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Keywords: pulmonary emphysema
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Clin Sci (Lond) (1983) 64 (2): 119–126.
Published: 01 February 1983
.... Much of this interest owes its existence to two observations in the early 1960s: firstly, the recognition that subjects with an inherited deficiency of α 1 -antitrypsin (α 1 -AT; the main serum inhibitor of proteolytic enzymes) had a high incidence of pulmonary emphysema [1], and secondly the...
Clin Sci (Lond) (1980) 58 (5): 403–409.
Published: 01 May 1980
...D. C. S. Hutchison; R. Desai; D. Bellamy; H. Baum 1. The lysosomal enzymes of circulating polymorphonuclear leucocytes contain a potent elastase; release of this enzyme within the lung is thought to be responsible for the destruction of elastic tissue in pulmonary emphysema. 2. The release of...