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Keywords: renal fibrosis
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Articles
Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... kidney, and depletion of endogenous kallistatin by antibody injection resulted in aggravated renal fibrosis, which was accompanied by enhanced Wnt/β-catenin activation. Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 409–427.
Published: 29 January 2021
...Daqian Gu; Dandong Fang; Mingming Zhang; Jingwen Guo; Hongmei Ren; Xinyue Li; Ziyue Zhang; Donghai Yang; Xue Zou; Yukai Liu; Wei Eric Wang; Gengze Wu; Pedro A. Jose; Yu Han; Chunyu Zeng Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
.... SMAD3 inhibition and global ablation in mice afford protection from fibrosis in response to unilateral ureteral obstruction (UUO), diabetes and renal toxins [ 18 , 20 , 21 ]. Conditional renal tubular specific up-regulation of TGF-β1, moreover, is sufficient to induce renal fibrosis, confirming the...
Articles
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
... with MI. Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established. Endoplasmic reticulum (ER) plays a central role in protein processing and folding. An...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of extracellular matrix (ECM) proteins in the tubulointerstitium and induction of epithelial–mesenchymal transition (EMT) during renal fibrosis. We tested the anti-fibrotic potential of vorapaxar, a clinically approved PAR-1 antagonist for cardiovascular protection, in an experimental kidney fibrosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... abnormalities induced by a high-fat diet [ 8 , 9 ], while TRAIL deficiency was found associated with worsening of glucose control in type 2 diabetes [ 10 ]. renal fibrosis TRAIL type 2 diabetes Correspondence: Stella Bernardi ( stella.bernardi@asuits.sanita.fvg.it , shiningstella@gmail.com...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate the...
Articles
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . inflammation renal fibrosis RNA-binding protein Chronic kidney disease (CKD) is characterized by persistent inflammation and...
Articles
Clin Sci (Lond) (2020) 134 (2): 103–122.
Published: 23 January 2020
... mechanism of the alcoholic kidney disease remains largely unknown. In the present study, an alcoholic renal fibrosis animal model was first employed which mice received liquid diet containing alcohol for 4 to 12 weeks. The Masson’s Trichrome staining analysis showed that kidney fibrosis increased at week 8...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1587–1602.
Published: 22 July 2019
... blunted these effects and led to significantly higher plasma erythropoietin (EPO) levels. Adenine-induced renal fibrosis, endoplasmic reticulum (ER) stress and apoptosis were significantly decreased by PBI-4050. In parallel, Gpr40 −/− mice were more susceptible to adenine-induced fibrosis, renal function...
Articles
Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
... Limited on behalf of the Biochemical Society 2019 angiogenesis epithelial-mesenchymal transition inflammation myofibroblasts Nintedanib renal fibrosis Nearly 45% of deaths in the developed world are attributable to some type of chronic fibro-proliferative disease, including idiopathic...
Articles
Clin Sci (Lond) (2018) 132 (21): 2339–2355.
Published: 13 November 2018
...Zhenzhen Li; Xianghua Liu; Fengyan Tian; Ji Li; Qingwei Wang; Chaohui Gu Epithelial-to-mesenchymal transition (EMT) is a phenotypic conversion that plays a crucial role in renal fibrosis leading to chronic renal failure. Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (21): 2299–2322.
Published: 02 November 2018
... renal fibroblasts and development of renal fibrosis and suggest that inhibition of autophagy may represent a potential therapeutic strategy for HN. Correspondence: Weijie Yuan ( ywj4169@163.com ) or Na Liu ( naliubrown@163.com ) 3-Methyladenine (3-MA) was purchased from Selleckchem...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (13): 1403–1415.
Published: 09 July 2018
... the progression of renal fibrosis in a mouse model of unilateral ureteral obstructive nephropathy (UUO). We found that preventive treatment with SIS3 at the time of disease induction largely suppressed progressive renal fibrosis by inhibiting α-smooth muscle actin (α-SMA) + myofibroblast accumulation...
Articles
Clin Sci (Lond) (2017) 131 (16): 2125–2143.
Published: 24 July 2017
... Src family kinase, which has recently been approved by FDA to treat idiopathic pulmonary fibrosis. Whether it affects renal fibrosis remains unknown. Here, we demonstrated that administration of nintedanib immediately or 3 days after unilateral ureteral obstruction (UUO) injury and with folic acid (FA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (7): 567–581.
Published: 17 March 2017
...Xing Wei; Peng Gao; Yunfei Pu; Qiang Li; Tao Yang; Hexuan Zhang; Shiqiang Xiong; Yuanting Cui; Li Li; Xin Ma; Daoyan Liu; Zhiming Zhu Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Articles
Clin Sci (Lond) (2013) 124 (4): 243–254.
Published: 31 October 2012
...-regulated. In the context of renal fibrosis, Smad3 is pathogenic, whereas Smad2 and Smad7 are renoprotective. However, this counter-balancing mechanism is also altered because TGF-β1 induces Smurf2, a ubiquitin E3-ligase, to target Smad7 as well as Smad2 for degradation. Thus overexpression of renal Smad7...