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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . diabetic nephropathy podocytes proteinuria The kidneys filter approximately 180 l of fluids everyday; however...
Clin Sci (Lond) (2019) 133 (1): 9–21.
Published: 03 January 2019
... pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES). Total mRNA and PODXL protein abundance were decreased in available peripheral blood cell samples of two affected patients undergoing hemodialysis, compared with those in healthy controls...
Includes: Supplementary data
Sandra Villanueva, Juan E. Carreño, Lorena Salazar, César Vergara, Rocío Strodthoff, Francisca Fajre, Carlos Céspedes, Pablo J. Sáez, Carlos Irarrázabal, Jorge Bartolucci, Fernando Figueroa, Carlos P. Vio
Clin Sci (Lond) (2013) 125 (4): 199–210.
Published: 01 May 2013
...Sandra Villanueva; Juan E. Carreño; Lorena Salazar; César Vergara; Rocío Strodthoff; Francisca Fajre; Carlos Céspedes; Pablo J. Sáez; Carlos Irarrázabal; Jorge Bartolucci; Fernando Figueroa; Carlos P. Vio Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce proteinuria...
Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
... Biochemical Society 2012 angiotensin angiotensin-converting enzyme 2 (ACE2) diabetes kidney nephropathy proteinuria The RAS (renin–angiotensin system) prominently regulates cardiovascular and renal function. Although the eight-amino-acid product AngII (angiotensin II) is the most well...
Clin Sci (Lond) (2004) 107 (6): 533–538.
Published: 24 November 2004
..., targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding of the cellular and molecular basis of albuminuria. This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states...
Clin Sci (Lond) (2003) 105 (1): 51–57.
Published: 01 July 2003
... 13 3 2003 13 3 2003 © 2003 The Biochemical Society 2003 adriamycin-induced nephrotic rat angiotensin-converting-enzyme (ACE) inhibition low-molecular-weight protein protein catabolism proteinuria Clinical Science (2003) 105, 51 57 (Printed in Great Britain) 51 Effects...
Clin Sci (Lond) (2000) 98 (3): 295–301.
Published: 09 February 2000
...Richard DIXON; Nigel J. BRUNSKILL The presence of protein in the urine of patients with renal disease is an adverse prognostic feature. It has therefore been suggested that proteinuria per se may be responsible for the development of renal tubulo-interstitial scarring and fibrosis, and disturbances...
Anne E. BARDEN, Lawrence J. BEILIN, Jackie RITCHIE, Barry N. WALTERS, Dorothy GRAHAM, Constantine A. MICHAEL
Clin Sci (Lond) (1999) 97 (4): 475–483.
Published: 01 September 1999
... to parity in a direction that would suggest a different pathophysiology. Groups of 27 primigravid and 35 multigravid women with pre-eclampsia (defined as blood pressure > 140/90 mmHg and 2+ proteinuria) were studied ante-partum, and at 6 weeks and 6 months post-partum. Clinical markers of severity of pre...
Clin Sci (Lond) (1999) 97 (3): 303–312.
Published: 21 July 1999
...Catheryne WHITTLE; Kathleen GILLESPIE; Rebecca HARRISON; Peter W. MATHIESON; Steve J. HARPER Vascular endothelial growth factor (VEGF) mediates increased vascular permeability and endothelial mitogenesis, and may orchestrate normal glomerular permselectivity and proteinuria. Distinct isoforms...
Rana Rustom, J. Steve Grime, Michael Costigan, Paul Maltby, Anthony Hughes, Alan Shenkin, Mair Critchley, J. Michael Bone
Clin Sci (Lond) (1998) 94 (4): 425–430.
Published: 01 April 1998
...Rana Rustom; J. Steve Grime; Michael Costigan; Paul Maltby; Anthony Hughes; Alan Shenkin; Mair Critchley; J. Michael Bone 1. Progression to renal failure may be linked to the degree of proteinuria through tubulo-interstitial mechanisms. However, there are no data in man on the kinetics of proximal...
Clin Sci (Lond) (1997) 93 (6): 565–571.
Published: 01 December 1997
...N. C. Turner; P. J. Morgan; A. C. Haynes; M. Vidgeon-Hart; N. Toseland; J. C. Clapham 1. The obese fa/fa Zucker rat is a genetic model of obesity and insulin resistance which develops a number of metabolic and endocrine features of non-insulin-dependent diabetes, including hypertension, proteinuria...
Clin Sci (Lond) (1996) 90 (5): 393–401.
Published: 01 May 1996
...Frits H. Wapstra; Harry Van Goor; Gerjan Navis; Paul E. De Jong; Dick De Zeeuw 1. The mechanism of renal protection by angiotensin-converting enzyme inhibition is still the subject of debate. Inhibition of proteinuria might play a role. If so, a good antiproteinuric response to angiotensin...
Clin Sci (Lond) (1995) 89 (6): 643–650.
Published: 01 December 1995
...D. Throssell; J. Brown; K. P. G. Harris; J. Walls 1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested...
Clin Sci (Lond) (1995) 88 (6): 623–627.
Published: 01 June 1995
...Mauro Rathaus; Eduardo Podjarny; Avishalom Pomeranz; Janice Green; Jacques Bernheim 1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase...
Clin Sci (Lond) (1994) 87 (4): 421–425.
Published: 01 October 1994
... amylase charge selectivity glomerulus proteinuria Clinical Science (1994) 87, 421425 (Printed in Great Britain) 42 I Glomerular charge selectivity in primary glomerulopathies J. G. FOX, J. D. QUIN*, D. ST. J. O REILLY? and J. M. BOULTON-JONES Renal Unit, *Diabetes Centre and ?Institute...
Clin Sci (Lond) (1994) 86 (4): 399–404.
Published: 01 April 1994
... with the control, and urine volume was increased in groups 3 and 4. The proteinuria was also decreased at week 10 in groups 2, 3 and 4. Differences in sodium excretion between all groups were not significant. Histopathological alterations in the kidneys of group 4 were significantly ameliorated. 4. These results...
Clin Sci (Lond) (1993) 84 (4): 449–454.
Published: 01 April 1993
...J. G. Fox; J. D. Quin; D. Stj. O'reilly; J. M. Boulton-Jones 1. Glomerular charge selectivity was assessed using the ratio of the clearance of pancreatic isoamylase to the clearance of the more anionic salivary isoamylase ( C PAm / C SAm ) in 30 normal subjects, 14 patients with minimal proteinuria...
Martin Muntzel, Thierry Hannedouche, Roberte Niesor, Laure-Helène Nöel, Jean-Claude Souberbielle, Bernard Lacour, Tilman Drüeke
Clin Sci (Lond) (1992) 83 (5): 575–581.
Published: 01 November 1992
... and the Medical Research Society 1992 diabetes hypertrophy octreotide proteinuria renal haemodynamics somatostatin streptozotocin Clinical Science (1992) 83, 575-581 (Printed in Great Britain) 575 Long-term effects of a somatostatin analogue on renal haemodynamics and hypertrophy in diabetic rats...
A. Fabbri, R. Boero, E. Degli Esposti, C. Guarena, A. Lucatello, A. Sturani, G. Piccoli, M. Fusaroli
Clin Sci (Lond) (1992) 83 (2): 241–245.
Published: 01 August 1992
... blood pressure, although within the normal range, and Na + /Li + countertransport activity were significantly higher in patients with proteinuria than in those without proteinuria. 4. Parents of proteinuric patients had a higher Na + /Li + countertransport activity than parents of non-proteinuric...
Clin Sci (Lond) (1992) 82 (6): 641–650.
Published: 01 June 1992
...Robert Zietse; Gerrit J. Wenting; Pieter Kramer; Maarten A. Schalekamp; Willem Weimar 1. To elucidate the mechanisms by which cyclosporin A diminishes proteinuria, we studied 20 patients with severe nephrotic syndrome. Biopsy-established pathologies included minimal change disease ( n = 5...
Clin Sci (Lond) (1992) 82 (1): 19–23.
Published: 01 January 1992
... atenolol diabetic nephropathy enalapril non-insulin-dependent diabetes proteinuria tissue angiotensin Clinical Science (I 992) 82, 19-23 (Printed in Great Britain) Persistent albuminuria in normotensive non-insulin- dependent (type II) diabetic patients: comparative effects of angiotensin...
Clin Sci (Lond) (1991) 81 (3): 367–372.
Published: 01 September 1991
...Jan E. Heeg; Paul E. de Jong; Dick de Zeeuw 1. Both the angiotensin-converting enzyme inhibitor, lisinopril, and the non-steroidal anti-inflammatory drug, indomethacin, lower urinary protein excretion in renal disease and improve the selectivity of the residual proteinuria. Despite the clearly...
Gian Marco Ghiggeri, Fabrizio Ginevri, Giovanni Cercignani, Roberta Oleggini, Alessando Garberi, Giovanni Candiano, Paola Altieri, Rosanna Gusmano
Clin Sci (Lond) (1990) 79 (6): 647–656.
Published: 01 December 1990
...Gian Marco Ghiggeri; Fabrizio Ginevri; Giovanni Cercignani; Roberta Oleggini; Alessando Garberi; Giovanni Candiano; Paola Altieri; Rosanna Gusmano 1. A low protein diet prevents the development of proteinuria and glomerular damage in adriamycin experimental nephrosis without affecting renal...
Fabrizio Ginevri, Rosanna Gusmano, Roberta Oleggini, Silvia Acerbo, Roberta Bertelli, Francesco Perfumo, Giovanni Cercignani, Simone Allegrini, Franco D'Allegri, Gianmarco Ghiggeri
Clin Sci (Lond) (1990) 78 (3): 283–293.
Published: 01 March 1990
... 18.104.22.168) in renal tissues were unchanged 1 day after puromycin aminonucleoside or hypoxanthine intoxication and only moderately increased in both groups at 13 days (the time of appearance of heavy proteinuria in the puromycin aminonucleoside-treated group). In contrast, xanthine oxidase and xanthine...
Masao Ishii, Yasunobu Hirata, Tokuichiro Sugimoto, Hiroaki Matsuoka, Kenjiro Kimura, Toshihiko Ishimitsu, Kazushige Fukui, Tsuneaki Sugimoto, Yuko Kurosawa, Hiroshi Kiyose, Kenji Kangawa, Hisayuki Matsuo
Clin Sci (Lond) (1989) 77 (6): 643–650.
Published: 01 December 1989
... excretion were examined in nine healthy subjects and 20 patients with primary glomerular diseases who had proteinuria of 1.0 g or more per day. Synthetic α-hANP was intravenously infused into supine subjects at a rate of 8.3 pmol min −1 kg −1 for 40 min 2. Before α-hANP infusion, the plasma concentration...
Clin Sci (Lond) (1989) 77 (1): 43–48.
Published: 01 July 1989
... rara iterna to 14.0 ± 2.7 per 1000 nm of lamina rara interna (mean ± sd) compared with 18.7 ± 2.1 ( P < 0.005) after infusion of plasma from normal subjects. 2. Proteinuria increased in all nine animals infused with nephrotic plasma and in two of seven infused with control plasma ( P < 0.01...
Akira Ohishi, Hiromichi Suzuki, Hidetomo Nakamoto, Hiroshige Katsumata, Hiroshi Sakaguchi, Takao Saruta
Clin Sci (Lond) (1989) 76 (4): 353–356.
Published: 01 April 1989
... (27.4 ± 0.9 kPa) at week 10]. 3. Massive proteinuria occurred in all groups. At the end of the experiment (at week 10), urinary protein excretion was significantly reduced in the captopril and cysteine groups compared with the control group. No manifest improvements appeared in the enalapril group. 4...
Clin Sci (Lond) (1988) 75 (6): 655–659.
Published: 01 December 1988
..., resulting in an almost complete normalization of glomerulotubular balance. 25 4 1988 17 5 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 glomerular filtration rate lithium clearance nephrectomy proteinuria Clinical Science ( 1 988) 75,655-659 655...
Clin Sci (Lond) (1987) 73 (4): 365–370.
Published: 01 October 1987
... the effective pores of the glomerular capillary wall. The increased permeability possibly is due to changes in prostanoid synthesis. dextrans frusemide glomerular permeability indomethacin prostaglandins proteinuria © 1970 The Biochemical Society and the Medical Research Society 1970 6 3...
Clin Sci (Lond) (1987) 72 (3): 289–296.
Published: 01 March 1987
.... In glomerulonephritis the process is different and there is a high degree of variation from case to case. 28 8 1986 16 9 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 clearance dextrans glomerular filtration rate glomerular permeability proteinuria...
Clin Sci (Lond) (1985) 69 (4): 395–401.
Published: 01 October 1985
...M. G. Koopman; R. T. Krediet; F. J. M. Zuyderhoudt; E. A. M. De Moor; L. Arisz 1. Circadian variations in proteinuria were studied in 17 patients with different types of glomerulopathies. During 3–4 successive days urine was collected over periods of 3 h under standardized conditions. 2. Thirteen...
Clin Sci (Lond) (1985) 69 (3): 321–326.
Published: 01 September 1985
... in the clearance of the negatively charged endogenous albumin may be due to a reduction in the glomerular charge barrier. albumin dextran glomerulus kidney proteinuria © 1985 The Biochemical Society and the Medical Research Society 1985 5 3 1985 19 3 1985 Clinical Science (1985) 69...
Clin Sci (Lond) (1985) 69 (1): 57–62.
Published: 01 July 1985
...Liisa Laitinen; Aaro Miettinen; Ilkka Tikkanen; Tom TÖrnroth; Stig Nordling 1. Glomerular sialic acid was chemically measured in rats with experimental proteinuria induced by N,N '-diacetylbenzidine (DAB) or with autoimmune Heymann nephritis. 2. In DAB nephrosis and in Heymann nephritis...
Clin Sci (Lond) (1984) 66 (2): 201–206.
Published: 01 February 1984
... albumin dose were significantly lower than those previously measured after the administration of normal bovine albumin. 3. The amount of epithelial cell foot process loss induced after the injection of carbamylated bovine albumin derivatives correlated well with the level of induced proteinuria...
Clin Sci (Lond) (1983) 65 (4): 399–406.
Published: 01 October 1983
... proteinuria subtotal nephrectomy © 1983 The Biochemical Society and the Medical Research Society 1983 18 3 1983 27 4 1983 Clinical Science (1983) 65, 399-406 399 Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats A. M. EL-NAHAS...
Clin Sci (Lond) (1982) 63 (4): 387–392.
Published: 01 October 1982
... 1982 12 1 1982 19 5 1982 cirrhosis liver proteinuria renal function Clinical Science (1982) 63, 387-392 387 Proteinuria in patients with cirrhosis: relationship between renal and hepatic fbnction L. M I L A N I , A . G A T T A , C . M E R K E L A N D A. R U O L Universitci...
Clin Sci (Lond) (1982) 62 (5): 495–502.
Published: 01 May 1982
...Gillian M. Lawrence; D. B. Brewer 1. The level of proteinuria induced in female Wistar rats after bovine albumin injection intraperitoneally was highly dose dependent. 2. The proteinuria remained highly selective, with albumin constituting approximately 90% of the total protein excreted, even...
Clin Sci (Lond) (1981) 60 (6): 693–702.
Published: 01 June 1981
... in the response to intraperitoneal injection of heterologous serum albumin since, during periods where no significant glomerular epithelial cell foot-process loss had been incurred, the levels of proteinuria induced correlated well with baseline albuminuria. 27 1 1981 9 2 1981 © 1981...
Clin Sci (Lond) (1980) 58 (1): 65–75.
Published: 01 January 1980
...Y. Vanrenterghem; R. Vanholder; M. Lammens-Verslijpe; P. P. Lambert 1. The intrarenal infusion of concentrated urea after clamping of the renal artery produced immediate proteinuria in the dog. The predominant lesion on ultramicroscopy was destruction of the epithelial layer. Colloidal iron...
Clin Sci Mol Med (1978) 55 (1): 113–119.
Published: 01 July 1978
... filtration kidney proteinuria Clinical Science andMolecular Medicine (1978) 55, 113-1 19 Effects of concentration-polarization on the filtration of proteins through filters constructed from isolated renal basement membrane T. G. COTTERAND G. B. ROBINSON Department of Biochemistry, University of Oxford...
Clin Sci Mol Med (1974) 46 (6): 775–784.
Published: 01 June 1974
... when patients with postural proteinuria were excluded. 3. The diurnal variation of C A /C C was investigated in twelve patients with renal disease. The individual values for C A /C C obtained throughout the day were within the limits of prediction of 24 h C A /C C already established. The diurnal...
Clin Sci Mol Med (1973) 45 (s1): 191s–193s.
Published: 01 August 1973
.... Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension renal failure proteinuria stroke Clinical Science and Molecular Medicine (1973) 45, 191s-193s. T...