... renin–angiotensin system (RAS) Regarding the specificity of Ang-(1–7)/A779 for Mas and AngII/C21/PD123319/PD123177 for AT 2 R, Widdop's group has previously published binding studies in which the affinity of AngII/Ang-(1–7)/A779/C21/PD123319 and some other ligands for the AT 2 R (and the AT 1...

... enzyme 2 (ACE2) baroreflex hypertension Mas receptor noradrenergic neurotransmission renin–angiotensin system (RAS) The RAS (renin–angiotensin system) is a hormonal cascade involved in arterial pressure and fluid homoeostasis, and cardiovascular function regulation. Deregulation of the RAS...

... the biological activity induced by AngII in skeletal muscle. angiotensin-(1–7) angiotensin II Mas renin–angiotensin system (RAS) skeletal muscle transforming growth factor-β1 (TGF-β1) We have demonstrated previously that the increase in the expression of the TGF-β1 gene induced by AngII...

... purified APA ( K i =0.20±0.02 μM) similarly to EC33 [ 62 ]. angiotensin III aminopeptidase A aminopeptidase A inhibitor brain hypertension Phase I clinical trial renin–angiotensin system (RAS) Arterial hypertension affects one-third of the adult population, according to the World...

... autonomic regulation dystrophin glycoprotein complex neuromuscular disorder renin–angiotensin system (RAS) sarcoglycan • Muscular dystrophy is a catastrophic disease that is in need of new therapies to delay pathogenicity of disease and improve quality of life in the afflicted population...

... compilation © 2014 Biochemical Society 2014 angiotensin cardiovascular system remodelling renin–angiotensin system (RAS) The RAS (renin–angiotensin system) is a key component of cardiovascular physiology, playing an integral role in the regulation of vascular tone, blood pressure...

... The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin-(1–7) angiotensin-converting enzyme 2 (ACE2) insulin Mas receptor renin–angiotensin system (RAS) Diabetes mellitus is emerging as a worldwide epidemic, and the clinical implications and healthcare costs from...

... 8 2013 4 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 aldosterone blood pressure endothelin inflammation innate and adaptive immunity interleukin renin–angiotensin system (RAS) target organ damage regulatory T-cell (T reg -cell) vascular...

... angiotensin inflammation Mas receptor renin renin–angiotensin system (RAS) stroke Stroke is a leading cause of death and serious long-term disability worldwide [ 1 ]. This disease can be broadly classified into two types: ischaemic and haemorrhagic strokes. Ischaemic stroke occurs when the blood...

... diabetic nephropathy prorenin renin–angiotensin system (RAS) urocortin vitamin D The renin molecule displays high species specificity, and human renin inhibitors can be effectively tested only in the marmoset and the guinea pig. Experimental studies in models of kidney disease...

.... angiotensin-converting enzyme angiotensin receptor blocker diabetic cardiomyopathy intracrine prorenin receptor renin–angiotensin system (RAS) • In view of the intracellular cardiac RAS activation by hyperglycaemia, we studied the comparative efficacy of a renin inhibitor, an ACEi and an ARB...

.... Activation is represented in green and inhibition in red. AA, amino acids; FA, fatty acid; PP, pentose pathway. angiotensin-(1–7) angiotensin-converting enayme 2 (ACE2) Mas receptor renin–angiotensin system (RAS) The textbook-like view of the RAS (renin–angiotensin system) as a linear...

... 2013 bone marrow cancer haematopoiesis neoplastic disorder renin–angiotensin system (RAS) We first proposed the concept that there exists a local haematopoietic RAS (renin–angiotensin system) in the BM (bone marrow) [ 1 , 2 ]. The main RAS molecules, including renin, angiotensinogen...

...), with permission from Elsevier. angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin–angiotensin system (RAS) ACE2 has been identified in many tissues, including the heart [ 5 , 7 , 8 ], blood vessels [ 9 – 11...

... 18 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis angiotensin II type 1 receptor (AT 1 R) angiotensin receptor blocker (ARB) renin–angiotensin system (RAS) vascular endothelial growth factor (VEGF) The majority of clinical trials...

... 5 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cytochrome P450 (CYP450) end-organ damage hypertension renin–angiotensin system (RAS) soluble epoxide hydrolase Chronic kidney disease and end-stage renal disease present severe medical problems...

... 25 11 2009 3 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 angiotensin-converting enzyme (ACE) angiotensinogen (AGT) gene human hypertension renin–angiotensin system (RAS) A high proportion of the risk for cardiovascular events is attributed...

... equally to the work. angiotensin-(1–7) kidney mas receptor renal injury renin–angiotensin system (RAS) Alterations within the RAS (renin–angiotensin system) are pivotal for the development and progression of renal disease [ 1 , 2 ]. ACE2 (angiotensin-converting enzyme 2) [ 3 – 5...

...–angiotensin system (RAS) One small study ( n =7) found that administration of the ARB losartan at 50 mg/day for 48 weeks in patients with NASH (non-alcoholic steatohepatitis) reduced serum TGF-β, ferritin and aminotransferases [ 62 ]. Five patients had improvement in the grade of hepatic...