J. Walls 1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested...

View articletitled, Metabolic Acidosis Does Not Contribute to Chronic Renal Injury in the Rat

Articles

Adriamycin-Related Hypertension in Pregnant Rats: Response to a Thromboxane Receptor Antagonist

Mauro Rathaus, Eduardo Podjarny, Avishalom Pomeranz, Janice Green, Jacques Bernheim

Clin Sci (Lond) (1995) 88 (6): 623–627.

https://doi.org/10.1042/cs0880623

Published: 01 June 1995

...Mauro Rathaus; Eduardo Podjarny; Avishalom Pomeranz; Janice Green; Jacques Bernheim 1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase...

View articletitled, Adriamycin-Related Hypertension in Pregnant Rats: Response to a Thromboxane Receptor Antagonist

Articles

Glomerular Charge Selectivity in Primary Glomerulopathies

J. G. Fox, J. D. Quin, D. St. J. O'Reilly, J. M. Boulton-Jones

Clin Sci (Lond) (1994) 87 (4): 421–425.

https://doi.org/10.1042/cs0870421

Published: 01 October 1994

... amylase charge selectivity glomerulus proteinuria Clinical Science (1994) 87, 421425 (Printed in Great Britain) 42 I Glomerular charge selectivity in primary glomerulopathies J. G. FOX, J. D. QUIN*, D. ST. J. O REILLY? and J. M. BOULTON-JONES Renal Unit, *Diabetes Centre and ?Institute...

View articletitled, Glomerular Charge Selectivity in Primary Glomerulopathies

Articles

Effects of Vasopressin V 1 and V 2 Receptor Antagonists on Progressive Renal Failure in Rats

Hirokazu Okada, Hiromichi Suzuki, Yoshihiko Kanno, Yoshitaka Yamamura, Takao Saruta

Clin Sci (Lond) (1994) 86 (4): 399–404.

https://doi.org/10.1042/cs0860399

Published: 01 April 1994

... with the control, and urine volume was increased in groups 3 and 4. The proteinuria was also decreased at week 10 in groups 2, 3 and 4. Differences in sodium excretion between all groups were not significant. Histopathological alterations in the kidneys of group 4 were significantly ameliorated. 4. These results...

View articletitled, Effects of Vasopressin V 1 and V 2 Receptor Antagonists on Progressive Renal Failure in Rats

Articles

Assessment of Glomerular Charge Selectivity in Man by Differential Clearance of Isoamylases

J. G. Fox, J. D. Quin, D. Stj. O'reilly, J. M. Boulton-Jones

Clin Sci (Lond) (1993) 84 (4): 449–454.

https://doi.org/10.1042/cs0840449

Published: 01 April 1993

...J. G. Fox; J. D. Quin; D. Stj. O'reilly; J. M. Boulton-Jones 1. Glomerular charge selectivity was assessed using the ratio of the clearance of pancreatic isoamylase to the clearance of the more anionic salivary isoamylase ( C PAm / C SAm ) in 30 normal subjects, 14 patients with minimal proteinuria...

View articletitled, Assessment of Glomerular Charge Selectivity in Man by Differential Clearance of Isoamylases

Articles

Long-term effects of a somatostatin analogue on renal haemodynamics and hypertrophy in diabetic rats

Martin Muntzel, Thierry Hannedouche, Roberte Niesor, Laure-Helène Nöel, Jean-Claude Souberbielle, Bernard Lacour, Tilman Drüeke

Clin Sci (Lond) (1992) 83 (5): 575–581.

https://doi.org/10.1042/cs0830575

Published: 01 November 1992

... and the Medical Research Society 1992 diabetes hypertrophy octreotide proteinuria renal haemodynamics somatostatin streptozotocin Clinical Science (1992) 83, 575-581 (Printed in Great Britain) 575 Long-term effects of a somatostatin analogue on renal haemodynamics and hypertrophy in diabetic rats...

View articletitled, Long-term effects of a somatostatin analogue on renal haemodynamics and hypertrophy in diabetic rats

Articles

Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy

A. Fabbri, R. Boero, E. Degli Esposti, C. Guarena, A. Lucatello, A. Sturani, G. Piccoli, M. Fusaroli

Clin Sci (Lond) (1992) 83 (2): 241–245.

https://doi.org/10.1042/cs0830241

Published: 01 August 1992

... blood pressure, although within the normal range, and Na + /Li + countertransport activity were significantly higher in patients with proteinuria than in those without proteinuria. 4. Parents of proteinuric patients had a higher Na + /Li + countertransport activity than parents of non-proteinuric...

View articletitled, Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy

Articles

Effects of cyclosporin A on glomerular barrier function in the nephrotic syndrome

Robert Zietse, Gerrit J. Wenting, Pieter Kramer, Maarten A. Schalekamp, Willem Weimar

Clin Sci (Lond) (1992) 82 (6): 641–650.

https://doi.org/10.1042/cs0820641

Published: 01 June 1992

...Robert Zietse; Gerrit J. Wenting; Pieter Kramer; Maarten A. Schalekamp; Willem Weimar 1. To elucidate the mechanisms by which cyclosporin A diminishes proteinuria, we studied 20 patients with severe nephrotic syndrome. Biopsy-established pathologies included minimal change disease ( n = 5...

View articletitled, Effects of cyclosporin A on glomerular barrier function in the nephrotic syndrome

Articles

Persistent albuminuria in normotensive non-insulin-dependent (type II) diabetic patients: comparative effects of angiotensin-converting enzyme inhibitors and β -adrenoceptor blockers

Michele Stornello, Enrico V. Valvo, Luigi Scapellato

Clin Sci (Lond) (1992) 82 (1): 19–23.

https://doi.org/10.1042/cs0820019

Published: 01 January 1992

..., enalapril, non-insulin-dependent diabetes, proteinuria, tissue angiotensin. Abbreviations: GFR, glomerular filtration rate; ERPF, effective renal plasma flow. Correspondence: Dr Michele Stornello, Centro Ipertensione. Ospedale Generale, 96100 Siracusa, Italy. 20 M. Stornello et al. 9, 12-14]. Moreover...

View articletitled, Persistent albuminuria in normotensive non-insulin-dependent (type II) diabetic patients: comparative effects of angiotensin-converting enzyme inhibitors and β -adrenoceptor blockers

Articles

Additive antiproteinuric effect of angiotensin-converting enzyme inhibition and non-steroidal anti-inflammatory drug therapy: A clue to the mechanism of action

Jan E. Heeg, Paul E. de Jong, Dick de Zeeuw

Clin Sci (Lond) (1991) 81 (3): 367–372.

https://doi.org/10.1042/cs0810367

Published: 01 September 1991

...Jan E. Heeg; Paul E. de Jong; Dick de Zeeuw 1. Both the angiotensin-converting enzyme inhibitor, lisinopril, and the non-steroidal anti-inflammatory drug, indomethacin, lower urinary protein excretion in renal disease and improve the selectivity of the residual proteinuria. Despite the clearly...

View articletitled, Additive antiproteinuric effect of angiotensin-converting enzyme inhibition and non-steroidal anti-inflammatory drug therapy: A clue to the mechanism of action

Articles

Effect of Dietary Protein Restriction on Renal Purines and Purine-Metabolizing Enzymes in Adriamycin Nephrosis in Rats: A Mechanism for Protection against Acute Proteinuria Involving Xanthine Oxidase Inhibition

Gian Marco Ghiggeri, Fabrizio Ginevri, Giovanni Cercignani, Roberta Oleggini, Alessando Garberi, Giovanni Candiano, Paola Altieri, Rosanna Gusmano

Clin Sci (Lond) (1990) 79 (6): 647–656.

https://doi.org/10.1042/cs0790647

Published: 01 December 1990

...Gian Marco Ghiggeri; Fabrizio Ginevri; Giovanni Cercignani; Roberta Oleggini; Alessando Garberi; Giovanni Candiano; Paola Altieri; Rosanna Gusmano 1. A low protein diet prevents the development of proteinuria and glomerular damage in adriamycin experimental nephrosis without affecting renal...

View articletitled, Effect of Dietary Protein Restriction on Renal Purines and Purine-Metabolizing Enzymes in Adriamycin Nephrosis in Rats: A Mechanism for Protection against Acute Proteinuria Involving Xanthine Oxidase Inhibition

Articles

Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: Difference between puromycin aminonucleoside and adriamycin nephrosis

Fabrizio Ginevri, Rosanna Gusmano, Roberta Oleggini, Silvia Acerbo, Roberta Bertelli, Francesco Perfumo, Giovanni Cercignani, Simone Allegrini, Franco D'Allegri, Gianmarco Ghiggeri

Clin Sci (Lond) (1990) 78 (3): 283–293.

https://doi.org/10.1042/cs0780283

Published: 01 March 1990

... 1.1.1.204) in renal tissues were unchanged 1 day after puromycin aminonucleoside or hypoxanthine intoxication and only moderately increased in both groups at 13 days (the time of appearance of heavy proteinuria in the puromycin aminonucleoside-treated group). In contrast, xanthine oxidase and xanthine...

View articletitled, Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: Difference between puromycin aminonucleoside and adriamycin nephrosis

Articles

Effect of α-Human Atrial Natriuretic Peptide on Proteinuria in Patients with Primary Glomerular Diseases

Masao Ishii, Yasunobu Hirata, Tokuichiro Sugimoto, Hiroaki Matsuoka, Kenjiro Kimura, Toshihiko Ishimitsu, Kazushige Fukui, Tsuneaki Sugimoto, Yuko Kurosawa, Hiroshi Kiyose, Kenji Kangawa, Hisayuki Matsuo

Clin Sci (Lond) (1989) 77 (6): 643–650.

https://doi.org/10.1042/cs0770643

Published: 01 December 1989

... excretion were examined in nine healthy subjects and 20 patients with primary glomerular diseases who had proteinuria of 1.0 g or more per day. Synthetic α-hANP was intravenously infused into supine subjects at a rate of 8.3 pmol min −1 kg −1 for 40 min 2. Before α-hANP infusion, the plasma concentration...

View articletitled, Effect of α-Human Atrial Natriuretic Peptide on Proteinuria in Patients with Primary Glomerular Diseases

Articles

Increase in Proteinuria and Reduction in Number of Anionic Sites on the Glomerular Basement Membrane in Rabbits by Infusion of Human Nephrotic Plasma in Vivo

Alan H. Wilkinson, Cecilia Gillespie, Barry Hartley, D. Gwyn Williams

Clin Sci (Lond) (1989) 77 (1): 43–48.

https://doi.org/10.1042/cs0770043

Published: 01 July 1989

... rara iterna to 14.0 ± 2.7 per 1000 nm of lamina rara interna (mean ± sd) compared with 18.7 ± 2.1 ( P < 0.005) after infusion of plasma from normal subjects. 2. Proteinuria increased in all nine animals infused with nephrotic plasma and in two of seven infused with control plasma ( P < 0.01...

View articletitled, Increase in Proteinuria and Reduction in Number of Anionic Sites on the Glomerular Basement Membrane in Rabbits by Infusion of Human Nephrotic Plasma in Vivo

Articles

Differences in the effects of angiotensin converting enzyme inhibitors with or without a thiol group in chronic renal failure in rats

Akira Ohishi, Hiromichi Suzuki, Hidetomo Nakamoto, Hiroshige Katsumata, Hiroshi Sakaguchi, Takao Saruta

Clin Sci (Lond) (1989) 76 (4): 353–356.

https://doi.org/10.1042/cs0760353

Published: 01 April 1989

... (27.4 ± 0.9 kPa) at week 10]. 3. Massive proteinuria occurred in all groups. At the end of the experiment (at week 10), urinary protein excretion was significantly reduced in the captopril and cysteine groups compared with the control group. No manifest improvements appeared in the enalapril group. 4...

View articletitled, Differences in the effects of angiotensin converting enzyme inhibitors with or without a thiol group in chronic renal failure in rats

Articles

Changes in glomerular filtration rate, lithium clearance and plasma protein clearances in the early phase after unilateral nephrectomy in living healthy renal transplant donors

S. Strandgaard, A. Kamper, P. Skaarup, N. H. Holstein-Rathlou, P. P. Leyssac, O. Munck

Clin Sci (Lond) (1988) 75 (6): 655–659.

https://doi.org/10.1042/cs0750655

Published: 01 December 1988

..., resulting in an almost complete normalization of glomerulotubular balance. 25 4 1988 17 5 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 glomerular filtration rate lithium clearance nephrectomy proteinuria Clinical Science ( 1 988) 75,655-659 655...

View articletitled, Changes in glomerular filtration rate, lithium clearance and plasma protein clearances in the early phase after unilateral nephrectomy in living healthy renal transplant donors

Articles

Intravenously administered frusemide increases glomerular permeability

I. Ala-Houhala, H. Vapaatalo, A. Pasternack

Clin Sci (Lond) (1987) 73 (4): 365–370.

https://doi.org/10.1042/cs0730365

Published: 01 October 1987

... prostaglandins proteinuria ...

View articletitled, Intravenously administered frusemide increases glomerular permeability

Articles

Fractional dextran and protein clearances in glomerulonephritis and in diabetic nephropathy

I. Ala-Houhala, A. Pasternack

Clin Sci (Lond) (1987) 72 (3): 289–296.

https://doi.org/10.1042/cs0720289

Published: 01 March 1987

... with a decrease of charge as renal function deterio- rates. In glomerulonephritis the process is different and there is a high degree of variation from case to case. Key words: clearance, dextrans, glomerular filtra- tion rate, glomerular permeability, proteinuria. Abbreviations: GFR, glomerular filtration rate...

View articletitled, Fractional dextran and protein clearances in glomerulonephritis and in diabetic nephropathy

Articles

A circadian rhythm of proteinuria in patients with a nephrotic syndrome

M. G. Koopman, R. T. Krediet, F. J. M. Zuyderhoudt, E. A. M. De Moor, L. Arisz

Clin Sci (Lond) (1985) 69 (4): 395–401.

https://doi.org/10.1042/cs0690395

Published: 01 October 1985

...M. G. Koopman; R. T. Krediet; F. J. M. Zuyderhoudt; E. A. M. De Moor; L. Arisz 1. Circadian variations in proteinuria were studied in 17 patients with different types of glomerulopathies. During 3–4 successive days urine was collected over periods of 3 h under standardized conditions. 2. Thirteen...

View articletitled, A circadian rhythm of proteinuria in patients with a nephrotic syndrome

Articles

Increased albumin and normal dextran clearances in protein-overload proteinuria in the rat

David J. Bliss, Douglas B. Brewer

Clin Sci (Lond) (1985) 69 (3): 321–326.

https://doi.org/10.1042/cs0690321

Published: 01 September 1985

... in the clearance of the negatively charged endogenous albumin may be due to a reduction in the glomerular charge barrier. 5 3 1985 19 3 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 albumin dextran glomerulus kidney proteinuria Clinical Science (1985) 69...

View articletitled, Increased albumin and normal dextran clearances in protein-overload proteinuria in the rat

Articles

Glomerular Sialic acid in Heymann Nephritis and Diacetylbenzidine induced Nephropathy in Rats

Liisa Laitinen, Aaro Miettinen, Ilkka Tikkanen, Tom TÖrnroth, Stig Nordling

Clin Sci (Lond) (1985) 69 (1): 57–62.

https://doi.org/10.1042/cs0690057

Published: 01 July 1985

...Liisa Laitinen; Aaro Miettinen; Ilkka Tikkanen; Tom TÖrnroth; Stig Nordling 1. Glomerular sialic acid was chemically measured in rats with experimental proteinuria induced by N,N '-diacetylbenzidine (DAB) or with autoimmune Heymann nephritis. 2. In DAB nephrosis and in Heymann nephritis...

View articletitled, Glomerular Sialic acid in Heymann Nephritis and Diacetylbenzidine induced Nephropathy in Rats

Articles

Effect of Molecular Charge on the Induction of Proteinuria and Glomerular Ultrastructural Damage in Hyperalbuminaemic Female Wistar Rats

Gillian M. Lawrence, D. B. Brewer

Clin Sci (Lond) (1984) 66 (2): 201–206.

https://doi.org/10.1042/cs0660201

Published: 01 February 1984

... albumin dose were significantly lower than those previously measured after the administration of normal bovine albumin. 3. The amount of epithelial cell foot process loss induced after the injection of carbamylated bovine albumin derivatives correlated well with the level of induced proteinuria...

View articletitled, Effect of Molecular Charge on the Induction of Proteinuria and Glomerular Ultrastructural Damage in Hyperalbuminaemic Female Wistar Rats

Articles

Effect of Dietary Protein Restriction on the Development of Renal Failure after Subtotal Nephrectomy in Rats

A. M. El-Nahas, H. Paraskevakou, S. Zoob, A. J. Rees, D. J. Evans

Clin Sci (Lond) (1983) 65 (4): 399–406.

https://doi.org/10.1042/cs0650399

Published: 01 October 1983

... and the Medical Research Society 1983 glomerular filtration rate glomerular sclerosis low protein diet proteinuria subtotal nephrectomy Clinical Science (1983) 65, 399-406 399 Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats A. M. EL-NAHAS...

View articletitled, Effect of Dietary Protein Restriction on the Development of Renal Failure after Subtotal Nephrectomy in Rats

Articles

Proteinuria in Patients with Cirrhosis: Relationship between Renal and Hepatic Function

L. Milani, A. Gatta, C. Merkel, A. Ruol

Clin Sci (Lond) (1982) 63 (4): 387–392.

https://doi.org/10.1042/cs0630387

Published: 01 October 1982

... and the Medical Research Society 1982 cirrhosis liver proteinuria renal function Clinical Science (1982) 63, 387-392 387 Proteinuria in patients with cirrhosis: relationship between renal and hepatic fbnction L. M I L A N I , A . G A T T A , C . M E R K E L A N D A. R U O L Universitci degli Studi di...

View articletitled, Proteinuria in Patients with Cirrhosis: Relationship between Renal and Hepatic Function

Articles

A Biochemical and Immunological Investigation into the Physiological Basis of the Increased Albumin Filtration Induced in Hyperalbuminaemic Female Wistar Rats

Gillian M. Lawrence, D. B. Brewer

Clin Sci (Lond) (1982) 62 (5): 495–502.

https://doi.org/10.1042/cs0620495

Published: 01 May 1982

...Gillian M. Lawrence; D. B. Brewer 1. The level of proteinuria induced in female Wistar rats after bovine albumin injection intraperitoneally was highly dose dependent. 2. The proteinuria remained highly selective, with albumin constituting approximately 90% of the total protein excreted, even...

View articletitled, A Biochemical and Immunological Investigation into the Physiological Basis of the Increased Albumin Filtration Induced in Hyperalbuminaemic Female Wistar Rats

Articles

Normal Urinary Protein Composition in the Female Wistar Rat and its Relationship to the Proteinuria Induced by Intraperitoneal Bovine Albumin

Gillian M. Lawrence, D. B. Brewer

Clin Sci (Lond) (1981) 60 (6): 693–702.

https://doi.org/10.1042/cs0600693

Published: 01 June 1981

... in the response to intraperitoneal injection of heterologous serum albumin since, during periods where no significant glomerular epithelial cell foot-process loss had been incurred, the levels of proteinuria induced correlated well with baseline albuminuria. 27 1 1981 9 2 1981 © 1981...

View articletitled, Normal Urinary Protein Composition in the Female Wistar Rat and its Relationship to the Proteinuria Induced by Intraperitoneal Bovine Albumin

Articles

Sieving Studies in ‘Urea-Induced Nephropathy’ in the Dog

Y. Vanrenterghem, R. Vanholder, M. Lammens-Verslijpe, P. P. Lambert

Clin Sci (Lond) (1980) 58 (1): 65–75.

https://doi.org/10.1042/cs0580065

Published: 01 January 1980

...Y. Vanrenterghem; R. Vanholder; M. Lammens-Verslijpe; P. P. Lambert 1. The intrarenal infusion of concentrated urea after clamping of the renal artery produced immediate proteinuria in the dog. The predominant lesion on ultramicroscopy was destruction of the epithelial layer. Colloidal iron...

View articletitled, Sieving Studies in ‘Urea-Induced Nephropathy’ in the Dog

Articles

Effects of Concentration-Polarization on the Filtration of Proteins through Filters Constructed from Isolated Renal Basement Membrane

T. G. Cotter, G. B. Robinson

Clin Sci Mol Med (1978) 55 (1): 113–119.

https://doi.org/10.1042/cs0550113

Published: 01 July 1978

... filtration kidney proteinuria Clinical Science andMolecular Medicine (1978) 55, 113-1 19 Effects of concentration-polarization on the filtration of proteins through filters constructed from isolated renal basement membrane T. G. COTTERAND G. B. ROBINSON Department of Biochemistry, University of Oxford...

View articletitled, Effects of Concentration-Polarization on the Filtration of Proteins through Filters Constructed from Isolated Renal Basement Membrane

Articles

Albumin and Creatinine Clearances in Renal Disease

S. Lavender, J. Bennett, P. F. Morse, A. Polak

Clin Sci Mol Med (1974) 46 (6): 775–784.

https://doi.org/10.1042/cs0460775

Published: 01 June 1974

... when patients with postural proteinuria were excluded. 3. The diurnal variation of C A /C C was investigated in twelve patients with renal disease. The individual values for C A /C C obtained throughout the day were within the limits of prediction of 24 h C A /C C already established. The diurnal...

View articletitled, Albumin and Creatinine Clearances in Renal Disease

Articles

The Natural History of Hypertension with Moderate Impairment of Renal Function

G. E. Bauer, T. J. Humphery

Clin Sci Mol Med (1973) 45 (s1): 191s–193s.

https://doi.org/10.1042/cs045191s

Published: 01 August 1973

.... Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension renal failure proteinuria stroke Clinical Science and Molecular Medicine (1973) 45, 191s-193s. T...

View articletitled, The Natural History of Hypertension with Moderate Impairment of Renal Function

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