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Keywords: pulmonary fibrosis
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Articles
Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective...
Articles
Clin Sci (Lond) (2020) 134 (7): 889–905.
Published: 17 April 2020
... that contribute to idiopathic pulmonary fibrosis (IPF); a lethal disease that manifests primarily in the elderly. Whilst evidence is accumulating that GMP-AMP synthase (cGAS) is crucial in perpetuating senescence by binding damaged DNA released into the cytosol, its role in IPF is not known. The present study...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 789–804.
Published: 02 April 2019
...Yunlong Lei; Kui Wang; Xuefeng Li; Yi Li; Xuping Feng; Jing Zhou; Zhe Zhang; Canhua Huang; Tao Zhang Bleomycin, a widely used anti-cancer drug, may give rise to pulmonary fibrosis, a serious side effect which is associated with significant morbidity and mortality. Despite the intensive efforts...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity...
Articles
Clin Sci (Lond) (2005) 108 (6): 479–491.
Published: 24 May 2005
..., as well as structural, cells pertinent to fibrogenesis. In general, leukotrienes promote, whereas prostaglandin E 2 opposes, fibrogenic responses. An imbalance of eicosanoids also exists in pulmonary fibrosis, which favours the production of leukotrienes over prostaglandin E 2 . This review highlights...
Articles
Clin Sci (Lond) (1994) 86 (2): 141–148.
Published: 01 February 1994
... and the Medical Research Society 1994 insulin—like growth factor-1 platelet-derived growth factor pulmonary fibrosis systemic sclerosis Clinical Science (1994) (16, 141-148 (Printed in Great Britain) 141 InsulirAike growth factor-I is partially responsible for fibroblast proliferation induced...
Articles
Clin Sci (Lond) (1981) 61 (6): 781–784.
Published: 01 December 1981
...J. Savoy; S. Dhingra; N. R. Anthonisen 1. in 10 patients with pulmonary fibrosis and in seven control subjects, we measured the pressure at the mouth 0.1 s after onset of an inspiration against occluded airway ( P 0.1 ), minute ventilation ( V I ), breathing frequency ( f r ), tidal volume ( V T...