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Keywords: reactive oxygen species
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Cardiovascular-Oncology
Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (3): 483–494.
Published: 01 February 2021
... Society 2021 allergic rhinitis high mobility group box 1 nasal epithelium reactive oxygen species Th2 cytokines A recent study suggested that extracellular HMGB1 is a novel mediator of type 2 helper T cell (Th2) response inflammatory condition. The sputum level of HMGB1 correlated...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... phospholipase RA rheumatoid arthritis RF rheumatoid factor ROS reactive oxygen species RNS reactive nitrogen species TNF-α tumor necrosis factor-α References 1. Silman A.J. and Pearson J.E. ( 2002 ) Epidemiology and Genetics of Rheumatoid Arthritis...
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Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
.... A key upstream driver of vascular oxidative stress is age-associated mitochondrial dysfunction. This review will focus on vascular mitochondria, mitochondrial dysregulation and mitochondrial reactive oxygen species (ROS) production and discuss current evidence for prevention and treatment of vascular...
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Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
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Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
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Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email [email protected] ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
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Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
... athletes DNA deletion exhaustive exercise peroxisome proliferator-activated receptor γ co-activator 1-α (PGC-1α) reactive oxygen species Extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced...
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Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
..., and promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles...
Articles
Clin Sci (Lond) (2015) 129 (2): 199–216.
Published: 30 April 2015
...), with Nox2 expressed mainly by macrophages and Nox4 also found in non-phagocytic vascular cells [ 38 ]. © The Authors Journal compilation © 2015 Biochemical Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species...
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Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
...Krishnendu Roy; Yongzhong Wu; Jennifer L. Meitzler; Agnes Juhasz; Han Liu; Guojian Jiang; Jiamo Lu; Smitha Antony; James H. Doroshow The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years...
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Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
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Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
...Chet E. Holterman; Naomi C. Read; Chris R. J. Kennedy Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent that the Nox family of reactive oxygen species (ROS) generating...
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Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
...Sebastiano Sciarretta; Derek Yee; Paul Ammann; Narayani Nagarajan; Massimo Volpe; Giacomo Frati; Junichi Sadoshima In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling...
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Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the impaired contractile and vasodilator responses, vascular remodelling and altered vascular mechanics of hypertension. Of particular interest is the cross-talk...
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Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
...Yves Gorin; Karen Block Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox...
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Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis...
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Clin Sci (Lond) (2012) 123 (7): 445–457.
Published: 07 June 2012
... hypertension reactive oxygen species sympathetic innervation where 1.055 is the density of the rat myocardium (in mg/mm 3 ). Measurements represented the mean of at least five consecutive cardiac cycles. Analyses were performed by an experienced observer blinded to the treatment groups to which...
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Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
.... Correspondence: Dr Henrik Ortsäter (email [email protected] ). 25 10 2010 2 11 2010 2 11 2010 2 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species...
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Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
...Augusto C. Montezano; Dylan Burger; Graziela S. Ceravolo; Hiba Yusuf; Maria Montero; Rhian M. Touyz The Noxes (NADPH oxidases) are a family of ROS (reactive oxygen species)-generating enzymes. Of the seven family members, four have been identified as important sources of ROS in the vasculature...
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Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...Alvaro Yogi; Glaucia E. Callera; Ulisses V. Hipólito; Catiane R. Silva; Rhian M. Touyz; Carlos R. Tirapelli The present study investigated the role of ROS (reactive oxygen species) and COX (cyclo-oxygenase) in ethanol-induced contraction and elevation of [Ca 2+ ] i (intracellular [Ca 2...
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Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
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Clin Sci (Lond) (2005) 108 (1): 73–80.
Published: 15 December 2004
... to reactive oxygen species. Correspondence: Dr Greg Whyte (email [email protected] ). Following approval by the local Research Ethics Committee, 52 runners [43 male and nine female; age, 35±10 years (range, 18–63 years); height, 1.74±0.08 m; BM (body mass), 75.9±8.9 kg; values are means±S.D...
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Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... 2 •− (superoxide anion radicals). O 2 •− , through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production...
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Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
...Carlene A. HAMILTON; William H. MILLER; Sammy AL-BENNA; M. Julia BROSNAN; Russell D. DRUMMOND; Martin W. McBRIDE; Anna F. DOMINICZAK A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved...
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Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
...G. J. QUINLAN; Y. CHEN; T. W. EVANS; J. M. C. GUTTERIDGE Reactive oxygen species produced at toxic levels are damaging species. When produced at sub-toxic levels, however, they are involved as second messengers in numerous signal transduction pathways. In addition to these findings, we can add...
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Clin Sci (Lond) (1994) 86 (4): 453–460.
Published: 01 April 1994
...($ of these pathological conditions are still not fully under- stood, it has long been known that anaesthesia, haemorrhage, hypovolaemic ischaemia, reperfusion and infection are likely contributory causes [2-51, and that reactive oxygen species (ROS) and oxida- tive stress are involved [4, 61. Previous studies on the role...
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Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...