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Keywords: renal interstitial fibrosis
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Articles
Interleukin-18 deficiency protects against renal interstitial fibrosis in aldosterone/salt-treated mice
Available to PurchaseAkiko Tanino, Takafumi Okura, Tomoaki Nagao, Masayoshi Kukida, Zuowei Pei, Daijiro Enomoto, Ken-ichi Miyoshi, Haruki Okamura, Jitsuo Higaki
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (19): 1727–1739.
Published: 23 August 2016
... in a concentration- and time-dependent manner. These effects were inhibited completely by spironolactone. IL-18 may be a key mediator of aldosterone-induced renal fibrosis by inducing OPN, thereby exacerbating renal interstitial fibrosis. Inhibition of IL-18 may therefore provide a potential target for therapeutic...
