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Keywords: rheumatoid arthritis
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Articles
Clin Sci (Lond) (2021) 135 (22): 2559–2573.
Published: 26 November 2021
... in, and a clinical target for, the treatment of inflammatory diseases including rheumatoid arthritis (RA). Therapeutic inhibition of GM-CSF signalling using monoclonal antibodies to the α-subunit of the GM-CSF receptor (GMCSFRα) has shown clear benefit in patients with RA, giant cell arteritis (GCAs) and some...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
...Maarten M. Steinz; Estela Santos-Alves; Johanna T. Lanner Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and the presence of serum autoantibodies. In addition, skeletal muscle weakness is a common comorbidity that contributes to inability to work and reduced...
Articles
Clin Sci (Lond) (2020) 134 (3): 331–347.
Published: 04 February 2020
..., China). Pannus is the important reason and basic pathological feature in rheumatoid arthritis (RA) causing joint destruction, and angiogenesis is a critical factor in the development of pannus and is considered to facilitate extravasation of inflammatory leukocytes, thereby further perpetuating...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 253–267.
Published: 25 January 2019
...; and Epstein–Barr virus transformed human lymphoblasts expressing MTHFR polymorphic allele 677C and 677T were used. Disease activity and DMARD use were compared between MTHFR- 677CC, CT and TT rheumatoid arthritis (RA) patients in a cross-sectional study ( n =120). Results: Compared with MTHFR -CC, MTHFR -TT...
Articles
Clin Sci (Lond) (2016) 130 (21): 1889–1899.
Published: 22 September 2016
...Javier Rodríguez-Carrio; Mercedes Alperi-López; Raquel López-Mejías; Patricia López; Francisco J. Ballina-García; Francisco Abal; Miguel Á. González-Gay; Ana Suárez Traditional and non-traditional cardiovascular (CV) risk factors underlie CV disease occurrence in rheumatoid arthritis (RA). Recently...
Articles
Clin Sci (Lond) (2015) 128 (8): 449–464.
Published: 23 December 2014
...Javier Rodríguez-Carrio; Patricia López; Ana Suárez RA (rheumatoid arthritis) is a chronic rheumatic condition hallmarked by joint inflammation and destruction by self-reactive immune responses. Clinical management of RA patients is often hampered by its heterogeneous nature in both clinical...
Articles
Clin Sci (Lond) (2015) 128 (7): 437–448.
Published: 16 December 2014
...Javier Rodríguez-Carrio; Mercedes Alperi-López; Patricia López; Sara Alonso-Castro; Santiago R. Carro-Esteban; Francisco J. Ballina-García; Ana Suárez Microparticles (MPs) could be considered biomarkers of cell damage and activation as well as novel signalling structures. Since rheumatoid arthritis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2007) 113 (3): 149–155.
Published: 02 July 2007
... (rheumatoid arthritis). Trx80, the 10 kDa C-terminal truncated form of Trx, is a potent mitogenic cytokine and is involved in the Th1 response. In the present study, we have investigated the ability of synoviocytes from five RA patients to induce Trx80 after ex vivo stimulation by the pro-inflammatory...
Articles
Clin Sci (Lond) (2005) 109 (2): 135–142.
Published: 25 July 2005
...Cristina Russo; Riccardo Polosa TNF-α (tumour necrosis factor-α) is known to play a critical role in the pathogenic mechanisms of a number of chronic inflammatory diseases, including RA (rheumatoid arthritis), Crohn's disease and psoriasis. The notion that TNF-α is released in allergic responses...
Articles
Clin Sci (Lond) (2004) 107 (3): 291–296.
Published: 24 August 2004
... (interferon-γ) and anti-inflammatory cytokines IL-4 and IL-13, and (ii) NO (nitric oxide) donors on HA (hyaluronic acid) production by synovial cells from patients with rheumatoid arthritis. Synovial cells obtained from five patients with rheumatoid arthritis were incubated for 24 h without or with IL-1β, TNF...
Articles
Clin Sci (Lond) (2004) 106 (3): 293–300.
Published: 01 March 2004
...Masato ISHIZUKA; Masahito HATORI; Takashi SUZUKI; Yasuhiro MIKI; Andrew D. DARNEL; Chika TAZAWA; Takashi SAWAI; Miwa UZUKI; Yasuhisa TANAKA; Shoichi KOKUBUN; Hironobu SASANO Rheumatoid arthritis (RA) is a disease characterized primarily by chronic inflammatory synovitis and is well-known...
Articles
Clin Sci (Lond) (2001) 101 (6): 593–599.
Published: 26 October 2001
...Ilaria MAZZETTI; Brunella GRIGOLO; Lia PULSATELLI; Paolo DOLZANI; Tania SILVESTRI; Livia ROSETI; Riccardo MELICONI; Andrea FACCHINI Osteoarthritis and rheumatoid arthritis are characterized by focal loss of cartilage due to an up-regulation of catabolic pathways, induced mainly by pro-inflammatory...
Articles
Clin Sci (Lond) (2001) 100 (6): 577–589.
Published: 25 April 2001
... process. We examined the expression of urocortin, CRF and their receptors (CRF receptor; CRF-R) in the synovial tissue of patients with rheumatoid arthritis (RA) in order to study the possible biological roles of urocortin. Synovial tissues/fluids were obtained from 38 patients with RA, nine patients...
Articles
Clin Sci (Lond) (1999) 97 (1): 85–89.
Published: 01 June 1999
...P. C. TAYLOR; A. M. PETERS; D. M. GLASS; R. N. MAINI The therapeutic effects of a monoclonal antibody against tumour necrosis factor α (TNFα) were evaluated objectively in 10 patients with rheumatoid arthritis by 111 In-labelled granulocyte imaging before and after treatment, and compared...
Articles
Clin Sci (Lond) (1998) 95 (1): 19–31.
Published: 01 July 1998
... diseases such as rheumatoid arthritis are conventionally thought of as ‘autoimmune'. No convincing candidate autoantigen has yet been identified in rheumatoid arthritis, and recent experiments in transgenic mice indicate that arthritis can be induced by an autoimmune T-cell response which does not target...
Articles
Clin Sci (Lond) (1994) 86 (5): 633–638.
Published: 01 May 1994
... with rheumatoid arthritis. 2. Out of 69 patients, 44 had anaemia with serum haemoglobin concentrations of 10.8 (SD 1.2) g/dl. In these patients erythropoietin levels were significantly higher than in non-anaemic patients [51.97 (SD 23.9) versus 26.06 (SD 11.9) m-units/ml; P < 0.0001; control patients: 18.1 (SD...
Articles
Clin Sci (Lond) (1993) 85 (3): 343–351.
Published: 01 September 1993
... course of examination, from the knee joints of patients attending rheumatology and orthopaedic clinics. Fluid was available from 16 patients with osteoarthritis, 18 patients with rheumatoid arthritis, four patients with meniscal tear and one patient each with systemic lupus erythematosis, mono-arthritis...
Articles
Clin Sci (Lond) (1992) 83 (6): 657–664.
Published: 01 December 1992
... Society 1992 inflammation low-density lipoprotein lipid peroxidation nuclear magnetic resonance rheumatoid arthritis synovial fluid α-tocopherol Clinical Science (1992) 83, 657-664 (Printed in Great Britain) 651 a -Tocopherol, lipids and lipoproteins in kneejoint synovial fluid and serum...
Articles
Clin Sci (Lond) (1991) 80 (4): 385–391.
Published: 01 April 1991
... by granulocytes (polymorphonuclear leucocytes) from normal blood and granulocytes obtained from the blood and synovial fluid of patients with rheumatoid arthritis was studied. 2. Similar rates of superoxide production by granulocytes from normal blood at rest and in the presence of any form of IgG were found...
Articles
Clin Sci (Lond) (1988) 74 (1): 97–99.
Published: 01 January 1988
... in arthritis. 2. We have quantified nucleosides and bases in synovial fluid and plasma by high-performance liquid chromatography in order to examine whether nucleotide metabolism is increased in patients with rheumatoid arthritis and osteoarthritis. 3. At least ten u.v.-absorbing compounds were detected...
Articles
Clin Sci (Lond) (1986) 71 (6): 693–701.
Published: 01 December 1986
...B. Danneskiold-Samsøe; G. Grimby 1. Thirty-five female patients, mean age 63 years, suffering from rheumatoid arthritis participated the study. Twenty patients had been on long-term low-dose corticosteroid treatment. Fifteen patients had never received corticosteroids. A control group of 15 age...
Articles
Clin Sci (Lond) (1986) 71 (6): 685–691.
Published: 01 December 1986
...B. Danneskiold-Samsøe; G. Grimby 1. Abnormal morphological and enzymatic patterns in the lateral vastus muscle have been found in women with corticosteroid treated rheumatoid arthritis. By means of biopsies from the lateral heads of right gastrocnemius muscles, the histology and enzyme activities...
Articles
Clin Sci (Lond) (1985) 69 (6): 727–735.
Published: 01 December 1985
...Robert J. Mairs; Josie A. Beeley 1. Isoelectric focusing of parotid saliva from 33 patients with rheumatoid arthritis but without clinical evidence of salivary gland involvement revealed multiple abnormal proteins of pI 3.95–4.25 in all cases, whereas only two out of 16 samples from normal healthy...
Articles
Clin Sci (Lond) (1985) 68 (3): 333–339.
Published: 01 March 1985
... with rheumatoid arthritis all showed ‘degrading factor activity’ against both AA amyloid fibrils and a non-fibrillar reticulin preparation of normal liver in an agarose plate assay. AL amyloid fibrils were not affected. 2. The ‘degrading activity’ of serum was correlated with the serum albumin concentration...
Articles
Clin Sci (Lond) (1983) 64 (5): 551–553.
Published: 01 May 1983
... that ferroxidase deficiency contributes to radical damage in the rheumatoid joint. 5 11 1982 16 12 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 caeruloplasmin synovial fluid rheumatoid arthritis iron ferroxidase Clinical Science (1983)64.551-553 SHORT...
Articles
Clin Sci (Lond) (1983) 64 (4): 453–454.
Published: 01 April 1983
...C. P. J. Maury; A.M. Teppo; B. Fröseth; O. Wegelius 1. Serum contains amyloid A-degrading activity. This activity is markedly reduced in patients with rheumatoid arthritis (RA) complicated by amyloidosis. α 1 -Antitrypsin inhibits the degradative activity. To test the hypothesis that the activity...
Articles
Clin Sci (Lond) (1982) 62 (1): 71–76.
Published: 01 January 1982
...D. L. Scott; M. Farr; A. P. Crockson; K. W. Walton 1. Plasma fibronectin levels were similar in 60 healthy subjects and 88 with rheumatoid arthritis. 2. In 42 patients with rheumatoid arthritis synovial fluid fibronectin levels were significantly higher than plasma levels ( P < 0.001...
Articles
Clin Sci (Lond) (1981) 61 (4): 483–486.
Published: 01 October 1981
... in inflammatory joint disease. 26 3 1981 1 5 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 ascorbic acid caeruloplasmin catalase hyaluronic acid hydrogen peroxide rheumatoid arthritis superoxide synovial fluid Clinical Science (1981) 61,483486 483...
Articles
Clin Sci Mol Med (1978) 55 (1): 31–40.
Published: 01 July 1978
...-penicillamine in rheumatoid arthritis does not appear to involve a direct effect on the synovial membrane collagen. 16 5 1977 25 11 1977 collagen d-penicillamine rheumatoid arthritis synovial membrane © 1978 The Biochemical Society and the Medical Research Society 1978 Clinical...
Articles
Clin Sci Mol Med (1976) 51 (2): 205–207.
Published: 01 August 1976
...A. C. Kennedy; R. Lindsay; W. W. Buchanan; B. F. Allam 1. Foetal rat hemi-calvaria were incubated in organ culture with sera from patients with active rheumatoid arthritis. 2. Increased 45 Ca resorption was produced by sera from patients who were hypercalcaemic. 3. This bone-resorbing effect could...
Articles
Clin Sci Mol Med (1974) 47 (5): 403–414.
Published: 01 November 1974
... found in granulocytes from blood and it is concluded that the synovial fluid enzyme is probably derived from granulocytes. 3 5 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 cartilage granulocytes protease proteoglycan rheumatoid arthritis synovial fluid...
Articles
Clin Sci (1972) 42 (3): 383–393.
Published: 01 March 1972
...W. C. Dick; K. E. Collins; W. W. Buchanan 1. The uptake of a low dose of intravenously administered 99m Tc over the distal and proximal interphalangeal joints was found to be lower in normal subjects than in patients suffering from rheumatoid arthritis, osteoarthritis and psoriatic arthritis. 2...