...Alan W. Stitt; Noemi Lois; Reinhold J. Medina; Peter Adamson; Timothy M. Curtis Diabetic retinopathy remains the most common complication of diabetes mellitus and is a leading cause of visual loss in industrialized nations. The clinicopathology of the diabetic retina has been extensively studied...

... retina Microvascular disease is a common and important consequence of diabetes mellitus that affects many tissues, including the eye. Diabetic eye disease is the commonest complication of diabetes, and remains the main cause of blindness in people of working age [ 1 ]. BP (blood pressure) plays...

... endothelial dysfunction flow-mediated vasodilatation intima-media thickness microvascular disorder retina There is growing evidence that microvascular disease plays a prominent role in the pathogenesis of macrovascular disease and mortality [ 1 – 3 ]. Previous studies have shown that coronary...

... systemic adverse effects and the effect of their intraocular injection is short-lived. Local gene transfer, however, offers the possibility of targeted, sustained and regulatable delivery of angiostatic proteins to the retina after a single procedure to introduce a vector to an intraocular site. The effect...

... the optimum. Retinal arteriolar bifurcation angles did not differ significantly between the groups. Atherosclerosis is associated with abnormalities in the arteriolar network of the retina. In view of the importance of the endothelium in maintaining network co-ordination of branch diameters this is suggestive...

... 28 8 2001 The Biochemical Society and the Medical Research Society © 2001 2001 lipid peroxidation membrane fluidity phytanic acid Refsum disease retina vitamin E. 697Clinical Science (2001) 101, 697 705 (Printed in Great Britain) Effects of phytanic acid on the vitamin E status...

...-related increases in protein kinase C (PKC) activity in the streptozotocin-diabetic rat. PKC activity in the glomeruli, retina and mesenteric artery was increased by 1.5–2-fold after induction of diabetes, and this increase was maintained over 24 weeks. Treatment with insulin at 2 units or 6 units per day...