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Keywords: proteinuria
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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . diabetic nephropathy podocytes proteinuria The kidneys filter approximately 180 l of fluids everyday; however...
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Clin Sci (Lond) (2019) 133 (1): 9–21.
Published: 03 January 2019
... pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES). Total mRNA and PODXL protein abundance were decreased in available peripheral blood cell samples of two affected patients undergoing hemodialysis, compared with those in healthy controls...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
... studies are required to delineate its signalling mechanisms in the kidney under physiological and pathophysiological conditions. angiotensin angiotensin-converting enzyme 2 (ACE2) diabetes kidney nephropathy proteinuria The RAS (renin–angiotensin system) prominently regulates...
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Clin Sci (Lond) (2004) 107 (6): 533–538.
Published: 24 November 2004
..., targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding of the cellular and molecular basis of albuminuria. This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states...
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Clin Sci (Lond) (2000) 98 (3): 295–301.
Published: 09 February 2000
...Richard DIXON; Nigel J. BRUNSKILL The presence of protein in the urine of patients with renal disease is an adverse prognostic feature. It has therefore been suggested that proteinuria per se may be responsible for the development of renal tubulo-interstitial scarring and fibrosis, and disturbances...
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Clin Sci (Lond) (1999) 97 (4): 475–483.
Published: 01 September 1999
... to parity in a direction that would suggest a different pathophysiology. Groups of 27 primigravid and 35 multigravid women with pre-eclampsia (defined as blood pressure > 140/90 mmHg and 2+ proteinuria) were studied ante-partum, and at 6 weeks and 6 months post-partum. Clinical markers of severity of pre...
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Clin Sci (Lond) (1995) 89 (6): 643–650.
Published: 01 December 1995
...D. Throssell; J. Brown; K. P. G. Harris; J. Walls 1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested...
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Clin Sci (Lond) (1995) 88 (6): 623–627.
Published: 01 June 1995
...Mauro Rathaus; Eduardo Podjarny; Avishalom Pomeranz; Janice Green; Jacques Bernheim 1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase...
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Clin Sci (Lond) (1994) 87 (4): 421–425.
Published: 01 October 1994
... amylase charge selectivity glomerulus proteinuria Clinical Science (1994) 87, 421425 (Printed in Great Britain) 42 I Glomerular charge selectivity in primary glomerulopathies J. G. FOX, J. D. QUIN*, D. ST. J. O REILLY? and J. M. BOULTON-JONES Renal Unit, *Diabetes Centre and ?Institute...
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Clin Sci (Lond) (1994) 86 (4): 399–404.
Published: 01 April 1994
... with the control, and urine volume was increased in groups 3 and 4. The proteinuria was also decreased at week 10 in groups 2, 3 and 4. Differences in sodium excretion between all groups were not significant. Histopathological alterations in the kidneys of group 4 were significantly ameliorated. 4. These results...
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Clin Sci (Lond) (1993) 84 (4): 449–454.
Published: 01 April 1993
...J. G. Fox; J. D. Quin; D. Stj. O'reilly; J. M. Boulton-Jones 1. Glomerular charge selectivity was assessed using the ratio of the clearance of pancreatic isoamylase to the clearance of the more anionic salivary isoamylase ( C PAm / C SAm ) in 30 normal subjects, 14 patients with minimal proteinuria...
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Clin Sci (Lond) (1992) 83 (5): 575–581.
Published: 01 November 1992
... these findings are encouraging, none has examined the preventative role of octreotide in the progression of diabetic glomerulosclerosis. We therefore assessed the effects of chronic octreotide therapy on the prevention of renal hypertrophy and Key words: diabetes, hypertrophy, octreotide, proteinuria, renal...
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Clin Sci (Lond) (1992) 83 (2): 241–245.
Published: 01 August 1992
... blood pressure, although within the normal range, and Na + /Li + countertransport activity were significantly higher in patients with proteinuria than in those without proteinuria. 4. Parents of proteinuric patients had a higher Na + /Li + countertransport activity than parents of non-proteinuric...
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Clin Sci (Lond) (1992) 82 (6): 641–650.
Published: 01 June 1992
...Robert Zietse; Gerrit J. Wenting; Pieter Kramer; Maarten A. Schalekamp; Willem Weimar 1. To elucidate the mechanisms by which cyclosporin A diminishes proteinuria, we studied 20 patients with severe nephrotic syndrome. Biopsy-established pathologies included minimal change disease ( n = 5...
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Clin Sci (Lond) (1987) 72 (3): 289–296.
Published: 01 March 1987
... with a decrease of charge as renal function deterio- rates. In glomerulonephritis the process is different and there is a high degree of variation from case to case. Key words: clearance, dextrans, glomerular filtra- tion rate, glomerular permeability, proteinuria. Abbreviations: GFR, glomerular filtration rate...
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Clin Sci (Lond) (1985) 69 (4): 395–401.
Published: 01 October 1985
...M. G. Koopman; R. T. Krediet; F. J. M. Zuyderhoudt; E. A. M. De Moor; L. Arisz 1. Circadian variations in proteinuria were studied in 17 patients with different types of glomerulopathies. During 3–4 successive days urine was collected over periods of 3 h under standardized conditions. 2. Thirteen...
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Clin Sci (Lond) (1985) 69 (3): 321–326.
Published: 01 September 1985
... in the clearance of the negatively charged endogenous albumin may be due to a reduction in the glomerular charge barrier. 5 3 1985 19 3 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 albumin dextran glomerulus kidney proteinuria Clinical Science (1985) 69...
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Clin Sci (Lond) (1985) 69 (1): 57–62.
Published: 01 July 1985
...Liisa Laitinen; Aaro Miettinen; Ilkka Tikkanen; Tom TÖrnroth; Stig Nordling 1. Glomerular sialic acid was chemically measured in rats with experimental proteinuria induced by N,N '-diacetylbenzidine (DAB) or with autoimmune Heymann nephritis. 2. In DAB nephrosis and in Heymann nephritis...
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Clin Sci (Lond) (1983) 65 (4): 399–406.
Published: 01 October 1983
... proteinuria subtotal nephrectomy © 1983 The Biochemical Society and the Medical Research Society 1983 18 3 1983 27 4 1983 Clinical Science (1983) 65, 399-406 399 Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats A. M. EL-NAHAS...
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Clin Sci (Lond) (1982) 63 (4): 387–392.
Published: 01 October 1982
... and the Medical Research Society 1982 cirrhosis liver proteinuria renal function Clinical Science (1982) 63, 387-392 387 Proteinuria in patients with cirrhosis: relationship between renal and hepatic fbnction L. M I L A N I , A . G A T T A , C . M E R K E L A N D A. R U O L Universitci degli Studi di...
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Clin Sci (Lond) (1980) 58 (1): 65–75.
Published: 01 January 1980
...Y. Vanrenterghem; R. Vanholder; M. Lammens-Verslijpe; P. P. Lambert 1. The intrarenal infusion of concentrated urea after clamping of the renal artery produced immediate proteinuria in the dog. The predominant lesion on ultramicroscopy was destruction of the epithelial layer. Colloidal iron...
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Clin Sci Mol Med (1978) 55 (1): 113–119.
Published: 01 July 1978
... of rejected protein is formed, which reduces hydraulic permeability and results in increased protein permeation through the filter. basement membrane concentration-polarization glomerular filtration kidney proteinuria © 1978 The Biochemical Society and the Medical Research Society 1978 29...
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Clin Sci Mol Med (1974) 46 (6): 775–784.
Published: 01 June 1974
... when patients with postural proteinuria were excluded. 3. The diurnal variation of C A /C C was investigated in twelve patients with renal disease. The individual values for C A /C C obtained throughout the day were within the limits of prediction of 24 h C A /C C already established. The diurnal...
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Clin Sci Mol Med (1973) 45 (s1): 191s–193s.
Published: 01 August 1973
.... Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension renal failure proteinuria stroke Clinical Science and Molecular Medicine (1973) 45, 191s-193s. T...