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Keywords: renal failure
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Clin Sci (Lond) (2019) 133 (1): 9–21.
Published: 03 January 2019
... and Western blot analysis. focal segmental glomerulosclerosis genetic kidney disease podocyte proteinuria renal failure Transwell cell culture inserts (Corning) were coated with type I collagen (Sigma-Aldrich), rinsed once with PBS and placed in RPMI medium in the lower compartment...
Includes: Supplementary data
Clin Sci (Lond) (2004) 107 (6): 617–623.
Published: 24 November 2004
...Giorgos K. SAKKAS; Derek BALL; Anthony J. SARGEANT; Thomas H. MERCER; Pelagia KOUFAKI; Patrick F. NAISH The morphology of gastrocnemius muscles was examined in RFPs (renal failure patients) being treated using HD (haemodialysis) and CAPD (continuous ambulatory peritoneal dialysis). RFPs ( n =24...
Clin Sci (Lond) (2001) 101 (3): 219–225.
Published: 03 August 2001
... 2001 12 3 2001 27 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 -blocker dilated left ventricle haemodialysis natriuretic peptides renal failure 219Clinical Science (2001) 101, 219 225 (Printed in Great Britain) Beneficial effect of b...
Clin Sci (Lond) (2001) 100 (6): 609–611.
Published: 25 April 2001
...Matthew L. P. HOWSE; Maureen LEONARD; Michael VENNING; Laurence SOLOMAN Metabolic acidosis frequently complicates end-stage renal failure. In haemodialysis patients its severity is usually monitored by measurement of the total CO 2 (TCO 2 ) level. Samples from ‘satellite dialysis’ patients are...
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
... cyclo-oxygenase exercise indomethacin kidney nabumetone non-steroidal anti-inflammatory drugs prostaglandins renal failure renal haemodynamics renin sodium excretion 457Clinical Science (1999) 97, 457 465 (Printed in Great Britain) Non-steroidal anti-inflammatory drugs and renal response to...
Clin Sci (Lond) (1997) 92 (1): 59–62.
Published: 01 January 1997
... essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart...
Clin Sci (Lond) (1996) 91 (3): 353–358.
Published: 01 September 1996
... vitro washing there is a fall in V max , and no longer any significant difference between pre- and post-dialysis samples. There remains a significant difference in the erythrocyte choline V max between samples from patients with chronic renal failure and from normal subjects ( P < 0.005). 4. Human...
Clin Sci (Lond) (1994) 87 (3): 319–322.
Published: 01 September 1994
... diseases have not yet been studied. 2. Plasma immunoreactive C-type natriuretic peptide concentrations were studied by radioimmunoassay in normal subjects, patients with congestive heart failure, non-dialysed patients with chronic renal failure and haemodialysis patients with chronic renal failure. The C...
Clin Sci (Lond) (1994) 86 (4): 399–404.
Published: 01 April 1994
...Hirokazu Okada; Hiromichi Suzuki; Yoshihiko Kanno; Yoshitaka Yamamura; Takao Saruta 1. The relationship between vasopressin and the progression of renal failure has been proposed, but not intensively investigated because of a lack of orally available, selective vasopressin antagonists. 2. The...
Clin Sci (Lond) (1994) 86 (2): 149–158.
Published: 01 February 1994
... and its variation in disease states such as hypertension, renal failure, Parkinsonism and congenital dopamine β-hydroxylase deficiency. 2. Authentic, physically stable dopamine β-hydroxylase immunoreactivity was present in normal human cerebrospinal fluid at a concentration of 31.3 ± 1.4 ng/ml (range...
Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... Although acute pancreatitis is a disease character- ized by rapid damage to such a specific organ as the pancreas, accompanying systemic complications are frequent and severe, and determine the final progno- sis of the disease in a large number of patients [l]. Acute renal failure sometimes appears in...
Clin Sci (Lond) (1992) 83 (4): 437–444.
Published: 01 October 1992
... (18.8 ± 3.9 pmol/l, n = 12) and in patients with dialysis-independent (8.8 ± 1.5 pmol/l, n = 11) or dialysis-dependent (41.6 ± 8.8 pmol/l, n = 14) chronic renal failure. Similarly, in these groups of patients plasma levels of atrial natriuretic peptide were also significantly raised when compared with...
Clin Sci (Lond) (1992) 83 (3): 313–318.
Published: 01 September 1992
... nitric oxide platelets renal failure Clinical Science (1992) 83, 313-318 (Printed in Great Britain) 313 Platelets from patients on haemodialysis show impaired responses to nitric oxide M. P. GORDGE and G. H. NEILD Department of Renal Medicine, Institute of Urology and Nephrology, University College...
Clin Sci (Lond) (1991) 80 (3): 191–197.
Published: 01 March 1991
...H. A. Simmonds; S. Reiter; P. M. Davies; J. S. Cameron 1. A compound identified as orotidine has been found in the erythrocytes of all subjects on allopurinol. 2. The erythrocyte orotidine concentrations were much higher in patients with renal failure or with the Lesch-Nyhan syndrome. 3. In...
Clin Sci (Lond) (1990) 78 (6): 591–596.
Published: 01 June 1990
...C. H. Kong; F. D. Thompson; F. J. Imms 1. Cardiac index, oxygen uptake and haemoglobin concentration have been measured in eight patients with end-stage renal failure, and the values compared with those in eight healthy control subjects. Assuming the arterial blood to be 97% saturated, the oxygen...
Clin Sci (Lond) (1989) 77 (5): 573–579.
Published: 01 November 1989
..., seven patients with dialysis-independent chronic renal failure and 11 patients with haemodialysis-dependent chronic renal failure. Plasma was extracted on Sep-Pak cartridges and N -terminal ANP immunoreactivity was measured using an antibody directed against pro-ANP (1–30). 2. Plasma levels of TV...
Clin Sci (Lond) (1989) 77 (2): 145–147.
Published: 01 August 1989
...Richard J. Barrett; David R. Taylor; Kathryn F. Wright 1. Studies were conducted to test the hypothesis that glycerol-induced acute renal failure in rats may be mediated by 5-hydroxytryptamine. 2. The tryptophan hydroxylase inhibitor, β-chlorophenylalanine, or saline was administered for 4 days...
Clin Sci (Lond) (1988) 74 (2): 155–163.
Published: 01 February 1988
... The Biochemical Society and the Medical Research Society 1970 leg (muscle) tissue renal failure splanchnic tissues uraemia Clinical Science (1988) 74,155-163 155 Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in...
Clin Sci (Lond) (1987) 73 (1): 33–39.
Published: 01 July 1987
... nephrotic syndrome nutrition protein restriction renal failure ...
Clin Sci (Lond) (1987) 72 (3): 329–334.
Published: 01 March 1987
... five anephric subjects, six patients with chronic renal failure (CRF), two patients with vitamin D intoxication and four patients with hypoparathyroidism. 2. In anephric subjects serum 25-hydroxyvitamin D [25-(OH)D] rose from 58 ± 48 ( sd ) to 377±221 ( sd ) nmol/l after administration of 150 μg of 25...
Clin Sci (Lond) (1986) 71 (6): 639–646.
Published: 01 December 1986
...T. H. Thomas; C. Mason; K. M. Illingworth 1. Rats were studied 7 days and 17 days after the onset of renal failure which was induced by a surgical technique. 2. Plasma urea, creatinine ( P Cr ) and potassium had increased after 7 days; plasma potassium increased much more after 17 days but P Cr was...
Clin Sci (Lond) (1986) 71 (5): 545–552.
Published: 01 November 1986
... cotransport countertransport dialysis erythrocytes ion transport renal failure ClinicalScience(1986) 71, 545-552 545 Intracellular ion metabolism in erythrocytes and uraemia: the effect of different dialysis treatments MAURIZIO TREVISANI, NATALE DE SANTO', MARTIN0 LAURENZI3, MICHELE DI MUROI, FRANC0...
Clin Sci (Lond) (1986) 71 (1): 89–95.
Published: 01 July 1986
... 1 1986 11 2 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 calcidiol lactone 1,25-dihydroxycholecalciferol 24,25-dihydroxycholecalciferol 25,26-dihydroxycholecalciferol renal failure vitamin D metabolism-extrarenal synthesis of metabolites...
Clin Sci (Lond) (1984) 67 (2): 249–258.
Published: 01 August 1984
...] and ribosephosphate pyrophosphokinase (PP-ribose-P synthetase;EC] and the concentration of phosphoribosylpyrophosphate (PP-ribose-P) in the erythrocytes of affected family members. 2. These subjects belong to families where hyperuricaemia and renal failure occur together early in life...
Clin Sci (Lond) (1984) 66 (5): 569–574.
Published: 01 May 1984
... in plasma rubidium concentrations and attenuated the rise in intra-erythrocytic rubidium concentrations after the oral load of rubidium chloride. 3. Ten patients with chronic renal failure, compared with a well-matched control group, were found to have changes similar to, but more marked than, those...
Clin Sci (Lond) (1984) 66 (5): 591–597.
Published: 01 May 1984
... clearance (RC Ox ), non-renal oxalate clearance (NRC Ox ) and the tissue oxalate accretion rate (TOA)= [(NRC Ox ) × (P Ox )] in three patients with severe renal failure due to primary hyperoxaluria who were being treated by peritoneal dialysis or haemodialysis, or by renal transplantation. The clearance...
Clin Sci (Lond) (1984) 66 (2): 229–232.
Published: 01 February 1984
... immunoglobulin isoelectric focussing light chain nephrotoxicity multiple myeloma renal failure © 1984 The Biochemical Society and the Medical Research Society 1984 Clinical Science (1984) 66, 229-232 229 SHOR T COMMUNICA TION The importance of urinary immunoglobulin light chain isoelectric point (PI...
Clin Sci (Lond) (1983) 64 (2): 153–160.
Published: 01 February 1983
... severe renal failure the control of fluid distribution is changed in a way which leads to a preferential distribution of rapidly infused saline into the intravascular compartment. 23 4 1982 13 9 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 extracellular...
Clin Sci (Lond) (1981) 61 (6): 757–764.
Published: 01 December 1981
...M. A. Mansell; J. Allsop; M. E. North; R. J. Simmonds; R. A. Harkness; R. W. E. Watts 1. We have studied purine metabolism in renal failure using high-pressure liquid chromatography to determine metabolite concentrations in erythrocytes and plasma, and microradiochemical assays of enzyme activity...
Clin Sci (Lond) (1981) 61 (6): 743–749.
Published: 01 December 1981
... cystine folic acid homocysteine homocystinuria pyridoxine renal failure vascular disease © 1981 The Biochemical Society and the Medical Research Society 1981 16 3 1981 11 6 1981 Clinical Science (1981) 61,743-749 743 Homocysteine in the plasma of renal transplant recipients...
Clin Sci (Lond) (1980) 58 (5): 427–430.
Published: 01 May 1980
...D. E. L. Wilcken; Vatsala J. Gupta; S. G. Reddy 1. Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine-homocysteine...
Clin Sci (Lond) (1980) 58 (4): 337–340.
Published: 01 April 1980
... production rose significantly when indomethacin was present, indicating a fall in the rate at which glycerol 3-phosphate was oxidized. 4. The results are discussed in relation to the observation that indomethacin increases the severity of glycerol-induced acute renal failure. 24 9 1979 6 12 1979...
Clin Sci (Lond) (1979) 57 (s5): 383s–385s.
Published: 01 December 1979
...G. S. Stokes; J. C. Monaghan; G. W. Frost; E. P. MacCarthy 1. The fall in blood pressure produced by a test dose of prazosin was greater in a group of patients with chronic renal failure than in a group with normal renal function. 2. This difference could not be attributed to increased reactivity...
Clin Sci (Lond) (1979) 57 (5): 435–443.
Published: 01 November 1979
... renal failure as compared with those of normal subjects. Mean amounts of peak II were higher in patients with chronic renal insufficiency than in nutritional vitamin D deficiency, in pseudohypoparathyroidism and in primary hyperparathyroidism, despite comparable amounts of PTH-(1–84). 3. In chronic...
Clin Sci (Lond) (1979) 57 (5): 445–451.
Published: 01 November 1979
... specimens. 9 1 1979 17 7 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 renal failure cystic fibrosis glycoproteins meconium, mucus Clinical Science (1979) 57,445-45 1 Study of the oligosaccharide units from mucus glycoproteins of meconium from normal...
Clin Sci (Lond) (1979) 57 (5): 473–476.
Published: 01 November 1979
...J. B. Eastwood; A. Daly; G. D. Carter; J. Alaghband-Zadeh; H. E. De Wardener 1. Plasma 25-hydroxy-vitamin D concentration was measured in 40 normal subjects, 19 patients with terminal renal failure, 137 patients who had been on dialysis up to 11 years and in 17 renal transplant patients. 2. The...
Clin Sci Mol Med (1978) 54 (6): 615–620.
Published: 01 June 1978
...J. P. Nolan; R. C. Venuto; Gwendolyn S. Goldmann 1. A relationship between bacterial endotoxin absorbed from the gut and acute renal failure has been postulated. Experiments employing either the endotoxin-tolerant state or the enhancement of endotoxin injury were undertaken to test this...
Clin Sci Mol Med (1978) 54 (2): 133–140.
Published: 01 February 1978
...S. Scherrer; B. Haldimann; A. Küpfer; F. Reubi; J. Bircher 1. To evaluate potential alterations in hepatic metabolism of drugs occurring in patients with renal insufficiency the fate of aminopyrine was studied in 17 patients with chronic renal failure and in 27 normal subjects. 2. Although patients...
Clin Sci Mol Med (1977) 53 (5): 479–484.
Published: 01 November 1977
...J. M. Letteri; R. M. Biltz; K. J. Ellis; A. Martino; S. Yasumura; D. Brook; S. H. Cohn; E. D. Pellegrino 1. Young, sub-totally nephrectomized rats were used to study the altered mineral metabolism of renal failure and its effects on bone growth and mineral maturation. 2. Rats killed at 4 weeks...
Clin Sci Mol Med (1977) 52 (6): 577–583.
Published: 01 June 1977
...R. Shainkin-Kestenbaum; R. Lerman; A. Reuben; G. M. Berlyne 1. Plasma concentrations of human calcitonin were measured in groups of patients with chronic renal failure, treated either conservatively or by haemodialysis, and compared with a normal group of persons. 2. Plasma calcitonin was...
Clin Sci Mol Med (1977) 52 (5): 499–508.
Published: 01 May 1977
...J. B. Eastwood; T. C. B. Stamp; H. E. De Wardener; P. J. Bordier; C. D. Arnaud 1. Five patients with the osteomalacia of chronic renal failure were given 50–100 nmol of 25-hydroxy vitamin D 3 intravenously per day for 24–28 days. 2. In all five patients, during administration of 25-hydroxy vitamin...
Clin Sci Mol Med (1976) 51 (s3): 211s–213s.
Published: 01 December 1976
... 1976 albumin blood pressure blood volume capillary Evans Blue heart failure liver cirrhosis packed cell volume renal artery stenosis renal failure renin Clinical Science and Molecular Medicine (1976) 51, 211s-213s. Significance of increase in labelled albumin disappearance rate in...
Clin Sci Mol Med (1976) 51 (s3): 335s–337s.
Published: 01 December 1976
... cortex adrenocorticotrophin aldosterone angiotensin II hyperkalaemia renin renal failure Clinical Science and Molecular Medicine (1976) 51. 335s-337s. Selective hypoaldosteronism: a study of steroid biosynthetic pathways under adrenocorticotrophin and angiotensin 11 infusion M. LEBEL A N D J. H...
Clin Sci Mol Med (1976) 51 (4): 407–414.
Published: 01 October 1976
.... This was accompanied by a rise in the concentration of the fasting morning plasma phosphorus. Calcium balance did not change. 3. The normal subjects absorbed 0·3–3·6 mmol of aluminium/day, which is significantly less than that absorbed by five patients with chronic renal failure, three of whom were...
Clin Sci Mol Med (1975) 49 (4): 301–304.
Published: 01 October 1975
...R. Ardaillou; M. Beaufils; Marie-Paule Nivez; R. Isaac; C. Mayaud; J.-D. Sraer 1. High plasma immunoreactive calcitonin concentrations were observed in ten of eleven patients with acute renal failure, particularly in the oliguric phase. 2. Immunoreactive calcitonin decreased progressively with time...
Clin Sci Mol Med (1974) 47 (5): 507–513.
Published: 01 November 1974
...J. A. Carruthers; I. Ralfs; T. M. D. Gimlette; R. Finn 1. Platelet survival was measured in patients with acute proliferative glomerulonephritis or chronic renal failure and also in control subjects. 2. Platelet survival is markedly reduced in acute proliferative glomerulonephritis as compared with...
Clin Sci Mol Med (1974) 47 (2): 143–151.
Published: 01 August 1974
... close at a lower lung volume. 2 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 renal failure pulmonary oedema closing volume lung function Clinical Science and Molecular Medicine (1974) 47, 143-151. L U N G F U N C T I O N I N CHRONIC U R A E M I A...
Clin Sci Mol Med (1974) 47 (1): 23–42.
Published: 01 July 1974
...J. B. Eastwood; P. J. Bordier; E. M. Clarkson; S. Tun Chot; H. E. De Wardener 1. The histological appearances of cancellous bone from the ilium have been quantified in thirteen patients with osteomalacia due to chronic renal failure. 2. There was an excess of osteoid tissue and a reduction in the...
Clin Sci Mol Med (1973) 45 (4): 417–428.
Published: 01 October 1973
... Medical Research Society 1973 hypertension renal failure renin renin substrate blood volume Clinical Science and Molecular Medicine (1973) 45,417428. INTERRELATIONSHIPS BETWEEN BLOOD PRESSURE, RENIN, RENIN SUBSTRATE A N D BLOOD VOLUME I N TERMINAL RENAL FAILURE M . A. D. H . SCHALEKAMP, M. P...
Clin Sci Mol Med (1973) 45 (s1): 155s–157s.
Published: 01 August 1973
... haemodialysis hypertension renal failure renal transplantation cardiac index blood volume Clinical Science and Molecular Medicine (1973) 45, 155s-157s. HAEMODYNAMIC A N D BLOOD VOLUME STUDIES I N LONG-TERM HAEMODIALYSIS PATIENTS, A N D I N PATIENTS WITH SUCCESSFULLY TRANSPLANTED KIDNEYS J. TUCKMAN. J.-L...