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Keywords: rat
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Clin Sci (Lond) (2015) 129 (8): 741–756.
Published: 22 July 2015
... a is both pro-angiogenic and neuroprotective, but pro-nociceptive and increases vascular permeability in animal models. Streptozotocin (STZ)-induced diabetic rats develop both hyperglycaemia and many of the resulting diabetic complications seen in patients, including peripheral neuropathy. In the present...
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Clin Sci (Lond) (2009) 116 (3): 249–255.
Published: 08 January 2009
...Junhua He; Yunfei Bian; Fen Gao; Maolian Li; Ling Qiu; Weidong Wu; Hua Zhou; Gaizhen Liu; Chuanshi Xiao The purpose of the present study was to investigate the effects on blood pressure and myocardial hypertrophy in SHRs (spontaneously hypertensive rats) of RNAi (RNA interference) targeting ACE...
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Clin Sci (Lond) (2002) 103 (s2002): 31S–34S.
Published: 01 September 2002
... were administered intravenously to anaesthetized rats. In a second series of experiments, animals were pretreated with the ET A receptor antagonists BQ-610 or ETR-P1/fl peptide, or with the ET B receptor antagonist IRL-1038. Intestinal perfusion changes were recorded, and the proportion of degranulated...
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Clin Sci (Lond) (2002) 102 (5): 541–546.
Published: 18 April 2002
...-Dawley rats, either intrajejunally or orally, and indices of mitochondrial function were determined. The parameters chosen for this purpose were oxygen uptake by, lactate levels in and the energy charge of jejunal tissue. Oxygen uptake by and energy charge in jejunal tissue were unaffected at 1 and 3h...
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Clin Sci (Lond) (2000) 98 (3): 269–275.
Published: 09 February 2000
...-protein-diet model of rat pregnancy suggest a role for the renin–angiotensin system in the programming mechanism, since fetal undernutrition permanently elevates pulmonary and plasma angiotensin-converting enzyme activity. Long-term beneficial effects of captopril on blood pressure in this model require...
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Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
... that angiotensin II has a role in airway remodelling. A total of 14 young male Wistar rats were randomly divided into two groups. All received 2-week infusions of bromodeoxyuridine, and the experimental group also received angiotensin II. Blood pressure rose in the angiotensin II-infused group [mean levels: pre...
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Clin Sci (Lond) (1999) 97 (3): 363–368.
Published: 06 August 1999
... and bicarbonate-treated uraemic Wistar rats using the remnant model. Leptin levels in the culture medium were decreased at an acid pH of 7.1 compared with a control pH of 7.5 at 96 h (562±78 and 831±103 pg·48 h -1 ·well -1 respectively; mean±S.E.M.; P = 0.037). Similarly, serum leptin in uraemic rats was found...
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Clin Sci (Lond) (1996) 91 (3): 337–345.
Published: 01 September 1996
...Ken D. O'halloran; Aidan K. Curran; Aidan Bradford 1. Ventilation was measured during normoxia, hypoxia and hypercapnia before and after administration of almitrine in conscious, unrestrained, tracheostomized rats with the superior laryngeal nerves intact or cut. In superior laryngeal nerve-intact...
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Clin Sci (Lond) (1996) 90 (5): 369–377.
Published: 01 May 1996
... was to evaluate the effects of l-canavanine, a potentially selective inhibitor of inducible nitric oxide synthase, in an animal model of septic shock. 2. Anaesthetized rats were challenged with 10 mg/kg lipopolysaccharide intravenously. One hour later, they randomly received a 5 h infusion of either l-canavanine...
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Clin Sci (Lond) (1985) 69 (6): 687–689.
Published: 01 December 1985
...D. B. Webb; R. Mackenzie; S. N. Zoob; A. J. Rees 1. The accelerated model of nephrotoxic serum nephritis (NTSN) was produced in 12 Sprague-Dawley rats. Six of these rats were administered superoxide dismutase (EC 1.15.1.1; SOD) subcutaneously (8 mg/kg) 8-hourly for 4 days. The first dose was given...
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Clin Sci (Lond) (1984) 67 (2): 237–241.
Published: 01 August 1984
...Ilkka Tikkanen; Frej Fyhrquist; Terje Forslund 1. Based on a specific binding of labelled inhibitor to the enzyme active centre, a new principle of enzyme assay, inhibitor binding assay (IBA), was developed and applied to measurement of rat serum angiotensin converting enzyme (ACE). 2. Serum...
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Clin Sci Mol Med (1974) 46 (4): 501–510.
Published: 01 April 1974
...Manjusri Das; A. N. Radhakrishnan 1. A comparative study has been made of glycyl-l-leucine hydrolase activity in the soluble and particulate fractions of intestinal mucosa from monkey, guinea-pig, rabbit and rat. The specific activity of the soluble enzyme is very high in monkey and guinea-pig...
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Clin Sci (1972) 43 (6): 731–742.
Published: 01 December 1972
...M. H. Gleeson; J. Cullen; R. H. Dowling 1. To study further the influence of luminal nutrition on small bowel structure and function, segments of rat jejunum and ileum were completely excluded from intestinal continuity by Thiry-Vella by-pass operations. The effect of partial deprivation of luminal...
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Clin Sci (1972) 43 (6): 743–757.
Published: 01 December 1972
... than in jejunum. 4. The adaptive changes seen in the by-passed intestine and the intestine in continuity are a result of ‘hypoplasia’ and ‘hyperplasia’ respectively. CIinical Science (1972) 43,743-757. BIOCHEMICAL CHANGES I N INTESTINAL MUCOSA AFTER EXPERIMENTAL SMALL BOWEL BY-PASS I N T H E RAT M. H...