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Keywords: renin—angiotensin system
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1145–1150.
Published: 09 August 2023
... 05 07 2023 07 07 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway Polycystic kidney disease renin-angiotensin system Autosomal-dominant polycystic kidney disease (ADPKD) is a form of PKD, which...
Articles
Brian C. Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jennifer Charlton, Agnes B. Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 35–45.
Published: 05 January 2023
... physiology renin-angiotensin system Polycystic kidney disease (PKD) is a major cause of end-stage kidney disease [ 1 ]. PKD is characterized by enlarged kidneys containing numerous fluid-filled cysts, hypertension, anemia, and progressive loss of kidney function. PKD is either autosomal dominant...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
Published: 18 August 2022
... understood, some systems appear to play major roles in its development. This review aims to update the current knowledge on the interaction of the intrarenal renin–angiotensin system (RAS) and dopaminergic system in the development of hypertension, focusing on recent scientific hallmarks in the field...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 799–802.
Published: 27 May 2022
... the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge. Since the present manuscript was published newer AT 2 R-selective peptide...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... renin–angiotensin system RVLM rostral ventrolateral medulla SD Sprague-Dawley SHR spontaneously hypertensive rats SNS sympathetic nervous system TPR total peripheral resistance References 1. Schmieder R.E. , Hilgers K.F. , Schlaich M.P...
Articles
Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2377–2391.
Published: 19 October 2021
... analyses. The heart and soleus were removed, and right and left tibia and femur were excised for isolation of BM. Angiotensin I-converting enzyme (ACE) plays a central role in the renin–angiotensin system (RAS). ACE cleaves angiotensin (Ang) I to produce Ang II, the main effector peptide...
Includes: Supplementary data
Articles
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
... is poorly understood. Angiotensin II (Ang II), the main effector of the renin–angiotensin system, increases arterial pressure and activates components of the inflammatory cascade, which promotes HT, endothelial dysfunction, and vascular damage [ 6 , 7 ]. Both IL-1α and IL-1β are potent proinflammatory...
Articles
Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
... 11 2020 23 03 2021 29 03 2021 30 03 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 angiotensin converting enzyme 2 Blood pressure hypertension immunsystem renin-angiotensin system Cardiovascular...
Includes: Supplementary data
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
,
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
...Xi Cao; Li-Ni Song; Jin-Kui Yang The renin–angiotensin system (RAS) has currently attracted increasing attention due to its potential function in regulating energy homeostasis, other than the actions on cellular growth, blood pressure, fluid, and electrolyte balance. The existence of RAS is well...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... agreement with CAUL. blood pressure placenta pregnancy renal physiology renin-angiotensin system Aberrant IRAP regulation has been implicated in pregnancy complications such as preterm birth and preeclampsia. Reduced serum IRAP activity has been reported in women who experienced...
Includes: Supplementary data
Articles
Milene Tavares Fontes, Suliana Mesquita Paula, Caroline Antunes Lino, Nathalia Senger, Gisele Kruger Couto, Maria Luiza de Morais Barreto-Chaves, José Geraldo Mill, Luciana Venturini Rossoni
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Published: 09 December 2020
... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin–angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key...
Articles
Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 COVID-19 renin-angiotensin system SARS-CoV-2 Angiotensin‐converting enzyme II (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme (ACE) that was first identified 20 years ago [ 1 , 2 ]. ACE2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2535–2547.
Published: 05 October 2020
...Mazher Mohammed; Clara Berdasco; Eric Lazartigues The brain renin–angiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
...-7) thereby counterbalancing the action of ACE on the renin–angiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... (CV) system. The apelin pathway’s dominant physiological role has delineated therapeutic implications for coronary artery disease, heart failure (HF), aortic aneurysm, pulmonary arterial hypertension (PAH), and transplant vasculopathy. Apelin peptides interact with the renin–angiotensin system (RAS...
Articles
Karina Pereira Gomes, Pedro Paulo Pereira Braga, Claudio Quintino de Lima, Jr, Poliana Peres Ghazale, Gustavo Rodrigues Pedrino, Elizabeth Pereira Mendes, Aline Priscila Pansani, Carlos Henrique Xavier, Carlos Henrique Castro, Diego Basile Colugnati
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2263–2277.
Published: 03 September 2020
... type of epilepsy and is often refractory to pharmacological treatment. In this scenario, extensive research has identified components of the renin–angiotensin system (RAS) as potential therapeutic targets. Therefore, the aim of the present study was to evaluate the effects of long-term treatment...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... homeostasis hypertension nephrology renin-angiotensin system vasculature Renin-expressing cells are fundamental for the maintenance of extracellular fluid volume, and blood pressure homeostasis. Through evolution, these cells have acquired additional roles in kidney vascular development...
Includes: Supplementary data
Articles
In Collection
Coronavirus
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
... to this, ACE inhibitors significantly improved life expectancy in a time-dependent manner [ 18 ]. However, in humans with a severe phenotype this still means that ESKD is reached at a relatively young age. chronic kidney disease renal glomerulus renin-angiotensin system SGLT2 inhibitors...
Articles
Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle renin–angiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62...
Includes: Supplementary data
Articles
Fernando Pedro de Souza-Neto, Mario de Morais e Silva, Melissa de Carvalho Santuchi, Thaís Cristina de Alcântara-Leonídio, Daisy Motta-Santos, Aline Cristina Oliveira, Marcos Barrouin Melo, Giovanni Naves Canta, Leandro Eziquiel de Souza, Maria Cláudia Costa Irigoyen, Maria José Campagnole-Santos, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silva
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (5): 629–643.
Published: 01 March 2019
...; Silvia Guatimosim; Robson Augusto Souza Santos; Rafaela Fernandes da Silva Aims: The renin–angiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala 1 -angiotensin-(1-7)) is a new...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... a key role in blood pressure control by tightly regulating the net balance of salt in the body [ 1 ]. aldosterone intercalated cells renin-angiotensin system renal physiology Figure 1 Mechanism of ENaC regulation by aldosterone Abbreviation: Aldo, aldosterone. In cortical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people with diabetes [ 1 ]. Reduction in blood pressure lowers cardiovascular risk [ 2 ]. As high dietary...
Includes: Supplementary data
Articles
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R.A. Silva-Alves, Leônidas G. Mendes-Júnior, Drielle D. Guimarães, Josiane C. Cruz, Thyago M. Queiroz, Camille M. Balarini, Valdir A. Braga, Catalin M. Filipeanu, Eric Lazartigues, Maria do Socorro de França-Silva
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... Limited on behalf of the Biochemical Society 2018 ADAM17 ACE2 Biased agonist hypertension renin-angiotensin system Arterial hypertension is an important health problem worldwide of difficult treatment due to the complexity of its underlying mechanisms. Diverse endogenous molecules...
Articles
Eliete Dalla Corte Frantz, Eliza Prodel, Igor Dutra Braz, Isabele Gomes Giori, Thereza Cristina Lonzetti Bargut, D’Angelo Carlo Magliano, Antonio Claudio Lucas Nobrega
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1487–1507.
Published: 23 July 2018
... Limited on behalf of the Biochemical Society 2018 exercise training renin-angiotensin system sarcopenic obesity skeletal muscle white adipose tissue Overweight and obesity are major global health problems, affecting approximately 39% of the world’s adult population. The World Health...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
A. Augusto Peluso, Jesper Bork Bertelsen, Kenneth Andersen, Tenna Pavia Mortsensen, Pernille B. Hansen, Colin Sumners, Michael Bader, Robson A. Santos, Ulrike Muscha Steckelings
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 777–790.
Published: 06 April 2018
... AT2-receptor endothelial nitric oxide synthase protein phosphatases renin-angiotensin system Angiotensin II (Ang II) exerts its actions through two main receptors, the Ang II type 1 receptor (AT 1 R) and the Ang II type 2 receptor (AT 2 R) [ 1 ]. These two receptors mediate opposing effects...
Articles
Paul-Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... concentrations on CYP11B2, do not support the contention that the protective arm of renin–angiotensin system (RAS) blunts aldosterone synthase in the normal adrenal cortex and primary aldosteronism. In NCI-H295R and HAC15, cells the relative expression levels of aldosterone synthase ( CYP11B2 ), cortisol...
Includes: Supplementary data
Articles
Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... studied relationships between salt intake, BP and renin–angiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...
Includes: Supplementary data
Articles
Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
..., by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS). Ercc1 Δ/− mice...
Includes: Supplementary data
Articles
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... of trophic factors and of renin–angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...
Articles
Lodi C.W. Roksnoer, Richard van Veghel, Marian C. Clahsen- van Groningen, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Jeanette M.G. van Gool, Edith C.H. Friesema, Frank P.J. Leijten, Ewout J. Hoorn, A.H. Jan Danser, Wendy W. Batenburg
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1209–1220.
Published: 01 June 2016
... hypoxanthine phosphoribosyltransferase-1, β 2 -microglobulin and β-actin for normalization. AT 1 receptor antagonist diabetes hypertension neprilysin inhibition renin–angiotensin system • Dual angiotensin II type 1 (AT 1 ) receptor–neprilysin inhibition (ARNI) exerts beneficial effects...
Includes: Supplementary data
Articles
Nadine Reichhart, Nadine Haase, Sergio Crespo-Garcia, Sergej Skosyrski, Christina Herrspiegel, Norbert Kociok, Rudolf Fuchshofer, Andrea Dillinger, Marco Poglitsch, Dominik N. Müller, Antonia M. Joussen, Friedrich C. Luft, Ralf Dechend, Olaf Strauß
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1075–1088.
Published: 23 May 2016
... (renin–angiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...
Includes: Supplementary data
Articles
Helena Pulido-Olmo, Concha F. García-Prieto, Gloria Álvarez-Llamas, María G. Barderas, Fernando Vivanco, Isabel Aranguez, Beatriz Somoza, Julián Segura, Reinhold Kreutz, María S. Fernández-Alfonso, Luis M. Ruilope, Gema Ruiz-Hurtado
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... of the renin–angiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal diseases...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 221–238.
Published: 14 January 2016
... literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical...
Articles
María Gabriela Morales, Hugo Olguín, Gabriella Di Capua, Enrique Brandan, Felipe Simon, Claudio Cabello-Verrugio
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
.... angiotensin-(1–7) lipopolysaccharide Mas receptor renin–angiotensin system sepsis syndrome skeletal muscle atrophy • During sepsis syndrome induced by endotoxaemia, loss of strength and muscle mass occur, resulting in a pathological condition called skeletal muscle atrophy. The RAS (renin...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The renin–angiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...
Articles
Esko Kankuri, Elina E. Mervaala, Markus Storvik, Aija M.J. Ahola, Jouko Levijoki, Dominik N. Müller, Piet Finckenberg, Eero M. Mervaala
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
... type 2 receptor (AT 2 R) heart failure renin–angiotensin system CHF (chronic heart failure) is the end result of various insults to the myocardium, the most common of which is ischaemic heart disease [ 1 ]. Whenever cardiac output falls, more than momentarily, compensatory mechanisms...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...) AMP-activated protein kinase (AMPK) angiotensin-(1–7) renin–angiotensin system SIRT1 • Recent work has provided evidence that enhancing ACE2 levels is able to reverse cardiac and renal pathologies in vivo and, in particular, may be a viable therapeutic option for ARDS...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (1): 31–39.
Published: 30 August 2013
... in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the renin–angiotensin system...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (9): 433–438.
Published: 27 June 2013
... both significantly decreased serum insulin levels, and non-additively elevated blood glucose levels. In conclusion, the present study suggests that a local pancreatic RAS (renin–angiotensin system), sensitive to acute administration of telmisartan and ramipril, controls pancreatic IBF and insulin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
.... In addition, the fact that renal denervation failed to reduce the blood pressure to normotensive levels suggests that there are other mechanisms responsible for the hypertension in male and female SHRs. Other mechanisms include the RAS (renin–angiotensin system). We found that blockade of the RAS...
Articles
Jiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang, Xiao-Ping Yang
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction renin–angiotensin system • CVD is the leading cause of death in the U.S.A. and worldwide. Activation of the RAS plays a crucial role in the pathophysiology of CVD and up until now...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
... 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II type 1 receptor blocker (ARB) brain inflammation neuronal injury renin–angiotensin system ARBs {AT 1 [AngII (angiotensin II) type 1] receptor blockers} have significant potential...
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