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Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (5): 543–568.
Published: 09 March 2018
... studies using rapamycin and its derivatives (rapalogs) demonstrated efficacy in many human cancer types, hence supporting the launch of numerous clinical trials aimed to evaluate the real effectiveness of mTOR-targeted therapies. However, rapamycin and rapalogs have shown very limited activity in most...