... and is a standard treatment for LN. The mammalian or mechanistic target of rapamycin (mTOR) pathway is activated in LN. Rapamycin inhibits mTOR and is effective in preventing kidney transplant rejection, with the additional merits of reduced incidence of malignancies and viral infections. The effect...

...Lei-Lei Ma; Yang Li; Pei-Pei Yin; Fei-Juan Kong; Jun-Jie Guo; Hong-Tao Shi; Jian-Bing Zhu; Yun-Zeng Zou; Jun-Bo Ge Left ventricular hypertrophy (LVH) is causally related to increased morbidity and mortality following acute myocardial infarction (AMI) via still unknown mechanisms. Although rapamycin...

...Uttara Saran; Michelangelo Foti; Jean-François Dufour mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its downstream targets, has been reported in various cancers. This has...