... investigated the acute effects of simvastatin on resistance arterial contractile function, evaluating the involvement of NO, Akt and AMPK. Isolated rat mesenteric resistance arteries were mounted on a wire myograph. The effects of incubation (1 and 2 h) with simvastatin (0.1 or 1 μM) on contractile responses...

.... cardiovascular disease diabetes end-stage renal disease endothelium flow-mediated dilatation nitric oxide resistance artery Despite the rapid progress in dialysis treatment, ESRD (end-stage renal disease) patients still die at a markedly accelerated rate, principally from CVD (cardiovascular...

...Michael A. Bennett; Herbert Thurston 1. This study was designed to examine the effect of angiotensin-converting enzyme inhibitors on resistance artery structure and endothelium-dependent relaxation in Goldblatt two-kidney, one-clip hypertensive rats. Four weeks after clipping, hypertensive and sham...

...P. D. Taylor; J. E. Graves; L. Poston 1. There is growing evidence that an impairment in the function of nitric oxide synthase may play a role in the vascular complications of diabetes mellitus. The relaxation of resistance arteries from the mesenteric and hindlimb circulations of streptozotocin...