... direct approaches. Thus, the effects of parathyroid hormone on renin secretion were investigated in two other renal preparations: isolated rabbit glomeruli and isolated rat juxtaglomerular cells. 3. In the isolated kidney, rat parathyroid hormone significantly stimulated renin accumulation...

... of inactive renin does occur. During propranolol treatment there is a tendency for secretion of active renin to be reduced. © 1978 The Biochemical Society and the Medical Research Society 1978 essential hypertension human kidney renin secretion Clinical Science and Molecular Medicine (1978...

...J. L. Imbs; M. Schmidt; J. Velly; J. Schwartz 1. The effects of two groups of diuretics on renin secretion have been compared in dogs anaesthetized with pentobarbital. 2. Frusemide, ethacrynic acid and bumetanide cause an immediate rise in renin secretion which is not inhibited either by dl...

... Research Society 1976 hypoplastic kidney renal ischaemia renin secretion renovascular hypertension Clinical Science and Molecular Medicine (1 976) 51, 235s-237s. Diazoxide-induced stimulation of renin release in renal vein renin sampling J. R. STOCKIGT, E. J. H I G G S A N D N. S A C H A R I...

...R. Vandongen; Dianne M. Greenwood 1. The effect of diazoxide (17·3 μmol min —1 g —1 ) and frusemide (0·12 μmol min —1 g —1 ) on renin secretion was examined in the isolated perfused rat kidney. These substances are potential renal vasodilators with opposite effects on urine sodium excretion. 2...

..., arterial pressure and heart rate and blocked the renin secretory and blood pressure responses to carotid occlusion. 3. These results support the hypothesis that the suppression of renin secretion by clonidine is a consequence of the decrease in sympathetic activity produced by this drug. carotid...

...R. Vandongen; Dianne M. Greenwood 1. The effect of adrenaline and noradrenaline on renin secretion in the isolated perfused rat kidney was examined. The doses of catecholamines used were such that renal vasoconstriction and therefore increases in renal perfusion pressure were avoided. Under...

...R. Vandongen 1. The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. 2. Intrarenal infusion of ADH effectively prevented stimulation of renin secretion by isoprenaline whilst...

...R. Vandongen; W. S. Peart 1. The respective role of alpha-adrenergic and beta-adrenergic receptors in mediating the effect of catecholamines on renin secretion was examined in the isolated perfused rat kidney. 2. Noradrenaline, which has combined alpha- and beta-adrenergic activity, stimulated...

... substrate occurred in animals receiving the high cholesterol diet. 4. Kinetic studies excluded the mediation of enzyme inhibitors in this response and made probable a true suppression of renin secretion. 5. Commonly recognized influences seemed not to account for the findings and the possibility is raised...

... PROPRANOLOL ON RENIN SECRETION STIMULATED BY ORTHOSTATIC STRESS J. A. TOBERT, J . D. H. SLATER, F. FOGELMAN, S . L. LIGHTMAN, A. B. K U R T Z AND N. N . P A Y N E The Institute of Clinical Research, The Middlesex Hospital, London (Received 26 September 1972) SUMMARY 1. The time-course of the rise in plasma...