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1-29 of 29
Keywords: renal fibrosis
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (03): 229–246.
Published: 06 February 2025
.... Neddylation is reported to be activated in diverse human diseases, and inhibition of protein neddylation has been regarded as a promising anticancer therapy. However, whether neddylation participates in renal fibrosis and whether blockade of neddylation through targeted inhibition of DCN1 play effects...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (22): 1451–1466.
Published: 15 November 2024
... elevated circulating and renal CXCL5 in CKD patients, and renal CXCL5 was correlated with increased renal fibrosis and decreased estimated glomerular filtration rate. Altogether, CXCL5 levels increased in experimental AKI and clinical CKD, and in vivo and in vitro CXCL5 inhibition may reduce acute tubular...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (20): 1285.
Published: 07 October 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chronic kidney disease inflammation mineralocorticoid receptor renal...
Articles
Roberto Palacios-Ramirez, Matthieu Soulié, Amaya Fernandez-Celis, Toshifumi Nakamura, Nabiha Boujardine, Benjamin Bonnard, Krister Bamberg, Natalia Lopez-Andres, Frederic Jaisser
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1025–1038.
Published: 22 August 2024
..., Tokyo, Japan. 25 02 2024 01 08 2024 01 08 2024 02 08 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 balcinrenone chronic kidney disease inflammation mineralocorticoid receptor renal fibrosis toll-like...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 991–1007.
Published: 14 August 2024
... nephropathy inlfammation renal fibrosis National Health and Medical Research Council (NHMRC) 501100000925 APP2011355 Cellular senescence is a physiological and natural process in organic systems. The word ‘senescence’ originates from the Latin word ‘senex’ which means ‘old man’ or ‘old...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (20): 1593.
Published: 20 October 2023
... renal fibrosis transforming growth factors The authors of the original article, “MKP2 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells through a JNK-dependent pathway” (doi: 10.1042/CS20180602 ), would like to correct their paper. The authors have...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
Includes: Supplementary data
Articles
Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
... parthenolide (NF-κB inhibitor, PTL) 3.5 μg/g body weight or its vehicle (0.05% DMSO) 1 day prior to 2.5 μg/g body weight recombinant WISP1 or saline by intraperitoneal injection [ 12 ]. The mice were killed after 48 h of WISP1 injection. fibroblasts inflammation renal fibrosis renal physiology...
Includes: Supplementary data
Articles
Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2127–2142.
Published: 10 September 2021
... of renal fibrosis via regulation of multiple profibrotic pathways. Chronic kidney disease (CKD) is characterized by persistent inflammation and a gradual increase in fibrosis including glomerulosclerosis and tubulointerstitial fibrosis, ultimately leading to end-stage renal disease (ESRD) regardless...
Includes: Supplementary data
Articles
Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
Published: 06 August 2021
...Wangqiu Gong; Congwei Luo; Fenfen Peng; Jing Xiao; Yiqun Zeng; Bohui Yin; Xiaowen Chen; Shuting Li; Xiaoyang He; Yanxia Liu; Huihui Cao; Jiangping Xu; Haibo Long Although accelerated cellular senescence is closely related to the progression of chronic kidney disease (CKD) and renal fibrosis...
Includes: Supplementary data
Articles
Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1273–1288.
Published: 26 May 2021
...Hao Zhao; Yachun Han; Na Jiang; Chenrui Li; Ming Yang; Ying Xiao; Ling Wei; Xiaofen Xiong; Jinfei Yang; Chengyuan Tang; Li Xiao; Fuyou Liu; Yu Liu; Lin Sun Cisplatin (Cis) can cause chronic kidney disease (CKD) and promote renal fibrosis, but the underlying mechanism is not fully understood...
Articles
Wai Han Yiu, Ye Li, Sarah W.Y. Lok, Kam Wa Chan, Loretta Y.Y. Chan, Joseph C.K. Leung, Kar Neng Lai, James H.L. Tsu, Julie Chao, Xiao-Ru Huang, Hui Yao Lan, Sydney C.W. Tang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... in the kidney, and depletion of endogenous kallistatin by antibody injection resulted in aggravated renal fibrosis, which was accompanied by enhanced Wnt/β-catenin activation. Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO...
Includes: Supplementary data
Articles
Daqian Gu, Dandong Fang, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Donghai Yang, Xue Zou, Yukai Liu, Wei Eric Wang, Gengze Wu, Pedro A. Jose, Yu Han, Chunyu Zeng
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (2): 409–427.
Published: 29 January 2021
...Daqian Gu; Dandong Fang; Mingming Zhang; Jingwen Guo; Hongmei Ren; Xinyue Li; Ziyue Zhang; Donghai Yang; Xue Zou; Yukai Liu; Wei Eric Wang; Gengze Wu; Pedro A. Jose; Yu Han; Chunyu Zeng Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney...
Includes: Supplementary data
Articles
Cody C. Gifford, Jiaqi Tang, Angelica Costello, Nidah S. Khakoo, Tri Q. Nguyen, Roel Goldschmeding, Paul J. Higgins, Rohan Samarakoon
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
... mouse kidneys resulting in increased renal fibrosis and inflammation, evident by increased ECM deposition, induction of pro-inflammatory cytokines, and greater macrophage infiltration. ANG II-mediated down-regulation of miR-29b (a microRNA exerting antifibrotic effects [ 60 ]), moreover, is further...
Articles
Beatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
... with MI. Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established. Endoplasmic reticulum (ER) plays a central role in protein processing and folding...
Includes: Supplementary data
Articles
Sarah W.Y. Lok, Wai Han Yiu, Hongyu Li, Rui Xue, Yixin Zou, Bin Li, Kam Wa Chan, Loretta Y.Y. Chan, Joseph C.K. Leung, Kar Neng Lai, Sydney C.W. Tang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of extracellular matrix (ECM) proteins in the tubulointerstitium and induction of epithelial–mesenchymal transition (EMT) during renal fibrosis. We tested the anti-fibrotic potential of vorapaxar, a clinically approved PAR-1 antagonist for cardiovascular protection, in an experimental kidney fibrosis model...
Includes: Supplementary data
Articles
Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... of the Biochemical Society 2020 renal fibrosis TRAIL type 2 diabetes TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that can be cleaved to form a circulating ligand, which belongs to the TNF family of apoptosis-inducing ligands. Both membrane-bound and circulating...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Simeng Liu, Zhimin Huang, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Changying Xing, Yufeng Huang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
... renal fibrosis RNA-binding protein Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive fibrosis including glomerulosclerosis and tubulointerstitial fibrosis, ultimately leading to end-stage renal disease (ESRD) regardless of the underlying disorder...
Articles
Qin Yang, Hai-Yong Chen, Jia-nan Wang, Huai-Qin Han, Ling Jiang, Wei-Feng Wu, Biao Wei, Li Gao, Qiu-ying Ma, Xue-qi Liu, Qi Chen, Jia-gen Wen, Juan Jin, Yan Huang, Wei-jian Ni, Tao-tao Ma, Jun Li, Xiao-Ming Meng
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 103–122.
Published: 23 January 2020
... mechanism of the alcoholic kidney disease remains largely unknown. In the present study, an alcoholic renal fibrosis animal model was first employed which mice received liquid diet containing alcohol for 4 to 12 weeks. The Masson’s Trichrome staining analysis showed that kidney fibrosis increased at week 8...
Includes: Supplementary data
Articles
Jean-François Thibodeau, Jean-Christophe Simard, Chet E. Holterman, Amélie Blais, Marie-Pier Cloutier, Thalia Medeiros, Martin Leduc, Brigitte Grouix, François A. Leblond, Dylan Burger, Richard L. Hébert, Christopher R.J. Kennedy, Lyne Gagnon
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1587–1602.
Published: 22 July 2019
... blunted these effects and led to significantly higher plasma erythropoietin (EPO) levels. Adenine-induced renal fibrosis, endoplasmic reticulum (ER) stress and apoptosis were significantly decreased by PBI-4050. In parallel, Gpr40 −/− mice were more susceptible to adenine-induced fibrosis, renal function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
...; UUO and folic acid injection induced renal fibrosis mouse models Kidney Inhibits renal fibroblasts activation, ECM overproduction and deposition, inflammatory cells infiltration and TGF-β-induced fibrotic events, may attenuate pre-established renal fibrosis [ 36 ] Dermal fibroblasts from...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2339–2355.
Published: 13 November 2018
...Zhenzhen Li; Xianghua Liu; Fengyan Tian; Ji Li; Qingwei Wang; Chaohui Gu Epithelial-to-mesenchymal transition (EMT) is a phenotypic conversion that plays a crucial role in renal fibrosis leading to chronic renal failure. Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2299–2322.
Published: 02 November 2018
... of renal fibroblasts and development of renal fibrosis and suggest that inhibition of autophagy may represent a potential therapeutic strategy for HN. Correspondence: Weijie Yuan ( [email protected] ) or Na Liu ( [email protected] ) * These authors contributed equally to this work. 28 06...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1403–1415.
Published: 09 July 2018
... the progression of renal fibrosis in a mouse model of unilateral ureteral obstructive nephropathy (UUO). We found that preventive treatment with SIS3 at the time of disease induction largely suppressed progressive renal fibrosis by inhibiting α-smooth muscle actin (α-SMA) + myofibroblast accumulation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2125–2143.
Published: 24 July 2017
...), and Src family kinase, which has recently been approved by FDA to treat idiopathic pulmonary fibrosis. Whether it affects renal fibrosis remains unknown. Here, we demonstrated that administration of nintedanib immediately or 3 days after unilateral ureteral obstruction (UUO) injury and with folic acid (FA...
Includes: Supplementary data
Articles
Xing Wei, Peng Gao, Yunfei Pu, Qiang Li, Tao Yang, Hexuan Zhang, Shiqiang Xiong, Yuanting Cui, Li Li, Xin Ma, Daoyan Liu, Zhiming Zhu
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (7): 567–581.
Published: 17 March 2017
...Xing Wei; Peng Gao; Yunfei Pu; Qiang Li; Tao Yang; Hexuan Zhang; Shiqiang Xiong; Yuanting Cui; Li Li; Xin Ma; Daoyan Liu; Zhiming Zhu Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (4): 243–254.
Published: 31 October 2012
...-regulated. In the context of renal fibrosis, Smad3 is pathogenic, whereas Smad2 and Smad7 are renoprotective. However, this counter-balancing mechanism is also altered because TGF-β1 induces Smurf2, a ubiquitin E3-ligase, to target Smad7 as well as Smad2 for degradation. Thus overexpression of renal Smad7...
