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Keywords: renin inhibition
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Articles
The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes
Available to PurchaseCarmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N. Muller, Massimo Volpe
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (4): 183–189.
Published: 01 May 2013
... and similarly reduced by both drugs. In conclusion, equieffective hypotensive doses of aliskiren or ramipril reduced the M/L ratio of mesenteric arteries and improved oxidative stress in dTGR. However, only aliskiren increased further NO production in the vasculature. Hence, in dTGR, direct renin inhibition...
