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Keywords: reactive oxygen species
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Articles
Wang-Hsin Lee, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Evelyn A. Bates, Olufunto O. Badmus, David E. Stec, Terry D. Hinds, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (02): 171–198.
Published: 28 January 2025
... mechanisms, analyzes the sex differences that might cause a dichotomy in responses, and examines the potential use of HMOX and bilirubin nanoparticle therapies in treating metabolic diseases. Bilir Blvra Hmox1 Inflammation Masld Metabolism Obesity Reactive oxygen species Ugt1a1 Urobilin...
Articles
Molecular mechanisms of anthracycline cardiovascular toxicity
Available to PurchaseIn Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
Articles
Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis
Available to PurchaseHyun Jin Min, Joon Soon Park, Kyung Soo Kim, Seung Yong Park, Honghwan Choi, Ju Hee Seo, Miran Kang, Joo-Heon Yoon, Chang-Hoon Kim, Sehoon Kim, Hyung-Ju Cho
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 483–494.
Published: 01 February 2021
... Society 2021 allergic rhinitis high mobility group box 1 nasal epithelium reactive oxygen species Th2 cytokines A recent study suggested that extracellular HMGB1 is a novel mediator of type 2 helper T cell (Th2) response inflammatory condition. The sputum level of HMGB1 correlated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... phospholipase RA rheumatoid arthritis RF rheumatoid factor ROS reactive oxygen species RNS reactive nitrogen species TNF-α tumor necrosis factor-α References 1. Silman A.J. and Pearson J.E. ( 2002 ) Epidemiology and Genetics of Rheumatoid Arthritis...
Articles
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
.... A key upstream driver of vascular oxidative stress is age-associated mitochondrial dysfunction. This review will focus on vascular mitochondria, mitochondrial dysregulation and mitochondrial reactive oxygen species (ROS) production and discuss current evidence for prevention and treatment of vascular...
Articles
Oxidative stress and reactive oxygen species: a review of their role in ocular disease
Available to PurchaseLawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation
Available to PurchaseImad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...
Articles
Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction
Available to PurchaseDarnel Prakoso, Miles J. De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L. Weeks, Paul Gregorevic, Julie R. McMullen, Rebecca H. Ritchie
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... 01 2017 21 04 2017 08 05 2017 09 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic cardiomyopathy gene therapy myocardial remodeling phosphoinositide 3-kinase reactive oxygen species superoxides...
Includes: Supplementary data
Articles
Kidney–brain axis inflammatory cross-talk: from bench to bedside
Available to PurchaseAline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
Articles
Oxidative stress–call for papers
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email [email protected] ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
Articles
Exercise-induced mitochondrial dysfunction: a myth or reality?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
... athletes DNA deletion exhaustive exercise peroxisome proliferator-activated receptor γ co-activator 1-α (PGC-1α) reactive oxygen species Extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced...
Articles
Nox1 in cardiovascular diseases: regulation and pathophysiology
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
..., and promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles...
Articles
Are reactive oxygen species still the basis for diabetic complications?
Available to PurchaseElyse Di Marco, Jay C. Jha, Arpeeta Sharma, Jennifer L. Wilkinson-Berka, Karin A. Jandeleit-Dahm, Judy B. de Haan
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 199–216.
Published: 30 April 2015
...), with Nox2 expressed mainly by macrophages and Nox4 also found in non-phagocytic vascular cells [ 38 ]. © The Authors Journal compilation © 2015 Biochemical Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species...
Articles
NADPH oxidases and cancer
Available to PurchaseKrishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
...Krishnendu Roy; Yongzhong Wu; Jennifer L. Meitzler; Agnes Juhasz; Han Liu; Guojian Jiang; Jiamo Lu; Smitha Antony; James H. Doroshow The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years...
Articles
Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
Articles
Nox and renal disease
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
...Chet E. Holterman; Naomi C. Read; Chris R. J. Kennedy Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent that the Nox family of reactive oxygen species (ROS) generating...
Articles
Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes
Available to PurchaseSebastiano Sciarretta, Derek Yee, Paul Ammann, Narayani Nagarajan, Massimo Volpe, Giacomo Frati, Junichi Sadoshima
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
...Sebastiano Sciarretta; Derek Yee; Paul Ammann; Narayani Nagarajan; Massimo Volpe; Giacomo Frati; Junichi Sadoshima In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling...
Articles
New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the impaired contractile and vasodilator responses, vascular remodelling and altered vascular mechanics of hypertension. Of particular interest is the cross-talk...
Articles
Nox as a target for diabetic complications
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
...Yves Gorin; Karen Block Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox...
Articles
Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
... purchased from Calbiochem and Tocris Bioscience respectively. DES (7-days release) and 17β-oestradiol tablets were obtained from Innovative Research of America. combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion...
Articles
Red wine extract protects against oxidative-stress-induced endothelial senescence
Available to PurchaseIlse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis...
Articles
Cardiac sympathetic hyperinnervation in deoxycorticosterone acetate-salt hypertensive rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 445–457.
Published: 07 June 2012
... hypertension reactive oxygen species sympathetic innervation where 1.055 is the density of the rat myocardium (in mg/mm 3 ). Measurements represented the mean of at least five consecutive cardiac cycles. Analyses were performed by an experienced observer blinded to the treatment groups to which...
Articles
Arachidonic acid fights palmitate: new insights into fatty acid toxicity in β-cells
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
.... Correspondence: Dr Henrik Ortsäter (email [email protected] ). 25 10 2010 2 11 2010 2 11 2010 2 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (5): 195–206.
Published: 19 November 2010
... acid pancreatic β-cell reactive oxygen species Type 2 diabetes mellitus T2DM (Type 2 diabetes mellitus) is a metabolic disorder characterized by elevated blood glucose concentrations. Most cases of T2DM are also characterized by elevated circulating fatty acid concentrations due to high...
Articles
Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
...Augusto C. Montezano; Dylan Burger; Graziela S. Ceravolo; Hiba Yusuf; Maria Montero; Rhian M. Touyz The Noxes (NADPH oxidases) are a family of ROS (reactive oxygen species)-generating enzymes. Of the seven family members, four have been identified as important sources of ROS in the vasculature...
Articles
Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms
Available to PurchaseAlvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...Alvaro Yogi; Glaucia E. Callera; Ulisses V. Hipólito; Catiane R. Silva; Rhian M. Touyz; Carlos R. Tirapelli The present study investigated the role of ROS (reactive oxygen species) and COX (cyclo-oxygenase) in ethanol-induced contraction and elevation of [Ca 2+ ] i (intracellular [Ca 2...
Articles
NADPH oxidase and endothelial cell function
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
Articles
Impact of marathon running on cardiac structure and function in recreational runners
Available to PurchaseGregory WHYTE, Keith GEORGE, Robert SHAVE, Ellen DAWSON, Claire STEPHENSON, Ben EDWARDS, David GAZE, David OXBOROUGH, Jan FORSTER, Rickie SIMSPON
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (1): 73–80.
Published: 15 December 2004
... to reactive oxygen species. Correspondence: Dr Greg Whyte (email [email protected] ). Following approval by the local Research Ethics Committee, 52 runners [43 male and nine female; age, 35±10 years (range, 18–63 years); height, 1.74±0.08 m; BM (body mass), 75.9±8.9 kg; values are means±S.D...
Articles
Mitochondrial DNA and aging
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Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... 2 •− (superoxide anion radicals). O 2 •− , through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production...
Articles
Strategies to reduce oxidative stress in cardiovascular disease
Available to PurchaseCarlene A. HAMILTON, William H. MILLER, Sammy AL-BENNA, M. Julia BROSNAN, Russell D. DRUMMOND, Martin W. McBRIDE, Anna F. DOMINICZAK
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
...Carlene A. HAMILTON; William H. MILLER; Sammy AL-BENNA; M. Julia BROSNAN; Russell D. DRUMMOND; Martin W. McBRIDE; Anna F. DOMINICZAK A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved...
Articles
Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods
Available to PurchaseM. S. SPENCE, P. G. McGLINCHEY, C. C. PATTERSON, A. R. ALLEN, G. MURPHY, U. BAYRAKTUTAN, D. G. FOGARTY, A. E. EVANS, P. P. McKEOWN
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (6): 677–682.
Published: 01 December 2003
...M. S. SPENCE; P. G. McGLINCHEY; C. C. PATTERSON; A. R. ALLEN; G. MURPHY; U. BAYRAKTUTAN; D. G. FOGARTY; A. E. EVANS; P. P. McKEOWN Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species...
Articles
Iron signalling regulated directly and through oxygen: implications for sepsis and the acute respiratory distress syndrome
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Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
...G. J. QUINLAN; Y. CHEN; T. W. EVANS; J. M. C. GUTTERIDGE Reactive oxygen species produced at toxic levels are damaging species. When produced at sub-toxic levels, however, they are involved as second messengers in numerous signal transduction pathways. In addition to these findings, we can add...
Articles
Studies in Surgical Trauma: Oxidative Stress in Ischaemia-Reperfusion of Rat Liver
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (4): 453–460.
Published: 01 April 1994
...($ of these pathological conditions are still not fully under- stood, it has long been known that anaesthesia, haemorrhage, hypovolaemic ischaemia, reperfusion and infection are likely contributory causes [2-51, and that reactive oxygen species (ROS) and oxida- tive stress are involved [4, 61. Previous studies on the role...
Articles
Interactions of Hydrogen Peroxide with Interleukin-6 and Platelet-Derived Growth Factor in Determining Mesangial Cell Growth: Effect of Repeated Oxidant Stress
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (6): 747–751.
Published: 01 December 1993
...). 3. These findings suggest that reactive oxygen species may play a major role in determining the mesangial cell proliferation that occurs in certain forms of glomerulonephritis, acting either alone or in combination with other growth factors. 10 3 1993 23 7 1993 © 1993...
Articles
Changes in Renal Function in Acute Experimental Pancreatitis in Rats: A Therapeutic Role for Somatostatin
Available to PurchaseM. González-Rubio, C. García-Escribano, M. L. Díez-Marqués, I. Arribas, P. Martínez-Onsurbe, M. Rodríguez-Puyol, D. Rodríguez-Puyol
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...
