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Keywords: reactive oxygen species
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
Articles
Hyun Jin Min, Joon Soon Park, Kyung Soo Kim, Seung Yong Park, Honghwan Choi, Ju Hee Seo, Miran Kang, Joo-Heon Yoon, Chang-Hoon Kim, Sehoon Kim, Hyung-Ju Cho
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 483–494.
Published: 01 February 2021
... is a critical molecular target in multiple human diseases [ 6 ]. allergic rhinitis high mobility group box 1 nasal epithelium reactive oxygen species Th2 cytokines © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 28 09 2020 14 01...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... ]. muscle weakness oxidative stress reactive oxygen species rheumatoid arthritis skeletal muscle Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases that more frequently afflicts women than men, with a disease debut around the age of 40 to 50 years [ 1–3...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
.... A key upstream driver of vascular oxidative stress is age-associated mitochondrial dysfunction. This review will focus on vascular mitochondria, mitochondrial dysregulation and mitochondrial reactive oxygen species (ROS) production and discuss current evidence for prevention and treatment of vascular...
Articles
Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Imad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...
Articles
Darnel Prakoso, Miles J. De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L. Weeks, Paul Gregorevic, Julie R. McMullen, Rebecca H. Ritchie
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... PowerLab System (AD Instruments, Bella Vista, NSW, Australia) [ 14 ]. diabetic cardiomyopathy gene therapy myocardial remodeling phosphoinositide 3-kinase reactive oxygen species superoxides The alarming global diabetes pandemic is predicted to affect almost 600 million adults by 2035 [ 1...
Includes: Supplementary data
Articles
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email mjryan@umc.edu ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
...-activated receptor γ co-activator 1-α (PGC-1α) reactive oxygen species Extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced mitochondrial dysfunction might be a key proxy for heart abnormalities...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
..., and promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles...
Articles
Elyse Di Marco, Jay C. Jha, Arpeeta Sharma, Jennifer L. Wilkinson-Berka, Karin A. Jandeleit-Dahm, Judy B. de Haan
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 199–216.
Published: 30 April 2015
... Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species The pre-clinical evidence in support of a role for reactive oxygen and nitrogen species (ROS/RNS) in diabetic complications such as atherosclerosis remains...
Articles
Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
...Krishnendu Roy; Yongzhong Wu; Jennifer L. Meitzler; Agnes Juhasz; Han Liu; Guojian Jiang; Jiamo Lu; Smitha Antony; James H. Doroshow The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
...Chet E. Holterman; Naomi C. Read; Chris R. J. Kennedy Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent that the Nox family of reactive oxygen species (ROS) generating...
Articles
Sebastiano Sciarretta, Derek Yee, Paul Ammann, Narayani Nagarajan, Massimo Volpe, Giacomo Frati, Junichi Sadoshima
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
...Sebastiano Sciarretta; Derek Yee; Paul Ammann; Narayani Nagarajan; Massimo Volpe; Giacomo Frati; Junichi Sadoshima In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the impaired contractile and vasodilator responses, vascular remodelling and altered vascular mechanics of hypertension. Of particular interest is the cross-talk...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
...Yves Gorin; Karen Block Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
... treatments but DES. combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase (XO) Gently collected endothelial cells were suspended in modified Kreb's/Hepes buffer containing deferoxamine (25 μmol...
Articles
Ilse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 445–457.
Published: 07 June 2012
... 2012 10 4 2012 17 4 2012 17 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 arrhythmia deoxycorticosterone acetate-salt hypertension reactive oxygen species sympathetic innervation Cardiovascular sympathetic activation is a common...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
... β-cell reactive oxygen species Type 2 diabetes mellitus Pancreatic β-cells are conspicuously vulnerable to saturated long-chain fatty acids [ 1 ]. Most extensively studied is the 16-carbon-long palmitate. When given acutely, this long-chain fatty acid, like other saturated and unsaturated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (5): 195–206.
Published: 19 November 2010
..., distribution and reproduction in any medium, provided the original work is properly cited. arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species Type 2 diabetes mellitus T2DM (Type 2 diabetes mellitus) is a metabolic disorder characterized by elevated blood...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
...Augusto C. Montezano; Dylan Burger; Graziela S. Ceravolo; Hiba Yusuf; Maria Montero; Rhian M. Touyz The Noxes (NADPH oxidases) are a family of ROS (reactive oxygen species)-generating enzymes. Of the seven family members, four have been identified as important sources of ROS in the vasculature...
Articles
Alvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...Alvaro Yogi; Glaucia E. Callera; Ulisses V. Hipólito; Catiane R. Silva; Rhian M. Touyz; Carlos R. Tirapelli The present study investigated the role of ROS (reactive oxygen species) and COX (cyclo-oxygenase) in ethanol-induced contraction and elevation of [Ca 2+ ] i (intracellular [Ca 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
Articles
Gregory WHYTE, Keith GEORGE, Robert SHAVE, Ellen DAWSON, Claire STEPHENSON, Ben EDWARDS, David GAZE, David OXBOROUGH, Jan FORSTER, Rickie SIMSPON
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (1): 73–80.
Published: 15 December 2004
... to reactive oxygen species. Correspondence: Dr Greg Whyte (email greg.whyte@eis2win.co.uk ). Doppler echocardiography was employed to assess diastolic function. An apical four-chamber view was imaged, taking care to maximize the diameter of the mitral valve annulus. Pulsed-wave Doppler interrogation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... 2 •− (superoxide anion radicals). O 2 •− , through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production...
Articles
Carlene A. HAMILTON, William H. MILLER, Sammy AL-BENNA, M. Julia BROSNAN, Russell D. DRUMMOND, Martin W. McBRIDE, Anna F. DOMINICZAK
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
...Carlene A. HAMILTON; William H. MILLER; Sammy AL-BENNA; M. Julia BROSNAN; Russell D. DRUMMOND; Martin W. McBRIDE; Anna F. DOMINICZAK A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved...
Articles
M. S. SPENCE, P. G. McGLINCHEY, C. C. PATTERSON, A. R. ALLEN, G. MURPHY, U. BAYRAKTUTAN, D. G. FOGARTY, A. E. EVANS, P. P. McKEOWN
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (6): 677–682.
Published: 01 December 2003
...M. S. SPENCE; P. G. McGLINCHEY; C. C. PATTERSON; A. R. ALLEN; G. MURPHY; U. BAYRAKTUTAN; D. G. FOGARTY; A. E. EVANS; P. P. McKEOWN Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
...G. J. QUINLAN; Y. CHEN; T. W. EVANS; J. M. C. GUTTERIDGE Reactive oxygen species produced at toxic levels are damaging species. When produced at sub-toxic levels, however, they are involved as second messengers in numerous signal transduction pathways. In addition to these findings, we can add...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (4): 453–460.
Published: 01 April 1994
... The Biochemical Society and the Medical Research Society 1994 leucocyte tissue infiltration liver ischaemia—reperfusion multisystem organ failure oxidative stress reactive oxygen species surgical trauma Clinical Science (1994) 86, 453460 (Printed i n Great Britain) 453 Studies in surgical trauma...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (6): 747–751.
Published: 01 December 1993
...). 3. These findings suggest that reactive oxygen species may play a major role in determining the mesangial cell proliferation that occurs in certain forms of glomerulonephritis, acting either alone or in combination with other growth factors. 10 3 1993 23 7 1993 © 1993...
Articles
M. González-Rubio, C. García-Escribano, M. L. Díez-Marqués, I. Arribas, P. Martínez-Onsurbe, M. Rodríguez-Puyol, D. Rodríguez-Puyol
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...
