... ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage. 2 2 2016 26 5 2016 13 6 2016 14 6 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 Stroke...

... ischaemic preconditioning platelets reperfusion PCI (percutaneous coronary intervention) has been widely performed in the management of coronary atherosclerosis, and has been shown to elicit an inflammatory response by activation of platelets and leucocytes [ 1 ]. Numerous inflammatory factors...

...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...

... endothelial proliferation and suppress tumour growth. However, to date, little is known about the pathophysiology of endostatin in ischaemia/reperfusion. To investigate the mechanisms of angiogenesis induced by myocardial ischaemia/reperfusion in more detail, we studied the circulating levels of endostatin...

... on cardiac function during reperfusion following prolonged hypothermic cardioplegic arrest in a protocol mimicking cardiac transplantation. Isolated working rat hearts were perfused with Krebs buffer to which increasing concentrations of ET-1 or sarafotoxin S6c had been added. Identical experiments were...

... in ischaemia/reperfusion-induced renal injury was investigated. Since NCX1 -/- homozygous mice die of heart failure before birth, we utilized NCX1 +/- heterozygous mice. The ischaemia/reperfusion-induced renal dysfunction in heterozygous mice were significantly attenuated compared with cases in wild-type mice...

... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...

...Jin-Gang ZHANG; Sudip GHOSH; Colin D. OCKLEFORD; Manuel GALIÑANES The mechanisms underlying myocardial ischaemia and reperfusion-induced injury have been investigated, mainly by using animal experimental preparations in vitro and in vivo , but little is known of the process in human myocardium...

... in closed-chest sheep by catheter delivery of thrombogenic coils, and compare this with a newly described open-artery model of cardiac injury in sheep. Sham controls were compared with animals subjected to (a) 90 min of coronary artery occlusion/reperfusion by PTCA (percutaneous transluminal coronary...

.... The antioxidant capacity of plasma decreased significantly on reperfusion of the donor liver ( P < 0.05) during liver transplantation, although levels were not lower in patients than in control subjects. 3. Pre-reperfusion antioxidant capacity correlated negatively with the concentration of lipid peroxidation...

...Rosaire P. Gray; David G. Wickens; David L. H. Patterson; John S. Yudkin 1. Oxygen-derived free radicals have been implicated in reperfusion injury after thrombolytic therapy in acute myocardial infarction. To test the hypothesis that diabetic patients may have increased oxidative stress which may...

...A. M. Dart; R. A. Riemersma 1. Reperfusion of the globally ischaemic isolated rat heart is associated with an enhanced overflow of endogenous noradrenaline (NA) after ischaemic periods of 20, 40 or 60 min but not of 10 min. 2. Reperfusion NA overflow, after 40 min of ischaemia, is suppressed...