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1-18 of 18
Keywords: proteomics
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1173–1177.
Published: 18 September 2024
... that physiological atrial enlargement resulted from increased atrial myocyte size and was associated with preserved atrial function, as determined by maintained LA ejection fraction (EF). The proteomic profile of IGF1R transgenic (Tg) mice was enriched for metabolic remodeling and showed a protein expression pattern...
Articles
Nicholas D. Camarda, Qing Lu, Dawn M. Meola, Joshua J. Man, Zeyuan Song, Richard J. Travers, Katherine E. Lopez, Sarah N. Powers, Malvina Papanastasiou, Katherine C. DeRuff, James Mullahoo, Shawn B. Egri, Desiree Davison, Paola Sebastiani, Scott T. Eblen, Rachel Buchsbaum, Gordon S. Huggins, Cheryl A. London, Jacob D. Jaffe, Jenica N. Upshaw, Vicky K. Yang, Iris Z. Jaffe
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1131–1150.
Published: 16 September 2024
... cancer patients. α-Adrenergic-antagonists were identified as drugs that most oppose the VEGFRi proteomic signature. Doxazosin, one such α-antagonist, prevented EC dysfunction in murine, canine, and human aortic ECs. In mice with sorafenib-induced-hypertension, doxazosin mitigated EC dysfunction...
Includes: Supplementary data
Articles
Yi Ching Chen, Seka Wijekoon, Aya Matsumoto, Jieting Luo, Helen Kiriazis, Emma Masterman, Gunes Yildiz, Jonathon Cross, Adam C. Parslow, Roger Chooi, Junichi Sadoshima, David W. Greening, Kate L. Weeks, Julie R. McMullen
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (15): 941–962.
Published: 30 July 2024
... failure gene expression pattern. Atrial proteomics identified protein networks related to cardiac contractility, sarcomere assembly, metabolism, mitochondria, and extracellular matrix which were differentially regulated in the models; many co-identified in atrial proteomics data sets from human AF...
Includes: Supplementary data
Articles
Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 87–104.
Published: 05 January 2023
...-converting enzyme inhibitor (ramipril), or a combination of both drugs for 8 weeks to diabetic (db/db) mice. Vehicle-treated db/db and db/m mice were used as controls. At the end of the experiment, mice were killed, and the kidneys were saved to perform a differential high-throughput proteomic analysis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2117–2120.
Published: 05 October 2018
... localise predominantly to the endosomal-recycling compartment . Biochem. Biophys. Res. Commun. 359 , 277 – 284 10.1016/j.bbrc.2007.05.100 17543888 17 Harshman S.W. , Canella A. , Ciarlariello P.D. , Agarwal K. , Branson O.E. , Rocci A. ( 2016 ) Proteomic...
Articles
Montserrat Baldan-Martin, Elena Rodríguez-Sánchez, Laura González-Calero, Luis M. Ruilope, Gloria Alvarez-Llamas, María G. Barderas, Gema Ruiz-Hurtado
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...
Articles
Arthur Goron, Frédéric Lamarche, Valérie Cunin, Hervé Dubouchaud, Christophe Hourdé, Philippe Noirez, Christelle Corne, Karine Couturier, Michel Sève, Eric Fontaine, Christophe Moinard
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (8): 775–790.
Published: 06 April 2017
... diet (by addition of nonessential amino acid) ( Ctrl ) and trained (running on treadmill 5 days·week −1 ) ( ex ) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure...
Includes: Supplementary data
Articles
Elena Burillo, Carlos Tarin, Monica-Maria Torres-Fonseca, Carlos-Ernesto Fernandez-García, Roxana Martinez-Pinna, Diego Martinez-Lopez, Patricia Llamas-Granda, Emilio Camafeita, Juan Antonio Lopez, Melina Vega de Ceniga, Michael Aviram, Jesus Egido, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (12): 1027–1038.
Published: 06 May 2016
... from four AAA patients and four controls were analysed by a label-free proteomic approach. Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of samples by ELISA. The phenylesterase enzymatic...
Includes: Supplementary data
Articles
Seung Hyo Jung, Kyung-Jong Won, Kang Pa Lee, Hyun-Joong Kim, Eun-Hye Seo, Hwan Myung Lee, Eun Seok Park, Seung Hyun Lee, Bokyung Kim
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (1): 27–38.
Published: 01 April 2015
... mechanism and causal risk factors for plaque rupture remain unclear. To identify a potential molecule that can influence atherosclerotic plaque rupture, we investigated protein expression in serum from patients with acute myocardial infarction (AMI) and stable angina (SA), using proteomic analysis...
Includes: Supplementary data
Articles
Klaus Distelmaier, Christopher Adlbrecht, Johannes Jakowitsch, Oswald Wagner, Christopher Gerner, Irene M. Lang, Markus Kubicek
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (2): 111–119.
Published: 27 March 2012
...). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial...
Includes: Supplementary data
Articles
Visith Thongboonkerd, Wararat Chiangjong, Jan Mares, Jiri Moravec, Zdenek Tuma, Thomas Karvunidis, Supachok Sinchaikul, Shui-Tein Chen, Karel Opatrný, Jr, Martin Matejovic
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (9): 721–730.
Published: 02 April 2009
... and high mortality rate. Its pathophysiology and molecular mechanisms are complicated and remain poorly understood. In the present study, we performed a proteomics investigation to characterize early host responses to sepsis as determined by an altered plasma proteome in a porcine model of peritonitis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (7): 499–507.
Published: 29 February 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 early insulin response plasma protein proteomics surface-enhanced laser-desorption ionization–time-of-flight MS (SELDI-TOF MS) Type 2 diabetes mellitus ULSAM (Uppsala Longitudinal Study of Adult Men) The pathophysiology of T2DM...
Articles
Laura Molero, Antonio García-Méndez, Sergio Alonso-Orgaz, Carolina Carrasco, Carlos Macaya, Antonio J. López Farré
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (5): 457–463.
Published: 24 October 2005
...Laura Molero; Antonio García-Méndez; Sergio Alonso-Orgaz; Carolina Carrasco; Carlos Macaya; Antonio J. López Farré The aim of the present study was to use proteomics to analyse modifications in the level of expression of different proteins in BVSMCs (bovine vascular smooth muscle cells) incubated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (5): 421–430.
Published: 24 October 2005
...Bernardo C. Vidal, Jr; Joseph V. Bonventre; Stephen I-Hong Hsu Proteomics is widely envisioned as playing a significant role in the translation of genomics to clinically useful applications, especially in the areas of diagnostics and prognostics. In the diagnosis and treatment of kidney disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (5): 369–383.
Published: 22 April 2005
...Walter KOLCH; Harald MISCHAK; Andrew R. PITT The enormous progress in proteomics, enabled by recent advances in MS (mass spectrometry), has brought protein analysis back into the limelight of cancer research, reviving old areas as well as opening new fields of study. In this review, we discuss...
Articles
Joan LÓPEZ-HELLÍN, Ricardo GONZALO, Mónica TEJEDA, Montserrat CARRASCAL, Maya R. VILÀ, Joaquín ABIÁN, Elena GARCÍA-ARUMÍ
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (2): 167–178.
Published: 21 January 2005
... or isotopic (with in vivo radioactive labelling of proteins) two-dimensional electrophoresis/MS proteomic analyses, to study differential expression of proteins. Many of the differentially expressed proteins identified in blood were specifically synthesized by the liver to participate in the stress response...
Articles
Harald MISCHAK, Thorsten KAISER, Michael WALDEN, Meike HILLMANN, Stefan WITTKE, Alena HERRMANN, Stefan KNUEPPEL, Hermann HALLER, Danilo FLISER
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (5): 485–495.
Published: 26 October 2004
... indicative of ‘diabetic renal damage’. We also found this pattern in 35% of those patients who had low-grade albuminuria and in 4% of patients with normal albumin excretion. Moreover, we could identify several of the indicative polypeptides using MS/MS sequencing. We conclude that proteomic analysis with CE...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (5): 483–490.
Published: 01 May 2003
...Pedro R. CUTILLAS; Anthony G.W. NORDEN; Rainer CRAMER; Alma L. BURLINGAME; Robert J. UNWIN Urinary proteomics has become a topical and potentially valuable field of study in relation to normal and abnormal renal function. Filtered bioactive peptides present in high concentration in the nephron...