... Journal compilation © 2013 Biochemical Society 2013 intracerebral haemorrhage ischaemic stroke risk factor telomere genetics • Inter-individual differences in biological aging could affect susceptibility to stroke, and telomere attrition represents one molecular mechanism...

...Allan D. Sniderman; Patrick R. Lawler; Ken Williams; George Thanassoulis; Jacqueline de Graaf; Curt D. Furberg Primary prevention of cardiovascular disease is governed at present by the risk factor model for cardiovascular events, a model which is widely accepted by physicians and professional...

... Journal compilation © 2012 Biochemical Society 2012 nitric oxide prognosis renal function risk factor symmetric dimethylarginine stroke Dimethylarginines are endogenously occurring structural analogues of the amino acid L -arginine that contain two methyl groups. ADMA (asymmetric...

... receptors) plays an important role in the pathogenesis of atherosclerosis. We hypothesized that cardiovascular risk factors are associated with the activation status of the innate immune system. We therefore assessed the responsiveness of TLRs on circulating cells in two groups of patients with established...

... as circulating or blood-borne TF. Many cardiovascular risk factors, such as hypertension, diabetes, dyslipidaemia and smoking, are associated with increased expression of TF. Furthermore, in patients presenting with acute coronary syndromes, elevated levels of circulating TF are found. Apart from its role...

... 2009 haplotype ischaemic stroke phosphodiesterase 4D gene ( PDE4D ) risk factor single nucleotide polymorphism (SNP) Stroke is a leading cause of death and disability in the world. In China, the incidence and mortality rate resulting from stroke events are higher when compared...

... (ADMA) dimethylarginine dimethylaminohydrolase 2 ( DDAH2 ) intracerebral haemorrhage nitric oxide synthase (NOS) risk factor stroke Stroke is a leading cause of death and disability in China [ 1 ]. The number of patients who die from stroke is three times more than that from CHD (coronary...

... risk for atherothrombotic strokes [OR (odds ratio), 1.51; 95% CI (confidence interval), 1.09–2.10] independent of conventional risk factors. Haplotype analysis confirmed that haplotype G-C-C was associated with increased risk for atherothrombotic stroke (OR, 1.80; 95% CI, 1.300–2.491). Our findings...

...Christopher J. Lockhart; Paul K. Hamilton; Cathy E. Quinn; Gary E. McVeigh Risk factors for cardiovascular disease mediate their effects by altering the structure and function of wall and endothelial components of arterial blood vessels. A pathological change in the microcirculation plays a pivotal...

... with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects. It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high...

...Caroline Watson; Nicholas J. Alp Cardiovascular disease, resulting from atherosclerosis, is a leading cause of global morbidity and mortality. Genetic predisposition and classical environmental risk factors explain much of the attributable risk for cardiovascular events in populations, but other...

... was not associated with classical cardiovascular risk factors (diabetes, hypercholesterolaemia, hypertension, obesity, smoking and C-reactive protein serum levels). No association was found between the CFH -Y402H variant and susceptibility to MI. Separate analyses in both men and women revealed no gender-specific...

... risk factors of the metabolic syndrome by multiple regression analysis after adjusting for age, sex and body mass index ( P <0.001). These results show that the metabolic syndrome is significantly correlated with the insulin resistance index, and that appropriate values of HOMA and fasting insulin...

... with AA carriers, as indicated by a larger decrease in MSD (mean segment diameter; 0.09 mm compared with 0.06 mm respectively; P =0.009) and MOD (minimum obstruction diameter; 0.09 mm compared with 0.05 mm respectively; P =0.024). Inclusion of risk factors for CHD in the model showed the same trend...

... between C3 and some cardiovascular risk factors when jointly analysed with CRP (C-reactive protein) and fibrinogen. In a cohort of 756 unselected adults, 39% of whom had the metabolic syndrome, C3 and other risk variables were evaluated in a cross-sectional manner. In a logistic regression model...

...Anthony S. WIERZBICKI; Philip J. CHOWIENCZYK; John R. COCKCROFT; Sally E. BRETT; Gerald F. WATTS; B. Stephen JENKINS; James M. RITTER Endothelial dysfunction is a feature of atherosclerosis and is associated with CHD (coronary heart disease) risk factors. This study aimed to determine...

... manner. Correspondence: Dr Alexandre Loktionov (e-mail asl@mrc-dunn.cam.ac.uk ). 18 11 2002 9 1 2003 14 1 2003 14 1 2003 The Biochemical Society, London ©2003 2003 apolipoprotein E colorectal cancer gene polymorphism risk factor Clinical Science (2003) 104...