1-50 of 92
Keyword: renin-angiotensin system
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle reninangiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62% by...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (5): 629–643.
Published: 01 March 2019
...; Silvia Guatimosim; Robson Augusto Souza Santos; Robson Augusto Souza Santos; Rafaela Fernandes da Silva Aims: The reninangiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala 1...
Articles
Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... regulation of renal RAS may need further evaluation. In clinical studies, urinary angiotensinogen levels are shown to be significantly correlated with albuminuria in patients with hypertension [ 24 ] and CKD [ 25–27 ]. These findings indicate that the regulation of the reninangiotensin system in the kidney...
Articles
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people with diabetes [ 1 ]. Reduction in blood pressure lowers cardiovascular risk [ 2 ]. As high dietary...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... 17898124 11 Coble J.P. , Grobe J.L. , Johnson A.K. and Sigmund C.D. ( 2015 ) Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ . Am. J. Physiol. Regul. Integr. Comp. Physiol. 308 , R238 – R249 10.1152...
Articles
Clin Sci (Lond) (2018) 132 (14): 1487–1507.
Published: 23 July 2018
... on behalf of the Biochemical Society 2018 exercise training renin-angiotensin system sarcopenic obesity skeletal muscle white adipose tissue Overweight and obesity are major global health problems, affecting approximately 39% of the world’s adult population. The World Health...
Articles
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The reninangiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
Clin Sci (Lond) (2018) 132 (7): 777–790.
Published: 06 April 2018
... Biochemical Society 2018 AT2-receptor endothelial nitric oxide synthase protein phosphatases renin-angiotensin system Angiotensin II (Ang II) exerts its actions through two main receptors, the Ang II type 1 receptor (AT 1 R) and the Ang II type 2 receptor (AT 2 R) [ 1 ]. These two receptors...
Articles
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... concentrations on CYP11B2, do not support the contention that the protective arm of reninangiotensin system (RAS) blunts aldosterone synthase in the normal adrenal cortex and primary aldosteronism. Correspondence: Gian Paolo Rossi ( gianpaolo.rossi@unipd.it ) 07 12 2017 03 02 2018 04 02...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... studied relationships between salt intake, BP and reninangiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
... dysfunction, by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... trophic factors and of reninangiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...
Articles
Clin Sci (Lond) (2016) 130 (14): 1209–1220.
Published: 01 June 2016
... 2015 18 4 2016 18 4 2016 19 4 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 AT 1 receptor antagonist diabetes hypertension neprilysin inhibition reninangiotensin system • Dual angiotensin II type 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1075–1088.
Published: 23 May 2016
... (reninangiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... of the reninangiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 221–238.
Published: 14 January 2016
... literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical...
Articles
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... that angiotensin-(1–7) is a novel peptide that prevents the skeletal muscle atrophy observed in a model of sepsis by inhibiting the catabolic response developed in skeletal muscle and improving its performance. angiotensin-(1–7) lipopolysaccharide Mas receptor reninangiotensin system sepsis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The reninangiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...
Articles
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the reninangiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (reninangiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and...
Articles
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
... type 2 receptor (AT 2 R) heart failure reninangiotensin system CHF (chronic heart failure) is the end result of various insults to the myocardium, the most common of which is ischaemic heart disease [ 1 ]. Whenever cardiac output falls, more than momentarily, compensatory mechanisms are...
Articles
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
... which levels of ACE2 are regulated by conditions of cell stress such as hypoxia and cytokine treatment. angiotensin-converting enzyme (ACE) angiotensin-converting enzyme 2 (ACE2) AMP-activated protein kinase (AMPK) angiotensin-(1–7) reninangiotensin system SIRT1 • Recent work has...
Articles
Clin Sci (Lond) (2014) 126 (1): 31–39.
Published: 30 August 2013
... relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the reninangiotensin system and...
Articles
Clin Sci (Lond) (2013) 125 (9): 433–438.
Published: 27 June 2013
... and ramipril both significantly decreased serum insulin levels, and non-additively elevated blood glucose levels. In conclusion, the present study suggests that a local pancreatic RAS (reninangiotensin system), sensitive to acute administration of telmisartan and ramipril, controls pancreatic IBF and...
Articles
Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
... Society 2013 androgen endothelin menopause obesity oestrogen reninangiotensin system sympathetic nervous system The roles played by sex and gender in controlling blood pressure have not been completely elucidated, and studies have shown that these mechanisms are not as easily...
Articles
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... 7 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin II type 2 receptor (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction reninangiotensin system • CVD is the leading cause of death...
Articles
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (reninangiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Articles
Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
... 14 5 2012 15 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II type 1 receptor blocker (ARB) brain inflammation neuronal injury reninangiotensin system ARBs {AT 1 [AngII (angiotensin II) type 1] receptor blockers} have significant...
Articles
Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
... diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (reninangiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed...
Articles
Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
.... In the present study, we examine the effect of ACE2 deficiency on the early cardiac and vascular changes associated with experimental diabetes. Streptozotocin diabetes was induced in male C57BL6 mice and Ace2 -KO (knockout) mice, and markers of RAS (reninangiotensin system) activity, cardiac...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
... become increasingly recognized. COPD (chronic obstructive pulmonary disease) is characterized by pathological inflammatory processes involving the lung parenchyma, airways and vascular bed. The aim of the present review is to outline the role of the RAS (reninangiotensin system) in the pathogenesis of...
Articles
Clin Sci (Lond) (2012) 123 (5): 273–284.
Published: 16 May 2012
...Rajesh Kumar; Candice M. Thomas; Qian Chen Yong; Wen Chen; Kenneth M. Baker The RAS (reninangiotensin system) is one of the earliest and most extensively studied hormonal systems. The RAS is an atypical hormonal system in several ways. The major bioactive peptide of the system, AngII (angiotensin...
Articles
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
...Matej Durik; Bruno Sevá Pessôa; Anton J. M. Roks Modulation of the RAS (reninangiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical view...
Articles
Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (reninangiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...
Articles
Clin Sci (Lond) (2012) 123 (4): 193–203.
Published: 20 April 2012
...Masatsugu Horiuchi; Jun Iwanami; Masaki Mogi The RAS (reninangiotensin system) plays a role not only in the cardiovascular system, including blood pressure regulation, but also in the central nervous system. AngII (angiotensin II) binds two major receptors: the AT 1 receptor (AngII type 1 receptor...
Articles
Clin Sci (Lond) (2011) 120 (8): 335–345.
Published: 22 December 2010
... cited. angiotensin peptide cardiac fibrosis kidney failure renal mass reduction reninangiotensin system Activation of the RAS (reninangiotensin system) and generation of Ang (angiotensin) II is pivotal for the development and progression of renal disease [ 1 ]. Current treatment...
Articles
Clin Sci (Lond) (2010) 119 (11): 477–482.
Published: 17 August 2010
...Marilia G.A.G. Pereira; Christiane Becari; José A.C. Oliveira; Maria Cristina O. Salgado; Norberto Garcia-Cairasco; Claudio M. Costa-Neto The RAS (reninangiotensin system) is classically involved in BP (blood pressure) regulation and water–electrolyte balance, and in the central nervous system it...
Articles
Clin Sci (Lond) (2010) 118 (4): 231–240.
Published: 09 November 2009
... remodelling reninangiotensin system The MS (metabolic syndrome) represents a constellation of several established and emerging risk factors in which insulin resistance may be recognized as a common pathophysiological background [ 1 ]. A universal definition of the MS does not exist; however, the two...
Articles
Clin Sci (Lond) (2009) 117 (11): 375–386.
Published: 14 September 2009
... (email johnlubel@me.com ). 15 12 2008 16 3 2009 16 4 2009 16 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiotensin-(1–7) angiotensin-converting enzyme cirrhosis hepatic fibrosis reninangiotensin system Ang-(1–7) (angiotensin 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2009) 116 (2): 125–136.
Published: 15 December 2008
... rats. Among the changes, up-regulation of members of the RAS (reninangiotensin system) was detected, with possible implications for vasocompensative mechanisms induced by arteriotomy. In particular, a selective increase in the 69 kDa isoform of the N-domain of ACE (angiotensin-converting enzyme), and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 111 (3): 217–224.
Published: 15 August 2006
... days significantly increased mean arterial pressure ( P <0.05), without pulmonary hypertension, lung remodelling or a change in AT1 receptor expression. We conclude that there is a modification of the pulmonary reninangiotensin system in CHF, with increased Ang II levels and AT1 receptor expression...
Articles
Clin Sci (Lond) (2004) 107 (2): 145–147.
Published: 27 July 2004
... not fall. The first attempts to actively immunize against components of the reninangiotensin system were performed by Goldblatt in the 1950s. In our experience, active immunization against renin was associated with a complete inhibition of endogeneous plasma renin activity and a decrease in blood...
Articles
Clin Sci (Lond) (1997) 92 (5): 455–465.
Published: 01 May 1997
...Martin P. Kelly; OLE Kahr; Christian Aalkjaer; Frederic Cumin; Nilesh J Samani 1. It has been suggested that local tissue reninangiotensin systems may be activated in heart failure and that effects on such systems may, at least partially, explain the beneficial effects of angiotensin-converting...
Articles
Clin Sci (Lond) (1995) 88 (1): 81–86.
Published: 01 January 1995
...—aldosterone system. 5 8 1994 11 8 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 atrial natriuretic peptide brain natriuretic peptide reninangiotensin system Clinical Science (1995) 88, 81-86 (Printed in Great Britain) Comparative effects of atrial...
Articles
Clin Sci (Lond) (1994) 86 (3): 233–237.
Published: 01 March 1994
...Hans Herlitz; Olof Jonsson; Bengt-Åke Bengtsson 1. The effect of treatment with recombinant human growth hormone on urinary sodium excretion, total body water, the renin-angiotensin system and erythrocyte sodium metabolism was investigated in 16 adults with growth hormone deficiency. 2. Total body...
Articles
Clin Sci (Lond) (1994) 86 (1): 1–9.
Published: 01 January 1994
...Nigel D.C. Sturrock; A.D. Struthers © 1994 The Biochemical Society and the Medical Research Society 1994 calcium cyclosporin hypertension nephrotoxicity prostaglandins renin-angiotensin system sodium Clinical Science (1994) 86, 1-9 (Printed in Great Britain) I Editorial Review...
Articles
Clin Sci (Lond) (1993) 85 (6): 661–670.
Published: 01 December 1993
...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...
Articles
Clin Sci (Lond) (1993) 85 (5): 643–649.
Published: 01 November 1993
...-angiotensin system Clinical Science (1993) lb, 6 4 3 4 9 (Printed in Great Britain) 643 Extracellular volume expansion inhibits antidiuretic hormone increase during positive enkxpiratory pressure in conscious dogs Gabriele KACZMARCZYK, Dinah JORRES, Rolf ROSSAINT, Martin KREBS, Volker UNGER and Konrad...
Articles
Clin Sci (Lond) (1993) 85 (4): 431–436.
Published: 01 October 1993
... Medical Research Society 1993 angiotensin II insulin resistance renin-angiotensin system Clinical Science (1993) US, 431436 (Printed in Great Britain) 43 I Effects of angiotensin I I on insulin sensitivity: a placebo-controlled study A. D. MORRIS, J. R. PETRIEI, J. ANDERSON2, J. M. C. CONNELL...
Articles
Clin Sci (Lond) (1993) 84 (1): 41–45.
Published: 01 January 1993
... 30 min after two different blood pressure-lowering procedures (enalaprilat or dihydralazine intravenously). 2. In one group of patients ( n = 10) blood pressure reduction by 7.5 mg of dihydralazine caused stimulation of the renin-angiotensin system and increased heart rate ( P < 0.01) as well as...