...Adam C. Jones; Oleg Palygin; Daria V. Ilatovskaya The commentary discusses the regenerative capacity of the kidneys; recent studies reveal that renal cells can regenerate when exposed to certain conditions. A major focus is on scattered tubular-like cells (STCs), which can dedifferentiate...

... fostering effective cardiac regeneration are the holy grail of cardiovascular research to stop the heart failure epidemic. The main goal of most myocardial regeneration protocols is the generation of new functional CMs through the differentiation of endogenous or exogenous cardiomyogenic cells...

... that the adult mammalian heart could potentially regenerate itself when exposed to appropriate stimuli. For example, centrosomes are functionally essential components of mitotic spindle poles. Thus, they play an important part in the organization of the mitotic spindle apparatus to faithfully separate...

... cardiac regeneration to replenish lost or damaged myocardial tissue. Long-term high-resolution intravital imaging of the behaviors and interactions of different cardiac cell types in their native environment could yield unprecedented insights into heart regeneration and repair. However, this task remains...

...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...

..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...

... and autoimmune diseases. The HGF/Met axis also plays an important role in regulating self-renewal and myocardial regeneration through the enhancement of cardiac progenitor cells. HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellular and molecular mechanisms...

..., and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support...

... very little ability to make new cardiomyocytes, stem-cell-based cardiac regeneration has attracted a great deal of interest to repair failing hearts resulting from acute MI (myocardial infarction), chronic ischaemia or idiopathic cardiomyopathy [ 3 ]. These stem cells have been delivered in diseased...

... κB (NF-κB) regeneration NF-κB (nuclear factor κB) was first described in 1986 as a nuclear transcription factor required for immunoglobulin kappa light chain transcription in B-cells [ 1 ]. Since then it has been demonstrated that NF-κB is constitutively expressed in all cell types and holds...

... of transdifferentiation, describe the theoretical and practical issues involved in transdifferentiation research and comment on the long-term therapeutic possibilities. The ability to regenerate cells and tissues is possessed by all organisms. However, regenerative capacity varies considerably between species...

... contraction mdx myofibre type necrosis regeneration Clinical Science (1995) 89, 447-452 (printed in Great Britain) Effects of treadmill exercise and high-fat feeding on muscle degeneration in mdx mice at the time of weaning Asghar MOKHTARIANI, Jean Pascal LEFAUCHEUR2, Patrick C. EVEN' and Alain SEBILLP...

..., at least in part, to accelerated tubular cell proliferation. 5 12 1989 20 12 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 creatinine epidermal growth factor epidermal growth factor receptor necrosis regeneration Clinical Science (1990) 78,445-450...