... interaction between the epidermis and both innate and adaptive immune compartments drives psoriatic inflammation. Furthermore, we highlight work done on biomarkers to predict the outcome of therapy as well as the transition from psoriasis to psoriatic arthritis. feedback loops IL-23/IL-17 axis...

... of psoriasis. Methods: Aldara-treated mice received daily topical application of albendazole. Keratinocyte proliferation and keratin (K) 6 and K16 expression were evaluated by immunohistochemistry and Western blotting and inflammatory cells/mediators were analysed by immunohistochemistry and real-time PCR...

...Iris Detrez; Kristel Van Steen; Siegfried Segaert; Ann Gils The association between etanercept serum concentration and psoriasis disease severity is poorly investigated, and currently etanercept serum concentration monitoring that is aiming to optimize the psoriasis treatment lacks evidence...

...Giovanni Monteleone; Francesco Pallone; Thomas T. MacDonald; Sergio Chimenti; Antonio Costanzo Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic...

...-dependent diabetes mellitus and Graves' disease. 3. Genome screens have also been completed in some of the non-organ-specific autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease and psoriasis. Many candidate genes have also been investigated although these are predominantly...

...A. J. Shaw; M. E. Hayes; M. Davies; B. D. Edwards; F. W. Ballardie; R. J. G. Chalmers; E. B. Mawer 1. Cyclosporin A, an immunosuppressive drug used to treat psoriasis, stimulates renal synthesis of 1,25-dihydroxyvitamin D in rats. 1,25-Dihydroxy vitamin D can also reduce the activity of psoriasis...

...S. Mac Neil; W. F. G. Tucker; R. A. Dawson; S. S. Bleehen; S. Tomlinson 1. The calmodulin content of epidermis was determined by assay of biologically active and radioimmunoassayable calmodulin in epidermal biopsy samples of 16 normal control subjects and 36 patients with psoriasis. 2. Calmodulin...

... Society 1984 epidermis glycogen psoriasis Clinical Science (1984) 67, 291-298 291 Glycogen metabolism in psoriatic epidermis and in regenerating epidermis C. S. H A R M O N * A N D P. J . R . PHIZACKERLEY Nuffield Department of Clinical Biochemistry, University of Oxford, Radcliffe Infirmary...