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Keywords: pulmonary fibrosisClose
Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal
Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective...
Michael Schuliga, Jane Read, Kaj E.C. Blokland, David W. Waters, Janette Burgess, Cecilia Prêle, Steven E. Mutsaers, Jade Jaffar, Glen Westall, Andrew Reid, Allen James, Christopher Grainge, Darryl A. Knight
Clin Sci (Lond) (2020) 134 (7): 889–905.
Published: 17 April 2020
... that contribute to idiopathic pulmonary fibrosis (IPF); a lethal disease that manifests primarily in the elderly. Whilst evidence is accumulating that GMP-AMP synthase (cGAS) is crucial in perpetuating senescence by binding damaged DNA released into the cytosol, its role in IPF is not known. The present study...
Includes: Supplementary data
Yunlong Lei, Kui Wang, Xuefeng Li, Yi Li, Xuping Feng, Jing Zhou, Zhe Zhang, Canhua Huang, Tao Zhang
Clin Sci (Lond) (2019) 133 (7): 789–804.
Published: 02 April 2019
...Yunlong Lei; Kui Wang; Xuefeng Li; Yi Li; Xuping Feng; Jing Zhou; Zhe Zhang; Canhua Huang; Tao Zhang Bleomycin, a widely used anti-cancer drug, may give rise to pulmonary fibrosis, a serious side effect which is associated with significant morbidity and mortality. Despite the intensive efforts...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity...
Clin Sci (Lond) (2005) 108 (6): 479–491.
Published: 24 May 2005
..., as well as structural, cells pertinent to fibrogenesis. In general, leukotrienes promote, whereas prostaglandin E 2 opposes, fibrogenic responses. An imbalance of eicosanoids also exists in pulmonary fibrosis, which favours the production of leukotrienes over prostaglandin E 2 . This review highlights...
Nicholas K. Harrison, Alison D. Cambrey, Allen R. Myers, Anne M. Southcott, Carol M. Black, Roland M. du Bois, Geoffrey J. Laurent, Robin J. McAnulty
Clin Sci (Lond) (1994) 86 (2): 141–148.
Published: 01 February 1994
... and the Medical Research Society 1994 insulin—like growth factor-1 platelet-derived growth factor pulmonary fibrosis systemic sclerosis Clinical Science (1994) (16, 141-148 (Printed in Great Britain) 141 InsulirAike growth factor-I is partially responsible for fibroblast proliferation induced...
Clin Sci (Lond) (1981) 61 (6): 781–784.
Published: 01 December 1981
...J. Savoy; S. Dhingra; N. R. Anthonisen 1. in 10 patients with pulmonary fibrosis and in seven control subjects, we measured the pressure at the mouth 0.1 s after onset of an inspiration against occluded airway ( P 0.1 ), minute ventilation ( V I ), breathing frequency ( f r ), tidal volume ( V T...