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1-16 of 16
Keywords: reactive oxygen species (ROS)
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Articles
Mitochondrial [dys]function; culprit in pre-eclampsia?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1179–1184.
Published: 01 June 2016
... and, operating with reduced glutathione as a cofactor, are proposed to scavenge ROS at higher intracellular concentrations. Catalase has an inferior affinity for H 2 O 2 and is limited to peroxisomes [ 16 ]. antioxidants mitochondria pre-eclampsia reactive oxygen species (ROS) Pre-eclampsia...
Articles
Angiotensin II and the ERK pathway mediate the induction of leptin by mechanical cyclic stretch in cultured rat neonatal cardiomyocytes
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (7): 483–495.
Published: 11 December 2013
... be prevented by ARBs, which repress the effect of AngII and leptin. angiotensin II cardiomyocyte hypertrophy extracellular signal-regulated kinase (ERK) leptin reactive oxygen species (ROS) transcriptional activity AngII (10 nM exogenously added) was measured in cell lysates...
Articles
The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes
Available to PurchaseCarmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N. Muller, Massimo Volpe
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (4): 183–189.
Published: 01 May 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide renin inhibition reactive oxygen species (ROS) small artery vascular remodelling • Aliskiren represents an antihypertensive agent with a new mechanism based on the inhibition of a catalytic activity...
Articles
The forgotten face of regular physical exercise: a ‘natural’ anti-atherogenic activity
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (3): 91–106.
Published: 15 April 2011
..., an increase in oxidant stress, an accumulation of lipids in the arterial wall, and chronic systemic and arterial wall inflammation. atherosclerosis exercise inflammation myokine obesity reactive oxygen species (ROS) sedentary lifestyle Cardiovascular diseases remain the leading cause...
Articles
Vitiligo, reactive oxygen species and T-cells
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (3): 99–120.
Published: 20 October 2010
... [email protected] ). 23 11 2009 26 8 2010 26 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 immune system melanocyte reactive oxygen species (ROS) skin T-cell vitiligo Vitiligo is a common skin disorder characterized by the acquired loss...
Articles
Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (1): 1–17.
Published: 07 April 2010
... reactive oxygen species (ROS) The brain has minimal storage of energy sources, making it exceptionally sensitive to interruptions in its blood supply. It is not therefore surprising that the cerebral circulation is a highly specialized vascular bed with a number of unique physiological mechanisms...
Articles
Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (3): 221–230.
Published: 01 February 2010
... Biochemical Society 2010 atherosclerosis mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) resistin smooth muscle cell signal transducer and activator of transcription (STAT) stretch Resistin is an adipocytokine and has been shown to have potent pro-inflammatory...
Includes: Supplementary data
Articles
Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide
Available to PurchasePhilip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (5): 341–349.
Published: 23 November 2009
... endothelial vascular cell exercise nitric oxide pancreatic β-cell reactive oxygen species (ROS) The beneficial effects of aerobic exercise of moderate intensity in T2DM (Type 2 diabetes mellitus) are well documented with regard to glycaemic control and multiple CVD (cardiovascular disease) risk...
Articles
Role of TNF-α in vascular dysfunction
Open AccessHanrui Zhang, Yoonjung Park, Junxi Wu, Xiu ping Chen, Sewon Lee, Jiyeon Yang, Kevin C. Dellsperger, Cuihua Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2009
.... Correspondence: Professor Cuihua Zhang (email [email protected] ). 3 6 2008 22 7 2008 12 8 2008 inflammation macrovascular circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease...
Articles
Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (8): 553–560.
Published: 13 March 2008
... 2008 antioxidant ischaemia/reperfusion liver oxidative stress Pringle manoeuvre reactive oxygen species (ROS) Blood was collected into EDTA-containing tubes (Vacutainer; Becton Dickinson). All blood samples were immediately put on ice, and kept on ice during sample...
Articles
Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (4): 331–337.
Published: 15 January 2008
... phosphoinositide 3-kinase (PI3K) reactive oxygen species (ROS) There is evidence that a diet rich in vegetables and fruit has a beneficial effect on blood pressure. This effect has been attributed to phenolic compounds present in the plants. These compounds have also been shown to influence endothelial...
Includes: Supplementary data
Articles
NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases
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Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (3): 173–182.
Published: 08 January 2008
... p22 phox subunit reactive oxygen species (ROS) superoxide anion NADPH oxidase is sensitively regulated by a wide range of (patho)physiologically relevant factors, which include (i) humoral factors, (ii) mechanical factors, and (iii) genetic variants [ 9 , 42 ]. Humoral factors...
Articles
The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction
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Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (1): 1–20.
Published: 14 June 2006
... cellular homoeostasis host defence NADPH oxidase pathogenesis phagocyte reactive oxygen species (ROS) superoxide anion ROS (reactive oxygen species) represent a diverse family of molecules that play roles in a myriad of physiological and pathophysiological events. ROS are comprised of highly...
Articles
How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?
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Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
... deoxycorticosterone acetate (DOCA) endothelin hypertension mitochondria NADPH oxidase reactive oxygen species (ROS) A major focus within the basic science community studying hypertension is related to the role of ROS (reactive oxygen species). The broad definition of ROS includes oxygen-containing species...
Articles
Effect of chronic N -acetylcysteine treatment on the development of spontaneous hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 235–242.
Published: 17 January 2006
... parameters. N -acetylcysteine genetic hypertension nuclear factor κB (NF-κB) nitric oxide synthase reactive oxygen species (ROS) NO (nitric oxide) plays an important role in the maintenance of vascular tone, which affects the level of BP (blood pressure) [ 1 – 3 ]. In various models...
Articles
Regulation of reactive oxygen species (ROS) production by C 18 fatty acids in Jurkat and Raji cells
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (3): 245–253.
Published: 18 February 2005
..., MO, U.S.A.). Sodium bicarbonate was purchased from Labsynth products (Diadema, SP, Brazil). Dihydroethidium was obtained from Molecular Probes (Eugene, OR, U.S.A.). linoleic acid oleic acid lymphocyte protein kinase C (PKC) reactive oxygen species (ROS) Generation of moderate...