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Keywords: reactive oxygen species
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Articles
Clin Sci (Lond) (2021) 135 (3): 483–494.
Published: 01 February 2021
... Press Limited on behalf of the Biochemical Society 2021 allergic rhinitis high mobility group box 1 nasal epithelium reactive oxygen species Th2 cytokines High mobility group box 1 (HMGB1) is a nuclear protein ubiquitous in a variety of cells, such as monocytes, macrophages, and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... Karolinska Institute in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. muscle weakness oxidative stress reactive oxygen species rheumatoid arthritis skeletal muscle Rheumatoid arthritis (RA) is one of the most common chronic inflammatory...
Articles
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... key upstream driver of vascular oxidative stress is age-associated mitochondrial dysfunction. This review will focus on vascular mitochondria, mitochondrial dysregulation and mitochondrial reactive oxygen species (ROS) production and discuss current evidence for prevention and treatment of vascular...
Articles
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...
Articles
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... myocardial remodeling phosphoinositide 3-kinase reactive oxygen species superoxides The alarming global diabetes pandemic is predicted to affect almost 600 million adults by 2035 [ 1 ]. In addition to substantial healthcare costs, diabetic patients suffer significantly poorer health outcomes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation of...
Articles
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
... reactive oxygen species (ROS) and ROS-induced ROS release Physiol. Rev. 2014 94 909 950 10.1152/physrev.00026.2013 24987008 3 Li R.X. Yiu W.H. Wu H.J. Wong D.W. Chan L.Y. Lin M. Leung J.C. Lai K.N. Tang S.C. BMP7 reduces inflammation and oxidative stress...
Articles
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
... proliferator-activated receptor γ co-activator 1-α (PGC-1α) reactive oxygen species Extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced mitochondrial dysfunction might be a key proxy for heart...
Articles
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
... promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles for...
Articles
Clin Sci (Lond) (2015) 129 (2): 199–216.
Published: 30 April 2015
... Biochemical Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species The pre-clinical evidence in support of a role for reactive oxygen and nitrogen species (ROS/RNS) in diabetic complications such as atherosclerosis...
Articles
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
...Krishnendu Roy; Yongzhong Wu; Jennifer L. Meitzler; Agnes Juhasz; Han Liu; Guojian Jiang; Jiamo Lu; Smitha Antony; James H. Doroshow The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years of the...
Articles
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells...
Articles
Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
...Chet E. Holterman; Naomi C. Read; Chris R. J. Kennedy Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent that the Nox family of reactive oxygen species (ROS) generating...
Articles
Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
...Sebastiano Sciarretta; Derek Yee; Paul Ammann; Narayani Nagarajan; Massimo Volpe; Giacomo Frati; Junichi Sadoshima In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling...
Articles
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the impaired contractile and vasodilator responses, vascular remodelling and altered vascular mechanics of hypertension. Of particular interest is the cross-talk...
Articles
Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
...Yves Gorin; Karen Block Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox...
Articles
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
... NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase (XO) In postmenopausal women, the incidence of CVD (cardiovascular disease) is much higher than in premenopausal women, implicating a potential impact of oestrogen in protecting cardiovascular health...
Articles
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis, as it...
Articles
Clin Sci (Lond) (2012) 123 (7): 445–457.
Published: 07 June 2012
...@tmu.edu.tw ). 14 2 2012 10 4 2012 17 4 2012 17 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 arrhythmia deoxycorticosterone acetate-salt hypertension reactive oxygen species sympathetic innervation Cardiovascular sympathetic activation...
Articles
Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
.... Correspondence: Dr Henrik Ortsäter (email henrik.ortsater@sodersjukhuset.se ). 25 10 2010 2 11 2010 2 11 2010 2 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species...
Articles
Clin Sci (Lond) (2011) 120 (5): 195–206.
Published: 19 November 2010
..., distribution and reproduction in any medium, provided the original work is properly cited. arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species Type 2 diabetes mellitus T2DM (Type 2 diabetes mellitus) is a metabolic disorder characterized by elevated blood...
Articles
Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
...Augusto C. Montezano; Dylan Burger; Graziela S. Ceravolo; Hiba Yusuf; Maria Montero; Rhian M. Touyz The Noxes (NADPH oxidases) are a family of ROS (reactive oxygen species)-generating enzymes. Of the seven family members, four have been identified as important sources of ROS in the vasculature...
Articles
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...Alvaro Yogi; Glaucia E. Callera; Ulisses V. Hipólito; Catiane R. Silva; Rhian M. Touyz; Carlos R. Tirapelli The present study investigated the role of ROS (reactive oxygen species) and COX (cyclo-oxygenase) in ethanol-induced contraction and elevation of [Ca 2+ ] i (intracellular [Ca 2...
Articles
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
Articles
Clin Sci (Lond) (2005) 108 (1): 73–80.
Published: 15 December 2004
... to reactive oxygen species. and was calculated as a surrogate for afterload [ 17 ]. Doppler echocardiography was employed to assess diastolic function. An apical four-chamber view was imaged, taking care to maximize the diameter of the mitral valve annulus. Pulsed-wave Doppler interrogation of...
Articles
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... 2 •− (superoxide anion radicals). O 2 •− , through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production...
Articles
Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
...Carlene A. HAMILTON; William H. MILLER; Sammy AL-BENNA; M. Julia BROSNAN; Russell D. DRUMMOND; Martin W. McBRIDE; Anna F. DOMINICZAK A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved...
Articles
Clin Sci (Lond) (2003) 105 (6): 677–682.
Published: 01 December 2003
...M. S. SPENCE; P. G. McGLINCHEY; C. C. PATTERSON; A. R. ALLEN; G. MURPHY; U. BAYRAKTUTAN; D. G. FOGARTY; A. E. EVANS; P. P. McKEOWN Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species...
Articles
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
...G. J. QUINLAN; Y. CHEN; T. W. EVANS; J. M. C. GUTTERIDGE Reactive oxygen species produced at toxic levels are damaging species. When produced at sub-toxic levels, however, they are involved as second messengers in numerous signal transduction pathways. In addition to these findings, we can add the...
Articles
Clin Sci (Lond) (1994) 86 (4): 453–460.
Published: 01 April 1994
...—reperfusion multisystem organ failure oxidative stress reactive oxygen species surgical trauma © 1994 The Biochemical Society and the Medical Research Society 1994 3 11 1993 15 11 1993 Clinical Science (1994) 86, 453460 (Printed i n Great Britain) 453 Studies in surgical trauma...
Articles
Clin Sci (Lond) (1993) 85 (6): 747–751.
Published: 01 December 1993
... <0.05). 3. These findings suggest that reactive oxygen species may play a major role in determining the mesangial cell proliferation that occurs in certain forms of glomerulonephritis, acting either alone or in combination with other growth factors. 10 3 1993 23 7 1993 © 1993 The...
Articles
Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...