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Keywords: renin—angiotensin system
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (24): 1561–1577.
Published: 24 December 2024
...Hikari Takeshita; Koichi Yamamoto; Masaki Mogi; Hiromi Rakugi The renin-angiotensin system (RAS) is a classically known circulatory regulatory system. In addition to the previously known multi-organ circulatory form of the RAS, the existence of tissue RASs in individual organs has been well...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1145–1150.
Published: 09 August 2023
... Notch signaling, the renin–angiotensin system, and renal cystic disease [ 2 ]. Figure 1 Renin expression in the developing and/or mature kidney Mouse Ren1 is expressed in development in cells that eventually become the vascular smooth muscles cells in renal arterioles (red), JG (blue) cells...
Articles
Brian C. Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jennifer Charlton, Agnes B. Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 35–45.
Published: 05 January 2023
.... Correspondence: Brian C. Belyea ( [email protected] ) 27 07 2022 06 12 2022 08 12 2022 12 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway renal physiology renin-angiotensin system...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
Published: 18 August 2022
... understood, some systems appear to play major roles in its development. This review aims to update the current knowledge on the interaction of the intrarenal renin–angiotensin system (RAS) and dopaminergic system in the development of hypertension, focusing on recent scientific hallmarks in the field...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 799–802.
Published: 27 May 2022
... the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge. Correspondence: U. Muscha Steckelings ( [email protected] ) 25...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin References 1. Schmieder R.E. , Hilgers K.F. , Schlaich M.P. and Schmidt B.M. ( 2007 ) Renin-angiotensin system and cardiovascular risk . Lancet 369...
Articles
Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2377–2391.
Published: 19 October 2021
... 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ACE activity erythropoiesis Exercise training renin-angiotensin system Endurance exercise training (ET) induces alterations in the hematopoietic system that increase oxygen...
Includes: Supplementary data
Articles
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chronic kidney disease inflammation interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause of deaths worldwide. Improved treatment strategies for HT, including antihypertensive...
Articles
Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
... pressure hypertension immunsystem renin-angiotensin system Primary human peripheral blood mononuclear cells (PBMCs) were isolated from peripheral blood using lymphocyte separation medium Histopaque 1077 (Sigma-Aldrich) via density gradient centrifugation. Human monocytes were further purified from...
Includes: Supplementary data
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
, Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
...Xi Cao; Li-Ni Song; Jin-Kui Yang The renin–angiotensin system (RAS) has currently attracted increasing attention due to its potential function in regulating energy homeostasis, other than the actions on cellular growth, blood pressure, fluid, and electrolyte balance. The existence of RAS is well...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... with Portland Press and the Biochemical Society under a transformative agreement with CAUL. blood pressure placenta pregnancy renal physiology renin-angiotensin system Female mice were anaesthetized (isoflurane; 2–5% v/v O 2 in N 2 ), and a radiotelemetry probe (PA-C10, Data Sciences...
Includes: Supplementary data
Articles
Milene Tavares Fontes, Suliana Mesquita Paula, Caroline Antunes Lino, Nathalia Senger, Gisele Kruger Couto, Maria Luiza de Morais Barreto-Chaves, José Geraldo Mill, Luciana Venturini Rossoni
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Published: 09 December 2020
... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin–angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key...
Articles
Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... ) 04 09 2020 14 10 2020 16 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 COVID-19 renin-angiotensin system SARS-CoV-2 Angiotensin‐converting enzyme II (ACE2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2535–2547.
Published: 05 October 2020
...Mazher Mohammed; Clara Berdasco; Eric Lazartigues The brain renin–angiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
...-7) thereby counterbalancing the action of ACE on the renin–angiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... (CV) system. The apelin pathway’s dominant physiological role has delineated therapeutic implications for coronary artery disease, heart failure (HF), aortic aneurysm, pulmonary arterial hypertension (PAH), and transplant vasculopathy. Apelin peptides interact with the renin–angiotensin system (RAS...
Articles
Karina Pereira Gomes, Pedro Paulo Pereira Braga, Claudio Quintino de Lima, Jr, Poliana Peres Ghazale, Gustavo Rodrigues Pedrino, Elizabeth Pereira Mendes, Aline Priscila Pansani, Carlos Henrique Xavier, Carlos Henrique Castro, Diego Basile Colugnati
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2263–2277.
Published: 03 September 2020
... type of epilepsy and is often refractory to pharmacological treatment. In this scenario, extensive research has identified components of the renin–angiotensin system (RAS) as potential therapeutic targets. Therefore, the aim of the present study was to evaluate the effects of long-term treatment...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... Gomez ( [email protected] ) 03 03 2020 23 06 2020 03 07 2020 03 07 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Ctcf homeostasis hypertension nephrology renin-angiotensin system vasculature Renin...
Includes: Supplementary data
Articles
In Collection
Coronavirus
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
... 2020 05 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 chronic kidney disease renal glomerulus renin-angiotensin system Clinical trials have recently been published regarding the use of sodium–glucose co-transporter...
Articles
Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle renin–angiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62...
Includes: Supplementary data
Articles
Fernando Pedro de Souza-Neto, Mario de Morais e Silva, Melissa de Carvalho Santuchi, Thaís Cristina de Alcântara-Leonídio, Daisy Motta-Santos, Aline Cristina Oliveira, Marcos Barrouin Melo, Giovanni Naves Canta, Leandro Eziquiel de Souza, Maria Cláudia Costa Irigoyen, Maria José Campagnole-Santos, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silva
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (5): 629–643.
Published: 01 March 2019
...; Silvia Guatimosim; Robson Augusto Souza Santos; Rafaela Fernandes da Silva Aims: The renin–angiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala 1 -angiotensin-(1-7)) is a new...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... on behalf of the Biochemical Society 2019 aldosterone intercalated cells renin-angiotensin system renal physiology Fluid volume regulation by the kidney plays a predominant role in the long-term control of blood pressure. Because of its importance, the decreased kidney function is a common...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... of RAAS blockade altered the association between circulating MPs and 24hUNa. cardiovascular disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people...
Includes: Supplementary data
Articles
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R.A. Silva-Alves, Leônidas G. Mendes-Júnior, Drielle D. Guimarães, Josiane C. Cruz, Thyago M. Queiroz, Camille M. Balarini, Valdir A. Braga, Catalin M. Filipeanu, Eric Lazartigues, Maria do Socorro de França-Silva
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... ACE2 Biased agonist hypertension renin-angiotensin system The experiments were carried out as described previously [ 29 ]. In brief, the cell lysates were separated by SDS/PAGE and transferred on to PVDF membranes. The signal was detected using ECL Plus (PerkinElmer) and a luminescent image...
Articles
Eliete Dalla Corte Frantz, Eliza Prodel, Igor Dutra Braz, Isabele Gomes Giori, Thereza Cristina Lonzetti Bargut, D’Angelo Carlo Magliano, Antonio Claudio Lucas Nobrega
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1487–1507.
Published: 23 July 2018
... on behalf of the Biochemical Society 2018 exercise training renin-angiotensin system sarcopenic obesity skeletal muscle white adipose tissue Overweight and obesity are major global health problems, affecting approximately 39% of the world’s adult population. The World Health Organization...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
A. Augusto Peluso, Jesper Bork Bertelsen, Kenneth Andersen, Tenna Pavia Mortsensen, Pernille B. Hansen, Colin Sumners, Michael Bader, Robson A. Santos, Ulrike Muscha Steckelings
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 777–790.
Published: 06 April 2018
... , which controls Akt kinase activity. AT2-receptor endothelial nitric oxide synthase protein phosphatases renin-angiotensin system Subconfluent HAEC were serum-starved in ECBM-2 starting 4 h before addition of drugs. Cells were stimulated for 0.5, 1, 3, 5, 10 or 15 min or for 24 or 48 h...
Articles
Paul-Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... concentrations on CYP11B2, do not support the contention that the protective arm of renin–angiotensin system (RAS) blunts aldosterone synthase in the normal adrenal cortex and primary aldosteronism. The polyclonal NCI-H295R and clonal HAC15 cell lines, the latter derived from H295R, were used as in vitro...
Includes: Supplementary data
Articles
Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... studied relationships between salt intake, BP and renin–angiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...
Includes: Supplementary data
Articles
Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
..., by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS). Ercc1 Δ/− mice...
Includes: Supplementary data
Articles
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... of trophic factors and of renin–angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...
Articles
Lodi C.W. Roksnoer, Richard van Veghel, Marian C. Clahsen- van Groningen, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Jeanette M.G. van Gool, Edith C.H. Friesema, Frank P.J. Leijten, Ewout J. Hoorn, A.H. Jan Danser, Wendy W. Batenburg
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1209–1220.
Published: 01 June 2016
... hypertension neprilysin inhibition renin–angiotensin system • Dual angiotensin II type 1 (AT 1 ) receptor–neprilysin inhibition (ARNI) exerts beneficial effects on blood pressure and kidney function in heart failure, compared with AT 1 receptor blockade (ARB) alone. We hypothesized that ARNI...
Includes: Supplementary data
Articles
Nadine Reichhart, Nadine Haase, Sergio Crespo-Garcia, Sergej Skosyrski, Christina Herrspiegel, Norbert Kociok, Rudolf Fuchshofer, Andrea Dillinger, Marco Poglitsch, Dominik N. Müller, Antonia M. Joussen, Friedrich C. Luft, Ralf Dechend, Olaf Strauß
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1075–1088.
Published: 23 May 2016
... (renin–angiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...
Includes: Supplementary data
Articles
Helena Pulido-Olmo, Concha F. García-Prieto, Gloria Álvarez-Llamas, María G. Barderas, Fernando Vivanco, Isabel Aranguez, Beatriz Somoza, Julián Segura, Reinhold Kreutz, María S. Fernández-Alfonso, Luis M. Ruilope, Gema Ruiz-Hurtado
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... of the renin–angiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal diseases...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 221–238.
Published: 14 January 2016
... literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical...
Articles
María Gabriela Morales, Hugo Olguín, Gabriella Di Capua, Enrique Brandan, Felipe Simon, Claudio Cabello-Verrugio
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... that angiotensin-(1–7) is a novel peptide that prevents the skeletal muscle atrophy observed in a model of sepsis by inhibiting the catabolic response developed in skeletal muscle and improving its performance. angiotensin-(1–7) lipopolysaccharide Mas receptor renin–angiotensin system sepsis syndrome...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The renin–angiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...
Articles
Esko Kankuri, Elina E. Mervaala, Markus Storvik, Aija M.J. Ahola, Jouko Levijoki, Dominik N. Müller, Piet Finckenberg, Eero M. Mervaala
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
... type 2 receptor (AT 2 R) heart failure renin–angiotensin system CHF (chronic heart failure) is the end result of various insults to the myocardium, the most common of which is ischaemic heart disease [ 1 ]. Whenever cardiac output falls, more than momentarily, compensatory mechanisms...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
... protein kinase (AMPK) angiotensin-(1–7) renin–angiotensin system SIRT1 • Recent work has provided evidence that enhancing ACE2 levels is able to reverse cardiac and renal pathologies in vivo and, in particular, may be a viable therapeutic option for ARDS. • In the present study, we...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (1): 31–39.
Published: 30 August 2013
... in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the renin–angiotensin system...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (9): 433–438.
Published: 27 June 2013
... both significantly decreased serum insulin levels, and non-additively elevated blood glucose levels. In conclusion, the present study suggests that a local pancreatic RAS (renin–angiotensin system), sensitive to acute administration of telmisartan and ramipril, controls pancreatic IBF and insulin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
... [ 17 ]. Other mechanisms include the RAS (renin–angiotensin system). We found that blockade of the RAS with enalapril, an ACEI (ACE inhibitor), reduces blood pressure in both males and females and removes the sex difference [ 39 ]. In addition, we found that treatment with ovariectomized females...
Articles
Jiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang, Xiao-Ping Yang
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... receptor B 2 kinin receptor heart failure inflammation myocardial infarction renin–angiotensin system • CVD is the leading cause of death in the U.S.A. and worldwide. Activation of the RAS plays a crucial role in the pathophysiology of CVD and up until now the standard therapy has been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
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