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Keywords: remodelling
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Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
... was enabled by the participation of Karolinska Institutet, in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. airway hyperresponsiveness asthma cough guinea pig model organisms remodelling Respiratory diseases have a complex pathobiology where...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (3): 327–338.
Published: 02 February 2018
...Kimberley C.W. Wang; Timothy D. Le Cras; Alexander N. Larcombe; Graeme R. Zosky; John G. Elliot; Alan L. James; Peter B. Noble Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The present...
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Clin Sci (Lond) (2017) 131 (14): 1723–1735.
Published: 30 June 2017
... pathogenesis. We discuss airway inflammation (both T2 HIGH and T2 LOW ), airway hyperresponsiveness (AHR) and airways remodelling as four key factors in asthma pathogenesis, and also outline other contributory factors such as genetics and co-morbidities. Response to current asthma therapies also varies greatly...
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Clin Sci (Lond) (2014) 126 (12): 815–827.
Published: 26 February 2014
... established that AngII (angiotensin II), the main effector of the RAS, engages the AT 1 R (angiotensin type 1 receptor) and promotes cell growth, proliferation, migration and oxidative stress, all processes which contribute to remodelling of the heart and vasculature, ultimately leading to the development...
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Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 chronic obstructive pulmonary disease (COPD) computed tomography imaging (CT imaging) genome-wide association inflammation remodelling COPD (chronic obstructive pulmonary disease) is an important cause...
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Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... remodelling, which contributes to the development of CV disease. Arterial calcification is a major event in the arterial remodelling process and is strongly linked to mineral metabolism abnormalities associated with CKD. Arterial remodelling is not limited to arterial calcification and modifications...
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Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
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Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... Biochemical Society 2010 endothelin end-organ damage fibrosis hypertrophy inflammation remodelling ET (endothelin)-1, the most abundant and best characterized of the ET family of peptides, was first identified as a potent vasoconstrictor secreted by vascular endothelial cells [ 1 ]. Since...
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Clin Sci (Lond) (2010) 118 (7): 439–450.
Published: 23 December 2009
... in barrier function and an impaired innate immune response to viral infection may provide the substrate upon which allergic sensitization takes place. Once sensitized, the repeated allergen exposure will lead to disease persistence. These mechanisms could also be used to explain airway wall remodelling...
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Clin Sci (Lond) (2010) 118 (4): 231–240.
Published: 09 November 2009
..., diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovascular remodelling. The metabolic syndrome is characterized by visceral obesity, hyperlipidaemia, vascular inflammation...
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Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
..., but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after...
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Clin Sci (Lond) (2008) 115 (3): 99–106.
Published: 02 July 2008
... strains is due to the difference in collagen content following MI. In the present study, we compared the difference in matrix remodelling post-MI between β 2 -TG and NTG mice and between mice and rats. MI was induced by ligation of the left main coronary artery. Following MI, tensile strength, insoluble...
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Clin Sci (Lond) (2008) 114 (4): 257–264.
Published: 15 January 2008
... in the case of balloon angioplasty. Post-angioplasty restenosis results from two major processes: neointimal formation and constrictive remodelling. Neointimal formation is initiated by arterial injury with a resultant loss of contractile phenotype in tunica media, leading to VSMC [vascular SM (smooth muscle...
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Clin Sci (Lond) (2007) 113 (8): 357–364.
Published: 12 September 2007
...Justin L. Grobe; Shant Der Sarkissian; Jillian M. Stewart; J. Gary Meszaros; Mohan K. Raizada; Michael J. Katovich Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. Our previous studies have shown an anti-remodelling...
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Clin Sci (Lond) (2007) 113 (3): 119–127.
Published: 02 July 2007
... (email [email protected] ). 16 1 2007 6 3 2007 15 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 clinical trial heart failure 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) infarction mortality remodelling statin...
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Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
...Maria E. JOHANSSON; Ulrika HÄGG; Johannes WIKSTRÖM; Anna WICKMAN; Göran BERGSTRÖM; Li-ming GAN Flow-mediated vasodilation is suggested as one of the mechanisms involved in arterial expansive remodelling, which is thought to be a defence mechanism in atherogenesis. In the present study, we tested...
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Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
... muscle mass in both large and small airways probably occurs via multiple mechanisms, and there are probably changes in the phenotype of smooth muscle cells, some showing enhanced synthetic capacity, others enhanced proliferation or contractility. Fixed airflow limitation is probably due to remodelling...
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Clin Sci (Lond) (2003) 105 (6): 683–689.
Published: 01 December 2003
... compared with PS and CS arterioles. Active pressure-dependent myogenic tone was completely absent in DS arterioles. The atrophic structural remodelling in DS arterioles were correlated with the changes in vascular mechanics, but not with the ability of these arterioles to contract in response to chemical...
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Clin Sci (Lond) (2001) 101 (5): 455–464.
Published: 21 September 2001
...-hypertensive agents atherosclerosis carotid artery hypertension intima-media thickness remodelling ultrasound. 455Clinical Science (2001) 101, 455 464 (Printed in Great Britain) Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery Alice V...
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Clin Sci (Lond) (2000) 98 (3): 291–294.
Published: 09 February 2000
...Esteban C. GABAZZA; Osamu TAGUCHI; Shigenori TAMAKI; Shuichi MURASHIMA; Hiroyasu KOBAYASHI; Hiroki YASUI; Tetsu KOBAYASHI; Osamu HATAJI; Yukihiko ADACHI Airway remodelling, which is manifested by thickening of bronchial wall, is an important causative factor of bronchial hyper-responsiveness...
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