... 15 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 amino acid cachexia heart failure inflammation insulin proteolysis sarcopenia The syndrome of CHF [chronic HF (heart failure)] is a complex multi-organ response mechanism to the primary inability...

... of nutritional deprivation, HF patients demonstrate an impaired muscle protein anabolic response to meal-related stimuli, due to an inability to suppress muscle proteolysis, and that this diminished protein anabolic response correlates with markers of immune activation. The inability to stimulate muscle protein...

... 12 2000 The Biochemical Society and the Medical Research Society © 2001 2001 gastric juice mucolysis proteolysis 411Clinical Science (2001) 100, 411 417 (Printed in Great Britain) Mucosal protective effects of ecabet sodium: pepsin inhibition and interaction with mucus J. P. PEARSON...

... cachexia muscle proteasome proteolysis ubiquitin 181Clinical Science (2000) 99, 181 187 (Printed in Great Britain) Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle Cheng-Hui FANG*, Bing-Guo LI*, David R. FISCHER , Jing Jing WANG , Herbert...

..., lactacystin and β-lactone supports the concept that the ubiquitin–proteasome pathway plays a central role in burn-induced muscle proteolysis. Because the proteasome has multiple important functions in the cell, in addition to regulating general protein breakdown, further studies are needed to test the role...

... synthesis by protein deficiency, mediated by reductions in both ribosomal capacity and activity in the 0.5% protein group, which preceded growth inhibition in the 7% and 3.5% groups, and which was progressive with time. Transient increases in proteolysis contributed to the growth inhibition is some groups...

... of most other amino acids, including phenylalanine, which fell by 34%. Plasma insulin levels were unchanged from basal levels (8 ± 1 μ-units/ml). 3. Whole-body phenylalanine flux, an index of proteolysis, was significantly suppressed by branched-chain amino acid infusion ( P < 0.002), and forearm...

...D. A. Hutton; J. P. Pearson; A. Allen; S. N. E. Foster 1. Mucolytic (mucus solubilizing) activity in human faeces has been characterized with both purified human and pig colonic mucin and shown to be mediated by proteolysis. 2. Mucolytic activity was demonstrated by: (i) a drop in mucin viscosity...

...-dependent manner, from 11% at 10 −10 mol/l to 68% at 10 −3 mol/l. 27 7 1988 18 11 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 elastase emphysema endotoxin neutrophil proteolysis tumour necrosis factor Clinical Science ( 1989) 77,3541 35 Effects...

... in lung secretions. Key words: antibody, al-antitrypsin, leucocyte elastase, lung secretions, proteolysis. Correspondence: Dr R. A. Stockley, The General Hospital, Steelhouse Lane, Birmingham B4 6NH, U.K. Abbreviations: q A T , al-antitrypsin; 2DIEP, two- dimensional immunoelectrophoresis; LE, leucocyte...

... endopeptidases proteinase inhibitors proteolysis pulmonary emphysema Clinical Science (1983) 64,119-126 119 I EDITORIAL REVIEW I Proteolytic enzymes, their inhibitors and lung diseases R. A. S T O C K L E Y The General Hospital, Birmingham, U.K. The pathogenesis of many acute and chronic lung diseases...